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Original Research

Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients

, MD PhD, , MD, , MD, , MD, , BD, , MD & , MD show all
Pages 1495-1506 | Published online: 24 Aug 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Adrian V. Hernandez, Jennifer Hwang, Iram Nasreen, Dakota Sicignano, Vinay Pasupuleti, Kimberly Snow-Caroti & C. Michael White. (2023) Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis. Journal of Dietary Supplements 0:0, pages 1-18.
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Babak Roshanravan, Shahnaz Yousefizadeh, Betul Apaydin Yildirim, Tahereh Farkhondeh, Alireza Amirabadizadeh, Milad Ashrafizadeh, Marjan Talebi & Saeed Samarghandian. (2023) The effects of Berberis vulgaris L. and Berberis aristata L. in metabolic syndrome patients: a systematic and meta-analysis study. Archives of Physiology and Biochemistry 129:2, pages 393-404.
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Giuseppe Derosa, Angela D’Angelo, Arianna Vanelli & Pamela Maffioli. (2020) An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia. Diabetes, Metabolic Syndrome and Obesity 13, pages 653-661.
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Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli & Nicola Villanova. (2017) Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in patients with dyslipidemia. Clinical Pharmacology: Advances and Applications 9, pages 1-7.
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Sergio D’Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli & Giuseppe Derosa. (2017) Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study. Drug Design, Development and Therapy 11, pages 1585-1592.
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Francesco Di Pierro, Iaele Bellone, Giuliana Rapacioli & Pietro Putignano. (2015) Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes, Metabolic Syndrome and Obesity 8, pages 89-96.
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Giuseppe Derosa & Pamela Maffioli. (2015) Nutraceuticals for the treatment of metabolic diseases: evidence from clinical practice. Expert Review of Endocrinology & Metabolism 10:3, pages 297-304.
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Francesco Di Pierro, Pietro Putignano, Nicola Villanova, Luca Montesi, Simona Moscatiello & Giulio Marchesini. (2013) Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes. Clinical Pharmacology: Advances and Applications 5, pages 167-174.
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Articles from other publishers (32)

