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Expert Opinion on Biological Therapy Volume 13, 2013 - Issue 12
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Clinical Trial Evaluation

Evaluation of ASPIRE trial: a Phase III pivotal registration trial, using intracoronary administration of Generx (Ad5FGF4) to treat patients with recurrent angina pectoris

Juan Carlos KaskiSt George's University of London, Cardiovascular Sciences Research Centre, Cranmer Terrace, London SW17 0RE [email protected]
, DSc MD DM (Hons) FRCP FACC FAHA FESC &
Luciano Consuegra-SanchezHospital Universitario de Santa Lucia, Cardiology Department, Interventional Cardiology Unit, Cartagena, Spain
, MD PhD
Pages 1749-1753 | Published online: 19 Aug 2013

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Bharat Narasimhan, Harish Narasimhan, Marta Lorente-Ros, Francisco Jose Romeo, Kirtipal Bhatia & Wilbert S. Aronow. (2021) Therapeutic angiogenesis in coronary artery disease: a review of mechanisms and current approaches. Expert Opinion on Investigational Drugs 30:9, pages 947-963.
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Gabor M. Rubanyi. (2016) Angiogenic gene therapy for refractory angina. Expert Opinion on Biological Therapy 16:3, pages 303-315.
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H. H. Pulkkinen, A. Kivistö-Rahnasto, H. Korpela, M. Heikkilä, N. Järveläinen, S. Siimes, L. Kilpeläinen, N. Laham-Karam, S. Ylä-Herttuala & J. P. Laakkonen. (2023) BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium. Frontiers in Cardiovascular Medicine 10.
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Francisco J. Romeo, Spyros A. Mavropoulos & Kiyotake Ishikawa. (2023) Progress in Clinical Gene Therapy for Cardiac Disorders. Molecular Diagnosis & Therapy 27:2, pages 179-191.
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Xueying Tian & Bin Zhou. (2022) Coronary vessel formation in development and regeneration: origins and mechanisms. Journal of Molecular and Cellular Cardiology 167, pages 67-82.
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Guillermo Luxán & Stefanie Dimmeler. (2022) The vasculature: a therapeutic target in heart failure?. Cardiovascular Research 118:1, pages 53-64.
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Jieting Wang, Luying Yu, Ao Zhou, Jie Liu, Kai Wang, Ying Luo & Fang Wang. (2021) Non-Viral Gene Delivery Systems for Treatment of Myocardial Infarction: Targeting Strategies and Cardiac Cell Modulation. Pharmaceutics 13:9, pages 1520.
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Yevgeniy Kim, Zharylkasyn Zharkinbekov, Madina Sarsenova, Gaziza Yeltay & Arman Saparov. (2021) Recent Advances in Gene Therapy for Cardiac Tissue Regeneration. International Journal of Molecular Sciences 22:17, pages 9206.
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Andreas H. Jacobs, Sonja Schelhaas, Thomas Viel, Yannic Waerzeggers, Alexandra Winkeler, Bastian Zinnhardt & Juri Gelovani. 2021. Molecular Imaging. Molecular Imaging 1539 1587 .
Henna Korpela, Jaakko Lampela, Jussi Nurro, Juho Pajula & Seppo Ylä-Herttuala. 2021. Vascularization for Tissue Engineering and Regenerative Medicine. Vascularization for Tissue Engineering and Regenerative Medicine 101 144 .
Henna Korpela, Jaakko Lampela, Jussi Nurro, Juho Pajula & Seppo Ylä-Herttuala. 2020. Vascularization for Tissue Engineering and Regenerative Medicine. Vascularization for Tissue Engineering and Regenerative Medicine 1 45 .
Maria Giovanna Scioli, Gabriele Storti, Federico D’Amico, Roger Rodríguez Guzmán, Federica Centofanti, Elena Doldo, Ela María Céspedes Miranda & Augusto Orlandi. (2020) Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets. Journal of Clinical Medicine 9:6, pages 1995.
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Antonio Cannatà, Hashim Ali, Gianfranco Sinagra & Mauro Giacca. (2020) Gene Therapy for the Heart Lessons Learned and Future Perspectives. Circulation Research 126:10, pages 1394-1414.
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Anna M.D. Végh, Harsha D. Devalla, Dirk Geerts, Hanno L. Tan, Vincent M. Christoffels, Marie José T.H. Goumans & Gerard J.J. Boink. 2020. Emerging Technologies for Heart Diseases. Emerging Technologies for Heart Diseases 811 840 .
Vivekkumar B. Patel, Christopher T. Ryan, Ronald G. Crystal & Todd K. Rosengart. 2020. Cardiac Surgery. Cardiac Surgery 269 275 .
Ariane A. Sickinghe, Suzanne J. A. Korporaal, Hester M. den Ruijter & Elise L. Kessler. (2019) Estrogen Contributions to Microvascular Dysfunction Evolving to Heart Failure With Preserved Ejection Fraction. Frontiers in Endocrinology 10.
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Paola Locatelli, Carlos Sebastián Giménez, Martín Uranga Vega, Alberto Crottogini & Mariano Nicolás Belaich. (2018) Targeting the Cardiomyocyte Cell Cycle for Heart Regeneration. Current Drug Targets 20:2, pages 241-254.
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Arita Dubnika, Martin A.C. Manoukian, M. Rezaa Mohammadi, Mansi Bharat Parekh, Abhijit Achyut Gurjarpadhye, Mohammed Inayathullah, Viktors Dubniks, Jonathan R.T. Lakey & Jayakumar Rajadas. (2018) Cytokines as therapeutic agents and targets in heart disease. Cytokine & Growth Factor Reviews 43, pages 54-68.
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Ming Guo, Jun-He Shi, Pei-Li Wang & Da-Zhuo Shi. (2017) Angiogenic Growth Factors for Coronary Artery Disease: Current Status and Prospects. Journal of Cardiovascular Pharmacology and Therapeutics 23:2, pages 130-141.
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Feng Zhu & Kai Huang. 2018. Heart Genomics. Heart Genomics 337 374 .
Seppo Ylä-Herttuala & Andrew H. Baker. (2017) Cardiovascular Gene Therapy: Past, Present, and Future. Molecular Therapy 25:5, pages 1095-1106.
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Seppo Yl?-Herttuala, Charles Bridges, Michael G. Katz & Petra Korpisalo. (2017) Angiogenic gene therapy in cardiovascular diseases: dream or vision?. European Heart Journal, pages ehw547.
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P N Matkar, H Leong-Poi & K K Singh. (2016) Cardiac gene therapy: are we there yet?. Gene Therapy 23:8-9, pages 635-648.
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Elie El Agha, Djuro Kosanovic, Ralph T. Schermuly & Saverio Bellusci. (2016) Role of fibroblast growth factors in organ regeneration and repair. Seminars in Cell & Developmental Biology 53, pages 76-84.
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Melvin Y. Rincon, Thierry VandenDriessche & Marinee K. Chuah. (2015) Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation. Cardiovascular Research 108:1, pages 4-20.
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Stephen M. KaminskyTodd K. RosengartJonathan RosenbergMaria J. ChiuchioloBenjamin Van de GraafDolan SondhiRonald G. Crystal. (2013) Gene Therapy to Stimulate Angiogenesis to Treat Diffuse Coronary Artery Disease. Human Gene Therapy 24:11, pages 948-963.
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