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Cancer testis antigens – their importance in immunotherapy and in the early detection of cancer

Pages 379-389 | Published online: 21 Mar 2006

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Anil Suri, Shikha Saini, Abhilasha Sinha, Sumit Agarwal, Archana Verma, Deepak Parashar, Swarnendra Singh, Namita Gupta & Nirmala Jagadish. (2012) Cancer testis antigens. OncoImmunology 1:7, pages 1194-1196.
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Liu Hong & Daiming Fan. (2008) Cancer mucosa antigens: novel immunotherapeutic targets. Expert Opinion on Therapeutic Targets 12:6, pages 749-756.
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Bingcan Zhang. (2021) Cancer Testis Antigens and Immunotherapy: A new Dawn. E3S Web of Conferences 251, pages 02033.
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Jiaqiang Li, Jianchun Yin, Jianhua Zhong, Zhilin Yang, Aifa Tang & Shoulin Li. (2020) Clinicopathological and Prognostic Significance of PRAME Overexpression in Human Cancer: A Meta-Analysis. BioMed Research International 2020, pages 1-9.
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Zhaoxu Xu, Haichao Tang, Tianshu Zhang, Mingli Sun, Qiang Han, Jiao Xu, Minjie Wei & Zhaojin Yu. (2020) TEX19 promotes ovarian carcinoma progression and is a potential target for epitope vaccine immunotherapy. Life Sciences 241, pages 117171.
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Joanne Ern Chi Soh, Nadiah Abu & Rahman Jamal. (2018) The potential immune-eliciting cancer testis antigens in colorectal cancer. Immunotherapy 10:12, pages 1093-1104.
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Guo-Hao Huang, Lei Du, Ningning Li, Ying Zhang, Yan Xiang, Jun-Hai Tang, Shuli Xia, Eric Erquan Zhang & Sheng-Qing Lv. (2018) Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas. Cancer Letters 432, pages 93-102.
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Claudia Augello, Federico Colombo, Andrea Terrasi, Elena Trombetta, Marco Maggioni, Laura Porretti, Giorgio Rossi, Silvana Guerneri, Rosamaria Silipigni, Silvano Bosari & Valentina Vaira. (2018) Expression of C19MC miRNAs in HCC associates with stem-cell features and the cancer-testis genes signature. Digestive and Liver Disease 50:6, pages 583-593.
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Biqiong Ren, Guoying Zou, Fei Xu, Yiran Huang, Guofeng Xu, Junyu He, Yong Li, Haowen Zhu & Ping Yu. (2017) Serum levels of anti‑sperm‑associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma. Oncology Letters.
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Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin & Zengjun Wang. (2017) Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma. Tumor Biology 39:3, pages 101042831769596.
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Anuj Kumar, Drista Sharma, M. L. Aggarwal, K. M. Chacko & Tarun Kumar Bhatt. (2016) Cancer/testis antigens as molecular drug targets using network pharmacology. Tumor Biology 37:12, pages 15697-15705.
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Angel Qin, David G. Coffey, Edus H. Warren & Nithya Ramnath. (2016) Mechanisms of immune evasion and current status of checkpoint inhibitors in non‐small cell lung cancer. Cancer Medicine 5:9, pages 2567-2578.
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Jianhua Zhong, Yan Chen, Xinhui Liao, Jiaqiang Li, Han Wang, Chenglong Wu, Xiaowen Zou, Gang Yang, Jing Shi, Liya Luo, Litao Liu, Jianping Deng & Aifa Tang. (2015) Testis expressed 19 is a novel cancer-testis antigen expressed in bladder cancer. Tumor Biology 37:6, pages 7757-7765.
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Hong‐Mei Li, Kang Guo, Xiao‐Yun Yu, Zhuang Yu & Ping Xu. (2015) Expression and clinical significance of A ‐kinase anchor protein 4 in lung adenocarcinoma tissue . Thoracic Cancer 7:3, pages 273-278.
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Biqiong Ren, Xiaobin Wei, Guoying Zou, Junyu He, Guofeng Xu, Fei Xu, Yiran Huang, Haowen Zhu, Yong Li, Guoan Ma & Ping Yu. (2016) Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer. Oncology Reports.
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Qi Wang, Xuefei Li, Shengxiang Ren, Ningning Cheng, Mingchuan Zhao, Yishi Zhang, Jiayu Li, Weijing Cai, Chao Zhao, Wa Cao & Caicun Zhou. (2015) Serum Levels of the Cancer-Testis Antigen POTEE and Its Clinical Significance in Non-Small-Cell Lung Cancer. PLOS ONE 10:4, pages e0122792.
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Karl Xaver Knaup, Juliana Monti, Thomas Hackenbeck, Tilmann Jobst‐Schwan, Bernd Klanke, Ruth Elisabeth Schietke, Ingrid Wacker, Juergen Behrens, Kerstin Amann, Kai‐Uwe Eckardt, Christina Warnecke & Michael Sean Wiesener. (2013) Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro. Molecular Carcinogenesis 53:12, pages 970-978.
