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Immune alterations and immunotherapy prospects in head and neck cancer

, MD, , MD & , MD PhD
Pages 1241-1256 | Published online: 24 Jun 2013

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Yihui Wen & Jennifer R Grandis. (2015) Emerging drugs for head and neck cancer. Expert Opinion on Emerging Drugs 20:2, pages 313-329.
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Articles from other publishers (39)

Xin Feng, Tan Zhang, Jeff Chou, Hafiz S. Patwa, Christopher A. Sullivan & J. Dale Browne. (2023) Y‐Chromosome‐Linked Genes Are Associated With Sex‐Related Head‐Neck Squamous Cell Carcinoma Survival. Otolaryngology–Head and Neck Surgery 169:6, pages 1533-1541.
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Chetna Yadav, Ritu Yadav, Ravindresh Chabbra, Smiti Nanda, Shalu Ranga, Lokesh Kadian & Parul Ahuja. (2023) Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer. Apoptosis 28:5-6, pages 683-701.
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Mingyu Li, Yeltai Nurzat, He Huang, Peiru Min & Xiaowen Zhang. (2023) Cuproptosis-related LncRNAs are correlated with immunity and predict prognosis in HNSC independent of TMB. Frontiers in Genetics 14.
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Shengjian Jin, Yasusei Kudo & Taigo Horiguchi. (2022) The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma. International Journal of Molecular Sciences 24:1, pages 552.
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Wenkai Zhou, Xu Zhang, Yisheng Feng, Yu Zhang & Zheqi Liu. (2022) The CC ligand chemokine family members CCL17/CCL22 predict the survival and response to immune checkpoint blockade therapy of patients with head and neck squamous cell carcinoma. Current Problems in Cancer 46:6, pages 100896.
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Nobuo Kondoh & Masako Mizuno-Kamiya. (2022) The Role of Immune Modulatory Cytokines in the Tumor Microenvironments of Head and Neck Squamous Cell Carcinomas. Cancers 14:12, pages 2884.
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Rahul Bhattacharjee, Sabya Sachi Das, Smruti Sudha Biswal, Arijit Nath, Debangshi Das, Asmita Basu, Sumira Malik, Lamha Kumar, Sulagna Kar, Sandeep Kumar Singh, Vijay Jagdish Upadhye, Danish Iqbal, Suliman Almojam, Shubhadeep Roychoudhury, Shreesh Ojha, Janne Ruokolainen, Niraj Kumar Jha & Kavindra Kumar Kesari. (2022) Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies. Critical Reviews in Oncology/Hematology 174, pages 103675.
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Maurice Duijvenvoorde, Sarah Derks, Idris Bahce, C René Leemans, Rieneke Ven & Marieke F Fransen. (2022) Comparison of the tumor microenvironments of squamous cell carcinoma at different anatomical locations within the upper aerodigestive tract in relation to response to ICI therapy. Clinical & Translational Immunology 11:1.
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Antian Gao, Xiao Pan, Xudong Yang & Zitong Lin. (2021) Predictive factors in the treatment of oral squamous cell carcinoma using PD-1/PD-L1 inhibitors. Investigational New Drugs 39:4, pages 1132-1138.
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Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin & Xin Jiang. (2021) Immunotherapy Advances in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Its Relationship With Human Papillomavirus. Frontiers in Immunology 12.
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Lucas V. dos Santos, Carina M. Abrahão & William N. WilliamJr.Jr.. (2021) Overcoming Resistance to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinomas. Frontiers in Oncology 11.
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Matthias Brand, Simon Laban, Marie-Nicole Theodoraki, Johannes Doescher, Thomas K. Hoffmann, Patrick J. Schuler & Cornelia Brunner. (2020) Characterization and Differentiation of the Tumor Microenvironment (TME) of Orthotopic and Subcutaneously Grown Head and Neck Squamous Cell Carcinoma (HNSCC) in Immunocompetent Mice. International Journal of Molecular Sciences 22:1, pages 247.
