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Expert Opinion on Biological Therapy Volume 6, 2006 - Issue 12
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Review

Cysteine cathepsins: regulators of antitumour immune response

Nataša Obermajer University of Ljubljana, Department of Pharmaceutical Biology, Faculty of Pharmacy, Askerceva 7, SI-1000 Ljubljana, Slovenia. [email protected]
,
Bojan Doljak University of Ljubljana, Department of Pharmaceutical Biology, Faculty of Pharmacy, Askerceva 7, SI-1000 Ljubljana, Slovenia. [email protected]
&
Janko Kos University of Ljubljana, Department of Pharmaceutical Biology, Faculty of Pharmacy, Askerceva 7, SI-1000 Ljubljana, Slovenia. [email protected]
Pages 1295-1309 | Published online: 22 Nov 2006

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Christopher S Gondi & Jasti S Rao. (2013) Cathepsin B as a cancer target. Expert Opinion on Therapeutic Targets 17:3, pages 281-291.
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Suman Gupta, Rakesh Kumar Singh, Sunanda Dastidar & Abhijit Ray. (2008) Cysteine cathepsin S as an immunomodulatory target: present and future trends. Expert Opinion on Therapeutic Targets 12:3, pages 291-299.
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Articles from other publishers (33)

Jinfen Wei, Wenqi Yu, Juanzhi Chen, Guanda Huang, Lingjie Zhang, Zixi Chen, Meiling Hu, Xiaocheng Gong & Hongli Du. (2023) Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE + CTSZ + TAM in cancers . Molecular Oncology 17:4, pages 611-628.
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Xiaodi Lu, Keming Zhang, Weiwei Jiang, Hang Li, Yue Huang, Mingwei Du, Jian Wan, Yanyun Cao, Lin Du, Xiaogang Liu & Weihua Pan. (2022) Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation. Frontiers in Immunology 13.
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Anja Pišlar, Lara Bolčina & Janko Kos. (2021) New Insights into the Role of Cysteine Cathepsins in Neuroinflammation. Biomolecules 11:12, pages 1796.
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Guilan Di, Guorong Zhu, Xinhua Chen, Xiulian Miao, Min Li, Jingqiang Fu, Ning Wang, Lei Zhu, Miaoqin Huang & Caihuan Ke. (2021) Quantitative proteomic analyses provide insights into the hyalinocytes and granulocytes phagocytic killing of ivory shell Babylonia areolata in vitro. Aquaculture 542, pages 736898.
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Janko Kos, Anahid Jewett, Anja Pišlar, Tanja Jakoš, Emanuela Senjor & Milica Perišić Nanut. 2021. Successes and Challenges of NK Immunotherapy. Successes and Challenges of NK Immunotherapy 83 100 .
Anja Pišlar, Larisa Tratnjek, Gordana Glavan, Nace Zidar, Marko Živin & Janko Kos. (2020) Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo. Frontiers in Molecular Neuroscience 13.
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Jinghua Chen, Lu Zhang, Ning Yang, Min Cao, Mengyu Tian, Qiang Fu, Baofeng Su & Chao Li. (2020) Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus L.) mucosal immunity. Fish & Shellfish Immunology 97, pages 322-335.
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Barbara Breznik, Ana Mitrović, Tamara T. Lah & Janko Kos. (2019) Cystatins in cancer progression: More than just cathepsin inhibitors. Biochimie 166, pages 233-250.
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Pey Yee Lee, Teck Yew Low & Rahman Jamal. 2019. 67 89 .
Anja Pišlar, Larisa Tratnjek, Gordana Glavan, Marko Živin & Janko Kos. (2018) Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson’s Disease. Frontiers in Molecular Neuroscience 11.
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Lian Chen, Shi-Yuan Liang, Rui Nian, Hong Li, Peng Li, Yan-Fu Qu, Ting Wu, Qing-Guo Meng & Xiang Ji. (2018) Molecular cloning and characterization of the cathepsin L gene in Pelodiscus sinensis and its expression in response to bacterial challenge . Aquaculture Research 49:9, pages 3071-3082.
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Christian Breuer, Carina Lemke, Janina Schmitz, Ulrike Bartz & Michael Gütschow. (2018) Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins. Bioorganic & Medicinal Chemistry Letters 28:11, pages 2008-2012.
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Chengbin Gao, Qiang Fu, Baofeng Su, Huanhuan Song, Shun Zhou, Fenghua Tan & Chao Li. (2017) The involvement of cathepsin F gene (CTSF) in turbot (Scophthalmus maximus L.) mucosal immunity. Fish & Shellfish Immunology 66, pages 270-279.
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Dalton Dittz Júnior, Fernanda de Oliveira Lemos & Ana Candida Araujo e Silva. 2017. Pathophysiological Aspects of Proteases. Pathophysiological Aspects of Proteases 119 145 .
