948
Views
101
CrossRef citations to date
0
Altmetric
Reviews

Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target

, , &
Pages 1149-1160 | Published online: 16 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Mahsa Eskian, MirHojjat Khorasanizadeh, Pier Luigi Zinzani, Tim M. Illidge & Nima Rezaei. (2019) Novel Methods to Improve the Efficiency of Radioimmunotherapy for Non-Hodgkin Lymphoma. International Reviews of Immunology 38:2, pages 79-91.
Read now
Haitao Pan, Jiayu Liu, Wentong Deng, Jieyu Xing, Qing Li & Zhong Wang. (2018) Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy. International Journal of Nanomedicine 13, pages 3189-3201.
Read now
Matthias Vandesquille, Tengfei Li, Chrystelle Po, Christelle Ganneau, Pascal Lenormand, Clémence Dudeffant, Christian Czech, Fiona Grueninger, Charles Duyckaerts, Benoît Delatour, Marc Dhenain, Pierre Lafaye & Sylvie Bay. (2017) Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease. mAbs 9:6, pages 1016-1027.
Read now
Sam Massa, Catarina Xavier, Serge Muyldermans & Nick Devoogdt. (2016) Emerging site-specific bioconjugation strategies for radioimmunotracer development. Expert Opinion on Drug Delivery 13:8, pages 1149-1163.
Read now
Yana Dekempeneer, Marleen Keyaerts, Ahmet Krasniqi, Janik Puttemans, Serge Muyldermans, Tony Lahoutte, Matthias D’huyvetter & Nick Devoogdt. (2016) Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle. Expert Opinion on Biological Therapy 16:8, pages 1035-1047.
Read now
Kendrick B. Turner, Nathan J. Alves, Igor L. Medintz & Scott A. Walper. (2016) Improving the targeting of therapeutics with single-domain antibodies. Expert Opinion on Drug Delivery 13:4, pages 561-570.
Read now
Matthias D’Huyvetter, Catarina Xavier, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans & Nick Devoogdt. (2014) Radiolabeled nanobodies as theranostic tools in targeted radionuclide therapy of cancer. Expert Opinion on Drug Delivery 11:12, pages 1939-1954.
Read now
Marina Kovaleva, Laura Ferguson, John Steven, Andrew Porter & Caroline Barelle. (2014) Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development. Expert Opinion on Biological Therapy 14:10, pages 1527-1539.
Read now

Articles from other publishers (93)

Noemi B. Declerck, Celine Huygen, Lukasz Mateusiak, Marcus C. M. Stroet & Sophie Hernot. (2023) The GEM-handle as convenient labeling strategy for bimodal single-domain antibody-based tracers carrying 99mTc and a near-infrared fluorescent dye for intra-operative decision-making. Frontiers in Immunology 14.
Crossref
Shulin Li, Sanne Johanna Maria Hoefnagel & Kausilia Krishnawatie Krishnadath. (2023) Single domain Camelid antibody fragments for molecular imaging and therapy of cancer. Frontiers in Oncology 13.
Crossref
Sarah Kunz, Manon Durandy, Laetitia Seguin & Chloe C. Feral. (2023) NANOBODY® Molecule, a Giga Medical Tool in Nanodimensions. International Journal of Molecular Sciences 24:17, pages 13229.
Crossref
Miusi Shi & Kevin J. McHugh. (2023) Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems. Advanced Drug Delivery Reviews 199, pages 114904.
Crossref
Xuemei Feng & Hu Wang. (2023) Emerging Landscape of Nanobodies and Their Neutralizing Applications against SARS-CoV-2 Virus. ACS Pharmacology & Translational Science 6:7, pages 925-942.
Crossref
Javier Narbona, Luisa Hernández-Baraza, Rubén G. Gordo, Laura Sanz & Javier Lacadena. (2023) Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment. Biomolecules 13:7, pages 1042.
Crossref
Chiara Castrignano, Federica Di Scipio, Francesco Franco, Barbara Mognetti & Giovanni Nicolao Berta. (2023) Reviving a Classic Antigen with a Cutting-Edge Approach: Nanobodies for HER2+ Breast Cancer. Pharmaceuticals 16:6, pages 794.
