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Expert Opinion on Biological Therapy Volume 6, 2006 - Issue 12
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Review

Ii-Key/MHC class II epitope hybrids: a strategy that enhances MHC class II epitope loading to create more potent peptide vaccines

Nikoletta L Kallinteris Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
,
Xueqing Lu Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
,
Catherine E Blackwell Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
,
Eric von Hofe Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
,
Robert E Humphreys Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
&
Minzhen Xu Antigen Express, Inc., 100 Barber Avenue, MA 01606, USA. [email protected]
Pages 1311-1321 | Published online: 22 Nov 2006

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Saman Soleimanpour & Atieh Yaghoubi. (2021) COVID-19 vaccine: where are we now and where should we go?. Expert Review of Vaccines 20:1, pages 23-44.
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Patrick M. McCarthy, G. Travis Clifton, Timothy J. Vreeland, Alexandra M. Adams, Anne E. O’Shea & George E. Peoples. (2021) AE37: a HER2-targeted vaccine for the prevention of breast cancer recurrence. Expert Opinion on Investigational Drugs 30:1, pages 5-11.
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Constantin N Baxevanis, Michael Papamichail & Sonia A Perez. (2014) Immunologic biomarkers in prostate cancer. Human Vaccines & Immunotherapeutics 10:5, pages 1244-1247.
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Alan K Sears, Sonia A Perez, Guy T Clifton, Linda C Benavides, Jeremy D Gates, Kevin S Clive, Jarrod P Holmes, Nathan M Shumway, David C Van Echo, Mark G Carmichael, Sathibalan Ponniah, Constantin N Baxevanis, Elizabeth A Mittendorf, Michael Papamichail & George E Peoples. (2011) AE37: a novel T-cell-eliciting vaccine for breast cancer. Expert Opinion on Biological Therapy 11:11, pages 1543-1550.
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Elizabeth A Mittendorf, Jarrod P Holmes, James L Murray, Eric von Hofe & George E Peoples. (2009) CD4+ T cells in antitumor immunity: utility of an Ii-Key HER2/neu hybrid peptide vaccine (AE37). Expert Opinion on Biological Therapy 9:1, pages 71-78.
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Alexandru Tîrziu, Speranța Avram, Leonard Madă, Mihaela Crișan-Vida, Casiana Popovici, Dan Popovici, Cosmin Faur, Corina Duda-Seiman, Virgil Păunescu & Corina Vernic. (2023) Design of a Synthetic Long Peptide Vaccine Targeting HPV-16 and -18 Using Immunoinformatic Methods. Pharmaceutics 15:7, pages 1798.
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Kiana Shahzamani, Fatemeh Mahmoudian, Shahrzad Ahangarzadeh, Mohammad Mehdi Ranjbar, Leila Beikmohammadi, Samira Bahrami, Elmira Mohammadi, Sahar Esfandyari, Abbas Alibakhshi & Shaghayegh Haghjooy Javanmard. (2021) Vaccine design and delivery approaches for COVID-19. International Immunopharmacology 100, pages 108086.
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Karthik Vivekanandhan, Poornima Shanmugam, Hamed Barabadi, Vigneshwaran Arumugam, Dharun Daniel Raj Daniel Paul Raj, Manikandan Sivasubramanian, Subbaiya Ramasamy, Krishnan Anand, Pandi Boomi, Balakumar Chandrasekaran, Selvaraj Arokiyaraj & Muthupandian Saravanan. (2021) Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives. Frontiers in Molecular Biosciences 8.
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Concetta Di Natale, Sara La Manna, Ilaria De Benedictis, Paola Brandi & Daniela Marasco. (2020) Perspectives in Peptide-Based Vaccination Strategies for Syndrome Coronavirus 2 Pandemic. Frontiers in Pharmacology 11.