Jos? Luis Peset. (2016) En recuerdo de Michael Heyd (1943-2014). Culture & History Digital Journal 5:2, pages e021.
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Hyun Kook Cho, Julan Kim, Ji Young Moon, Bo-Hye Nam, Young-Ok Kim, Woo-Jin Kim, Jung Youn Park, Cheul Min An, Jaehun Cheong & Hee Jeong Kong. (2016) Microarray analysis of gene expression in olive flounder liver infected with viral haemorrhagic septicaemia virus (VHSV). Fish & Shellfish Immunology 49, pages 66-78.
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Xiaoyu Dong, Zhi Ye, Lin Song, Baofeng Su, Honggang Zhao, Eric Peatman & Chao Li. (2016) Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge. Fish & Shellfish Immunology 48, pages 112-118.
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Renjie Wang, Lin Song, Baofeng Su, Honggang Zhao, Dongdong Zhang, Eric Peatman & Chao Li. (2015) Mucosal expression signatures of two Cathepsin L in channel catfish ( Ictalurus punctatus ) following bacterial challenge. Fish & Shellfish Immunology 47:1, pages 582-589.
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Špela Magister, Han-Ching Tseng, Vickie T. Bui, Janko Kos & Anahid Jewett. (2015) Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F. Oncotarget 6:26, pages 22310-22327.
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Janina Schmitz, Norbert Furtmann, Moritz Ponert, Maxim Frizler, Reik Löser, Ulrike Bartz, Jürgen Bajorath & Michael Gütschow. (2015) Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors. ChemMedChem 10:8, pages 1365-1377.
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Natalie Lorenz, Evert Jan Loef, Daniel J Verdon, Chun-Jen J Chen, Claudia J Mansell, Catherine E Angel, Anna E S Brooks, P Rod Dunbar & Nigel P Birch. (2015) Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease. Journal of Leukocyte Biology 97:4, pages 699-710.
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Janko Kos, Tjaša Vižin, Urša Pečar Fonović & Anja Pišlar. (2015) Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer. Seminars in Cancer Biology 31, pages 76-83.
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Milica PeriÅ¡ić Nanut, Jerica SabotiÄ, Anahid Jewett & Janko Kos. (2014) Cysteine Cathepsins as Regulators of the Cytotoxicity of NK and T Cells. Frontiers in Immunology 5.
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Janko Kos, Ana Mitrović & Bojana Mirković. (2014) The current stage of cathepsin B inhibitors as potential anticancer agents. Future Medicinal Chemistry 6:11, pages 1355-1371.
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Anja Hafner Pišlar, Nace Zidar, Danijel Kikelj & Janko Kos. (2014) Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. Neuropharmacology 82, pages 121-131.
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Anja Pišlar & Janko Kos. (2013) Cysteine Cathepsins in Neurological Disorders. Molecular Neurobiology 49:2, pages 1017-1030.
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Stephanie Schulte, Jiusong Sun, Peter Libby, Lindsey MacFarlane, Chongxiu Sun, Marco Lopez-Ilasaca, Guo-Ping Shi & Galina K. Sukhova. (2010) Cystatin C Deficiency Promotes Inflammation in Angiotensin II–Induced Abdominal Aortic Aneurisms in Atherosclerotic Mice. The American Journal of Pathology 177:1, pages 456-463.
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Hisataka Kobayashi, Mikako Ogawa, Raphael Alford, Peter L. Choyke & Yasuteru Urano. (2009) New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging. Chemical Reviews 110:5, pages 2620-2640.
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Ge Wu. 2010. Assay Development. Assay Development 155 179 .
Nataša Obermajer, Špela Magister, Andreja Nataša Kopitar, Bojan Tepeš, Alojz Ihan & Janko Kos. (2009) Cathepsin X prevents an effective immune response against Helicobacter pylori infection. European Journal of Cell Biology 88:8, pages 461-471.
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Milena Mladenovic, Kay Ansorg, Reinhold F. Fink, Walter Thiel, Tanja Schirmeister & Bernd Engels. (2008) Atomistic Insights into the Inhibition of Cysteine Proteases: First QM/MM Calculations Clarifying the Stereoselectivity of Epoxide-Based Inhibitors. The Journal of Physical Chemistry B 112:37, pages 11798-11808.
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Zala Jevnikar, Nataša Obermajer, Matthew Bogyo & Janko Kos. (2008) The role of cathepsin X in the migration and invasiveness of T lymphocytes. Journal of Cell Science 121:16, pages 2652-2661.
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Nataša Obermajer, Urška Repnik, Zala Jevnikar, Boris Turk, Marko Kreft & Janko Kos. (2008) Cysteine protease cathepsin X modulates immune response via activation of β 2 integrins . Immunology 124:1, pages 76-88.
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