Crossref
Sunanda Singh, Samara P. Singh & Ashutosh S. Parihar. (2023) Application of Nano-Antibodies for Cancer Immunotherapy. Current Tissue Microenvironment Reports 4:2, pages 17-27.
Crossref
Zixuan Bai, Jiewen Wang, Jiaqi Li, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario de Marco & He Huang. (2023) Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations. Computational and Structural Biotechnology Journal 21, pages 601-613.
Crossref
Domenico Marson, Maria Russi, Alice Fermeglia, Erik Laurini & Sabrina Pricl. 2023. Advanced and Modern Approaches for Drug Delivery. Advanced and Modern Approaches for Drug Delivery 649 681 .
Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans & Yurong Wen. (2022) Single Domain Antibody application in bacterial infection diagnosis and neutralization. Frontiers in Immunology 13.
Crossref
Pierre-Florent Petit, Raphaële Bombart, Pierre-Hubert Desimpel, Stefan Naulaerts, Laurie Thouvenel, Jean-François Collet, Benoit J. Van den Eynde & Jingjing Zhu. (2022) T Cell–Mediated Targeted Delivery of Anti–PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site. Cancer Immunology Research 10:6, pages 713-727.
Crossref
Nils Rouven Hansmeier, Ina Sophie Büschlen, Rose Yinghan Behncke, Sascha Ulferts, Radjesh Bisoendial & René Hägerling. (2022) 3D Visualization of Human Blood Vascular Networks Using Single-Domain Antibodies Directed against Endothelial Cell-Selective Adhesion Molecule (ESAM). International Journal of Molecular Sciences 23:8, pages 4369.
Crossref
Sarah Barakat, Melike Berksöz, Pegah Zahedimaram, Sofia Piepoli & Batu Erman. (2022) Nanobodies as molecular imaging probes. Free Radical Biology and Medicine 182, pages 260-275.
Crossref
Yue Wang, Yaxian Mei, Zhenghong Ao, Yuanzhi Chen, Yichao Jiang, Xiaoqing Chen, Ruoyao Qi, Baorong Fu, Jixian Tang, Mujin Fang, Min You, Tianying Zhang, Quan Yuan, Wenxin Luo & Ningshao Xia. (2022) A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy. Antiviral Research 199, pages 105265.
Crossref
Ivana Jovčevska. 2022. Nanocarriers for Drug-Targeting Brain Tumors. Nanocarriers for Drug-Targeting Brain Tumors 797 820 .
Fangling Ji, Jun Ren, Cécile Vincke, Lingyun Jia & Serge Muyldermans. 2022. Single-Domain Antibodies. Single-Domain Antibodies 3 17 .
Heleen Hanssens, Fien Meeus, Kim De Veirman, Karine Breckpot & Nick Devoogdt. (2021) The antigen‐binding moiety in the driver's seat of CARs. Medicinal Research Reviews 42:1, pages 306-342.
Crossref
Guangfa Bao, Ming Tang, Jun Zhao & Xiaohua Zhu. (2021) Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Research 11:1.
Crossref
Thinzar M. Lwin, Michael A. Turner, Siamak Amirfakhri, Hiroto Nishino, Pieterjan Debie, Bard C. Cosman, Robert M. Hoffman, Sophie Hernot & Michael Bouvet. (2021) Rapid tumor‐labeling kinetics with a site‐specific near‐infrared anti‐CEA nanobody in a patient‐derived orthotopic xenograft mouse model of colon cancer. Journal of Surgical Oncology 124:7, pages 1121-1127.
Crossref
Ivanna Hrynchak, Liliana Santos, Amílcar Falcão, Célia M. Gomes & Antero J. Abrunhosa. (2021) Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies. International Journal of Molecular Sciences 22:19, pages 10745.
Crossref
Yang Gao, Jianwei Zhu & Huili Lu. (2020) Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review. Drug Delivery and Translational Research 11:5, pages 1818-1828.
