1,128
Views
61
CrossRef citations to date
0
Altmetric
Reviews

Initiation and early control of tissue regeneration – bone healing as a model system for tissue regeneration

, , , &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Mark Heyland. (2019) Brief Commentary on Mechano-Biological Fixation. Journal of Investigative Surgery 32:3, pages 255-256.
Read now
Timo Gaber, Cindy Strehl, Birgit Sawitzki, Paula Hoff & Frank Buttgereit. (2015) Cellular Energy Metabolism in T-Lymphocytes. International Reviews of Immunology 34:1, pages 34-49.
Read now

Articles from other publishers (59)

Xiaoyu Han, Qimanguli Saiding, Xiaolu Cai, Yi Xiao, Peng Wang, Zhengwei Cai, Xuan Gong, Weiming Gong, Xingcai Zhang & Wenguo Cui. (2023) Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds. Nano-Micro Letters 15:1.
Crossref
Seyed Ebrahim Alavi, Max Gholami, Hasan Ebrahimi Shahmabadi & Peter Reher. (2023) Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications. Journal of Clinical Medicine 12:22, pages 6962.
Crossref
Alexandra Dreanca, Sidonia Bogdan, Andra Popescu, Denisa Sand, Emoke Pall, Andreea Niculina Astilean, Cosmin Pestean, Corina Toma, Sorin Marza, Marian Taulescu, Mihai Cenariu, Bogdan Sevastre, Liviu Oana, Milica Todea, Lucian Baia & Klara Magyari. (2023) The evaluation of the osteopromoting capabilities of composites based on biopolymers and gold/silver nanoparticles doped bioactive glasses on an experimental rat bone defect. Biomedical Materials 18:5, pages 055014.
Crossref
Youliang Ren, Shiyang Zhang, Jason Weeks, Javier Rangel Moreno, Bin He, Thomas Xue, Joshua Rainbolt, Yugo Morita, Ye Shu, Yuting Liu, Stephen L. Kates, Edward M. Schwarz & Chao Xie. (2023) Reduced angiogenesis and delayed endochondral ossification in CD163 −/− mice highlights a role of M2 macrophages during bone fracture repair . Journal of Orthopaedic Research.
Crossref
Gehan Abd-Elfatah Tawfeek, Mostafa Abdelgaber, Shaaban Gadallah, Anis Anis & Ahmed Sharshar. (2023) A Novel Construct of Coral Granules-Poly-L-Lactic Acid Nanomembrane Sandwich Double Stem Cell Sheet Transplantation as Regenerative Therapy of Bone Defect Model. Experimental and Clinical Transplantation 21:2, pages 158-170.
Crossref
Zhang Bin-bin, Zha Xi Da-wa, Li Chao, Zhang Lan-tao, Wu Tao, Lu Chuan, Liu Chao-zheng, Li De-chun, Feng Chang, Wei Shu-qing, Dong Zu-nan, Pei Xian-wei, Zhi-xia Zhang & Li Ke-wen. (2022) M2 macrophagy-derived exosomal miRNA-26a-5p induces osteogenic differentiation of bone mesenchymal stem cells. Journal of Orthopaedic Surgery and Research 17:1.
Crossref
A. Polikarpova, A. Ellinghaus, O. Schmidt-Bleek, L. Grosser, C. H. Bucher, G. N. Duda, E. M. Tanaka & K. Schmidt-Bleek. (2022) The specialist in regeneration—the Axolotl—a suitable model to study bone healing?. npj Regenerative Medicine 7:1.
Crossref
Bing Wang, Chengmin Feng, Yiming Liu, Fanglin Mi & Jun Dong. (2022) Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review. Japanese Dental Science Review 58, pages 233-248.
Crossref
A. M. Fain, A. Yu. Vaza, S. F. Gnetetskiy, K. I. Skuratovskaya, V. B. Bondarev, Yu. A. Bogolyubskiy, R. S. Titov & A. Yu. Sergeev. (2022) Available methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 3. Use of autologous human red bone marrow. Transplantologiya. The Russian Journal of Transplantation 14:3, pages 344-356.
