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Expert Opinion on Biological Therapy Volume 13, 2013 - Issue 12
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Immunogenicity of anti-TNFα therapy in psoriasis: a clinical issue?

Clara De SimoneCatholic University of the Sacred Heart, Department of Dermatology, L.go A.Gemelli 8; 00168 Rome, Italy+390630154227; +39063016293; [email protected]
,
Paolo AmerioUniversity G. D'Annunzio, Dermatologic Clinic, Department of Oncology and Neuroscience, Chieti, Italy
,
Giuseppe AmorusoUniversity of Catanzaro (Italy) C/O Fondazione per la Ricerca e la Cura dei Tumori ‘Tommaso Campanella' COE, Dermatology Unit, Viale Europa, 88100 Germaneto di Catanzaro (CZ), Italy
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Federico BardazziUniversity of Bologna, S.Orsola-Malpighi Hospital, Department of Specialistic, Diagnostic and Experimental Medicine, Dermatology Unit, Via Albertoni 15, 40138 Bologna, Italy
,
Anna CampanatiMarche Polytechinic University, Department of Medicine and Applied Biotechnology, Section of dermatology, Via Brecce Bianche, 1, 60131 Ancona, Italy
,
Andrea ContiUniversity of Modena and Reggio Emilia, Department of Dermatology, Via Del Pozzo 71 - 41100, Modena, Italy
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Paolo GisondiUniversity of Verona, Department of Medicine, Section of Dermatology and Venereology, Verona, Italy
,
Giulio GualdiUniversity of Brescia, Department of Dermatology, Piazzale Spedali Civili 1, 25123 Brescia, Italy
,
Claudio GuarneriUniversity of Messina (Italy) c/o A.O.U, Department of Clinical and Experimental Medicine, Section of Dermatology, ‘G. Martino', Consolare Valeria, 1, 98125 Messina, Italy
,
Luca LeoniIDI-IRCCS, Via Monti Creta, 104, 00167 Rome, Italy
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Francesco LoconsoleUniversity of Bari, Dermatology Clinic, Piazza Giulio Cesare 11, 70124 Bari, Italy
,
Annamaria MazzottaUniversity of Rome ‘Tor Vergata’, Department of Dermatology, Viale Oxford 81, 00133 Rome, Italy
,
Maria Letizia MusumeciAOU Policlinico-Vittorio Emanuele, Department of Dermatology, PO G. Rodolico, Via S. Sofia 78 – 95123 Catania, Italy
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Stefano PiasericoUniversity of Padova, Department of Medicine, Dermatology Unit, via Cesare Battisti 206, 35128 Padova, Italy
,
Concetta PotenzaSapienza University, Polo Pontino, A. Fiorni Terracina Hospital, UOC of Dermatology ‘Daniele Innocenzi’, Rome, Italy
&
Francesca PrestinariS.Anna Hospital, Department of Dermatology, Como, Italy
 show all
Pages 1673-1682 | Published online: 10 Oct 2013

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Alexandra Norden, Aislyn Oulee, Leena Munawar, Sogol Stephanie Javadi, George Han & Jashin J. Wu. (2022) Anti-drug antibodies of IL-17 inhibitors for psoriasis: a systematic review. Journal of Dermatological Treatment 33:8, pages 3080-3085.
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Teodora-Larisa Timis, Ioan-Alexandru Florian, Stefan-Cristian Vesa & Remus-Ioan Orasan. (2022) Treatment of psoriasis – unburdened by fear during SARS-CoV2 menace. Journal of Dermatological Treatment 33:2, pages 662-665.
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Clara De Simone, Maria Concetta Fargnoli, Paolo Amerio, Luca Bianchi, Maria Esposito, Federico Pirro, Concetta Potenza, Federica Ricceri, Franco Rongioletti, Luca Stingeni & Francesca Prignano. (2021) Risk of infections in psoriasis: assessment and challenges in daily management. Expert Review of Clinical Immunology 17:11, pages 1211-1220.
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Nishadh Sutaria & Shiu-Chung Au. (2021) Failure rates and survival times of systemic and biologic therapies in treating psoriasis: a retrospective study. Journal of Dermatological Treatment 32:6, pages 617-620.
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Marco Galluzzo, Valeria Manfreda, Alessandra Petruzzellis, Luca Bianchi & Marina Talamonti. (2021) The value of genotyping patients for the presence of HLA-C in the personalized treatment of psoriasis. Expert Review of Precision Medicine and Drug Development 6:2, pages 131-137.
