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Editorial

Probody therapeutics for targeting antibodies to diseased tissue

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Carolina T. Orozco, Manuela Bersellini, Lorraine M. Irving, Wesley W. Howard, David Hargreaves, Paul W. A. Devine, Elise Siouve, Gareth J. Browne, Nicholas J. Bond, Jonathan J. Phillips, Peter Ravn & Sophie E. Jackson. (2022) Mechanistic insights into the rational design of masked antibodies. mAbs 14:1.
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Rebecca P Chen, Kenta Shinoda, Pragya Rampuria, Fang Jin, Tin Bartholomew, Chunxia Zhao, Fan Yang & Javier Chaparro-Riggers. (2022) Bispecific antibodies for immune cell retargeting against cancer. Expert Opinion on Biological Therapy 22:8, pages 965-982.
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W. Michael Kavanaugh. (2020) Antibody prodrugs for cancer. Expert Opinion on Biological Therapy 20:2, pages 163-171.
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Alexis D. Leal, Anuradha Krishnamurthy, Lia Head & Wells A. Messersmith. (2018) Antibody drug conjugates under investigation in phase I and phase II clinical trials for gastrointestinal cancer. Expert Opinion on Investigational Drugs 27:11, pages 901-916.
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Mahendra P Deonarain, Gokhan Yahioglu, Ioanna Stamati & Jared Marklew. (2015) Emerging formats for next-generation antibody drug conjugates. Expert Opinion on Drug Discovery 10:5, pages 463-481.
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Toan D. Nguyen, Brandon M. Bordeau & Joseph P. Balthasar. (2023) Use of Payload Binding Selectivity Enhancers to Improve Therapeutic Index of Maytansinoid–Antibody–Drug Conjugates. Molecular Cancer Therapeutics 22:11, pages 1332-1342.
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Han Han, Lei Xing, Bi-Te Chen, Yang Liu, Tian-Jiao Zhou, Yi Wang, Ling-Feng Zhang, Ling Li, Chong-Su Cho & Hu-Lin Jiang. (2023) Progress on the pathological tissue microenvironment barrier-modulated nanomedicine. Advanced Drug Delivery Reviews 200, pages 115051.
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Mengyu Li, Sen Mei, Yi Yang, Yuelei Shen & Lei Chen. (2022) Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective. Antibody Therapeutics 5:3, pages 164-176.
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Jonathan M. Labriola, Shane Miersch, Gang Chen, Chao Chen, Alevtina Pavlenco, Reza Saberianfar, Francesca Caccuri, Alberto Zani, Nitin Sharma, Annie Feng, Daisy W. Leung, Arnaldo Caruso, Giuseppe Novelli, Gaya K. Amarasinghe & Sachdev S. Sidhu. (2022) Peptide–Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants. ACS Chemical Biology 17:7, pages 1978-1988.
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Erwin R. BoghaertMegan C. Cox & Kedar S. Vaidya. (2022) Pathophysiologic and Pharmacologic Considerations to Improve the Design and Application of Antibody–Drug Conjugates. Cancer Research 82:10, pages 1858-1869.
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Valentina Boni, Mary J. Fidler, Hendrik-Tobias Arkenau, Alexander Spira, Funda Meric-Bernstam, Nataliya Uboha, Rachel E. Sanborn, Randy F. Sweis, Patricia LoRusso, Misako Nagasaka, Javier Garcia-Corbacho, Shadia Jalal, James J. Harding, Stella K. Kim, Iris H.C. Miedema, Danielle J. Vugts, Marc C. Huisman, Gerben J.C. Zwezerijnen, Guus A.M.S. van Dongen, C. Willemien Menke van der Houven van Oordt, Song Wang, Tam Dang, Ivan A. Zein, Olga Vasiljeva, Susan K. Lyman, Virginia Paton, Alison Hannah & Joyce F. Liu. (2022) Praluzatamab Ravtansine, a CD166-Targeting Antibody–Drug Conjugate, in Patients with Advanced Solid Tumors: An Open-Label Phase I/II Trial. Clinical Cancer Research 28:10, pages 2020-2029.
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Evanthia T. Roussos Torres & Leisha A. Emens. (2021) Emerging combination immunotherapy strategies for breast cancer: dual immune checkpoint modulation, antibody–drug conjugates and bispecific antibodies. Breast Cancer Research and Treatment 191:2, pages 291-302.
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Morse Faria, Varun Ramani & Seema Kumar. 2022. An Introduction to Bioanalysis of Biopharmaceuticals. An Introduction to Bioanalysis of Biopharmaceuticals 49 74 .
Dominique Lesuisse. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain 27 69 .
Md Abdus Subhan & Vladimir P. Torchilin. (2021) Advances with antibody-drug conjugates in breast cancer treatment. European Journal of Pharmaceutics and Biopharmaceutics 169, pages 241-255.
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Jungheun Hyun, Soyeong Jun, Hyeonseob Lim, Hyunjun Cho, Sung-Hwan You, Sang-Jun Ha, Jung-Joon Min & Duhee Bang. (2021) Engineered Attenuated Salmonella typhimurium Expressing Neoantigen Has Anticancer Effects . ACS Synthetic Biology 10:10, pages 2478-2487.