Crossref
Sara Nadine, Clara R. Correia & João F. Mano. (2022) Engineering immunomodulatory hydrogels and cell-laden systems towards bone regeneration. Biomaterials Advances 140, pages 213058.
Crossref
Christian H. Bucher, Julia C. Berkmann, Lisa-Marie Burkhardt, Carolin Paschke, Claudia Schlundt, Annemarie Lang, Angelique Wolter, Alexandra Damerau, Sven Geissler, Hans-Dieter Volk, Georg N. Duda & Katharina Schmidt-Bleek. (2022) Local immune cell contributions to fracture healing in aged individuals – A novel role for interleukin 22. Experimental & Molecular Medicine 54:8, pages 1262-1276.
Crossref
Jianfeng Ping, Laifeng Li, Yongqiang Dong, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Fangming Xu & Wenqing Liang. (2022) The role of long non‐coding RNAs and circular RNAs in bone regeneration: Modulating miRNAs function. Journal of Tissue Engineering and Regenerative Medicine 16:3, pages 227-243.
Crossref
Hao-Kuen Lin, Jen-Hao Cheng, Chia-Chou Wu, Feng-Shu Hsieh, Carolyn Dunlap & Sheng-hong Chen. (2022) Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness. Scientific Reports 12:1.
Crossref
Milena Suemi Irie, Rubens Spin-Neto, Juliana Simeão Borges, Ann Wenzel & Priscilla Barbosa Ferreira Soares. (2022) Effect of data binning and frame averaging for micro-CT image acquisition on the morphometric outcome of bone repair assessment. Scientific Reports 12:1.
Crossref
V.N. Borschevskaya, I.A. Kolomoyets, A.V. Kopylov, I.Yu. Makarov, D.P. Berezovskiy & Yu.I. Pigolkin. (2022) Microcirculation in fractures of long bones of the lower extremity. Sudebno-meditsinskaya ekspertiza 65:4, pages 14.
Crossref
Weichen Qi, Xiaoreng Feng, Teng Zhang, Hao Wu, Christian Fang & Frankie Leung. (2021) Development and validation of a modularized external fixator for generating standardized fracture healing micromotions in rats. Bone & Joint Research 10:11, pages 714-722.
Crossref
Claudia Schlundt, Heilwig Fischer, Christian H. Bucher, Carsten Rendenbach, Georg N. Duda & Katharina Schmidt-Bleek. (2021) The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time. Acta Biomaterialia 133, pages 46-57.
Crossref
Jessika Appelt, Serafeim Tsitsilonis, Ellen Otto, Denise Jahn, Paul Köhli, Anke Baranowsky, Shan Jiang, Melanie Fuchs, Christian H. Bucher, Georg N. Duda, Karl-Heinz Frosch & Johannes Keller. (2021) Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing. Cells 10:9, pages 2304.
Crossref
Wenwen Liu, Fengyi Zhang, Yuanyang Yan, Chenguang Zhang, Han Zhao, Boon Chin Heng, Ying Huang, Yang Shen, Jinxing Zhang, Lili Chen, Xiufang Wen & Xuliang Deng. (2020) Remote Tuning of Built‐In Magnetoelectric Microenvironment to Promote Bone Regeneration by Modulating Cellular Exposure to Arginylglycylaspartic Acid Peptide. Advanced Functional Materials 31:6, pages 2006226.
Crossref
Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi & Guohui Liu. (2020) M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3. Journal of Nanobiotechnology 18:1.
Crossref
Victoria Schemenz, André Gjardy, Fereshteh F. Chamasemani, Andreas Roschger, Paul Roschger, Paul Zaslansky, Lukas Helfen, Manfred Burghammer, Peter Fratzl, Richard Weinkamer, Roland Brunner, Bettina M. Willie & Wolfgang Wagermaier. (2020) Heterogeneity of the osteocyte lacuno-canalicular network architecture and material characteristics across different tissue types in healing bone. Journal of Structural Biology 212:2, pages 107616.