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Ayumu Taguchi, Allen D. Taylor, Jaime Rodriguez, Müge Çeliktaş, Hui Liu, Xiaotu Ma, Qing Zhang, Chee-Hong Wong, Alice Chin, Luc Girard, Carmen Behrens, Wan L. Lam, Stephen Lam, John D. Minna, Ignacio I. Wistuba, Adi F. Gazdar & Samir M. Hanash. (2014) A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets. Cancer Research 74:17, pages 4694-4705.
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Wei Rao, Haowen Li, Feifei Song, Renfeng Zhang, Qinqin Yin, Ying Wang, Yebin Xi & Hailiang Ge. (2014) OVA66 increases cell growth, invasion and survival via regulation of IGF-1R–MAPK signaling in human cancer cells. Carcinogenesis 35:7, pages 1573-1581.
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Daniel Abate-Daga, Daniel E. Speiser, Nachimuthu Chinnasamy, Zhili Zheng, Hui Xu, Steven A. Feldman, Steven A. Rosenberg & Richard A. Morgan. (2014) Development of a T Cell Receptor Targeting an HLA-A*0201 Restricted Epitope from the Cancer-Testis Antigen SSX2 for Adoptive Immunotherapy of Cancer. PLoS ONE 9:3, pages e93321.
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Eralp Baser, Cihan Togrul, Emre Ozgu, Sevgi Ayhan, Mete Caglar, Salim Erkaya & Tayfun Gungor. (2013) Sperm-Associated Antigen 9 is a Promising marker for Early Diagnosis of Endometrial Cancer. Asian Pacific Journal of Cancer Prevention 14:12, pages 7635-7638.
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Deepika Kanojia, Manoj Garg, Shikha Saini, Sumit Agarwal, Deepak Parashar, Nirmala Jagadish, Amlesh Seth, Amar Bhatnagar, Anju Gupta, Rajive Kumar, Nirmal Kumar Lohiya & Anil Suri. (2013) Sperm Associated Antigen 9 Plays an Important Role in Bladder Transitional Cell Carcinoma. PLoS ONE 8:12, pages e81348.
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LIN XIN, JIAQING CAO, CHUAN LIU, FEI ZENG, HUA CHENG, XIAOYUN HU, PEIQIAN ZHU & JIANGHUA SHAO. (2013) Selection of anti-cancer-associated gene single-chain variable fragments derived from gastric cancer patients using ribosome display. Molecular Medicine Reports 8:2, pages 631-637.
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Shikha Saini, Nirmala Jagadish, Anju Gupta, Amar Bhatnagar & Anil Suri. (2013) A Novel Cancer Testis Antigen, A-Kinase Anchor Protein 4 (AKAP4) Is a Potential Biomarker for Breast Cancer. PLoS ONE 8:2, pages e57095.
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Richard A. Morgan. 2013. Cancer Immunotherapy. Cancer Immunotherapy 261 272 .
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Kiran H. Lagisetty & Richard A. Morgan. (2012) Cancer therapy with genetically‐modified T cells for the treatment of melanoma. The Journal of Gene Medicine 14:6, pages 400-404.
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Jin-xue Zhou, Yin Li, Sun-xiao Chen & An-mei Deng. (2011) Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma. Journal of Experimental & Clinical Cancer Research 30:1.
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Anu Sharma, Beata Bode, Roland H. Wenger, Kuno Lehmann, Alessandro A. Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer & Maries van den Broek. (2011) γ-Radiation Promotes Immunological Recognition of Cancer Cells through Increased Expression of Cancer-Testis Antigens In Vitro and In Vivo. PLoS ONE 6:11, pages e28217.
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Meixiang Sang, Yishui Lian, Xinliang Zhou & Baoen Shan. (2011) MAGE-A family: Attractive targets for cancer immunotherapy. Vaccine 29:47, pages 8496-8500.
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Tamaki Yamada, Masumi Tsuda, Tomomi Takahashi, Yasunori Totsuka, Masanobu Shindoh & Yusuke Ohba. (2011) RANKL Expression Specifically Observed in Vivo Promotes Epithelial Mesenchymal Transition and Tumor Progression. The American Journal of Pathology 178:6, pages 2845-2856.
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Deepika Kanojia, Manoj Garg, Samir Gupta, Anju Gupta & Anil Suri. (2011) Sperm-Associated Antigen 9 Is a Novel Biomarker for Colorectal Cancer and Is Involved in Tumor Growth and Tumorigenicity. The American Journal of Pathology 178:3, pages 1009-1020.
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Nachimuthu Chinnasamy, Jennifer A. Wargo, Zhiya Yu, Mahadev Rao, Timothy L. Frankel, John P. Riley, Jenny J. Hong, Maria R. Parkhurst, Steven A. Feldman, David S. Schrump, Nicholas P. Restifo, Paul F. Robbins, Steven A. Rosenberg & Richard A. Morgan. (2011) A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer. The Journal of Immunology 186:2, pages 685-696.