Firdaus Jahan, Sahir Sultan Alvi & Mohammad Hayatul Islam. (2022) Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications. Pharmacological Research - Modern Chinese Medicine 5, pages 100184.
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Giuseppe Derosa, Angela D'Angelo & Pamela Maffioli. (2022) The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Phytotherapy Research 36:10, pages 3709-3765.
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Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, Govind Singh, Ravinder Verma, Vineet Mittal, Inderbir Singh, Deepak Kaushik & Philippe Jeandet. (2022) Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules 27:16, pages 5327.
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Fatemeh Mohtashaminia, Mohammad Reza Amini, Fatemeh Sheikhhossein, Kurosh Djafarian & Sakineh Shab-Bidar. (2022) Effects berberine–silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN 49, pages 181-186.
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Jean M. Bokelmann. 2022. Medicinal Herbs in Primary Care. Medicinal Herbs in Primary Care 495 509 .
Karla MacDonald-Ramos, Layla Michán, Alejandra Martínez-Ibarra & Marco Cerbón. (2021) Silymarin is an ally against insulin resistance: A review. Annals of Hepatology 23, pages 100255.
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Bhanu Malhotra, Giriraj T. Kulkarni, Neerupma Dhiman, D.D. Joshi, Subhash Chander, Amit Kharkwal, Arun K. Sharma & Harsha Kharkwal. (2021) Recent advances on Berberis aristata emphasizing berberine alkaloid including phytochemistry, pharmacology and drug delivery system. Journal of Herbal Medicine 27, pages 100433.
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Farzaneh Barzkar, Hamid Reza Baradaran, Mohammad Ebrahim Khamseh, Roya Vesal Azad, Jalil Koohpayehzadeh & Yousef Moradi. (2020) Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinical trials. Journal of Diabetes & Metabolic Disorders 19:2, pages 1917-1929.
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Tapan Behl, Simona Bungau, Keshav Kumar, Gokhan Zengin, Fazlullah Khan, Arun Kumar, Rajwinder Kaur, Thangaval Venkatachalam, Delia Mirela Tit, Cosmin Mihai Vesa, Ghita Barsan & Danut-Eugeniu Mosteanu. (2020) Pleotropic Effects of Polyphenols in Cardiovascular System. Biomedicine & Pharmacotherapy 130, pages 110714.
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Giuseppe Derosa, Pamela Maffioli, Angela D’Angelo, Paola S. Preti, Giancarlo Tenore & Ettore Novellino. (2020) Abscisic Acid Treatment in Patients with Prediabetes. Nutrients 12:10, pages 2931.
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Mojgan Sanjari, Behrang Shamsinejad, Payam Khazaeli, Zohreh Safi, Fatemeh Mirrashidi & Ahmad Naghibzadeh-Tahami. (2020) Safety and efficacy of Berberis integerrima root extract in patients with type 2 diabetes. A parallel intervention based triple blind clinical trial. Journal of Diabetes & Metabolic Disorders 19:1, pages 71-80.
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Mohammad Reza Amini, Fatemeh Sheikhhossein, Sina Naghshi, Farhang Djafari, Mohammadreza Askari, Hossein Shahinfar, Maryam Safabakhsh, Alireza Jafari & Sakineh Shab-Bidar. (2020) Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine 49, pages 102337.
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Alexander BertuccioliSara MoricoliStefano AmatoriMarco Bruno Luigi RocchiGiorgia ViciDavide Sisti. (2020) Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis. Journal of Medicinal Food 23:2, pages 101-113.
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Tarun Belwal, Aseesh Pandey, Indra D. Bhatt & Ranbeer S. Rawal. (2020) Optimized microwave assisted extraction (MAE) of alkaloids and polyphenols from Berberis roots using multiple-component analysis. Scientific Reports 10:1.
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Fengyan Xiao, Feng Gao, Shengxue Zhou & Lina Wang. (2020) The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction. Medicine 99:40, pages e22249.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 421 428 .
Eleni Pappa, Christos V. Rizos, Theodosios D. Filippatos & Moses S. Elisaf. (2019) Emerging Fixed-Dose Combination Treatments for Hyperlipidemia. Journal of Cardiovascular Pharmacology and Therapeutics 24:4, pages 315-322.
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Federica Fogacci, Davide Grassi, Manfredi Rizzo & Arrigo F.G. Cicero. (2019) Metabolic effect of berberine–silymarin association: A meta‐analysis of randomized, double‐blind, placebo‐controlled clinical trials. Phytotherapy Research 33:4, pages 862-870.
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Atefeh Tajmohammadi, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review . Phytotherapy Research 32:10, pages 1933-1949.
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Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F.G. Cicero, Atanas G. Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M. Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G.B. John Mancini, Dimitri P. Mikhailidis, Olena Mitchenko, Patrick M. Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B. Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M.C. Rosano, Robert S. Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F. Watts, Nathan D. Wong & Manfredi Rizzo. (2018) The Role of Nutraceuticals in Statin Intolerant Patients. Journal of the American College of Cardiology 72:1, pages 96-118.
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Arrigo F.G. Cicero & Alessandro Colletti. (2017) Food and plant bioactives for reducing cardiometabolic disease: How does the evidence stack up?. Trends in Food Science & Technology 69, pages 192-202.
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Arrigo F G Cicero, Alessandro Colletti, Gani Bajraktari, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, Demosthenes B Panagiotakos, Gyorgy Paragh, Dimitri P Mikhailidis, Olena Mitchenko, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Kausik K Ray, Manfredi Rizzo, Amirhossein Sahebkar, Maria-Corina Serban, Laurence S Sperling, Peter P Toth, Dragos Vinereanu, Michal Vrablík, Nathan D Wong & Maciej Banach. (2017) Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutrition Reviews 75:9, pages 731-767.
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Derosa Giuseppe, D’Angelo Angela, Romano Davide & Maffioli Pamela. (2017) Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial. International Journal of Molecular Sciences 18:2, pages 343.
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Arrigo F. G. Cicero, Federica Fogacci & Alessandro Colletti. (2017) Food and plant bioactives for reducing cardiometabolic disease risk: an evidence based approach. Food & Function 8:6, pages 2076-2088.
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Arrigo F.G. Cicero & Alessandro Colletti. (2016) Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: The available clinical data. Phytomedicine 23:11, pages 1113-1118.
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Giuseppe Derosa, Angela D'Angelo & Pamela Maffioli. (2016) The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clinical Nutrition 35:5, pages 1091-1095.
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Rakhi Chakraborty, Swarnendu Roy & Vivekananda Mandal. (2016) Assessment of traditional knowledge of the antidiabetic plants of Darjeeling and Sikkim Himalayas in the context of recent phytochemical and pharmacological advances. Journal of Integrative Medicine 14:5, pages 336-358.
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Chang-Shun Liu, Yu-Rong Zheng, Ying-Feng Zhang & Xiao-Ying Long. (2016) Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia 109, pages 274-282.
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Angela Pirillo & Alberico Luigi Catapano. (2015) Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis 243:2, pages 449-461.
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Giuseppe Derosa & Pamela Maffioli. (2015) Possible therapies for obesity: Focus on the available options for its treatment. Nutrition 31:3, pages 542-543.
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Giuseppe Derosa, Davide Romano, Angela D'Angelo & Pamela Maffioli. (2015) Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses. Atherosclerosis 239:1, pages 87-92.
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Giuseppe Derosa, Davide Romano, Angela D'Angelo & Pamela Maffioli. (2015) Berberis aristata/Silybum marianum fixed combination (Berberol®) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial. Phytomedicine 22:2, pages 231-237.
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