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Review

Adipose-derived stem cells for wound repair and regeneration

(PhD student) , (Visiting Project Scientist) & , MD

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jian Yang, Xuanhao Zhang, Guanyu Wang, Shixing Ma, Yejia Yu, Chengcheng Liao, Zhuo Wang, Cheng Liang, Maojiao Li, Weidong Tian & Li Liao. (2023) ApoSEVs-Mediated Modulation of Versatile Target Cells Promotes Diabetic Wound Healing: Unveiling a Promising Strategy. International Journal of Nanomedicine 18, pages 6955-6977.
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Xiaotong Wu, Yuanyuan Jia, Xiuli Sun & Jianliu Wang. (2022) Acceleration of pelvic tissue generation by overexpression of basic fibroblast growth factor in stem cells. Connective Tissue Research 63:3, pages 256-268.
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Preethi G. U.Unnikrishnan B. S.Sreekutty J.Archana M. G.Deepa Mohan, Raveendran Pillai K.Sreelekha T. T.. (2022) Electrospun polysaccharide scaffolds: wound healing and stem cell differentiation. Journal of Biomaterials Science, Polymer Edition 33:7, pages 858-877.
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Bingmin Li, Wenzhi Hu, Kui Ma, Cuiping Zhang & Xiaobing Fu. (2019) Are hair follicle stem cells promising candidates for wound healing?. Expert Opinion on Biological Therapy 19:2, pages 119-128.
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Articles from other publishers (82)

Johannes Eschborn, Philipp Kruppa, Iakovos Georgiou, Manfred Infanger & Mojtaba Ghods. (2021) Long-term Results After Autologous Fat Transfer for Treatment of Chronic Lower Extremity Wounds. The International Journal of Lower Extremity Wounds 22:3, pages 524-530.
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Camelia Mihaela Zară-Dănceanu, Cristina Stavilă, Anca Emanuela Minuti, Luminiţa Lăbușcă, Valentin Nastasa, Dumitru-Daniel Herea, Răzvan-Nicolae Malancus, Daniel Ghercă, Sorin-Aurelian Pasca, Horia Chiriac, Mihai Mares & Nicoleta Lupu. (2023) Magnetic Nanoemulsions for the Intra-Articular Delivery of Ascorbic Acid and Dexamethasone. International Journal of Molecular Sciences 24:15, pages 11916.
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Yuan Cai, Fang Zhang, Jingwei Feng, Bihua Wu, Hai Li, Shune Xiao, Feng Lu, Zairong Wei & Chengliang Deng. (2023) Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds. Stem Cell Research & Therapy 14:1.
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Mohsen Ghiasi, Mehrdad Hashemi, Ali Salimi, Khosrow Jadidi, Mahmood Tavallaie & Hossein Aghamollaei. (2023) Combination of natural scaffolds and conditional medium to induce the differentiation of adipose-derived mesenchymal stem cells into keratocyte-like cells and its safety evaluation in the animal cornea. Tissue and Cell 82, pages 102117.
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Fahimeh Ghasemi Moravej, Abdollah Amini, Reza Masteri Farahani, Samira Mohammadi-Yeganeh, Atarodalsadat Mostafavinia, Houssein Ahmadi, Hamidreza Omidi, Fatemehalsadat Rezaei, Latif Gachkar, Michael R Hamblin, Sufan Chien & Mohammad Bayat. (2023) Photobiomodulation, alone or combined with adipose-derived stem cells, reduces inflammation by modulation of microRNA-146a and interleukin-1ß in a delayed-healing infected wound in diabetic rats. Lasers in Medical Science 38:1.
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Dmytro Oliinyk, Andreas Eigenberger, Oliver Felthaus, Silke Haerteis & Lukas Prantl. (2023) Chorioallantoic Membrane Assay at the Cross-Roads of Adipose-Tissue-Derived Stem Cell Research. Cells 12:4, pages 592.
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Isabelle Schneider, Maurizio Calcagni & Johanna Buschmann. (2023) Adipose-derived stem cells applied in skin diseases, wound healing and skin defects: a review. Cytotherapy 25:2, pages 105-119.
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Gabriella Lupo, Aleksandra Agafonova, Alessia Cosentino, Giovanni Giurdanella, Giuliana Mannino, Debora Lo Furno, Ivana Roberta Romano, Rosario Giuffrida, Floriana D’Angeli & Carmelina Daniela Anfuso. (2023) Protective Effects of Human Pericyte-like Adipose-Derived Mesenchymal Stem Cells on Human Retinal Endothelial Cells in an In Vitro Model of Diabetic Retinopathy: Evidence for Autologous Cell Therapy. International Journal of Molecular Sciences 24:2, pages 913.
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Mario F. Muñoz, Francesco Marotta, Amir Moghadam Ahmadi, Azam Yazdani, Fang He, Roberto Catanzaro, Cristina Garzón-Rodriguez & Antonio Ayala. 2023. Emerging Anti-Aging Strategies. Emerging Anti-Aging Strategies 79 98 .