Crossref
Angela Rita Armiento, Luan Phelipe Hatt, Guillermo Sanchez Rosenberg, Keith Thompson & Martin James Stoddart. (2020) Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology. Advanced Functional Materials 30:44, pages 1909874.
Crossref
Subhasmita Swain, Rabindra Nath Padhy & Tapash Ranjan Rautray. (2020) Electrically stimulated hydroxyapatite–barium titanate composites demonstrate immunocompatibility in vitro. Journal of the Korean Ceramic Society 57:5, pages 495-502.
Crossref
Julia C. Berkmann, Aaron X. Herrera Martin, Carlotta Pontremoli, Kai Zheng, Christian H. Bucher, Agnes Ellinghaus, Aldo R. Boccaccini, Sonia Fiorilli, Chiara Vitale Brovarone, Georg N. Duda & Katharina Schmidt-Bleek. (2020) In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration. Pharmaceutics 12:9, pages 823.
Crossref
Joseph G. Lyons, Mark A. Plantz, Wellington K. Hsu, Erin L. Hsu & Silvia Minardi. (2020) Nanostructured Biomaterials for Bone Regeneration. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Wei Chen QI, Xiao Reng FENG, Teng ZHANG & Li Ka Frankie LEUNG. (2020) The development and in vivo validation of an external fixation device with standardized micromotion for accelerating fracture healing * . The development and in vivo validation of an external fixation device with standardized micromotion for accelerating fracture healing * .
Jonathan Stefanowski, Alexander F. Fiedler, Markus Köhler, Robert Günther, Wjatscheslaw Liublin, Martin Tschaikner, Ariana Rauch, David Reismann, Romano Matthys, Reto Nützi, Maria Gabriele Bixel, Ralf H. Adams, Raluca A. Niesner, Georg N. Duda & Anja E. Hauser. (2020) Limbostomy: Longitudinal Intravital Microendoscopy in Murine Osteotomies. Cytometry Part A 97:5, pages 483-495.
Crossref
Julia C. Berkmann, Aaron X. Herrera Martin, Agnes Ellinghaus, Claudia Schlundt, Hanna Schell, Evi Lippens, Georg N. Duda, Serafeim Tsitsilonis & Katharina Schmidt-Bleek. (2020) Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH. International Journal of Molecular Sciences 21:7, pages 2513.
Crossref
Jonathan Stefanowski, Annemarie Lang, Ariana Rauch, Linus Aulich, Markus Köhler, Alexander F. Fiedler, Frank Buttgereit, Katharina Schmidt-Bleek, Georg N. Duda, Timo Gaber, Raluca A. Niesner & Anja E. Hauser. (2019) Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels. Frontiers in Immunology 10.
Crossref
Christin Neuber, Sabine Schulze, Yvonne Förster, Frank Hofheinz, Johanna Wodke, Stephanie Möller, Matthias Schnabelrauch, Vera Hintze, Dieter Scharnweber, Stefan Rammelt & Jens Pietzsch. (2019) Biomaterials in repairing rat femoral defects: In vivo insights from small animal positron emission tomography/computed tomography (PET/CT) studies. Clinical Hemorheology and Microcirculation 73:1, pages 177-194.
Crossref
Julia Löffler, F. Andrea Sass, Sebastian Filter, Alexander Rose, Agnes Ellinghaus, Georg N. Duda & Anke Dienelt. (2019) Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. Frontiers in Immunology 10.
Crossref
Michiel Croes, Bart C. H. Wal & H. Charles Vogely. (2019) Impact of Bacterial Infections on Osteogenesis: Evidence From In Vivo Studies. Journal of Orthopaedic Research 37:10, pages 2067-2076.