Crossref
Henri Baudhuin, Pieter-Jan Van Bockstal, Thomas De Beer, Ilse Vaneycken, Jessica Bridoux, Geert Raes, Vicky Caveliers, Marleen Keyaerts, Nick Devoogdt, Tony Lahoutte & Catarina Xavier. (2021) Lyophilization of NOTA-sdAbs: First step towards a cold diagnostic kit for 68Ga-labeling. European Journal of Pharmaceutics and Biopharmaceutics 166, pages 194-204.
Crossref
Jim Küppers, Stefan Kürpig, Ralph A. Bundschuh, Markus Essler & Susanne Lütje. (2021) Radiolabeling Strategies of Nanobodies for Imaging Applications. Diagnostics 11:9, pages 1530.
Crossref
Vladimir Tolmachev, Anna Orlova & Jens Sörensen. (2021) The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer. Seminars in Cancer Biology 72, pages 185-197.
Crossref
Manman Liu, Li Li, Duo Jin & Yangzhong Liu. (2021) Nanobody—A versatile tool for cancer diagnosis and therapeutics. WIREs Nanomedicine and Nanobiotechnology 13:4.
Crossref
Alizée Bouleau, Vincent Lebon & Charles Truillet. (2021) PET imaging of immune checkpoint proteins in oncology. Pharmacology & Therapeutics 222, pages 107786.
Crossref
Betül Altunay, Agnieszka Morgenroth, Mohsen Beheshti, Andreas Vogg, Nicholas C. L. Wong, Hong Hoi Ting, Hans-Jürgen Biersack, Elmar Stickeler & Felix M. Mottaghy. (2020) HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and radioimmunoimaging. European Journal of Nuclear Medicine and Molecular Imaging 48:5, pages 1371-1389.
Crossref
Henri Baudhuin, Janik Puttemans, Heleen Hanssens, Philippe Vanwolleghem, Sophie Hernot, Geert Raes, Catarina Xavier, Tony Lahoutte & Pieterjan Debie. (2021) Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality. Pharmaceuticals 14:5, pages 407.
Crossref
Vladimir N. Uversky, Elrashdy M. Redwan & Abdullah A. Aljadawi. (2021) Protein Intrinsic Disorder and Evolvability of MERS-CoV. Biomolecules 11:4, pages 608.
Crossref
Serge Muyldermans. (2020) A guide to: generation and design of nanobodies. The FEBS Journal 288:7, pages 2084-2102.
Crossref
Majid Piramoon, Fatemeh Khodadust & Seyed Jalal Hosseinimehr. (2021) Radiolabeled nanobodies for tumor targeting: From bioengineering to imaging and therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:2, pages 188529.
Crossref
Thinzar M. Lwin, Robert M. Hoffman & Michael Bouvet. (2021) Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules 11:2, pages 311.
Crossref
Elisha R. Verhaar, Andrew W. Woodham & Hidde L. Ploegh. (2021) Nanobodies in cancer. Seminars in Immunology 52, pages 101425.
Crossref
Ahmet Krasniqi, Catarina Xavier & Nick Devoogdt. 2021. Molecular Imaging. Molecular Imaging 517 529 .
Wenyi Wang, Jumao Yuan & Changan Jiang. (2020) Applications of nanobodies in plant science and biotechnology. Plant Molecular Biology 105:1-2, pages 43-53.
Crossref
Marco Erreni, Tilo Schorn, Francesca D’Autilia & Andrea Doni. (2020) Nanobodies as Versatile Tool for Multiscale Imaging Modalities. Biomolecules 10:12, pages 1695.
Crossref
Akihito Inoue, Yuki Ohmuro-Matsuyama, Tetsuya Kitaguchi & Hiroshi Ueda. (2020) Creation of a Nanobody-Based Fluorescent Immunosensor Mini Q-body for Rapid Signal-On Detection of Small Hapten Methotrexate. ACS Sensors 5:11, pages 3457-3464.
