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Original Research

Effects of berberine on lipid profile in subjects with low cardiovascular risk

, MD PhD, , BD, , MD, , MD, , MD & , MD
Pages 475-482 | Published online: 27 Feb 2013

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Adrian V. Hernandez, Jennifer Hwang, Iram Nasreen, Dakota Sicignano, Vinay Pasupuleti, Kimberly Snow-Caroti & C. Michael White. (2023) Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis. Journal of Dietary Supplements 0:0, pages 1-18.
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Song Liu, Xiaojun Cai, Tao Wang, Jiwen Xu, Weilun Cheng, Xuling Wang, Gangjie Wei & Shuang Yan. (2022) Downregulation of ALDH6A1 is a New Marker of Muscle Insulin Resistance in Type 2 Diabetes Mellitus. International Journal of General Medicine 15, pages 2137-2147.
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Giuseppe Derosa, Angela D’Angelo, Arianna Vanelli & Pamela Maffioli. (2020) An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes, Metabolic Syndrome and Obesity 13, pages 653-661.
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Sergio D’Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli & Giuseppe Derosa. (2017) Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study. Drug Design, Development and Therapy 11, pages 1585-1592.
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Sandy Elbitar, Petra El Khoury, Youmna Ghaleb, Jean-Pierre Rabès, Mathilde Varret, Nabil G. Seidah, Catherine Boileau & Marianne Abifadel. (2016) Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015). Expert Opinion on Therapeutic Patents 26:12, pages 1377-1392.
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Giuseppe Derosa & Pamela Maffioli. (2015) Nutraceuticals for the treatment of metabolic diseases: evidence from clinical practice. Expert Review of Endocrinology & Metabolism 10:3, pages 297-304.
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Giuseppe Derosa, Aldo Bonaventura, Lucio Bianchi, Davide Romano, Angela D'Angelo, Elena Fogari & Pamela Maffioli. (2013) Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients. Expert Opinion on Biological Therapy 13:11, pages 1495-1506.
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Paramjit S Tappia, Yan–Jun Xu & Naranjan S Dhalla. (2013) Reduction of cholesterol and other cardiovascular disease risk factors by alternative therapies. Clinical Lipidology 8:3, pages 345-359.
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Articles from other publishers (67)

Jie V. Zhao, Xin Huang, Junmeng Zhang, Yap-Hang Chan, Hung-Fat Tse & Joseph E. Blais. (2023) Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. The Journal of Nutrition 153:10, pages 2939-2950.
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Alfredo Caturano, Margherita D’Angelo, Andrea Mormone, Vincenzo Russo, Maria Pina Mollica, Teresa Salvatore, Raffaele Galiero, Luca Rinaldi, Erica Vetrano, Raffaele Marfella, Marcellino Monda, Antonio Giordano & Ferdinando Carlo Sasso. (2023) Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Current Issues in Molecular Biology 45:8, pages 6651-6666.
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Hao-Jian Zhang, Yan Wang & Jian-Dong Jiang. (2023) Drug-gut Microbiome Interaction in Atherosclerosis Therapeutics. Current Drug Metabolism 24:7, pages 482-492.
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Lianliang Liu, Yueqin Li, Lezhen Dong, Yunzhen Zhang, Zufang Wu & Jianbo Xiao. 2023. Dietary Supplements with Antioxidant Activity. Dietary Supplements with Antioxidant Activity 40 79 .
Lubi Lei, Jingkuo Li & Bin Wang. (2023) Efficacy and Safety Profile of Berberine Treatment in Improving Risk Factors for Cardiovascular Disease: A Systematic Review and Meta-analysis of Randomized, Double-blind Trials. Cardiology Discovery 3:2, pages 112-121.
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Xiaoyu Xuan, Jingyi Zhang, Jilin Fan & Shiliang Zhang. (2023) Research progress of Traditional Chinese Medicine (TCM) in targeting inflammation and lipid metabolism disorder for arteriosclerosis intervention: A review. Medicine 102:18, pages e33748.