Yu Yuan, Xiaonan Zhang, Yuzhen Zhan, Song Tang, Pingmeng Deng, Zhenxiang Wang & Jie Li. (2022) Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture. Stem Cell Research & Therapy 13:1.
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Jiahui Ma, Ling Yong, Pengyu Lei, Hua Li, Yimeng Fang, Lei Wang, Haojie Chen, Qi Zhou, Wei Wu, Libo Jin, Da Sun & Xingxing Zhang. (2022) Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing. Journal of Materials Chemistry B 10:46, pages 9565-9577.
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Chia-Fen Hsieh, Chih-Hao Chen, Hao-Hsi Kao, Darshan Tagadur Govindaraju, Banendu Sunder Dash & Jyh-Ping Chen. (2022) PLGA/Gelatin/Hyaluronic Acid Fibrous Membrane Scaffold for Therapeutic Delivery of Adipose-Derived Stem Cells to Promote Wound Healing. Biomedicines 10:11, pages 2902.
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S. Ceccarelli, G. Gerini, F. Megiorni, P. Pontecorvi, E. Messina, S. Camero, E. Anastasiadou, E. Romano, M. G. Onesti, C. Napoli & C. Marchese. (2022) Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesis. Frontiers in Cell and Developmental Biology 10.
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Reema FadoulTharwat Haj KhalilIdan Redenski, Daniel OrenAsaf ZigronAvishalom SharonAmiel A. DrorMizied FalahSamer Srouji. (2022) The Modulatory Effect of Adipose-Derived Stem Cells on Endometrial Polyp Fibroblasts. Stem Cells and Development 31:11-12, pages 311-321.
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Xiao Guo, Christoph Schaudinn, Ulrike Blume-Peytavi, Annika Vogt & Fiorenza Rancan. (2022) Effects of Adipose-Derived Stem Cells and Their Conditioned Medium in a Human Ex Vivo Wound Model. Cells 11:7, pages 1198.
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Preethi Gopalakrishnan UshaSreekutty JalajakumariUnnikrishnan Babukuttan SheelaDeepa MohanArchana Meena GopalakrishnanMaya SreeranganathanRaveendran Kuttan Pillai, Catherine Berry, Kaustabh Kumar Maiti & Sreelekha Therakathinal Thankappan. (2022) Porous polysaccharide scaffolds: Proof of concept study on wound healing and stem cell differentiation. Journal of Bioactive and Compatible Polymers 37:2, pages 115-133.
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Jie Ma, Zhaofeng Zhang, Yinmin Wang & Hua Shen. (2021) Investigation of miR‐126‐3p loaded on adipose stem cell‐derived exosomes for wound healing of full‐thickness skin defects. Experimental Dermatology 31:3, pages 362-374.
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Katherine A Cook, Edith Martinez-Lozano, Robert Sheridan, Edward K Rodriguez, Ara Nazarian & Mark W Grinstaff. (2022) Hydrogels for the management of second-degree burns: currently available options and future promise. Burns & Trauma 10.
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Yazeed Abdulilah Alsuliman, Marc A. Tewfik & Peter-John Wormald. 2022. CSF Rhinorrhea. CSF Rhinorrhea 167 173 .
Hui-Nee Hon, Pei-Yi Ho, Jing-Wen Lee, Nur Amalin Amni Mahmud, Hafsa Binte Munir, Thamil Selvee Ramasamy, Vijayendran Govindasamy, Kong-Yong Then, Anjan Kumar Das & Soon-Keng Cheong. 2022. Cell Biology and Translational Medicine, Volume 17. Cell Biology and Translational Medicine, Volume 17 73 95 .
Xuejun Ni, Xiuying Shan, Lili Xu, Wenjun Yu, Mingliang Zhang, Chen Lei, Nating Xu, Junyu Lin & Biao Wang. (2021) Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects. Stem Cell Research & Therapy 12:1.
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Shilpa Sharma, Sathish Muthu, Madhan Jeyaraman, Rajni Ranjan & Saurabh Kumar Jha. (2021) Translational products of adipose tissue-derived mesenchymal stem cells: Bench to bedside applications. World Journal of Stem Cells 13:10, pages 1360-1381.
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Wenpei Dong, Zhicheng Song, Suihong Liu, Ping Yu, Zhipeng Shen, Jianjun Yang, Dongchao Yang, Qinxi Hu, Haiguang Zhang & Yan Gu. (2021) Adipose-Derived Stem Cells Based on Electrospun Biomimetic Scaffold Mediated Endothelial Differentiation Facilitating Regeneration and Repair of Abdominal Wall Defects via HIF-1α/VEGF Pathway. Frontiers in Bioengineering and Biotechnology 9.
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Yun Li, Zhencheng Yu, Danyang Zhao & Dong Han. (2021) Corilagin alleviates hypertrophic scars via inhibiting the transforming growth factor (TGF)-β/Smad signal pathway. Life Sciences 277, pages 119483.
