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Expert Opinion on Biological Therapy Volume 14, 2014 - Issue 8
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Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery

Meghna TalekarNortheastern University, Pharmaceutical Sciences, 360 Huntington Avenue, 140 The Fenway Building, Boston, MA 02115, USA
,
Srinivas Reddy BoreddyNortheastern University, Pharmaceutical Sciences, 360 Huntington Avenue, 140 The Fenway Building, Boston, MA 02115, USA
,
Amit SinghNortheastern University, Pharmaceutical Sciences, 360 Huntington Avenue, 140 The Fenway Building, Boston, MA 02115, USA
&
Mansoor AmijiNortheastern University, Department of Pharmaceutical Sciences, 360 Huntington Avenue, 140 The Fenway Building, Boston, MA 02115, [email protected]
Pages 1145-1159 | Published online: 25 Apr 2014

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Lukasz Pulaski, Izabela Jatczak-Pawlik, Marta Sobalska-Kwapis, Dominik Strapagiel, Grzegorz Bartosz & Izabela Sadowska-Bartosz. (2019) 3-Bromopyruvate induces expression of antioxidant genes. Free Radical Research 53:2, pages 170-178.
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Shanmugasundaram Ganapathy-Kanniappan. (2018) Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype. Critical Reviews in Biochemistry and Molecular Biology 53:6, pages 667-682.
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Øystein Bruserud, Ina Nepstad, Michelle Hauge, Kimberley Joanne Hatfield & Håkon Reikvam. (2015) STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia. Expert Review of Hematology 8:1, pages 29-41.
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Fan Gao, JianHui Dong, Chun Xue, Lei An, Tian Zhang, Wen-Jun Wang, ChangJin Ou & XiaoChen Dong. (2023) Nanomaterials-involved strategies for reversing the immunosuppressive factors and improving antitumor immunotherapy. Nano Today 50, pages 101831.
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Hariprasad Thangavel, Kezia Lizardo, Dhanya Dhanyalayam, Sonia De Assis & Jyothi F. Nagajyothi. (2023) Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model. Journal of Clinical Medicine 12:2, pages 413.
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Zhengying Gu & Chengzhong Yu. (2022) Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism. Journal of Nanobiotechnology 20:1.
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Kuanchun Shao, Wenlong Zhang, Jiajia Shen & Yaning He. (2022) Hypoxia‐Activated Fluorescent Probe Based on Self‐Immolative Block Copolymer. Macromolecular Bioscience 22:3, pages 2100417.
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Kening Zhou, Jing Lin, Mimi Dai, Yingying He, Jingui Xu & Qian Lin. (2021) KIFC1 promotes aerobic glycolysis in endometrial cancer cells by regulating the c-myc pathway. Journal of Bioenergetics and Biomembranes 53:6, pages 703-713.
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Jieming Ni & Anping Ni. (2021) Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system. PLOS ONE 16:7, pages e0248019.
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Chunhui Wang, Jingxian Yang, Chunyan Dong & Shuo Shi. (2020) Glucose Oxidase‐Related Cancer Therapies. Advanced Therapeutics 3:10, pages 2000110.
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Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock & Rajkumar Savai. (2020) Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment . European Respiratory Review 29:157, pages 200134.
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Jin-Young Lee, Changwon Yang, Whasun Lim & Gwonhwa Song. (2020) Methiothepin Suppresses Human Ovarian Cancer Cell Growth by Repressing Mitochondrion-Mediated Metabolism and Inhibiting Angiogenesis In Vivo. Pharmaceutics 12:7, pages 686.
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Song-Tao Wu, Bo Liu, Zhong-Zhu Ai, Zong-Chao Hong, Peng-Tao You, He-Zhen Wu & Yan-Fang Yang. (2020) Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI. Frontiers in Pharmacology 11.
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Xiaoping Lin, Zizheng Xiao, Tao Chen, Steven H. Liang & Huiqin Guo. (2020) Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment. Frontiers in Oncology 10.
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Amit Singh & Mansoor Amiji. 2020. Biomaterials for Cancer Therapeutics. Biomaterials for Cancer Therapeutics 569 597 .
Jianshuang Guo, Qingqing Xue, Kaihui Liu, Weizhi Ge, Wenjie Liu, Jiyan Wang, Mengyi Zhang, Qiu-ying Li, Dongpo Cai, Changliang Shan, Chunze Zhang, Xinqi Liu & Jing Li. (2019) Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Frontiers in Oncology 9.