Crossref
Ivan Peyron, Claire Kizlik‐Masson, Marie‐Daniéla Dubois, Sénadé Atsou, Stephen Ferrière, Cécile V. Denis, Peter J. Lenting, Caterina Casari & Olivier D. Christophe. (2020) Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications. Research and Practice in Thrombosis and Haemostasis 4:7, pages 1087-1100.
Crossref
Emily Y. Yang & Khalid Shah. (2020) Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics. Frontiers in Oncology 10.
Crossref
Xinyu Yu, Qilan Xu, Yuan Wu, Huijun Jiang, Wei Wei, Azhati Zulipikaer, Yan Guo, Jirimutu & Jin Chen. (2020) Nanobodies derived from Camelids represent versatile biomolecules for biomedical applications. Biomaterials Science 8:13, pages 3559-3573.
Crossref
Weijun Wei, Zachary T. Rosenkrans, Jianjun Liu, Gang Huang, Quan-Yong Luo & Weibo Cai. (2020) ImmunoPET: Concept, Design, and Applications. Chemical Reviews 120:8, pages 3787-3851.
Crossref
Ivana Jovčevska & Serge Muyldermans. (2019) The Therapeutic Potential of Nanobodies. BioDrugs 34:1, pages 11-26.
Crossref
Kritee Pant, Christin Neuber, Kristof Zarschler, Johanna Wodtke, Sebastian Meister, Rainer Haag, Jens Pietzsch & Holger Stephan. (2019) Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging. Small 16:7, pages 1905013.
Crossref
Pieterjan Debie, Chrystel Lafont, Michel Defrise, Inge Hansen, Danny M. van Willigen, Fijs W.B. van Leeuwen, Rik Gijsbers, Matthias D'Huyvetter, Nick Devoogdt, Tony Lahoutte, Patrice Mollard & Sophie Hernot. (2020) Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours. Journal of Controlled Release 317, pages 34-42.
Crossref
Rose H. Reader, Robert G. Workman, Ben C. Maddison & Kevin C. Gough. (2019) Advances in the Production and Batch Reformatting of Phage Antibody Libraries. Molecular Biotechnology 61:11, pages 801-815.
Crossref
O. D. Bragina, V. I. Chernov, R. V. Zeltchan, I. G. Sinilkin, A. A. Medvedeva & M. S. Larkina. (2019) Alternative scaffolds in radionuclide diagnosis of malignancies. Bulletin of Siberian Medicine 18:3, pages 125-133.
Crossref
Timothy J. Henrich, Priscilla Y. Hsue & Henry VanBrocklin. (2019) Seeing Is Believing: Nuclear Imaging of HIV Persistence. Frontiers in Immunology 10.
Crossref
Roman V. Kholodenko, Daniel V. Kalinovsky, Igor I. Doronin, Eugene D. Ponomarev & Irina V. Kholodenko. (2019) Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations. Current Medicinal Chemistry 26:3, pages 396-426.
Crossref
Pieterjan Debie, Nick Devoogdt & Sophie Hernot. (2019) Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery. Antibodies 8:1, pages 12.
Crossref
Frederik Cleeren, Joan Lecina, Jessica Bridoux, Nick Devoogdt, Térence Tshibangu, Catarina Xavier & Guy Bormans. (2018) Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al18F-RESCA method. Nature Protocols 13:10, pages 2330-2347.
Crossref
Ahmet Krasniqi, Magdalena Bialkowska, Catarina Xavier, Kevin Van der Jeught, Serge Muyldermans, Nick Devoogdt & Matthias D’Huyvetter. (2018) Pharmacokinetics of radiolabeled dimeric sdAbs constructs targeting human CD20. New Biotechnology 45, pages 69-79.
Crossref
Shahryar Khoshtinat Nikkhoi, Fatemeh Rahbarizadeh, Davoud Ahmadvand & Seyed Moein Moghimi. (2018) Multivalent targeting and killing of HER2 overexpressing breast carcinoma cells with methotrexate-encapsulated tetra-specific non-overlapping variable domain heavy chain anti-HER2 antibody-PEG-liposomes: In vitro proof-of-concept. European Journal of Pharmaceutical Sciences 122, pages 42-50.