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Anna Campanati, Federico Diotallevi, Emanuela Martina, Matteo Paolinelli, Giulia Radi & Annamaria Offidani. (2020) Safety update of etanercept treatment for moderate to severe plaque psoriasis. Expert Opinion on Drug Safety 19:4, pages 439-448.
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Anna Campanati, Matteo Paolinelli, Frederico Diotallevi, Emanuela Martina, Elisa Molinelli & Annamaria Offidani. (2019) Pharmacodynamics OF TNF α inhibitors for the treatment of psoriasis. Expert Opinion on Drug Metabolism & Toxicology 15:11, pages 913-925.
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Wolf-Henning Boehncke & Nicolo Costantino Brembilla. (2018) Immunogenicity of biologic therapies: causes and consequences. Expert Review of Clinical Immunology 14:6, pages 513-523.
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Mariano Ara-Martín, Pedro Herranz Pinto & Dora Pascual-Salcedo. (2017) Impact of immunogenicity on response to anti-TNF therapy in moderate-to-severe plaque psoriasis: results of the PREDIR study. Journal of Dermatological Treatment 28:7, pages 606-612.
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J. M. Norlin, P. S. Calara, U. Persson & M. Schmitt-Egenolf. (2017) Real-world outcomes in 2646 psoriasis patients: one in five has PASI ≥10 and/or DLQI ≥10 under ongoing systemic therapy. Journal of Dermatological Treatment 28:6, pages 500-504.
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A. Campanati, E. Molinelli, G. Ganzetti, K. Giuliodori, I. Minetti, M. Taus, M. Catani, E. Martina, L. Conocchiari & A. Offidani. (2017) The effect of low-carbohydrates calorie-restricted diet on visceral adipose tissue and metabolic status in psoriasis patients receiving TNF-alpha inhibitors: results of an open label controlled, prospective, clinical study. Journal of Dermatological Treatment 28:3, pages 206-212.
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A. Campanati, D. Benfaremo, M. M. Luchetti, G. Ganzetti, A. Gabrielli & A. Offidani. (2017) Certolizumab pegol for the treatment of psoriasis. Expert Opinion on Biological Therapy 17:3, pages 387-394.
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V Di Lernia & F Bardazzi. (2016) Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis. Drug Design, Development and Therapy 10, pages 533-539.
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Anette Karle, Sebastian Spindeldreher & Frank Kolbinger. (2016) Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity. mAbs 8:3, pages 536-550.
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Francesco Caso, Ennio Lubrano, Antonio Del Puente, Paolo Caso, Rosario Peluso, Francesca Foglia, Carolina Benigno, Nicolò Girolimetto, Paolo Bottiglieri, Raffaele Scarpa & Luisa Costa. (2016) Progress in understanding and utilizing TNF-α inhibition for the treatment of psoriatic arthritis. Expert Review of Clinical Immunology 12:3, pages 315-331.
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Eduardo Fonseca, Raquel Iglesias, Sabela Paradela, Rosa M. Fernández-Torres & Laida Elberdín. (2015) Efficacy and safety of adalimumab in psoriatic patients previously treated with etanercept in a real-world setting. Journal of Dermatological Treatment 26:3, pages 217-222.
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Andrew Blauvelt, Andrea Chiricozzi, Benjamin D. Ehst & Mark G. Lebwohl. (2023) Safety of IL-23 p19 Inhibitors for the Treatment of Patients With Moderate-to-Severe Plaque Psoriasis: A Narrative Review. Advances in Therapy 40:8, pages 3410-3433.
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Sunil Bellur, Matthew McHarg, Wijak Kongwattananon, Susan Vitale, H. Nida Sen & Shilpa Kodati. (2023) Antidrug Antibodies to Tumor Necrosis Factor α Inhibitors in Patients With Noninfectious Uveitis. JAMA Ophthalmology 141:2, pages 150.
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Irmina Olejniczak-Staruch, Joanna Narbutt, Justyna Ceryn, Małgorzata Skibińska, Igor Bednarski, Anna Woźniacka, Joanna Sieniawska, Marzena Kraska-Gacka, Magdalena Ciążyńska, Janusz Śmigielski, Marcin Noweta, Michał Waszczykowski, Witold Owczarek, Adam Reich & Aleksandra Lesiak. (2021) AntiTNF-alpha therapy normalizes levels of lipids and adipokines in psoriatic patients in the real-life settings. Scientific Reports 11:1.
