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Expert Opinion on Biological Therapy Volume 15, 2015 - Issue 7
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Drug Evaluation

Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives

Beverly G TchangWeill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism, 1165 York Avenue, New York, NY, 10065, [email protected]
, MD,
Alpana P ShuklaWeill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism, 1165 York Avenue, New York, NY, 10065, [email protected]
, MD MRCP(UK) &
Louis J AronneWeill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism, 1165 York Avenue, New York, NY, 10065, USA
, MD FACP (Sanford I. Weill Professor of Metabolic Research, Medical Director)
Pages 1061-1075 | Published online: 10 Jun 2015

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Alexander J Rodriguez, Claudio A Mastronardi & Gilberto J Paz-Filho. (2015) New advances in the treatment of generalized lipodystrophy: role of metreleptin. Therapeutics and Clinical Risk Management 11, pages 1391-1400.
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Articles from other publishers (16)

Mohamed E. Elrggal, Ahmed Elkeraie, Sol Carriazo, Hany Sawaf, Si Yuan Khor, Yasmine Elkeraie, Issa Haddad, Khaled Moustafa & Mohamed Hassanein. 2023. Frontiers in Clinical Drug Research-Diabetes and Obesity: Volume 7. Frontiers in Clinical Drug Research-Diabetes and Obesity: Volume 7 168 207 .
Kai‐Wen Zhang, Yuan Jia, Yue‐Yue Li, Dan‐Yang Guo, Xiao‐Xiao Li, Kai Hu, Xiao‐Xi Qian, Zhong‐Hua Chen, Jun‐Jie Wu, Zheng‐Dong Yuan & Feng‐Lai Yuan. (2022) LEP and LEPR are possibly a double‐edged sword for wound healing. Journal of Cellular Physiology 238:2, pages 355-365.
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Francesca Mainieri, Veronica Maria Tagi & Francesco Chiarelli. (2022) Treatment Options for Lipodystrophy in Children. Frontiers in Endocrinology 13.
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Yue Peng, Qianyu Tang, Fan Xiao & Nian Fu. (2022) Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases. Frontiers in Pharmacology 13.
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João V. S. Guerra, Marieli M. G. Dias, Anna J. V. C. Brilhante, Maiara F. Terra, Marta García-Arévalo & Ana Carolina M. Figueira. (2021) Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases. Nutrients 13:8, pages 2830.
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Young Jin Tak & Sang Yeoup Lee. (2021) Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?. Current Obesity Reports 10:1, pages 14-30.
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Boris RosinTareq Jaouni. (2020) CASE REPORT OF SEVERE PROLIFERATIVE RETINOPATHY IN A PATIENT WITH CONGENITAL LIPODYSTROPHY. RETINAL Cases & Brief Reports 14:1, pages 69-71.
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Shinji Takeyari, Satoshi Takakuwa, Kei Miyata, Kenichi Yamamoto, Hirofumi Nakayama, Yasuhisa Ohata, Makoto Fujiwara, Taichi Kitaoka, Takuo Kubota, Noriyuki Namba, Norio Sakai & Keiichi Ozono. (2019) Metreleptin treatment for congenital generalized lipodystrophy type 4 (CGL4): a case report. Clinical Pediatric Endocrinology 28:1, pages 1-7.
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Michael Rosenbaum & Rudolph L. Leibel. (2018) Physiological responses to leptin levels in lipodystrophy: a model for other hypoleptinemias?. Journal of Clinical Investigation 128:8, pages 3237-3239.
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Vera Francisco, Jesús Pino, Victor Campos-Cabaleiro, Clara Ruiz-Fernández, Antonio Mera, Miguel A. Gonzalez-Gay, Rodolfo Gómez & Oreste Gualillo. (2018) Obesity, Fat Mass and Immune System: Role for Leptin. Frontiers in Physiology 9.
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Michaela Gebauer & Arne Skerra. (2018) Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action. Bioorganic & Medicinal Chemistry 26:10, pages 2882-2887.
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Gitanjali Srivastava & Caroline Apovian. (2018) Future Pharmacotherapy for Obesity: New Anti-obesity Drugs on the Horizon. Current Obesity Reports 7:2, pages 147-161.
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Laura Papendieck & María B. Araujo. (2018) Clinical outcome in a series of pediatric patients with congenital generalized lipodystrophies treated with dietary therapy. Journal of Pediatric Endocrinology and Metabolism 31:1, pages 77-83.
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Uli Binder & Arne Skerra. (2017) PASylation®: A versatile technology to extend drug delivery. Current Opinion in Colloid & Interface Science 31, pages 10-17.
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Vanessa Abella, Morena Scotece, Javier Conde, Jesús Pino, Miguel Angel Gonzalez-Gay, Juan J. Gómez-Reino, Antonio Mera, Francisca Lago, Rodolfo Gómez & Oreste Gualillo. (2017) Leptin in the interplay of inflammation, metabolism and immune system disorders. Nature Reviews Rheumatology 13:2, pages 100-109.
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Renato Pasquali, Evanthia Diamanti-Kandarakis & Alessandra Gambineri. (2016) MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects. European Journal of Endocrinology 175:4, pages R157-R169.
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