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Bruce Howng, Michael B. Winter, Carol LePage, Irina Popova, Michael Krimm & Olga Vasiljeva. (2021) Novel Ex Vivo Zymography Approach for Assessment of Protease Activity in Tissues with Activatable Antibodies. Pharmaceutics 13:9, pages 1390.
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Melissa Johnson, Anthony El-Khoueiry, Navid Hafez, Nehal Lakhani, Hirva Mamdani, Jordi Rodon, Rachel E. Sanborn, Javier Garcia-Corbacho, Valentina Boni, Mark Stroh, Alison L. Hannah, Song Wang, Henry Castro & Alexander Spira. (2021) Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies. Clinical Cancer Research 27:16, pages 4521-4530.
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Adrian Elter, Desislava Yanakieva, David Fiebig, Kerstin Hallstein, Stefan Becker, Ulrich Betz & Harald Kolmar. (2021) Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity. Frontiers in Immunology 12.
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Aung Naing, Fiona Thistlethwaite, Elisabeth G.E. De Vries, Ferry A.L.M. Eskens, Nataliya Uboha, Patrick A. Ott, Patricia LoRusso, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A. Autio, Manreet Randhawa, Greg Durm, Marta Gil-Martin, Mark Stroh, Alison L. Hannah, Hendrik-Tobias Arkenau & Alexander Spira. (2021) CX-072 (pacmilimab), a Probody ® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study . Journal for ImmunoTherapy of Cancer 9:7, pages e002447.
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Rachel E Sanborn, Omid Hamid, Elisabeth GE de Vries, Patrick A Ott, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A Autio, Daniel C Cho, Ruth Plummer, Mark Stroh, Lawrence Lu & Fiona Thistlethwaite. (2021) CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study. Journal for ImmunoTherapy of Cancer 9:7, pages e002446.
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E. A. Bocharova, N. I. Kopytina & Е. Е. Slynko. (2021) Anti-tumour drugs of marine origin currently at various stages of clinical trials (review). Regulatory Mechanisms in Biosystems 12:2, pages 265-280.
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Xiaotian Zhong & Aaron M. D’Antona. (2021) Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics. Antibodies 10:2, pages 13.
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Hwai Wen Chang, Gerhard Frey, Haizhen Liu, Charles Xing, Lawrence Steinman, William J. Boyle & Jay M. Short. (2021) Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches. Proceedings of the National Academy of Sciences 118:9.
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Johanna Utterström, Sajjad Naeimipour, Robert Selegård & Daniel Aili. (2021) Coiled coil-based therapeutics and drug delivery systems. Advanced Drug Delivery Reviews 170, pages 26-43.
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Mathilde Lorscheider, Alice Gaudin, Jessica Nakhlé, Kadi-Liis Veiman, Joël Richard & Christophe Chassaing. (2021) Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress. Therapeutic Delivery 12:1, pages 55-76.
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Ava P. Soleimany, Jesse D. Kirkpatrick, Susan Su, Jaideep S. Dudani, Qian Zhong, Ahmet Bekdemir & Sangeeta N. Bhatia. (2021) Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer . Cancer Research 81:1, pages 213-224.
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Jessica C. Graham, Jedd Hillegass & Gene Schulze. (2020) Considerations for setting occupational exposure limits for novel pharmaceutical modalities. Regulatory Toxicology and Pharmacology 118, pages 104813.
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Ling Li, Zhen Yang & Xiaoyuan Chen. (2020) Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy. Accounts of Chemical Research 53:10, pages 2044-2054.
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Valentina Boni, Manish R. Sharma & Amita Patnaik. (2020) The Resurgence of Antibody Drug Conjugates in Cancer Therapeutics: Novel Targets and Payloads. American Society of Clinical Oncology Educational Book:40, pages e58-e74.
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Karen A. Autio, Valentina Boni, Rachel W. Humphrey & Aung Naing. (2020) Probody Therapeutics: An Emerging Class of Therapies Designed to Enhance On-Target Effects with Reduced Off-Tumor Toxicity for Use in Immuno-Oncology. Clinical Cancer Research 26:5, pages 984-989.
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Vivian H. Trang, Xinqun Zhang, Roma C. Yumul, Weiping Zeng, Ivan J. Stone, Serena W. Wo, Melissa M. Dominguez, Julia H. Cochran, Jessica K. Simmons, Maureen C. Ryan, Robert P. Lyon, Peter D. Senter & Matthew R. Levengood. (2019) A coiled-coil masking domain for selective activation of therapeutic antibodies. Nature Biotechnology 37:7, pages 761-765.
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Robbie G. Majzner, Johanna L. Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui, Christopher W. Mount, Skyler P. Rietberg, Miles H. Linde, Peng Xu, Christopher Rota, Elena Sotillo, Louai Labanieh, Daniel W. Lee, Rimas J. Orentas, Dimiter S. Dimitrov, Zhongyu Zhu, Brad St Croix, Alberto Delaidelli, Alla Sekunova, Ezio Bonvini, Siddhartha S. Mitra, Martha M. Quezado, Ravindra Majeti, Michelle Monje, Poul H.B. Sorensen, John M. Maris & Crystal L. Mackall. (2019) CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors. Clinical Cancer Research 25:8, pages 2560-2574.
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