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Xingyu Liu, Jiarui Chen, Wei Lu, Zihang Zeng, Jiali Li, Xueping Jiang, Yanping Gao, Yan Gong, Qiuji Wu & Conghua Xie. (2020) Systematic Profiling of Immune Risk Model to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. Frontiers in Genetics 11.
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Katie Meehan, Connull Leslie, Michaela Lucas, Angela Jacques, Bob Mirzai, James Lim, Max Bulsara, Yasir Khan, Nicholas C. Wong, Benjamin Solomon, Chady Sader, Peter Friedland, Gisela Mir Arnau, Timothy Semple & Annette M. Lim. (2020) Characterization of the immune profile of oral tongue squamous cell carcinomas with advancing disease. Cancer Medicine 9:13, pages 4791-4807.
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Asmita Pal & Rita Kundu. (2020) Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy. Frontiers in Microbiology 10.
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Muzafar A. Macha, Nissar A. Wani, Rais A. Ganai, Ajaz A. Bhat, Abid Hamid, Sheema Hashem, Mohammad Haris, Sham S. Chauhan, Mohammad A. Zargar & Surinder K. Batra. 2020. Tumor Microenvironments in Organs. Tumor Microenvironments in Organs 11 31 .
Filippo Marchi, Francesco Missale, Fabiola Incandela, Marta Filauro, Francesco Mazzola, Francesco Mora, Alberto Paderno, Giampiero Parrinello, Cesare Piazza & Giorgio Peretti. (2019) Prognostic Significance of Peripheral T‐Cell Subsets in Laryngeal Squamous Cell Carcinoma. Laryngoscope Investigative Otolaryngology 4:5, pages 513-519.
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Guendalina Lucarini, Antonio Zizzi, Massimo Re, Md. Abu Sayeed, Roberto Di Primio & Corrado Rubini. (2018) Prognostic implication of CEACAM1 expression in squamous cell carcinoma of the larynx: Pilot study. Head & Neck 41:6, pages 1615-1621.
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Junyu Li, Yuehua Li, Xiaoping Wu & Ying Li. (2019) Identification and validation of potential long non‑coding RNA biomarkers in predicting survival of patients with head and neck squamous cell carcinoma. Oncology Letters.
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Madison Canning, Gang Guo, Miao Yu, Calvin Myint, Michael W. Groves, James Kenneth Byrd & Yan Cui. (2019) Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy. Frontiers in Cell and Developmental Biology 7.
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Felix Sim, Rom Leidner & Richard Bryan Bell. (2019) Immunotherapy for Head and Neck Cancer. Hematology/Oncology Clinics of North America 33:2, pages 301-321.
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Felix Sim, Rom Leidner & Richard Bryan Bell. (2019) Immunotherapy for Head and Neck Cancer. Oral and Maxillofacial Surgery Clinics of North America 31:1, pages 85-100.
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Charu Aggarwal, Roger B. Cohen, Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Dawson M. Knoblock, Joshua M. Bauml, Gregory S. Weinstein, Alexander Lin, Jean Boyer, Lindsay Sakata, Sophie Tan, Aubrey Anton, Kelsie Dickerson, Drishty Mangrolia, Russell Vang, Michael Dallas, Sandra Oyola, Susan Duff, Mark Esser, Rakesh Kumar, David Weiner, Ildiko Csiki & Mark L. Bagarazzi. (2019) Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer. Clinical Cancer Research 25:1, pages 110-124.
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Xiaofei ChenJade MimsXiumei HuangNaveen SinghEdward MoteaSarah M. PlanchonMuhammad BegAllen W. TsangMercedes PorosnicuMelissa L. KempDavid A. BoothmanCristina M. Furdui. (2018) Modulators of Redox Metabolism in Head and Neck Cancer. Antioxidants & Redox Signaling 29:16, pages 1660-1690.