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D Joseph-Pietras, Y Gao, N Zojer, K Ait-Tahar, A H Banham, K Pulford, J Rice, N Savelyeva & S S Sahota. (2010) DNA vaccines to target the cancer testis antigen PASD1 in human multiple myeloma. Leukemia 24:11, pages 1951-1959.
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NACHIMUTHU CHINNASAMY & RICHARD A. MORGAN. (2010) RECENT PROGRESS AND FUTURE DIRECTIONS USING ENGINEERED T CELLS FOR THE TREATMENT OF CANCER. Gene Therapy and Regulation 05:01, pages 67-80.
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Deepika Kanojia, Manoj Garg, Shikha Saini, Sumit Agarwal, Rajive Kumar & Anil Suri. (2010) Sperm associated antigen 9 expression and humoral response in chronic myeloid leukemia. Leukemia Research 34:7, pages 858-863.
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Manoj Garg, Deepika Kanojia, Sushma Suri & Anil Suri. (2009) Small interfering RNA‐mediated down‐regulation of SPAG9 inhibits cervical tumor growth . Cancer 115:24, pages 5688-5699.
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Urs DA Müller-Richter, Albert Dowejko, Tobias Reuther, Johannes Kleinheinz, Torsten E Reichert & Oliver Driemel. (2009) Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines. Head & Face Medicine 5:1.
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Kamel Ait-Tahar, Amanda P. Liggins, Graham P. Collins, Andrew Campbell, Martin Barnardo, Charles Lawrie, Donald Moir, Chris Hatton, Alison H. Banham & Karen Pulford. (2009) Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with diffuse large B-cell lymphoma. British Journal of Haematology 146:4, pages 396-407.
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Manoj Garg, Deepika Kanojia, Sudha Salhan, Sushma Suri, Anju Gupta, Nirmal Kumar Lohiya & Anil Suri. (2009) Sperm‐associated antigen 9 is a biomarker for early cervical carcinoma. Cancer 115:12, pages 2671-2683.
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Jan Rohozinski, Matthew L. Anderson, Russell E. Broaddus, Creighton L. Edwards & Colin E. Bishop. (2009) Spermatogenesis Associated Retrogenes Are Expressed in the Human Ovary and Ovarian Cancers. PLoS ONE 4:3, pages e5064.
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Deepika Kanojia, Manoj Garg, Samir Gupta, Anju Gupta & Anil Suri. (2009) Sperm-Associated Antigen 9, a Novel Biomarker for Early Detection of Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention 18:2, pages 630-639.
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Manoj Garg, Deepika Kanojia, Aashima Khosla, Namrata Dudha, Satish Sati, Dipak Chaurasiya, Nirmala Jagadish, Amlesh Seth, Rajive Kumar, Samir Gupta, Anju Gupta, Nirmal Kumar Lohiya & Anil Suri. (2008) Sperm-Associated Antigen 9 Is Associated With Tumor Growth, Migration, and Invasion in Renal Cell Carcinoma. Cancer Research 68:20, pages 8240-8248.
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Ena Wang, Andrea Worschech & Francesco M. Marincola. (2008) The immunologic constant of rejection. Trends in Immunology 29:6, pages 256-262.
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Raphael B. Parmigiani, Fabiana Bettoni, Daniela M Grosso, Ademar Lopes, Isabela W. Cunha, Fernando A. Soares, André L. Carvalho, Francisco Fonseca & Anamaria A. Camargo. (2008) Antibodies against the cancer‐testis antigen CTSP‐1 are frequently found in prostate cancer patients and are an independent prognostic factor for biochemical‐recurrence. International Journal of Cancer 122:10, pages 2385-2390.
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GURO E. LIND, ROLF I. SKOTHEIM & RAGNHILD A. LOTHE. (2007) The epigenome of testicular germ cell tumors. APMIS 115:10, pages 1147-1160.
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Stefan Krüger, Vladislava Ola, Alfred C. Feller, Dorothea Fischer & Michael Friedrich. (2007) Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: An immunohistochemical study with emphasis on prognostic utility. Pathology & Oncology Research 13:2, pages 91-96.
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Manoj Garg, Dipak Chaurasiya, Ritu Rana, Nirmala Jagadish, Deepika Kanojia, Namrata Dudha, Neha Kamran, Sudha Salhan, Amar Bhatnagar, Sushma Suri, Anju Gupta & Anil Suri. (2007) Sperm-Associated Antigen 9, a Novel Cancer Testis Antigen, Is a Potential Target for Immunotherapy in Epithelial Ovarian Cancer. Clinical Cancer Research 13:5, pages 1421-1428.
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Hidekata Yasuoka & Masataka Kuwana. (2007) Autoantibody response against a novel testicular antigen protein highly expressed in testis (PHET) in SSc patients. Autoimmunity Reviews 6:4, pages 228-231.
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Sergio Comincini, Igor Vecchio & Alberto Azzalin. (2006) The doppel gene biology: a scientific journey from brain to testis, and return. Open Life Sciences 1:4.
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