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Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer

, , , , & , PhD
Pages 45-57 | Published online: 17 Dec 2007

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Helen Blanchard, Khuchtumur Bum-Erdene, Mohammad Hussaini Bohari & Xing Yu. (2016) Galectin-1 inhibitors and their potential therapeutic applications: a patent review. Expert Opinion on Therapeutic Patents 26:5, pages 537-554.
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Christophe Meynier, Françoise Guerlesquin & Philippe Roche. (2009) Computational Studies of Human Galectin-1: Role of Conserved Tryptophan Residue in Stacking Interaction with Carbohydrate Ligands. Journal of Biomolecular Structure and Dynamics 27:1, pages 49-57.
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Articles from other publishers (69)

Zeynep Nur Karadogan, Yasar Tanir, Ali Karayagmurlu, Canan Kucukgergin & Murat Coskun. (2023) Higher Levels of Galectin-1 and Galectin-3 in Young Subjects with Autism Spectrum Disorder Compared to Unaffected Siblings and Healthy Controls. Clinical Psychopharmacology and Neuroscience 21:4, pages 749-757.
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Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang & Chen-Ching Lin. (2023) Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers. Journal of Translational Medicine 21:1.
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Muhammad Reza Arifianto, Rizki Meizikri, Irwan Barlian Immadoel Haq, Rahadian Indarto Susilo, Joni Wahyuhadi, Yulius Hermanto & Ahmad Faried. (2023) Emerging hallmark of gliomas microenvironment in evading immunity: a basic concept. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 59:1.
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Haotian Huanggu, Dan Yang & Yuehong Zheng. (2023) Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury. Autoimmunity Reviews 22:3, pages 103258.
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Adel Abo Mansour, Franziska Krautter, Zhaogong Zhi, Asif Jilani Iqbal & Carlota Recio. (2022) The interplay of galectins-1, -3, and -9 in the immune-inflammatory response underlying cardiovascular and metabolic disease. Cardiovascular Diabetology 21:1.
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Yi-Sheng He, Yu-Qian Hu, Kun Xiang, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Gui-Hong Wang & Hai-Feng Pan. (2021) Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases. Current Pharmaceutical Design 27.
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Marta Maruszewska-Cheruiyot, Michael Stear & Katarzyna Donskow-Łysoniewska. (2021) Galectins - Important players of the immune response to CNS parasitic infection. Brain, Behavior, & Immunity - Health 13, pages 100221.
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Alberto Valdés, Athanasios Bitzios, Eszter Kassa, Ganna Shevchenko, Alexander Falk, Per-Uno Malmström, Anca Dragomir, Ulrika Segersten & Sara Bergström Lind. (2021) Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer. Scientific Reports 11:1.
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Katarzyna Nazimek & Krzysztof Bryniarski. (2020) Approaches to inducing antigen‐specific immune tolerance in allergy and autoimmunity: Focus on antigen‐presenting cells and extracellular vesicles. Scandinavian Journal of Immunology 91:6.
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Rosa Lippolis, Davide Gnocchi, Luigi Santacroce, Rosa Anna Siciliano, Maria Fiorella Mazzeo, Salvatore Scacco, Carlo Sabbà & Antonio Mazzocca. (2020) A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications 526:4, pages 1150-1156.
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Yunxiang Lv, Mengyuan Dai, Muzi Wang, Fangfang Chen & Rongyu Liu. (2019) Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation. Journal of Immunology Research 2019, pages 1-10.
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Dominic Laaf, Pavla Bojarová, Lothar Elling & Vladimír Křen. (2019) Galectin–Carbohydrate Interactions in Biomedicine and Biotechnology. Trends in Biotechnology 37:4, pages 402-415.
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Tsung-Chieh Shih, Ruiwu Liu, Chun-Te Wu, Xiaocen Li, Wenwu Xiao, Xiaojun Deng, Sophie Kiss, Ting Wang, Xiao-Jia Chen, Randy Carney, Hsing-Jien Kung, Yong Duan, Paramita M. Ghosh & Kit S. Lam. (2018) Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion. Clinical Cancer Research 24:17, pages 4319-4331.
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Victoria Sundblad, Luciano G. Morosi, Jorge R. Geffner & Gabriel A. Rabinovich. (2017) Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation. The Journal of Immunology 199:11, pages 3721-3730.
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Nadja Bertleff-Zieschang, Julian Bechold, Clemens Grimm, Michael Reutlinger, Petra Schneider, Gisbert Schneider & Jürgen Seibel. (2017) Exploring the Structural Space of the Galectin-1-Ligand Interaction. ChemBioChem 18:15, pages 1477-1481.