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Payel Roy, Amal J. Ali, Kouji Kobiyama, Yanal Ghosheh & Klaus Ley. (2020) Opportunities for an atherosclerosis vaccine: From mice to humans. Vaccine 38:28, pages 4495-4506.
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Jan NilssonGöran K. Hansson. (2020) Vaccination Strategies and Immune Modulation of Atherosclerosis. Circulation Research 126:9, pages 1281-1296.
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Kyle Saylor, Frank Gillam, Taylor Lohneis & Chenming Zhang. (2020) Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy. Frontiers in Immunology 11.
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Akira Yamada, Tetsuro Sasada, Masanori Noguchi & Kyogo Itoh. (2012) Next‐generation peptide vaccines for advanced cancer. Cancer Science 104:1, pages 15-21.
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M. Bonvalet, H. Moussu, E. Wambre, C. Ricarte, S. Horiot, A.-C. Rimaniol, W. W. Kwok, F. Horak, O. de Beaumont, V. Baron-Bodo & P. Moingeon. (2012) Allergen-specific CD4 + T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy . Clinical & Experimental Allergy 42:12, pages 1745-1755.
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Sonia A. Perez, Nikoletta L. Kallinteris, Stratos Bisias, Panagiotis K. Tzonis, Katerina Georgakopoulou, Marighoula Varla-Leftherioti, Michael Papamichail, Anastasios Thanos, Eric von Hofe & Constantin N. Baxevanis. (2010) Results from a Phase I Clinical Study of the Novel Ii-Key/HER-2/ neu (776–790) Hybrid Peptide Vaccine in Patients with Prostate Cancer . Clinical Cancer Research 16:13, pages 3495-3506.
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Angelos D. Gritzapis, Ioannis F. Voutsas, Eftychia Lekka, Michael Papamichail & Constantin N. Baxevanis. (2010) Peptide Vaccination Breaks Tolerance to HER-2/ neu by Generating Vaccine-Specific FasL+ CD4+ T Cells: First Evidence for Intratumor Apoptotic Regulatory T Cells . Cancer Research 70:7, pages 2686-2696.
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Constantin N BaxevanisIoannis F VoutsasAngelos D GritzapisSonia A PerezMichael Papamichail. (2010) HER-2/neu as a target for cancer vaccines. Immunotherapy 2:2, pages 213-226.
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Sonia A. Perez, Eric von Hofe, Nikoletta L. Kallinteris, Angelos D. Gritzapis, George E. Peoples, Michael Papamichail & Constantin N. Baxevanis. (2010) A new era in anticancer peptide vaccines. Cancer, pages NA-NA.
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Minzhen Xu, Xueqing Lu, Margaret Sposato, John W. Zinckgraf, Shuzhen Wu & Eric von Hofe. (2009) Ii-Key/HPV16 E7 hybrid peptide immunotherapy for HPV16+ cancers. Vaccine 27:34, pages 4641-4647.
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J. M. Martínez-Gómez, P. Johansen, H. Rose, M. Steiner, G. Senti, C. Rhyner, R. Crameri & T. M. Kündig. (2009) Targeting the MHC class II pathway of antigen presentation enhances immunogenicity and safety of allergen immunotherapy. Allergy 64:1, pages 172-178.
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Laurence Van Overtvelt, Erik Wambre, Bernard Maillère, Eric von Hofe, Anne Louise, Anne Marie Balazuc, Barbara Bohle, Didier Ebo, Christophe Leboulaire, Gilles Garcia & Philippe Moingeon. (2008) Assessment of Bet v 1-Specific CD4+ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers. The Journal of Immunology 180:7, pages 4514-4522.
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Erik Wambre, Laurence Van Overtvelt, Bernard Maillère, Robert Humphreys, Eric von Hofe, Lydia Ferhat, Didier Ebo & Philippe Moingeon. (2008) Single Cell Assessment of Allergen-Specific T Cell Responses with MHC Class II Peptide Tetramers: Methodological Aspects. International Archives of Allergy and Immunology 146:2, pages 99-112.
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