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Joseph E. Blais, Xin Huang & Jie V. Zhao. (2023) Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs 83:5, pages 403-427.
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Caroline Bertoncini‐Silva, Jean‐Marc Zingg, Priscila Giacomo Fassini & Vivian Marques Miguel Suen. (2022) Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation. BioFactors 49:2, pages 297-321.
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Mohammad Zamani, Mahtab Zarei, Mahlagha Nikbaf-Shandiz, Shabnam Hosseini, Farideh Shiraseb & Omid Asbaghi. (2022) The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Frontiers in Nutrition 9.
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Ashwani Kumar, Komal, Rakesh Kumar, Ghan Shyam Abrol, Pooja Kumari & P. Nirmal. (2022) A review on the nutritional composition, phytochemicals, and health benefits of barberry: An insight into culinary applications and future prospects. Journal of Food Processing and Preservation 46:10.
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Anlu Wang, Baoyi Guan, Chang Shao, Lin Zhao, Qiuyi Li, Haiping Hao, Zhuye Gao, Keji Chen, Yuanlong Hou & Hao Xu. (2022) Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice. Phytomedicine 103, pages 154220.
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Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan, Jie Fu, Ran Peng, Xian-Feng Zhang, Zhen-Xiong Zhao, Yang Li, Jin-Bo Yu, Lin Cong, Pei Han, Zheng-Wei Zhang, Hang Yu, Yan Wang & Jian-Dong Jiang. (2022) Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. Signal Transduction and Targeted Therapy 7:1.
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Tapan Behl, Sukhbir Singh, Neelam Sharma, Ishrat Zahoor, Ali Albarrati, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi & Simona Bungau. (2022) Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends. Molecules 27:12, pages 3705.
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Dongdong Wang, Jiansheng Huang, Ting Gui, Yaxin Yang, Tingting Feng, Nikolay T. Tzvetkov, Tao Xu, Zhibo Gai, Ying Zhou, Jingjie Zhang & Atanas G. Atanasov. (2022) SR-BI as a target of natural products and its significance in cancer. Seminars in Cancer Biology 80, pages 18-38.
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Smriti Suri, Prasenjit Mitra, Abhilasha Abhilasha, Indu Saxena, Mahendra K. Garg, Gopal Krishna Bohra & Praveen Sharma. (2022) Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus. Journal of Basic and Clinical Physiology and Pharmacology 33:2, pages 185-190.
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Xianzhi Liu, Lifu Wang, Siwei Tan, Zebin Chen, Bin Wu & Xiaoying Wu. (2022) Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. Frontiers in Pharmacology 13.
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MeiYan Chan, Zongshi Qin, Sui‐Cheung Man, Ming Lam, Wing Him Lai, Roger Man Kin Ng, Che Kin Lee, Tak Luen Wong, Edwin Ho Ming Lee, Hei Kiu Wong, Yibin Feng, Lanying Liu, Feng Han, Eric Yu Hai Chen & Zhang‐Jin Zhang. (2022) Adjunctive berberine reduces antipsychotic‐associated weight gain and metabolic syndrome in patients with schizophrenia: a randomized controlled trial . Psychiatry and Clinical Neurosciences 76:3, pages 77-85.
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Richard Y. Cao, Ying Zhang, Zhen Feng, Siyu Liu, Yifan Liu, Hongchao Zheng & Jian Yang. (2021) The Effective Role of Natural Product Berberine in Modulating Oxidative Stress and Inflammation Related Atherosclerosis: Novel Insights Into the Gut-Heart Axis Evidenced by Genetic Sequencing Analysis. Frontiers in Pharmacology 12.
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Narges Hedayati, Zahra Oskouei, Jamshid Tabeshpour & Mehri Bemani Naeini. (2021) Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review. European Journal of Pharmacology 913, pages 174590.
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Lu Xing, Xin Zhou, Ai-Hong Li, Hui-Jin Li, Chun-Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Li Zhu & Hui-Ling Cao. (2021) Atheroprotective Effects and Molecular Mechanism of Berberine. Frontiers in Molecular Biosciences 8.