Crossref
Yu‐Qing Xie, Lixia Wei & Li Tang. (2018) Immunoengineering with biomaterials for enhanced cancer immunotherapy. WIREs Nanomedicine and Nanobiotechnology 10:4.
Crossref
Ahmet Krasniqi, Matthias D’Huyvetter, Nick Devoogdt, Fredrik Y. Frejd, Jens Sörensen, Anna Orlova, Marleen Keyaerts & Vladimir Tolmachev. (2018) Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology. Journal of Nuclear Medicine 59:6, pages 885-891.
Crossref
Pieterjan Debie, Marian Vanhoeij, Natalie Poortmans, Janik Puttemans, Kris Gillis, Nick Devoogdt, Tony Lahoutte & Sophie Hernot. (2017) Improved Debulking of Peritoneal Tumor Implants by Near-Infrared Fluorescent Nanobody Image Guidance in an Experimental Mouse Model. Molecular Imaging and Biology 20:3, pages 361-367.
Crossref
Jessica R. Ingram, Florian I. Schmidt & Hidde L. Ploegh. (2018) Exploiting Nanobodies’ Singular Traits. Annual Review of Immunology 36:1, pages 695-715.
Crossref
Dan Li, Siyuan Cheng, Sijuan Zou, Dongling Zhu, Tinghui Zhu, Pilin Wang & Xiaohua Zhu. (2018) Immuno-PET Imaging of 89 Zr Labeled Anti-PD-L1 Domain Antibody . Molecular Pharmaceutics 15:4, pages 1674-1681.
Crossref
Andrew M. Prantner, Catherine Yin, Kalika Kamat, Khushboo Sharma, Andrew C. Lowenthal, Peter B. Madrid & Nathalie Scholler. (2018) Molecular Imaging of Mesothelin-Expressing Ovarian Cancer with a Human and Mouse Cross-Reactive Nanobody. Molecular Pharmaceutics 15:4, pages 1403-1411.
Crossref
Patricia M.R. Pereira, Lolkje Abma, Kelly E. Henry & Jason S. Lewis. (2018) Imaging of human epidermal growth factor receptors for patient selection and response monitoring – From PET imaging and beyond. Cancer Letters 419, pages 139-151.
Crossref
Thomas Eden, Stephan Menzel, Janusz Wesolowski, Philine Bergmann, Marion Nissen, Gudrun Dubberke, Fabienne Seyfried, Birte Albrecht, Friedrich Haag & Friedrich Koch-Nolte. (2018) A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation. Frontiers in Immunology 8.
Crossref
Ahmet Krasniqi, Matthias D'Huyvetter, Catarina Xavier, Kevin Van der Jeught, Serge Muyldermans, José Van Der Heyden, Tony Lahoutte, Jan Tavernier & Nick Devoogdt. (2017) Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma. Molecular Cancer Therapeutics 16:12, pages 2828-2839.
Crossref
Peter Bannas, Julia Hambach & Friedrich Koch-Nolte. (2017) Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics. Frontiers in Immunology 8.
Crossref
Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik & Nick Devoogdt. (2017) A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells. Scientific Reports 7:1.
Crossref
Matthias D'Huyvetter, Jens De Vos, Catarina Xavier, Marek Pruszynski, Yann G.J. Sterckx, Sam Massa, Geert Raes, Vicky Caveliers, Michael R. Zalutsky, Tony Lahoutte & Nick Devoogdt. (2017) 131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment. Clinical Cancer Research 23:21, pages 6616-6628.
Crossref
Benoit Stijlemans, Patrick De Baetselier, Guy Caljon, Jan Van Den Abbeele, Jo A. Van Ginderachter & Stefan Magez. (2017) Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis. Frontiers in Immunology 8.
Crossref
Katrijn Broos, Marleen Keyaerts, Quentin Lecocq, Dries Renmans, Tham Nguyen, David Escors, Adrian Liston, Geert Raes, Karine Breckpot & Nick Devoogdt. (2017) Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers. Oncotarget 8:26, pages 41932-41946.