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Savita P. Rao, Xiao Na Ge & P. Sriramarao. (2017) Regulation of Eosinophil Recruitment and Activation by Galectins in Allergic Asthma. Frontiers in Medicine 4.
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Mariana Rinaldi, Laura Thomas, Patricia Mathieu, Pablo Carabias, Maria F. Troncoso, Juana M. Pasquini, Gabriel A. Rabinovich & Laura A. Pasquini. (2016) Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation. Neurobiology of Disease 96, pages 127-143.
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Yu You, Jia-Xin Tan, Hai-Su Dai, Hao-Wei Chen, Xue-Jun Xu, Ai-Gang Yang, Yu-Jun Zhang, Lian-Hua Bai & Ping Bie. (2016) MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma. Oncotarget 7:35, pages 57099-57116.
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Yuri Noda, Yuko Kondo, Manabu Sakai, Sunao Sato & Mitsunobu Kishino. (2016) Galectin-1 is a useful marker for detecting neoplastic squamous cells in oral cytology smears. Human Pathology 52, pages 101-109.
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Ada G. Blidner, Santiago P. Méndez-Huergo, Alejandro J. Cagnoni & Gabriel A. Rabinovich. (2015) Re-wiring regulatory cell networks in immunity by galectin-glycan interactions. FEBS Letters 589:22, pages 3407-3418.
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Nassrene Y. Elmadhun, Ahmed A. Sadek, Ashraf A. Sabe, Antonio D. Lassaletta & Frank W. Sellke. (2015) Alcohol and the Heart: A Proteomics Analysis of Pericardium and Myocardium in a Swine Model of Myocardial Ischemia. The Annals of Thoracic Surgery 100:5, pages 1627-1635.
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Dong Tang, Jun Gao, Sen Wang, Zhongxu Yuan, Nianyuan Ye, Yang Chong, Chuanqi Xu, Xuetong Jiang, Bin Li, Wei Yin, Yi Miao, Daorong Wang & Kuirong Jiang. (2015) Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer. Tumor Biology 36:7, pages 5617-5626.
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Zsófia Hegedüs, Edit Wéber, Lea Végh, Balázs Váczi, Vilmos Tubak, Éva Kriston-Pál, Zoltán Kele, Éva Monostori & Tamás A. Martinek. (2014) Two-stage interaction of the tumor nursing galectin-1 with the antiangiogenic peptide anginex. Journal of Thermal Analysis and Calorimetry 120:1, pages 449-456.
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Sadhna Aggarwal, Suresh C. Sharma & Satya N. Das. (2015) Galectin-1 and galectin-3: Plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population. Clinica Chimica Acta 442, pages 13-21.
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Yueh-Te Lin, Jhih-Sian Chen, Ming-Heng Wu, I-Shan Hsieh, Chen-Hsien Liang, Cheng-Lung Hsu, Tse-Ming Hong & Yuh-Ling Chen. (2015) Galectin-1 Accelerates Wound Healing by Regulating the Neuropilin-1/Smad3/NOX4 Pathway and ROS Production in Myofibroblasts. Journal of Investigative Dermatology 135:1, pages 258-268.
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Damiano Cancogni, Matteo Fusari, Niccolò Poggi & Luigi Lay. 2015. Polysaccharides. Polysaccharides 2065 2116 .
Karina Alves Toledo, Marise Lopes Fermino, Camillo del Cistia Andrade, Thalita Bachelli Riul, Renata Tom? Alves, Vanessa Danielle Menjon Muller, Raquel Rinaldi Russo, Sean R. Stowell, Richard D. Cummings, Victor Hugo Aquino & Marcelo Dias-Baruffi. (2014) Galectin-1 Exerts Inhibitory Effects during DENV-1 Infection. PLoS ONE 9:11, pages e112474.
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Ming-Heng Wu, Nien-Wen Ying, Tse-Ming Hong, Wei-Fan Chiang, Yueh-Te Lin & Yuh-Ling Chen. (2014) Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex. Angiogenesis 17:4, pages 839-849.
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Lucile Astorgues-Xerri, Maria E. Riveiro, Annemilaï Tijeras-Raballand, Maria Serova, Cindy Neuzillet, Sébastien Albert, Eric Raymond & Sandrine Faivre. (2014) Unraveling galectin-1 as a novel therapeutic target for cancer. Cancer Treatment Reviews 40:2, pages 307-319.
