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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 11
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Review

Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96

Eckhard R Podack Professor and Chairman, University of Miami School of Medicine, Department of Microbiology & Immunology, 1600 NW 10th Avenue, Room 3045D, Miami, FL 33136, USA +1 305 243 6694; +1 305 243 5522; [email protected]
, MD &
Luis E Raez Co-Leader Thoracic Oncology Group, Associate Professor of Medicine, University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Epidemiology and Public Health, Division of Hematology-Oncology, 1475 NW 12th Avenue, Miami, FL 33136, USA
, MD FACP FCCP
Pages 1679-1688 | Published online: 26 Oct 2007

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Matthew P. Rausch & Aparna Ranganathan Sertil. (2015) A Stressful Microenvironment: Opposing Effects of the Endoplasmic Reticulum Stress Response in the Suppression and Enhancement of Adaptive Tumor Immunity. International Reviews of Immunology 34:2, pages 104-122.
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Articles from other publishers (13)

Laura Padula, Eva Fisher, Katelyn Rivas, Kristin Podack, Daniela Frasca, Jonah Kupritz, Matthew M. Seavey, Padmini Jayaraman, Eric Dixon, Rahul Jasuja & Natasa Strbo. (2022) Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses. Vaccine: X 12, pages 100202.
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Andrew Samy, Noriko Yamano‐Adachi, Yuichi Koga & Takeshi Omasa. (2021) Secretion of a low‐molecular‐weight species of endogenous GRP94 devoid of the KDEL motif during endoplasmic reticulum stress in Chinese hamster ovary cells . Traffic.
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L. Pirdel & A. Zavaran Hosseini. (2017) Immune response to recombinant Leishmania infantum lipophosphoglycan 3 plus CpG oligodeoxynucleotides in BALB/c mice . Parasite Immunology 39:3, pages e12345.
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Katherine Kunigelis & Michael Graner. (2015) The Dichotomy of Tumor Exosomes (TEX) in Cancer Immunity: Is It All in the ConTEXt?. Vaccines 3:4, pages 1019-1051.
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Taylor H. Schreiber. 2014. Advances in Tumor Immunology and Immunotherapy. Advances in Tumor Immunology and Immunotherapy 37 56 .
Louis Gonzalez, Natasa Strbo & Eckhard R. Podack. (2013) Humanized mice: novel model for studying mechanisms of human immune-based therapies. Immunologic Research 57:1-3, pages 326-334.
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B Luo & A S Lee. (2012) The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 32:7, pages 805-818.
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Marco Randazzo, Peter Terness, Gerhard Opelz & Christian Kleist. (2012) Active‐specific immunotherapy of human cancers with the heat shock protein Gp96—revisited. International Journal of Cancer 130:10, pages 2219-2231.
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Michal Marzec, Davide Eletto & Yair Argon. (2012) GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823:3, pages 774-787.
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N Strbo, S Pahwa, M A Kolber, L Gonzalez, E Fisher & E R Podack. (2010) Cell-secreted Gp96-Ig-peptide complexes induce lamina propria and intraepithelial CD8+ cytotoxic T lymphocytes in the intestinal mucosa. Mucosal Immunology 3:2, pages 182-192.
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AnnaMaria De Filippo, Robert J. Binder, Chiara Camisaschi, Valeria Beretta, Flavio Arienti, Antonello Villa, Pamela Della Mina, Giorgio Parmiani, Licia Rivoltini & Chiara Castelli. (2008) Human Plasmacytoid Dendritic Cells Interact with gp96 via CD91 and Regulate Inflammatory Responses. The Journal of Immunology 181:9, pages 6525-6535.
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Weichun Guo & Anmin Chen. (2008) Expression of heat shock protein gp96 in osteosarcoma and its clinical significance. Frontiers of Medicine in China 2:2, pages 200-203.
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Laurence H. PearlChrisostomos ProdromouPaul Workman. (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochemical Journal 410:3, pages 439-453.
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