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Fernando Valenzuela & Rodrigo Flores. (2021) Immunogenicity to biological drugs in psoriasis and psoriatic arthritis. Clinics 76, pages e3015.
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Paolo Amerio, Francesca Prignano, Federica Giuliani & Giulio Gualdi. (2020) COVID ‐19 and psoriasis: Should we fear for patients treated with biologics? . Dermatologic Therapy 33:4.
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Agnieszka Owczarczyk-Saczonek, Witold Owczarek, Agnieszka Osmola-Mańkowska, Zygmunt Adamski, Waldemar Placek & Adriana Rakowska. (2019) Secondary failure of TNF-α inhibitors in clinical practice. Dermatologic Therapy 32:1, pages e12760.
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Francesco Caso, Luisa Costa, Rosario Peluso, Antonio Del Puente & Raffaele Scarpa. 2019. Mosaic of Autoimmunity. Mosaic of Autoimmunity 527 540 .
Heejin Lim, Sang Lee, Hyun Lee, Jee Lee, Ji Son, Woori Shin & Yong-Seok Heo. (2018) Structural Biology of the TNFα Antagonists Used in the Treatment of Rheumatoid Arthritis. International Journal of Molecular Sciences 19:3, pages 768.
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Sebastian Spindeldreher, Bernard Maillère, Evelyne Correia, Maxime Tenon, Anette Karle, Philip Jarvis & Frank Kolbinger. (2018) Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab. Dermatology and Therapy 8:1, pages 57-68.
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F. Hjalte, K.S. Carlsson & M. Schmitt‐Egenolf. (2018) Sustained Psoriasis Area and Severity Index, Dermatology Life Quality Index and EuroQol‐5D response of biological treatment in psoriasis: 10 years of real‐world data in the Swedish National Psoriasis Register. British Journal of Dermatology 178:1, pages 245-252.
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Alexandra G. Florek & Kennethk B. Gordon. 2018. Biologic and Systemic Agents in Dermatology. Biologic and Systemic Agents in Dermatology 93 99 .
Júlia Vide & Sofia Magina. (2017) Moderate to severe psoriasis treatment challenges through the era of biological drugs. Anais Brasileiros de Dermatologia 92:5, pages 668-674.
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Joseph F. Merola, Benjamin Lockshin & Elinor A. Mody. (2017) Switching biologics in the treatment of psoriatic arthritis. Seminars in Arthritis and Rheumatism 47:1, pages 29-37.
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Madhukar S. Patel, David Miranda-Nieves, Jiaxuan Chen, Carolyn A. Haller & Elliot L. Chaikof. (2017) Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome. Translational Research 183, pages 1-13.
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Crossref
K. Reich, A. BlauveltA. ArmstrongR.G. Langley, T. Fox, J. HuangC. Papavassilis, E. Liang, P. Lloyd & G. Bruin. (2017) Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits minimal immunogenicity in patients with moderate-to-severe plaque psoriasis. British Journal of Dermatology 176:3, pages 752-758.
Crossref
Claudio Guarneri, Valentina Bevelacqua, James W. Patterson & Georgi Tchernev. (2016) Cutaneous and visceral leishmaniasis during anti-TNFα therapy. Wiener Medizinische Wochenschrift 167:3-4, pages 78-82.
Crossref
Jee Lee, Woori Shin, Ji Son, Ki-Young Yoo & Yong-Seok Heo. (2017) Molecular Basis for the Neutralization of Tumor Necrosis Factor α by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases. International Journal of Molecular Sciences 18:1, pages 228.
Crossref
F. Bardazzi, F. Savoia, V. Di Lernia, V. Tengattini, R. Balestri, A. Patrizi & M. Magnano. (2016) To pretreat or not to pretreat? The experience of three Italian Psoriasis centres on the use of premedication with Infliximab. Journal of the European Academy of Dermatology and Venereology 30:10, pages e55-e57.
Crossref
Anna Campanati, Monia Orciani, Giulia Ganzetti, Veronica Consales, Roberto Di Primio & Annamaria Offidani. (2016) The effect of etanercept on vascular endothelial growth factor production by cutaneous mesenchymal stem cells from patients with psoriasis. Journal of International Medical Research 44:1_suppl, pages 6-9.