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Kazuhito Yuhashi, Shin Ohnishi, Tatsuhiko Kodama, Kazuhiko Koike & Hiroshi Kanamori. (2014) In vitro selection of the 3′-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B. Virology 450-451, pages 13-23.
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Rishi Sharma, Kottari Naresh, Yoann M. Chabre, Rabindra Rej, Nadim K. Saadeh & René Roy. (2014) “Onion peel” dendrimers: a straightforward synthetic approach towards highly diversified architectures. Polym. Chem. 5:14, pages 4321-4331.
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Damiano Cancogni, Matteo Fusari, Niccolò Poggi & Luigi Lay. 2021. Polysaccharides. Polysaccharides 1 45 .
Charles J. Dimitroff & Gabriel A. Rabinovich. 2014. Tumor-Induced Immune Suppression. Tumor-Induced Immune Suppression 347 367 .
J. Ye, H. Liu, Y. Hu, G. Wan, J. Li, Z. Wang, P. Li, G. Zhang & Y. Li. (2013) The clinical implication of tumoral Gal-1 expression in laryngeal squamous cell carcinomas. Clinical and Translational Oncology 15:8, pages 608-618.
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Batya Barkan, Adrienne D. Cox & Yoel Kloog. (2013) Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. Oncotarget 4:2, pages 256-268.
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Tomás Dalotto-Moreno, Diego O. Croci, Juan P. Cerliani, Verónica C. Martinez-Allo, Sebastián Dergan-Dylon, Santiago P. Méndez-Huergo, Juan C. Stupirski, Daniel Mazal, Eduardo Osinaga, Marta A. Toscano, Victoria Sundblad, Gabriel A. Rabinovich & Mariana Salatino. (2013) Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease. Cancer Research 73:3, pages 1107-1117.
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Han Wu, Pei Chen, Rui Liao, Yi-Wei Li, Yong Yi, Jia-Xing Wang, Tai-Wei Sun, Jian Zhou, Ying-Hong Shi, Xin-Rong Yang, Jian-Jun Jin, Yun-Feng Cheng, Jia Fan & Shuang-Jian Qiu. (2012) Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection. Journal of Gastroenterology and Hepatology 27:8, pages 1312-1319.
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Ha-Jeong Kim, Hye-Kyung Jeon, Young Jae Cho, Young Ae Park, Jung-Joo Choi, In-Gu Do, Sang Young Song, Yoo-Young Lee, Chel Hun Choi, Tae-Joong Kim, Duk-Soo Bae, Jeong-Won Lee & Byoung-Gie Kim. (2012) High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion. European Journal of Cancer 48:12, pages 1914-1921.
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Eliezer Zomer, Anatole A. Klyosov & David Platt. 2012. Glycobiology and Drug Design. Glycobiology and Drug Design 69 87 .
Sonsoles Martín-Santamaría, Hans-Joachim Gabius & Jesús Jiménez-Barbero. (2011) Structural studies on the interaction of saccharides and glycomimetics with galectin-1: A 3D perspective using a combined molecular modeling and NMR approach. Pure and Applied Chemistry 84:1, pages 49-64.
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Koichi Ito, Stacy A. Scott, Samuel Cutler, Lan-Feng Dong, Jiri Neuzil, Helen Blanchard & Stephen J. Ralph. (2011) Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress. Angiogenesis 14:3, pages 293-307.
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Steven R. Barthel, Aristotelis Antonopoulos, Filiberto Cedeno-Laurent, Lana Schaffer, Gilberto Hernandez, Shilpa A. Patil, Simon J. North, Anne Dell, Khushi L. Matta, Sriram Neelamegham, Stuart M. Haslam & Charles J. Dimitroff. (2011) Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation. Journal of Biological Chemistry 286:24, pages 21717-21731.
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Ya Zhuo & Susan L. Bellis. (2011) Emerging Role of α2,6-Sialic Acid as a Negative Regulator of Galectin Binding and Function. Journal of Biological Chemistry 286:8, pages 5935-5941.
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Mustafa Kh. Dabbous, M. Margaret Jefferson, Lena Haney & Edwin L. Thomas. (2010) Biomarkers of metastatic potential in cultured adenocarcinoma clones. Clinical & Experimental Metastasis 28:2, pages 101-111.
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Weixing Guo, Jie Xue, Jie Shi, Nan Li, Yu Shao, Xiya Yu, Feng Shen, Mengchao Wu, Shanrong Liu & Shuqun Cheng. (2010) Proteomics Analysis of Distinct Portal Vein Tumor Thrombi in Hepatocellular Carcinoma Patients. Journal of Proteome Research 9:8, pages 4170-4175.
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