Crossref
Claudia Schlundt, Simon Reinke, Sven Geissler, Christian H. Bucher, Carolin Giannini, Sven Märdian, Michael Dahne, Christian Kleber, Björn Samans, Udo Baron, Georg N. Duda, Hans-Dieter Volk & Katharina Schmidt-Bleek. (2019) Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration. Frontiers in Immunology 10.
Crossref
Dominik Sieger, Tadas Korzinskas, Ole Jung, Sanja Stojanovic, Sabine Wenisch, Ralf Smeets, Martin Gosau, Reinhard Schnettler, Stevo Najman & Mike Barbeck. (2019) The Addition of High Doses of Hyaluronic Acid to a Biphasic Bone Substitute Decreases the Proinflammatory Tissue Response. International Journal of Molecular Sciences 20:8, pages 1969.
Crossref
Sebastian Wendler, Claudia Schlundt, Christian H. Bucher, Jan Birkigt, Christian J. Schipp, Hans-Dieter Volk, Georg N. Duda & Katharina Schmidt-Bleek. (2019) Immune Modulation to Enhance Bone Healing—A New Concept to Induce Bone Using Prostacyclin to Locally Modulate Immunity. Frontiers in Immunology 10.
Crossref
Alyaa I. Naser. (2018) The effect of the new hemostatic agent Ostene® on bone healing: An experimental study in rabbits.. Journal of Oral Research 7:8, pages 286-291.
Crossref
Sabrina Ehnert, Caren Linnemann, Romina Aspera-Werz, Daria Bykova, Sara Biermann, Leonie Fecht, Peter De Zwart, Andreas Nussler & Fabian Stuby. (2018) Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase. International Journal of Molecular Sciences 19:8, pages 2239.
Crossref
Claudia Schlundt, Christian H. Bucher, Serafeim Tsitsilonis, Hanna Schell, Georg N. Duda & Katharina Schmidt-Bleek. (2018) Clinical and Research Approaches to Treat Non-union Fracture. Current Osteoporosis Reports 16:2, pages 155-168.
Crossref
F. Sass, Michael Fuchs, Matthias Pumberger, Sven Geissler, Georg Duda, Carsten Perka & Katharina Schmidt-Bleek. (2018) Immunology Guides Skeletal Muscle Regeneration. International Journal of Molecular Sciences 19:3, pages 835.
Crossref
T. Winkler, F. A. Sass, G. N. Duda & K. Schmidt-Bleek. (2018) A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering. Bone & Joint Research 7:3, pages 232-243.
Crossref
Julia Loeffler, Georg N. Duda, F. Andrea Sass & Anke Dienelt. (2018) The Metabolic Microenvironment Steers Bone Tissue Regeneration. Trends in Endocrinology & Metabolism 29:2, pages 99-110.
Crossref
Claudia Schlundt, Thaqif El Khassawna, Alessandro Serra, Anke Dienelt, Sebastian Wendler, Hanna Schell, Nico van Rooijen, Andreas Radbruch, Richard Lucius, Susanne Hartmann, Georg N. Duda & Katharina Schmidt-Bleek. (2018) Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone 106, pages 78-89.
Crossref
Jimeng Wang, Yi Gao, Pengzhen Cheng, Donglin Li, Huijie Jiang, Chuanlei Ji, Shuaishuai Zhang, Chao Shen, Junqin Li, Yue Song, Tianqing Cao, Chunmei Wang, Liu Yang & Guoxian Pei. (2017) CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process. Scientific Reports 7:1.
Crossref
Chi Zhang, Zhongqiang Chen, Xiangyu Meng, Mengtao Li, Li Zhang & Ann Huang. (2017) The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum. PLOS ONE 12:6, pages e0178986.
Crossref
Mohammad S. Ghiasi, Jason Chen, Ashkan Vaziri, Edward K. Rodriguez & Ara Nazarian. (2017) Bone fracture healing in mechanobiological modeling: A review of principles and methods. Bone Reports 6, pages 87-100.