Crossref
Francesco Prattichizzo, Angelica Giuliani, Rina Recchioni, Massimiliano Bonafè, Fiorella Marcheselli, Sabrina De Carolis, Anna Campanati, Katia Giuliodori, Maria Rita Rippo, Francesca Brugè, Luca Tiano, Carla Micucci, Antonio Ceriello, Annamaria Offidani, Antonio Domenico Procopio & Fabiola Olivieri. (2016) Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells. Oncotarget 7:11, pages 11945-11958.
Crossref
Azeen Sadeghian, Virginia Alldredge, Ardalan Minokadeh & Erin Boh. (2015) A Clinician's Guide to Diagnosing and Managing Psoriatic Arthritis. Journal of Psoriasis and Psoriatic Arthritis 1:1, pages 9-25.
Crossref
Francisco Kerdel & Martin Zaiac. (2015) An evolution in switching therapy for psoriasis patients who fail to meet treatment goals. Dermatologic Therapy 28:6, pages 390-403.
Crossref
M. Giannoni, V. Consales, A. Campanati, G. Ganzetti, K. Giuliodori, V. Postacchini, G. Liberati, L. Azzaretto, S. Vichi, F. Guanciarossa & A. Offidani. (2015) Homocysteine plasma levels in psoriasis patients: our experience and review of the literature. Journal of the European Academy of Dermatology and Venereology 29:9, pages 1781-1785.
Crossref
Michael E. Farhangian & Steven R. Feldman. (2015) Immunogenicity of Biologic Treatments for Psoriasis: Therapeutic Consequences and the Potential Value of Concomitant Methotrexate. American Journal of Clinical Dermatology 16:4, pages 285-294.
Crossref
Anna Campanati, Giulia Ganzetti, Katia Giuliodori, Maurizio Marra, Annarita Bonfigli, Roberto Testa & Annamaria Offidani. (2015) Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor- ? inhibitors: results of a retrospective analysis . International Journal of Dermatology 54:7, pages 839-845.
Crossref
A. Campanati, P. Neri, K. Giuliodori, I. Arapi, G. Carbonari, E. Borioni, C. P. Herbort, C. Mariotti, A. Giovannini & A. Offidani. (2014) Psoriasis beyond the skin surface: a pilot study on the ocular involvement. International Ophthalmology 35:3, pages 331-340.
Crossref
Anna Campanati, Giulia Ganzetti, Emanuela Martina, Melania Giannoni, Rosaria Gesuita, Emanuele Bendia, Katia Giuliodori, Lucia Sandroni & Annamaria Offidani. (2015) Helicobacter pylori infection in psoriasis: results of a clinical study and review of the literature . International Journal of Dermatology 54:5, pages e109-e114.
Crossref
J.M. Carrascosa, I. Belinchón, P. de-la-Cueva, R. Izu, J. Luelmo & R. Ruiz-Villaverde. (2015) Expert Recommendations on Treating Psoriasis in Special Circumstances. Actas Dermo-Sifiliográficas (English Edition) 106:4, pages 292-309.
Crossref
J.M. Carrascosa, I. Belinchón, P. de-la-Cueva, R. Izu, J. Luelmo & R. Ruiz-Villaverde. (2015) Recomendaciones de expertos para el tratamiento de la psoriasis en situaciones especiales. Actas Dermo-Sifiliográficas 106:4, pages 292-309.
Crossref
G. Ganzetti, A. Campanati, A. Santarelli, V. Pozzi, E. Molinelli, I. Minnetti, V. Brisigotti, M. Procaccini, M. Emanuelli & A. Offidani. (2015) Involvement of the oral cavity in psoriasis: results of a clinical study. British Journal of Dermatology 172:1, pages 282-285.
Crossref
A. Campanati, M. Orciani, V. Consales, R. Lazzarini, G. Ganzetti, G. Di Benedetto, R. Di Primio & A. Offidani. (2014) Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis. Archives of Dermatological Research 306:10, pages 915-920.
Crossref
Giulia Ganzetti, Anna Campanati, Andrea Santarelli, Valentina Pozzi, Elisa Molinelli, Ilaria Minnetti, Valerio Brisigotti, Maurizio Procaccini, Monica Emanuelli & Annamaria Offidani. (2014) Periodontal Disease: An Oral Manifestation of Psoriasis or an Occasional Finding?. Drug Development Research 75, pages S46-S49.
Crossref
G. Tchernev, C. Guarneri, V. Bevelacqua & U. Wollina. (2014) Carcinoma Cuniculatum in Course of Etanercept: Blocking Autoimmunity but Propagation of Carcinogenesis?. International Journal of Immunopathology and Pharmacology 27:2, pages 261-266.
Crossref

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