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Allergen immunotherapy for house dust mite: clinical efficacy and immunological mechanisms in allergic rhinitis and asthma

, MD, , MD & , MD
Pages 1543-1556 | Published online: 08 Oct 2013

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Shipeng Zhang, Chenxin Liu, Qiqi Liu, Xingyi He, Qinwei Fu, Xi Chen, Xin Jin, Ze Chen, Xiang Yang, Qinxiu Zhang & Xinrong Li. (2023) The relationship between sublingual immunotherapy for allergic rhinitis and the risk of symptoms in patients with COVID-19 infection. Human Vaccines & Immunotherapeutics 19:2.
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Baharudin Abdullah, Amir Hamzah Abdul Latiff, Anura Michelle Manuel, Faizah Mohamed Jamli, Harvinder Singh Dalip Singh, Intan Hakimah Ismail, Jeevanan Jahendran, Jeyasakthy Saniasiaya, Kent Chee Keen Woo, Phaik Choo Khoo, Kuljit Singh, Nurashikin Mohammad, Sakinah Mohamad, Salina Husain & Ralph Mösges. (2022) Pharmacological Management of Allergic Rhinitis: A Consensus Statement from the Malaysian Society of Allergy and Immunology. Journal of Asthma and Allergy 15, pages 983-1003.
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Lin Yang & Rongfei Zhu. (2017) Immunotherapy of house dust mite allergy. Human Vaccines & Immunotherapeutics 13:10, pages 2390-2396.
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Pascal Demoly, Yoshitaka Okamoto, William H. Yang, Philippe Devillier & Karl-Christian Bergmann. (2016) 300 IR HDM tablet: a sublingual immunotherapy tablet for the treatment of house dust mite-associated allergic rhinitis. Expert Review of Clinical Immunology 12:11, pages 1141-1151.
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Alessandra Sandrini, Jennifer M Rolland & Robyn E O’Hehir. (2015) Current developments for improving efficacy of allergy vaccines. Expert Review of Vaccines 14:8, pages 1073-1087.
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Nerin N Bahceciler, Arzu Babayigit Hocaoglu & Nilufer Galip. (2014) A milestone in house dust-mite-allergen immunotherapy: the new sublingual tablet S-524101 (actair). Expert Review of Vaccines 13:12, pages 1427-1438.
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Yusuf Alif Pratama, Honey Dzikri Marhaeny, Lutfiatur Rohmah, Salsabilla Madudari Kasatu, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi & Junaidi Khotib. (2023) Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy. Journal of Public Health in Africa.
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Amy P. Stallings & Edwin H. Kim. 2023. Reference Module in Food Science. Reference Module in Food Science.
Varsha Reddy S. V.Kiran Kumar Mudnakudu-Nagaraju. (2022) Screening of B-cell epitopes of Der-p1 and Der-p2 major aeroallergens by computational approach for designing immunotherapeutics. Biomedicine 42:5, pages 898-905.
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Yifan Li, Changshan Liu, Huiqiang Li & Xueyan Wang. (2022) Exploring the role of basophil activation test in diagnosis of Dermatophagoides farinae sensitization and evaluation of therapeutic efficacy of subcutaneous immunotherapy in children. Scandinavian Journal of Immunology 96:2.
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Jenna Sjoerdsma, Franklin Mejia & Basar Bilgicer. (2022) Determination of immunogenic epitopes in major house dust mite allergen, Der p 2, via nanoallergens. Annals of Allergy, Asthma & Immunology 129:2, pages 231-240.e2.
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Zuhal Karalı, Şükrü Çekiç, Yağmur Hazal Şadırvan, Yakup Canıtez & Nihat Sapan. (2022) The Evaluation of Local and Systemic Reactions to Subcutaneous House Dust Mite Allergen Immunotherapy. Trends in Pediatrics 3:2, pages 43-46.
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Clara Padró, Diego Gutiérrez, Francisco Moreno, Antonio Parra, Manuel J. Rial, Ramón Lleonart, Carla Torán‐Barona, José L. Justicia & Albert Roger. (2022) Effectiveness and safety of a microcrystalline tyrosine‐adjuvanted Dermatophagoides pteronyssinus allergoid immunotherapy in adult patients with allergic asthma and rhinitis: A real‐life prospective observational study . Immunity, Inflammation and Disease 10:5.
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Huijuan Yuan, Jie Chen, Sanmei Hu, Timothy B. Oriss, Sagar Laxman Kale, Sudipta Das, Seyed M. Nouraie, Prabir Ray & Anuradha Ray. (2022) Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H2O2. Mucosal Immunology 15:1, pages 154-164.
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Kazuyuki Nakagome & Makoto Nagata. (2021) Allergen Immunotherapy in Asthma. Pathogens 10:11, pages 1406.
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Johav Yael Sánchez-Villalobos, Chrystopherson Caballero-López, Aída Inés López-García, Daniela Rivero-Yeverino, Oswaldo Arana-Muñoz, José Sergio Papaqui-Tapia, Juan Jesús Ríos-López, Jonathan Higgins Payán-Diaz, Carlos David López-Romero & Erika Villada-Villada. (2021) Eficacia y seguridad de la inmunoterapia subcutánea para alérgenos inhalables en pacientes con alergia respiratoria a un año de tratamiento. Revista Alergia México 67:4.
