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Drug Evaluation

Ranpirnase – an antitumour ribonuclease: its potential role in malignant mesothelioma

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Pages 391-399 | Published online: 21 Mar 2006

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Read on this site (3)

Thomas Schirrmann, Jürgen Krauss, Michaela AE Arndt, Susanna M Rybak & Stefan Dübel. (2009) Targeted therapeutic RNases (ImmunoRNases). Expert Opinion on Biological Therapy 9:1, pages 79-95.
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Camillo Porta, Chiara Paglino & Luciano Mutti. (2008) Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma. Biologics: Targets and Therapy 2:4, pages 601-609.
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Articles from other publishers (46)

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Jessica Castro, Giusy Tornillo, Gerardo Ceada, Beatriz Ramos-Neble, Marlon Bravo, Marc Ribó, Maria Vilanova, Matthew J. Smalley & Antoni Benito. (2021) A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells. Cancers 13:17, pages 4350.
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Todd G. Smith, Felix R. Jackson, Clint N. Morgan, William C. Carson, Brock E. Martin, Nadia Gallardo-Romero, James A. Ellison, Lauren Greenberg, Thomas Hodge, Luis Squiquera, Jamie Sulley, Victoria A. Olson & Christina L. Hutson. (2020) Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro. Viruses 12:2, pages 177.
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Santiago Ruiz-Martínez, Jessica Castro, Maria Vilanova, Marta Bruix, Douglas V. Laurents, Marc Ribó & Antoni Benito. (2017) A truncated apoptin protein variant selectively kills cancer cells. Investigational New Drugs 35:3, pages 260-268.
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Anna Vert, Jessica Castro, Marc Ribó, Antoni Benito & Maria Vilanova. (2016) Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase. Oncotarget 8:7, pages 11692-11707.
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Gargi K. Vora, Hakan Demirci, Brian Marr & Prithvi Mruthyunjaya. (2017) Advances in the management of conjunctival melanoma. Survey of Ophthalmology 62:1, pages 26-42.
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Yukiko Kariya, Takeo Tatsuta, Shigeki Sugawara, Yoshinobu Kariya, Kazuo Nitta & Masahiro Hosono. (2016) RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38?MAPK to caspase-3/7 signaling pathway in human breast cancer cells. International Journal of Oncology.
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Miaonan Sun, Huichun Tang, Yan Gao, Xinxuan Dai, Yue Yuan, Chunmei Zhang & Dejun Sun. (2016) Constitutive expression and anticancer potency of a novel immunotoxin onconase-DV3. Oncology Reports.
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Xiaomin Wang & Zhanyun Guo. (2015) Anti-gliomas Effect of Chlorotoxin-Conjugated Onconase at High Dose. Cell Biochemistry and Biophysics 73:2, pages 389-392.
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Christian Cremer, Tim Vierbuchen, Lea Hein, Rainer Fischer, Stefan Barth & Thomas Nachreiner. (2015) Angiogenin Mutants as Novel Effector Molecules For the Generation of Fusion Proteins With Increased Cytotoxic Potential. Journal of Immunotherapy 38:3, pages 85-95.
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XIAOMIN WANG & ZHANYUN GUO. (2015) Chlorotoxin-conjugated onconase as a potential anti-glioma drug. Oncology Letters 9:3, pages 1337-1342.
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Christian Cremer, Grit Hehmann-Titt, Sonja Schiffer, Georg Melmer, Paolo Carloni, Stefan Barth & Thomas Nachreiner. 2015. Resistance to Immunotoxins in Cancer Therapy. Resistance to Immunotoxins in Cancer Therapy 185 219 .
Katarzyna Kurpiewska, Gerard Torrent, Marc Ribó, Joanna I. Loch, Maria Vilanova & Krzysztof Lewiński. (2014) Investigating the effects of double mutation C30A/C75A on onconase structure: Studies at atomic resolution. Biopolymers 101:5, pages 454-460.
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Yan-Ping Shih, Chi-Chi Chou, Yi-Ling Chen, Kai-Fa Huang & Andrew H.- J. Wang. (2014) Linked Production of Pyroglutamate-Modified Proteins via Self-Cleavage of Fusion Tags with TEV Protease and Autonomous N-Terminal Cyclization with Glutaminyl Cyclase In Vivo. PLoS ONE 9:4, pages e94812.
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XIAO-MIN WANG & ZHAN-YUN GUO. (2013) Recombinant expression, different downstream processing of the disulfide-rich anti-tumor peptide Ranpirnase and its effect on the growth of human glioma cell line SHG-44. Biomedical Reports 1:5, pages 747-750.
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Sumit Goswami, Wei Wang, Tsutomu Arakawa & Satoshi Ohtake. (2013) Developments and Challenges for mAb-Based Therapeutics. Antibodies 2:4, pages 452-500.
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Wojciech Ardelt. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 337 353 .
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Meng Qiao, Li-Dong Zu, Xiao-Hong He, Ru-Ling Shen, Qing-Cheng Wang & Mo-Fang Liu. (2012) Onconase downregulates microRNA expression through targeting microRNA precursors. Cell Research 22:7, pages 1199-1202.
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Jo E. Lomax, Chelcie H. Eller & Ronald T. Raines. 2012. Protein Engineering for Therapeutics, Part A. Protein Engineering for Therapeutics, Part A 273 290 .
Daniel E. Holloway, Umesh P. Singh, Kuslima Shogen & K. Ravi Acharya. (2011) Crystal structure of Onconase at 1.1 Å resolution – insights into substrate binding and collective motion. The FEBS Journal 278:21, pages 4136-4149.
