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Editorials

How to train your T cell: genetically engineered chimeric antigen receptor T cells versus bispecific T-cell engagers to target CD19 in B acute lymphoblastic leukemia

, MD & , MD PhD

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Utkarsh H. Acharya, Tejaswini Dhawale, Seongseok Yun, Caron A. Jacobson, Julio C. Chavez, Jorge D. Ramos, Jacob Appelbaum & David G. Maloney. (2019) Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor (CAR) T cell therapy. Expert Review of Hematology 12:3, pages 195-205.
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Giuseppe Gaipa, Chiara Buracchi & A Biondi. (2018) Flow cytometry for minimal residual disease testing in acute leukemia: opportunities and challenges. Expert Review of Molecular Diagnostics 18:9, pages 775-787.
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Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti & Giorgio Inghirami. (2018) Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. OncoImmunology 7:4.
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Josep-Maria Ribera, Albert Ferrer, Jordi Ribera & Eulàlia Genescà. (2015) Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia. OncoTargets and Therapy 8, pages 1567-1574.
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Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Jo, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung Hyun Kim, Ji Hyun Lee, Mathew Angelos, Puneeth Guruprasad, Ivan Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Michael Wang, Soohwan Kim, Sung-Min Kim, Hyun-Jong Lee, Ji-Ho Park, Leiguang Cui, Tae Bum Lee, In-Sik Hwang, Young-Ha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Dok Hyun Yoon, Junho Chung & Marco Ruella. (2023) Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study. Molecular Cancer 22:1.
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Yong Gu Lee, Nicholas Yang, Inkook Chun, Patrizia Porazzi, Alberto Carturan, Luca Paruzzo, Christopher Tor Sauter, Puneeth Guruprasad, Raymone Pajarillo & Marco Ruella. (2023) Apoptosis: a Janus bifrons in T-cell immunotherapy . Journal for ImmunoTherapy of Cancer 11:4, pages e005967.
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Yong Gu Lee, Puneeth Guruprasad, Guido Ghilardi, Raymone Pajarillo, Christopher Tor Sauter, Ruchi Patel, Hatcher J. Ballard, Seok Jae Hong, Inkook Chun, Nicholas Yang, Kimberly V. Amelsberg, Katherine D. Cummins, Jakub Svoboda, Saar Gill, Elise A. Chong, Khrystyna North, Sarah E. Church, Joseph A. Fraietta, Wan-Jung Chang, Simon F. Lacey, Xueqing Maggie Lu, Yunlin Zhang, Kanupriya Whig, David C. Schultz, Sara Cherry, James Gerson, Stephen J. Schuster, Patrizia Porazzi & Marco Ruella. (2022) Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer. Cancer Discovery 12:10, pages 2372-2391.
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Sisi Wang, Lijun Peng, Wenqian Xu, Yuebo Zhou, Ziyan Zhu, Yushan Kong, Stewart Leung, Jin Wang, Xiaoqiang Yan & Jian-Qing Mi. (2021) Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia. Frontiers of Medicine 16:1, pages 139-149.
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Lijun Xu, Shanlong Wang, Jie Li & Bingyu Li. (2019) CD47/SIRPα blocking enhances CD19/CD3-bispecific T cell engager antibody-mediated lysis of B cell malignancies. Biochemical and Biophysical Research Communications 509:3, pages 739-745.
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De-Xiu Bu, Reshma Singh, Eugene E. Choi, Marco Ruella, Selene Nunez-Cruz, Keith G. Mansfield, Paul Bennett, Nathanial Barton, Qilong Wu, Jiquan Zhang, Yongqiang Wang, Lai Wei, Shawn Cogan, Tucker Ezell, Shree Joshi, Kellie J. Latimer, Brian Granda, William R. Tschantz, Regina M. Young, Heather A. Huet, Celeste J. Richardson & Michael C. Milone. (2018) Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma. Oncotarget 9:40, pages 25764-25780.
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William R. Strohl. (2017) Current progress in innovative engineered antibodies. Protein & Cell 9:1, pages 86-120.
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Marjan Abedi & Zohre Khosravi Dehaghi. (2017) Immunotherapy for Acute Lymphoblastic Leukemia: Challenge and Promise. Focus on Sciences 3:4, pages 1-6.
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Marco Pizzi & Giorgio Inghirami. (2017) Patient-derived tumor xenografts of lymphoproliferative disorders. Current Opinion in Hematology 24:4, pages 384-392.
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M. Pizzi & G. Inghirami. 2017. Patient Derived Tumor Xenograft Models. Patient Derived Tumor Xenograft Models 305 339 .
Marco Ruella, David M. Barrett, Saad S. Kenderian, Olga Shestova, Ted J. Hofmann, Jessica Perazzelli, Michael Klichinsky, Vania Aikawa, Farzana Nazimuddin, Miroslaw Kozlowski, John Scholler, Simon F. Lacey, Jan J. Melenhorst, Jennifer J.D. Morrissette, David A. Christian, Christopher A. Hunter, Michael Kalos, David L. Porter, Carl H. June, Stephan A. Grupp & Saar Gill. (2016) Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies. Journal of Clinical Investigation 126:10, pages 3814-3826.
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Marco Ruella & Carl H. June. (2016) Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You. Current Hematologic Malignancy Reports 11:5, pages 368-384.
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M Pizzi, M Boi, F Bertoni & G Inghirami. (2016) Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells. Leukemia 30:9, pages 1805-1815.
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Michael Hettich, Jayashree Lahoti, Shruthi Prasad & Gabriele Niedermann. (2016) Checkpoint Antibodies but not T Cell–Recruiting Diabodies Effectively Synergize with TIL-Inducing γ-Irradiation. Cancer Research 76:16, pages 4673-4683.
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Marco Ruella, Saad S. Kenderian, Olga Shestova, Joseph A. Fraietta, Sohail Qayyum, Qian Zhang, Marcela V. Maus, Xiaobin Liu, Selene Nunez-Cruz, Michael Klichinsky, Omkar U. Kawalekar, Michael Milone, Simon F. Lacey, Anthony Mato, Stephen J. Schuster, Michael Kalos, Carl H. June, Saar Gill & Mariusz A. Wasik. (2016) The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma. Clinical Cancer Research 22:11, pages 2684-2696.
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Marco Ruella & Marcela V. Maus. (2016) Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies. Computational and Structural Biotechnology Journal 14, pages 357-362.
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Jason B. Kaplan, Marina Grischenko & Francis J. Giles. (2015) Blinatumomab for the treatment of acute lymphoblastic leukemia. Investigational New Drugs 33:6, pages 1271-1279.
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