Crossref
Fang Zheng, Amanda Sparkes, Patrick De Baetselier, Steve Schoonooghe, Benoit Stijlemans, Serge Muyldermans, Véronique Flamand, Jo A Van Ginderachter, Nick Devoogdt, Geert Raes & Alain Beschin. (2016) Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. Molecular Imaging and Biology 19:1, pages 49-58.
Crossref
Shahryar Khoshtinat Nikkhoi, Fatemeh Rahbarizadeh & Davoud Ahmadvand. (2017) Oligo-clonal nanobodies as an innovative targeting agent for cancer therapy: New biology and novel targeting systems. Protein Expression and Purification 129, pages 115-121.
Crossref
Gezim Bala, Anneleen Blykers, Catarina Xavier, Benedicte Descamps, Alexis Broisat, Catherine Ghezzi, Daniel Fagret, Guy Van Camp, Vicky Caveliers, Christian Vanhove, Tony Lahoutte, Steven Droogmans, Bernard Cosyns, Nick Devoogdt & Sophie Hernot. (2016) Targeting of vascular cell adhesion molecule-1 by 18 F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques . European Heart Journal – Cardiovascular Imaging 17:9, pages 1001-1008.
Crossref
Sam Massa, Niravkumar Vikani, Cecilia Betti, Steven Ballet, Saskia Vanderhaegen, Jan Steyaert, Benedicte Descamps, Christian Vanhove, Anton Bunschoten, Fijs W. B. van Leeuwen, Sophie Hernot, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans, Catarina Xavier & Nick Devoogdt. (2016) Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities. Contrast Media & Molecular Imaging 11:5, pages 328-339.
Crossref
Kristof Zarschler, Louise Rocks, Nadia Licciardello, Luca Boselli, Ester Polo, Karina Pombo Garcia, Luisa De Cola, Holger Stephan & Kenneth A. Dawson. (2016) Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications. Nanomedicine: Nanotechnology, Biology and Medicine 12:6, pages 1663-1701.
Crossref
Sophie Steeland, Roosmarijn E. Vandenbroucke & Claude Libert. (2016) Nanobodies as therapeutics: big opportunities for small antibodies. Drug Discovery Today 21:7, pages 1076-1113.
Crossref
Catarina Xavier, Anneleen Blykers, Ilse Vaneycken, Matthias D'Huyvetter, Jan Heemskerk, Tony Lahoutte, Nick Devoogdt & Vicky Caveliers. (2016) 18F-nanobody for PET imaging of HER2 overexpressing tumors. Nuclear Medicine and Biology 43:4, pages 247-252.
Crossref
Tao Fang, Joao N. Duarte, Jingjing Ling, Zeyang Li, Jonathan S. Guzman & Hidde L. Ploegh. (2016) Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angewandte Chemie International Edition 55:7, pages 2416-2420.
Crossref
Tao Fang, Joao N. Duarte, Jingjing Ling, Zeyang Li, Jonathan S. Guzman & Hidde L. Ploegh. (2016) Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angewandte Chemie 128:7, pages 2462-2466.
Crossref
Serge Muyldermans & Cécile Vincke. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 153 159 .
Gustav Rodrigo, Mats Gruvegård & James Van Alstine. (2015) Antibody Fragments and Their Purification by Protein L Affinity Chromatography. Antibodies 4:3, pages 259-277.
Crossref
Anneleen Blykers, Steve Schoonooghe, Catarina Xavier, Kevin D’hoe, Damya Laoui, Matthias D’Huyvetter, Ilse Vaneycken, Frederik Cleeren, Guy Bormans, Johannes Heemskerk, Geert Raes, Patrick De Baetselier, Tony Lahoutte, Nick Devoogdt, Jo A. Van Ginderachter & Vicky Caveliers. (2015) PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18 F-Radiolabeled Camelid Single-Domain Antibody Fragments . Journal of Nuclear Medicine 56:8, pages 1265-1271.