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Pere Tubert, Montserrat Rodríguez, Marc Ribó, Antoni Benito & Maria Vilanova. (2010) The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity. Investigational New Drugs 29:5, pages 811-817.
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C M Goparaju, J D Blasberg, S Volinia, J Palatini, S Ivanov, J S Donington, C Croce, M Carbone, H Yang & H I Pass. (2011) Onconase mediated NFKβ downregulation in malignant pleural mesothelioma. Oncogene 30:24, pages 2767-2777.
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Marc Ribó, Antoni Benito & Maria Vilanova. 2011. Ribonucleases. Ribonucleases 55 88 .
Thomas J. Rutkoski, John A. Kink, Laura E. Strong, Christine I. Schilling & Ronald T. Raines. (2010) Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering. Bioconjugate Chemistry 21:9, pages 1691-1702.
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Mary Frances McAleer, Reza J. Mehran & Anne Tsao. 2010. Lung Cancer. Lung Cancer 435 465 .
Rebecca F. Turcotte, Luke D. Lavis & Ronald T. Raines. (2009) Onconase cytotoxicity relies on the distribution of its positive charge. FEBS Journal 276:14, pages 3846-3857.
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Anne S. TsaoIgnacio WistubaJack A. RothHedy Lee Kindler. (2009) Malignant Pleural Mesothelioma. Journal of Clinical Oncology 27:12, pages 2081-2090.
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Claudia De Lorenzo & Giuseppe D’Alessio. (2009) Human anti‐ErbB2 immunoagents – immunoRNases and compact antibodies. The FEBS Journal 276:6, pages 1527-1535.
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Rebecca F. Turcotte & Ronald T. Raines. (2008) Interaction of onconase with the human ribonuclease inhibitor protein. Biochemical and Biophysical Research Communications 377:2, pages 512-514.
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Chuang-Xin Lu, Ke-Jun Nan & Yan Lei. (2008) Agents from amphibians with anticancer properties. Anti-Cancer Drugs 19:10, pages 931-939.
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Rebecca F. TurcotteRonald T. Raines. (2008) Design and Characterization of an HIV-Specific Ribonuclease Zymogen. AIDS Research and Human Retroviruses 24:11, pages 1357-1363.
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Amanda K Beck, Harvey I Pass, Michele CarboneHaining Yang. (2008) Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies. Future Oncology 4:3, pages 341-349.
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Helene F Rosenberg. (2008) RNase A ribonucleases and host defense: an evolving story. Journal of Leukocyte Biology 83:5, pages 1079-1087.
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Olga N. Ilinskaya, Andreas Koschinski, Holger Repp, Vladimir A. Mitkevich, Florian Dreyer, J. Martin Scholtz, C. Nick Pace & Alexander A. Makarov. (2008) RNase-induced apoptosis: Fate of calcium-activated potassium channels. Biochimie 90:5, pages 717-725.
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Luciano Mutti & Giovanni Gaudino. (2008) The therapeutic potential of the novel ribonuclease ranpirnase (Onconase®) in the treatment of malignant mesothelioma. Oncology Reviews 2:1, pages 61-65.
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J Eugene Lee & Ronald T Raines. (2008) Ribonucleases as Novel Chemotherapeutics. BioDrugs 22:1, pages 53-58.
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J. Eugene Lee, Euiyoung Bae, Craig A. Bingman, George N. PhillipsJrJr & Ronald T. Raines. (2008) Structural Basis for Catalysis by Onconase. Journal of Molecular Biology 375:1, pages 165-177.
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Avvaru N. Suhasini & Ravi Sirdeshmukh. (2007) Onconase action on tRNALys3, the primer for HIV-1 reverse transcription. Biochemical and Biophysical Research Communications 363:2, pages 304-309.
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Olga N. Ilinskaya, Pavel V. Zelenikhin, Irina Yu. Petrushanko, Vladimir A. Mitkevich, Vladimir S. Prassolov & Alexander A. Makarov. (2007) Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response. Biochemical and Biophysical Research Communications 361:4, pages 1000-1005.
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Franziska Leich, Nadine Stöhr, Anne Rietz, Renate Ulbrich-Hofmann & Ulrich Arnold. (2007) Endocytotic Internalization as a Crucial Factor for the Cytotoxicity of Ribonucleases. Journal of Biological Chemistry 282:38, pages 27640-27646.
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Umesh P. Singh, Wojciech Ardelt, Shailendra K. Saxena, Daniel E. Holloway, Eugene Vidunas, Hung-Suen Lee, Abha Saxena, Kuslima Shogen & K. Ravi Acharya. (2007) Enzymatic and Structural Characterisation of Amphinase, a Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes. Journal of Molecular Biology 371:1, pages 93-111.
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Ester Boix & M. Victòria Nogués. (2007) Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence. Molecular BioSystems 3:5, pages 317.
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Roohi Ismail-KhanLary A. RobinsonCharles C WilliamsJr.Jr., Christopher R. GarrettGerold BeplerGeorge R. Simon. (2017) Malignant Pleural Mesothelioma: A Comprehensive Review. Cancer Control 13:4, pages 255-263.
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Ulrich Arnold & Renate Ulbrich-Hofmann. (2006) Natural and engineered ribonucleases as potential cancer therapeutics. Biotechnology Letters 28:20, pages 1615-1622.
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