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Yuyi Li, Qianfei Xu, Wei Yang, Tongli Wu & Xirong Lu. (2019) Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells. Gene 712, pages 143956.
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Xiao‐Wen Yu, Dandan Wei, Ying‐Sheng Gao, Hong‐Zhi Du, Bo‐Yang Yu, Rui‐Ming Li, Chang‐Min Qian, Xue‐Jun Luo, Sheng‐Tao Yuan, Jun‐Song Wang & Li Sun. (2019) Synergistic combination of DT‐13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC‐823 cells via NM IIA/EGFR/HK II axis. Journal of Cellular and Molecular Medicine.
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Ma Carmen Ocaña, Beatriz Martínez-Poveda, Ana R. Quesada & Miguel Ángel Medina. (2019) Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target. Medicinal Research Reviews 39:1, pages 70-113.
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Elena A. Pudova, Anna V. Kudryavtseva, Maria S. Fedorova, Andrew R. Zaretsky, Dmitry S. Shcherbo, Elena N. Lukyanova, Anatoly Y. Popov, Asiya F. Sadritdinova, Ivan S. Abramov, Sergey L. Kharitonov, George S. Krasnov, Kseniya M. Klimina, Nadezhda V. Koroban, Nadezhda N. Volchenko, Kirill M. Nyushko, Nataliya V. Melnikova, Maria A. Chernichenko, Dmitry V. Sidorov, Boris Y. Alekseev, Marina V. Kiseleva, Andrey D. Kaprin, Alexey A. Dmitriev & Anastasiya V. Snezhkina. (2018) HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer. BMC Genomics 19:S3.
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Amit Singh & Mansoor M. Amiji. 2018. Biomedical Applications of Functionalized Nanomaterials. Biomedical Applications of Functionalized Nanomaterials 371 398 .
F Graziano, A Ruzzo, E Giacomini, T Ricciardi, G Aprile, F Loupakis, P Lorenzini, E Ongaro, F Zoratto, V Catalano, D Sarti, E Rulli, C Cremolini, M De Nictolis, G De Maglio, A Falcone, G Fiorentini & M Magnani. (2016) Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer. The Pharmacogenomics Journal 17:3, pages 258-264.
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Shanmugasundaram Ganapathy-Kanniappan. (2017) Taming Tumor Glycolysis and Potential Implications for Immunotherapy. Frontiers in Oncology 7.
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Ubaldo E. Martinez-Outschoorn, Maria Peiris-Pagés, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2016) Cancer metabolism: a therapeutic perspective. Nature Reviews Clinical Oncology 14:1, pages 11-31.
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Teng Wang, Kuan Ning, Ting-Xun Lu & Dong Hua. (2016) Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer. Oncology Reports.
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Izabela Sadowska-Bartosz, Jacek Grębowski, Ewa Kępka, Maciej Studzian, Grzegorz Bartosz & Łukasz Pułaski. (2016) ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid. Life Sciences 162, pages 138-144.
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Renee C. Geck & Alex Toker. (2016) Nonessential amino acid metabolism in breast cancer. Advances in Biological Regulation 62, pages 11-17.
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Li Yu, Xun Chen, Liantang Wang & Shangwu Chen. (2016) The sweet trap in tumors: aerobic glycolysis and potential targets for therapy. Oncotarget 7:25, pages 38908-38926.
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Hong-Sheng Zhang, Feng-Juan Zhang, Hu Li, Yang Liu, Guang-Yuan Du & Ying-Hui Huang. (2016) Tanshinone ⅡA inhibits human esophageal cancer cell growth through miR-122-mediated PKM2 down-regulation. Archives of Biochemistry and Biophysics 598, pages 50-56.
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Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park & Mijin Yun. (2015) The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells. BMC Cancer 15:1.
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Meghna Talekar, Qijun Ouyang, Michael S. Goldberg & Mansoor M. Amiji. (2015) Cosilencing of PKM-2 and MDR-1 Sensitizes Multidrug-Resistant Ovarian Cancer Cells to Paclitaxel in a Murine Model of Ovarian Cancer . Molecular Cancer Therapeutics 14:7, pages 1521-1531.
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Ana M. Abrantes, Ludgero C. Tavares, Salomé Pires, João Casalta-Lopes, Cândida Mendes, Marta Simões, Manuela M. Grazina, Rui A. Carvalho & Maria Filomena Botelho. (2014) Metabolic Effects of Hypoxia in Colorectal Cancer by 13 C NMR Isotopomer Analysis . BioMed Research International 2014, pages 1-10.
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