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Stefan Riwaldt, Thomas J. Corydon, Desiré Pantalone, Jayashree Sahana, Petra Wise, Markus Wehland, Marcus Krüger, Daniela Melnik, Sascha Kopp, Manfred Infanger & Daniela Grimm. (2021) Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity. Frontiers in Bioengineering and Biotechnology 9.
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Sahar Shafiee, Maryam Heidarpour, Sima Sabbagh, Elham Amini, Hanieh Saffari, Sara Dolati & Rokhsareh Meamar. (2021) Stem cell transplantation therapy for diabetic foot ulcer: a narrative review. Asian Biomedicine 15:1, pages 3-18.
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Houssein Ahmadi, Abdollah Amini, Fatemeh Fadaei Fathabady, Atarodsadat Mostafavinia, Fatemeh Zare, Roohollah Ebrahimpour-malekshah, Mustafa Neshat Ghalibaf, Matin Abrisham, Fatemehalsadat Rezaei, Richard Albright, Seyed Kamran Ghoreishi, Sufan Chien & Mohammad Bayat. (2020) Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats. Stem Cell Research & Therapy 11:1.
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Qiliang Yin, Na Xu, Dongsheng Xu, Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin & Wensen Liu. (2020) Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells. Stem Cell Research & Therapy 11:1.
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Constanze Kuhlmann, Thilo Ludwig Schenck, Elisabeth Maria Haas, Riccardo Giunta & Paul Severin Wiggenhauser. (2020) Eine aktuelle Übersicht über die Einflussfaktoren der Stammzellspender auf das regenerative Potential von Fettgewebsstammzellen. Handchirurgie · Mikrochirurgie · Plastische Chirurgie 52:06, pages 521-532.
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Simona Ceccarelli, Paola Pontecorvi, Eleni Anastasiadou, Claudio Napoli & Cinzia Marchese. (2020) Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application. Frontiers in Cell and Developmental Biology 8.
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Masayoshi IshidaKohei TatsumiKatsumi OkumotoHiroshi Kaji. (2020) Adipose Tissue-Derived Stem Cell Sheet Improves Glucose Metabolism in Obese Mice. Stem Cells and Development 29:8, pages 488-497.
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Junnan Chen, Zhihua Li, Zhenya Huang, Liming Liang & Minliang Chen. (2019) Chyle Fat–Derived Stem Cells Conditioned Medium Inhibits Hypertrophic Scar Fibroblast Activity. Annals of Plastic Surgery 83:3, pages 271-277.
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Mohammadhossein Hassanshahi, Samira Khabbazi, Yaser Peymanfar, Alireza Hassanshahi, Zahra Hosseini‐Khah, Yu‐Wen Su & Cory J. Xian. (2019) Critical limb ischemia: Current and novel therapeutic strategies. Journal of Cellular Physiology 234:9, pages 14445-14459.
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Zhao Zheng & Jiaqi Liu. (2019) GDNF‐ADSCs‐APG embedding enhances sciatic nerve regeneration after electrical injury in a rat model. Journal of Cellular Biochemistry 120:9, pages 14971-14985.
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O. Tykhvynska, O. Rogulska, R. Vasilyev & Yu. Petrenko. (2019) Fluorescent Visualization of Mesenchymal Stromal Cells on the Surface of Full-Layer Excisional Skin Wounds in Mice. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 4:4, pages 280-285.
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Alireza Hassanshahi, Mohammadhossein Hassanshahi, Samira Khabbazi, Zahra Hosseini‐Khah, Yaser Peymanfar, Saman Ghalamkari, Yu‐Wen Su & Cory J. Xian. (2018) Adipose‐derived stem cells for wound healing. Journal of Cellular Physiology 234:6, pages 7903-7914.
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Letícia D. Lucke, Fernanda O. Bortolazzo, Viviane Theodoro, Lucas Fujii, André L. Bombeiro, Maíra Felonato, Rodrigo A. Dalia, Giane D. Carneiro, Luciana P. Cartarozzi, Cristina Pontes Vicente, Alexandre L. R. Oliveira, Fernanda A. S. Mendonça, Marcelo A. M. Esquisatto, Edson R. Pimentel & Andrea A. de Aro. (2019) Low‐level laser and adipose‐derived stem cells altered remodelling genes expression and improved collagen reorganization during tendon repair. Cell Proliferation 52:3.
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Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng & Minliang Chen. (2018) Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions. Stem Cell Research & Therapy 9:1.
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Zhi‑Qiang Zhou, Yi Chen, Mi Chai, Ran Tao, Yong‑Hong Lei, Yi‑Qing Jia, Jun Shu, Jing Ren, Guo Li, Wen‑Xin Wei, Yu‑Di Han & Yan Han. (2018) Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose‑derived stem cells into fibroblasts. International Journal of Molecular Medicine.
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