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Azahara Rodríguez-Domínguez, Margot Berings, Alexander Rohrbach, Huey-Jy Huang, Mirela Curin, Philippe Gevaert, Paolo M. Matricardi, Rudolf Valenta & Susanne Vrtala. (2020) Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy. Journal of Allergy and Clinical Immunology 146:5, pages 1097-1108.
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X. Yang, H. Wang, D. Zhao, J. Wang, X. Liu, X. Yuan, M. Zhang, G. Li, P. Ran, P. Yang & Z. Liu. (2020) Dust mite-derived Enterobacterial fimbriae H protein enforces the allergen specific immunotherapy in asthma mice. Allergologia et Immunopathologia 48:6, pages 654-665.
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Yuwei Li, Yuwei Wang, Pixin Ran, Pingchang Yang & Zhigang Liu. (2019) IgE binding activities and in silico epitope prediction of Der f 32 in Dermatophagoides farinae. Immunology Letters 213, pages 46-54.
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Yao-zu Zhang, Juan Luo, Zi-han Wang & Jie Wang. (2019) Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic rhinitis. American Journal of Otolaryngology 40:5, pages 755-760.
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Filippo Fassio & Fabio Guagnini. (2018) House dust mite-related respiratory allergies and probiotics: a narrative review. Clinical and Molecular Allergy 16:1.
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Katie Bonner & Graham Roberts. (2018) Does allergy explain why some children have severe asthma?. Clinical & Experimental Allergy 48:12, pages 1594-1605.
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Ivan Mrkić, Rajna Minić, Dragan Popović, Irena Živković & Marija Gavrović-Jankulović. (2018) Newly designed hemagglutinin-Der p 2 chimera is a potential candidate for allergen specific immunotherapy. Life Sciences 213, pages 158-165.
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Kim A. T. Verheijden, Saskia Braber, Thea Leusink-Muis, Prescilla V. Jeurink, Suzan Thijssen, Aletta D. Kraneveld, Johan Garssen, Gert Folkerts & Linette E. M. Willemsen. (2018) The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma. Frontiers in Immunology 9.
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Silviya M. Novakova, Plamena I. Novakova, Plamen H. Yakovliev, Maria T. Staevska, Nonka G. Mateva, Teodora D. Dimcheva & Jivko L. Peichev. (2018) A Three-Year Course of House Dust Mite Sublingual Immunotherapy Appears Effective in Controlling the Symptoms of Allergic Rhinitis. American Journal of Rhinology & Allergy 32:3, pages 147-152.
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Ling Li, Jun Qian, Ying Zhou & Yubao Cui. (2018) Domestic mite–induced allergy: Causes, diagnosis, and future prospects. International Journal of Immunopathology and Pharmacology 32, pages 205873841880409.
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Silviya Mihaylova Novakova, Maria Toncheva Staevska, Plamena Ivanova Novakova, Manuela Dimitrova Yoncheva, Maria Stoykova Bratoycheva, Nina Mihaylova Musurlieva, Valeri Dimitrov Tzekov & Dimitar Georgiev Nicolov. (2017) Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life. Health and Quality of Life Outcomes 15:1.
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E Sahin, D Dizdar, M E Dinc & A A Cirik. (2017) Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis. The Journal of Laryngology & Otology 131:11, pages 997-1001.
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Blaise Corthésy & Gilles Bioley. (2017) Therapeutic intranasal instillation of allergen-loaded microbubbles suppresses experimental allergic asthma in mice. Biomaterials 142, pages 41-51.
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G. K. Scadding, H. H. Kariyawasam, G. Scadding, R. Mirakian, R. J. Buckley, T. Dixon, S. R. Durham, S. Farooque, N. Jones, S. Leech, S. M. Nasser, R. Powell, G. Roberts, G. Rotiroti, A. Simpson, H. Smith & A. T. Clark. (2017) BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007). Clinical & Experimental Allergy 47:7, pages 856-889.
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Mois?s A. Calder?n, Jean Bousquet, G. Walter Canonica, Lars-Olaf Cardell, Dolores Hernandez Fernandez de Rojas, J?rg Kleine-Tebbe & Pascal Demoly. (2017) Guideline recommendations on the use of allergen immunotherapy in house dust mite allergy: Time for a change?. Journal of Allergy and Clinical Immunology 140:1, pages 41-52.
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Edith Schussler & Linda S. Cox. (2017) Efficacy of House Dust Mite Sublingual Immunotherapy in Adults with Allergic Asthma. The Journal of Allergy and Clinical Immunology: In Practice 5:3, pages 870-872.
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Wei-Wei Ni, Li-Bing Wang, Yan-Jun Zhou, Meng-Da Cao, Wen Huang, Miao Guo, Chun-Mei Ji, Jin-Lu Sun & Ji-Fu Wei. (2017) Expression, purification and epitope analysis of Pla a 3 allergen from Platanus acerifolia pollen. Molecular Medicine Reports 16:3, pages 2851-2855.