Crossref
Xiaozhou Fan, Luofu Wang, Yanli Guo, Zhui Tu, Lang Li, Haipeng Tong, Yang Xu, Rui Li & Kejing Fang. (2015) Ultrasonic Nanobubbles Carrying Anti-PSMA Nanobody: Construction and Application in Prostate Cancer-Targeted Imaging. PLOS ONE 10:6, pages e0127419.
Crossref
M. Oteo & M.A. Morcillo. (2015) Small Animal PET as Non-Invasive Tool for Preclinical Imaging. Acta Physica Polonica A 127:5, pages 1483-1486.
Crossref
Coralie Pain, Janice Dumont & Mireille Dumoulin. (2015) Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena. Biochimie 111, pages 82-106.
Crossref
Fang Zheng, Nick Devoogdt, Amanda Sparkes, Yannick Morias, Chloé Abels, Benoit Stijlemans, Tony Lahoutte, Serge Muyldermans, Patrick De Baetselier, Steve Schoonooghe, Alain Beschin & Geert Raes. (2015) Monitoring liver macrophages using nanobodies targeting Vsig4: Concanavalin A induced acute hepatitis as paradigm. Immunobiology 220:2, pages 200-209.
Crossref
Cleo Goyvaerts & Karine Breckpot. (2015) Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines. Journal of Immunology Research 2015, pages 1-18.
Crossref
Ryan M. Williams & Letha J. Sooter. (2015) In Vitro Selection of Cancer Cell-Specific Molecular Recognition Elements from Amino Acid Libraries . Journal of Immunology Research 2015, pages 1-12.
Crossref
Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt & Tony Lahoutte. (2014) Camelid reporter gene imaging: a generic method for in vivo cell tracking. EJNMMI Research 4:1.
Crossref
H. Blom & H. Brismar. (2014) STED microscopy: increased resolution for medical research?. Journal of Internal Medicine 276:6, pages 560-578.
Crossref
Jens De Vos, Iris Mathijs, Catarina Xavier, Sam Massa, Ulrich Wernery, Luc Bouwens, Tony Lahoutte, Serge Muyldermans & Nick Devoogdt. (2014) Specific Targeting of Atherosclerotic Plaques in ApoE−/− Mice Using a New Camelid sdAb Binding the Vulnerable Plaque Marker LOX-1. Molecular Imaging and Biology 16:5, pages 690-698.
Crossref
Katrin Viehweger, Lisa Barbaro, Karina Pombo García, Tanmaya Joshi, Gerhard Geipel, Jörg Steinbach, Holger Stephan, Leone Spiccia & Bim Graham. (2014) EGF Receptor-Targeting Peptide Conjugate Incorporating a Near-IR Fluorescent Dye and a Novel 1,4,7-Triazacyclononane-Based 64 Cu(II) Chelator Assembled via Click Chemistry . Bioconjugate Chemistry 25:5, pages 1011-1022.
Crossref
Sam Massa, Catarina Xavier, Jens De Vos, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans & Nick Devoogdt. (2014) Site-Specific Labeling of Cysteine-Tagged Camelid Single-Domain Antibody-Fragments for Use in Molecular Imaging. Bioconjugate Chemistry 25:5, pages 979-988.
Crossref
M Lemaire, M D'Huyvetter, T Lahoutte, E Van Valckenborgh, E Menu, E De Bruyne, P Kronenberger, U Wernery, S Muyldermans, N Devoogdt & K Vanderkerken. (2013) Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies. Leukemia 28:2, pages 444-447.
Crossref
Achim Doerner, Laura Rhiel, Stefan Zielonka & Harald Kolmar. (2014) Therapeutic antibody engineering by high efficiency cell screening. FEBS Letters 588:2, pages 278-287.
Crossref
Kristof Zarschler, Stefanie Witecy, Franz Kapplusch, Christian Foerster & Holger Stephan. (2013) High-yield production of functional soluble single-domain antibodies in the cytoplasm of Escherichia coli. Microbial Cell Factories 12:1, pages 97.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.