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Xiao-Fang Yang, Ming Lu, Lijiao You, Huan Gen, Lin Yuan, Tianning Tian, Chun-Yu Li, Kailiang Xu, Jie Hou & Ming Lei. (2021) Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology. Chinese Medicine 16:1.
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Jie V. Zhao, Wai-Fung Yeung, Yap-Hang Chan, Dana Vackova, June Y. Y. Leung, Dennis K. M. Ip, Jiaxi Zhao, Wai-Kwan Ho, Hung-Fat Tse & Catherine Mary Schooling. (2021) Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial. Nutrients 13:8, pages 2550.
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Shengju Wang, Zhang Xu, Baochao Cai & Qiu Chen. (2021) Berberine as a Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine. Endocrine, Metabolic & Immune Disorders - Drug Targets 21:6, pages 971-979.
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Haixia Du, Chang Li, Zhixiong Wang, Yu He, Yu Wang, Huifen Zhou, Haitong Wan & Jiehong Yang. (2021) Effects of Danhong injection on dyslipidemia and cholesterol metabolism in high-fat diets fed rats. Journal of Ethnopharmacology 274, pages 114058.
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Xingxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang, Jiandong Jiang & Bin Hong. (2021) Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. npj Biofilms and Microbiomes 7:1.
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Juan M. León-MartínezEsperanza Martínez-AbundisManuel González-OrtizKarina G. Pérez-Rubio. (2021) Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial. Journal of Medicinal Food 24:2, pages 111-115.
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Xinmei Xu, Huan Yi, Jiasi Wu, Tingting Kuang, Jing Zhang, Qi Li, Huan Du, Tong Xu, Guihua Jiang & Gang Fan. (2021) Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomedicine & Pharmacotherapy 133, pages 110984.
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Giuseppe DerosaAlessandro CollettiPamela MaffioliAngela D’AngeloAlessandro LupiGiovanni B. ZitoGian Francesco MuredduRiccardo RaddinoFrancesco FedeleArrigo F.G. Cicero. (2020) Lipid-lowering nutraceuticals update on scientific evidence. Journal of Cardiovascular Medicine 21:11, pages 845-859.
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T Santhi & K Balu Mahendran. (2020) High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c)in type 2 diabetes patients. International Journal of Clinical Biochemistry and Research 7:1, pages 57-61.
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Mohammad Reza Amini, Fatemeh Sheikhhossein, Sina Naghshi, Farhang Djafari, Mohammadreza Askari, Hossein Shahinfar, Maryam Safabakhsh, Alireza Jafari & Sakineh Shab-Bidar. (2020) Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 49, pages 102337.
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Alireza Fatahian, Saeed Mohammadian Haftcheshmeh, Sara Azhdari, Helaleh Kaboli Farshchi, Banafsheh Nikfar & Amir Abbas Momtazi-Borojeni. 2020. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 83 110 .
Liangzhen Xie, Duojia Zhang, Hongli Ma, Hui He, Qing Xia, Wenjuan Shen, Hui Chang, Yingying Deng, Qi Wu, Jing Cong, Chi Chiu Wang & Xiaoke Wu. (2019) The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-14.
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Nan Zhang, Mingwei Sheng, Man Wu, Xinyue Zhang, Yijie Ding, Yuanbang Lin, Wenli Yu, Shusen Wang & Hongyin Du. (2019) Berberine protects steatotic donor undergoing liver transplantation via inhibiting endoplasmic reticulum stress-mediated reticulophagy. Experimental Biology and Medicine 244:18, pages 1695-1704.
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Xinyu Ji, Shuai Shi, Bin Liu, Mingxu Shan, Danli Tang, Wantong Zhang, Yin Zhang, Lulu Zhang, Huamin Zhang, Cheng Lu & Yongyan Wang. (2019) Bioactive compounds from herbal medicines to manage dyslipidemia. Biomedicine & Pharmacotherapy 118, pages 109338.
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