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Yubao Cui, Feixiang Teng, LiLi Yu, Ying Zhou, Chengbo Zhang & Li Yang. (2017) Dermatophagoides farinae allergen Der f 9: Cloning, expression, purification, characterization and IgE-binding in children with atopic asthma . Pediatric Pulmonology 52:3, pages 282-292.
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L.-H. Mo, L.-T. Yang, L. Zeng, L.-Z. Xu, H.-P. Zhang, L.-J. Li, J.-Q. Liu, X.-J. Xiao, P.-Y. Zheng, Z.-G. Liu & P.-C. Yang. (2017) Dust mite allergen, glutathione S-transferase, induces T cell immunoglobulin mucin domain-4 in dendritic cells to facilitate initiation of airway allergy. Clinical & Experimental Allergy 47:2, pages 264-270.
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C. Hüser, P. Dieterich, J. Singh, K. Shah-Hosseini, S. Allekotte, W. Lehmacher, E. Compalati & R. Mösges. (2017) A 12-week DBPC dose-finding study with sublingual monomeric allergoid tablets in house dust mite-allergic patients. Allergy 72:1, pages 77-84.
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Pascal Demoly, Anne Brou?-Chabbert, Fran?ois Wessel & Antoine Chartier. (2016) Severity and disease control before house dust mite immunotherapy initiation: ANTARES a French observational survey. Allergy, Asthma & Clinical Immunology 12:1.
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Yoshihisa Hiraishi, Aya Nambu, Akiko Shibui, Wakako Nakanishi, Sachiko Yamaguchi, Hideaki Morita, Motoyasu Iikura, Andrew N.J. McKenzie, Kenji Matsumoto, Katsuko Sudo, Tatsuya Yamasoba, Takahide Nagase & Susumu Nakae. (2016) TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens. Allergology International 65:4, pages 459-465.
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David El-Qutob, Francisco Moreno & Alicia Subtil-Rodríguez. (2016) Specific immunotherapy for rhinitis and asthma with a subcutaneous hypoallergenic high-dose house dust mite extract: results of a 9-month therapy. Immunotherapy 8:8, pages 867-876.
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Victoria Moreno, Marta Alvariño, Fernando Rodríguez, Albert Roger, María Isabel Peña-Arellano, Ramón Lleonart, Juan Antonio Pagán, José Antonio Navarro, Luís Angel Navarro, Carmen Vidal, Ana Ponte-Tellechea, María Cruz Gómez-Fernández, Begoña Madariaga-Goirigolzarri, Juan Andrés Asturias & Dolores Hernández-Fernandezde Rojas. (2016) Randomized dose–response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in patients with respiratory allergy . Immunotherapy 8:3, pages 265-277.
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Chunqing Ai, Qiuxiang Zhang, Junrong Ding, Gang Wang, Xiaoming Liu, Fengwei Tian, Jianxin Zhao, Hao Zhang & Wei Chen. (2015) Mucosal delivery of allergen peptides expressed by Lactococcus lactis inhibit allergic responses in a BALB/c mouse model. Applied Microbiology and Biotechnology 100:4, pages 1915-1924.
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Hyun Jung JinMoon-Gyung YoonYoung-Hee NamJune Hong AhnHae-Sim ParkJin Hong Chung. (2016) Comparison of IgE-binding components between 2 house dust mites in adult allergic patients. Allergy, Asthma & Respiratory Disease 4:3, pages 199.
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K S Pavlova & O M Kurbacheva. (2015) Current strategies of allergen-specific immunotherapy. Russian Journal of Allergy 12:4, pages 16-26.
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Q. Zhang, C. Ai, G. Wang, X. Liu, F. Tian, J. Zhao, H. Zhang, Y.Q. Chen & W. Chen. (2015) Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation. Journal of Applied Microbiology 119:3, pages 809-817.
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J. S?nchez. (2015) Adherence to allergen immunotherapy improves when patients choose the route of administration: Subcutaneous or sublingual. Allergologia et Immunopathologia 43:5, pages 436-441.
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Wei Liao, Qi Hu, Lei-Lei Shen, Ying Hu, Hai-feng Tao, Hui-fan Li & Wen-ting Fan. (2015) Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite. Medicine 94:24, pages e701.
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Chunqing Ai, Qiuxiang Zhang, Junrong Ding, Chengcheng Ren, Gang Wang, Xiaoming Liu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Yong Q. Chen & Wei Chen. (2015) Suppression of dust mite allergy by mucosal delivery of a hypoallergenic derivative in a mouse model. Applied Microbiology and Biotechnology 99:10, pages 4309-4319.
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Yuko Mitobe, Yasuki Yokomoto & Katsuyo Ohashi-Doi. (2015) Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy. Regulatory Toxicology and Pharmacology 71:3, pages 529-540.
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Oliver Pfaar & Roy Gerth van Wijk. (2015) Mite-Allergic Rhinitis: How to Evaluate Clinical Efficacy in Allergen-Specific Immunotherapy Trials?. Current Treatment Options in Allergy 2:1, pages 1-9.
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