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Orit Kaidar-Person, Ziv Gil & Salem Billan. (2018) Precision medicine in head and neck cancer. Drug Resistance Updates 40, pages 13-16.
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Carole Fakhry, Fares Qeadan, Robert H. Gilman, Pablo Yori, Margaret Kosek, Nicole Patterson, David W. Eisele, Christine G. Gourin, Chandala Chitguppi, Morgan Marks & Patti Gravitt. (2017) Oral sampling methods are associated with differences in immune marker concentrations. The Laryngoscope 128:6.
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Karl T. Kelsey & John K. Wiencke. (2018) Immunomethylomics: A Novel Cancer Risk Prediction Tool. Annals of the American Thoracic Society 15:Supplement_2, pages S76-S80.
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Sat Parmar, James Good, Laith Al-Qamachi, Camilla Dawson & Matthew Idle. 2018. Oral, Head and Neck Oncology and Reconstructive Surgery. Oral, Head and Neck Oncology and Reconstructive Surgery 761 773 .
Kellie A. Charles, Benjamin D. W. Harris, Carol R. Haddad, Stephen J. Clarke, Alex Guminski, Mark Stevens, Tristan Dodds, Anthony J. Gill, Michael Back, David Veivers & Thomas Eade. (2016) Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients. BMC Cancer 16:1.
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Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, Anis El Meddeb Hamrouni, Claire Rodriguez-Lafrasse, Cyrus Chargari, Eric Deutsch & Nicolas Magné. (2016) Immunotherapy in head and neck cancer: Harnessing profit on a system disruption. Oral Oncology 62, pages 153-162.
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P. Economopoulou, S. Agelaki, C. Perisanidis, E.I. Giotakis & A. Psyrri. (2016) The promise of immunotherapy in head and neck squamous cell carcinoma. Annals of Oncology 27:9, pages 1675-1685.
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M. Mandapathil. (2016) Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neckAdenosinvermittelte Immunsuppression bei Patienten mit Kopf-Hals-Plattenepithelkarzinomen. HNO 64:5, pages 303-309.
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Stephan Klöss, Nicole Chambron, Tanja Gardlowski, Sandra Weil, Joachim Koch, Ruth Esser, Elke Pogge von Strandmann, Michael A. Morgan, Lubomir Arseniev, Oliver Seitz & Ulrike Köhl. (2015) Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids. Frontiers in Immunology 6.
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Francesc Xavier Avilés-Jurado, Ximena Terra, David Gómez, Joan Carles Flores, Antoni Raventós, Elsa Maymó-Masip, Xavier León, Vicente Serrano-Gonzalvo, Joan Vendrell, Enric Figuerola & Matilde R. Chacón. (2014) Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer. European Archives of Oto-Rhino-Laryngology 272:7, pages 1733-1741.
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Annette Rossmann, Robert Mandic, Jochen Heinis, Helmut Höffken, Oliver Küssner, Ralf Kinscherf, Eberhard Weihe & Michael Bette. (2014) Intraperitoneal Oxidative Stress in Rabbits with Papillomavirus-Associated Head and Neck Cancer Induces Tumoricidal Immune Response That Is Adoptively Transferable. Clinical Cancer Research 20:16, pages 4289-4301.
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Daniel W Bowles, Jessica D McDermott & Antonio Jimeno. (2014) Novel treatments for head and neck squamous cell carcinoma: preclinical identification and clinical investigation. Future Oncology 10:6, pages 1065-1080.
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C. M. O'Connor & H. Wilson-Robles. (2014) Developing T Cell Cancer Immunotherapy in the Dog with Lymphoma. ILAR Journal 55:1, pages 169-181.
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Monika E. Freiser, Paolo Serafini & Donald T. Weed. (2013) The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities. Immunologic Research 57:1-3, pages 52-69.
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Walter T Lee. (2013) Dendritic cell vaccines targeting survivin in head and neck cancer. Immunotherapy 5:11, pages 1169-1171.
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