Crossref
Thaqif El Khassawna, Alessandro Serra, Christian H. Bucher, Ansgar Petersen, Claudia Schlundt, Ireen Könnecke, Deeksha Malhan, Sebastian Wendler, Hanna Schell, Hans-Dieter Volk, Katharina Schmidt-Bleek & Georg N. Duda. (2017) T Lymphocytes Influence the Mineralization Process of Bone. Frontiers in Immunology 8.
Crossref
Edoardo Borgiani, Georg N. Duda & Sara Checa. (2017) Multiscale Modeling of Bone Healing: Toward a Systems Biology Approach. Frontiers in Physiology 8.
Crossref
F Andrea Sass, Katharina Schmidt-Bleek, Agnes Ellinghaus, Sebastian Filter, Alexander Rose, Bernd Preininger, Simon Reinke, Sven Geissler, Hans-Dieter Volk, Georg N Duda & Anke Dienelt. (2017) CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis. Journal of Bone and Mineral Research 32:5, pages 902-912.
Crossref
Diogo Godoy Zanicotti, Dawn Elizabeth Coates & Warwick John Duncan. (2017) In vivo bone regeneration on titanium devices using serum-free grown adipose-derived stem cells, in a sheep femur model . Clinical Oral Implants Research 28:1, pages 64-75.
Crossref
Annemarie Lang, Anja Schulz, Agnes Ellinghaus & Katharina Schmidt-Bleek. (2016) Osteotomy models – the current status on pain scoring and management in small rodents. Laboratory Animals 50:6, pages 433-441.
Crossref
Katharina Schmidt-Bleek, Ralph Marcucio & Georg Duda. (2016) Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach. Journal of the American Academy of Orthopaedic Surgeons 24:10, pages e134-e135.
Crossref
J. Stanovici, L.-R. Le Nail, M.A. Brennan, L. Vidal, V. Trichet, P. Rosset & P. Layrolle. (2016) Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery. Current Research in Translational Medicine 64:2, pages 83-90.
Crossref
Michiel Croes, F. Cumhur Öner, Danihel van Neerven, Ekrem Sabir, Moyo C. Kruyt, Taco J. Blokhuis, Wouter J.A. Dhert & Jacqueline Alblas. (2016) Proinflammatory T cells and IL-17 stimulate osteoblast differentiation. Bone 84, pages 262-270.
Crossref
Claudia Schlundt, Hanna Schell, Stuart B Goodman, Gordana Vunjak-Novakovic, Georg N Duda & Katharina Schmidt-Bleek. (2015) Immune modulation as a therapeutic strategy in bone regeneration. Journal of Experimental Orthopaedics 2:1.
Crossref
Hong Lei, Katharina Schmidt-Bleek, Anke Dienelt, Petra Reinke & Hans-Dieter Volk. (2015) Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners. Frontiers in Pharmacology 6.
Crossref
Katharina Schmidt-BleekBrian J. KweeDavid J. MooneyGeorg N. Duda. (2015) Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis. Tissue Engineering Part B: Reviews 21:4, pages 354-364.
Crossref
Michiel Croes, F. Cumhur Oner, Moyo C. Kruyt, Taco J. Blokhuis, Okan Bastian, Wouter J. A. Dhert & Jacqueline Alblas. (2015) Proinflammatory Mediators Enhance the Osteogenesis of Human Mesenchymal Stem Cells after Lineage Commitment. PLOS ONE 10:7, pages e0132781.
Crossref
Ireen Könnecke, Alessandro Serra, Thaqif El Khassawna, Claudia Schlundt, Hanna Schell, Anja Hauser, Agnes Ellinghaus, Hans-Dieter Volk, Andreas Radbruch, Georg N. Duda & Katharina Schmidt-Bleek. (2014) T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion. Bone 64, pages 155-165.
Crossref
James L. Rutkowski. (2014) Controlled Early Inflammation and Bone Healing—Potential New Treatments. Journal of Oral Implantology 40:3, pages 229-230.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.