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Rationale for anti-CD200 immunotherapy in B-CLL and other hematologic malignancies: new concepts in blocking immune suppression

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Pages 5-15 | Published online: 17 Dec 2007

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Maria Rita Gaiser, Cleo-Aron Weis, Timo Gaiser, Hong Jiang, Kristina Buder-Bakhaya, Esther Herpel, Arne Warth, Ying Xiao, Lingling Miao & Isaac Brownell. (2018) Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells. OncoImmunology 7:5.
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Jin Lu, Jing Lu, Wenming Chen, Jing Wang, Yuliang Huo, Jian Hou & Xiaojun Huang. (2016) More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis. Drug Design, Development and Therapy 10, pages 3673-3679.
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Lei Fan, Yi Miao, Yu-Jie Wu, Yan Wang, Rui Guo, Li Wang, An-Li Shen, Yao-Yu Chen, Wei Xu & Jian-Yong Li. (2015) Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis. Leukemia & Lymphoma 56:12, pages 3329-3335.
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Articles from other publishers (33)

Pavuluri Divya, Navatha Vangala, MeghaS Uppin, ShantveerG Uppin, Sadashivudu Gundeti, Srinivas Bacchu, KK Radhika, A Parvathi & TaraRoshni Paul. (2023) Utility of CD200 expression by flow cytometry in lymphoproliferative disorders and plasma cell dyscrasias. Medical Journal of Dr. D.Y. Patil Vidyapeeth 16:7, pages 80.
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Xiaohong Mary Zhang & Yi Ding. 2022. Handbook of Practical Immunohistochemistry. Handbook of Practical Immunohistochemistry 751 798 .
Renata B. Staub, Natália A. Marcondes & Liane N. Rotta. (2021) CD200 expression in hematopoietic neoplasms: Beyond a marker for diagnosis of B-cell neoplasms. Critical Reviews in Oncology/Hematology 167, pages 103509.
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Michiel van der Vlist, M. Inês Pascoal Ramos, Lucas L. van den HoogenSanne Hiddingh, Laura M. Timmerman, Titus A. P. de HondEllen D. Kaan, Maarten van der KroefRobert Jan Lebbink, Florence M. A. Peters, William Khoury-Hanold, Ruth Fritsch-StorkTimothy R. D. J. Radstake & Linde Meyaard. (2021) Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Science Signaling 14:704.
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Giovanni D’Arena, Vincenzo De Feo, Giuseppe Pietrantuono, Elisa Seneca, Giovanna Mansueto, Oreste Villani, Francesco La Rocca, Fiorella D’Auria, Teodora Statuto, Luciana Valvano, Francesca Arruga, Silvia Deaglio, Dimitar G. Efremov, Alessandro Sgambato & Luca Laurenti. (2020) CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance. Frontiers in Oncology 10.
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James W. Vaughan, Min Shi, Pedro Horna & Horatiu Olteanu. (2020) Increased CD200 expression in post-transplant lymphoproliferative disorders correlates with an increased frequency of FoxP3(+) regulatory T cells. Annals of Diagnostic Pathology 48, pages 151585.
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Christiana M. Neophytou, Chryso Pierides, Maria-Ioanna Christodoulou, Paul Costeas, Theodora-Christina Kyriakou & Panagiotis Papageorgis. (2020) The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy. Frontiers in Oncology 10.
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Jin-Qing Liu, Aiyan Hu, Jianmin Zhu, Jianyu Yu, Fatemeh Talebian & Xue-Feng Bai. 2020. Tumor Microenvironment. Tumor Microenvironment 155 165 .
Tina Vosoughi, Marziye Bagheri, Mehran Hosseinzadeh, Ali Ehsanpour, Nader Davari & Najmaldin Saki. (2019) CD markers variations in chronic lymphocytic leukemia: New insights into prognosis. Journal of Cellular Physiology 234:11, pages 19420-19439.
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Jason E Love, Kimberly Thompson, Mark R Kilgore, Maria Westerhoff, Claire E Murphy, Antonios Papanicolau-Sengos, Kinsey A McCormick, Veena Shankaran, Natalie Vandeven, Faith Miller, Astrid Blom, Paul T Nghiem & Steven J Kussick. (2017) CD200 Expression in Neuroendocrine Neoplasms. American Journal of Clinical Pathology 148:3, pages 236-242.
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Emily F Mason, Olga Pozdnyakova, Betty Li, Graham Dudley & David M Dorfman. (2017) Flow Cytometric Patterns of CD200 and CD1d Expression Distinguish CD10-Negative, CD5-Negative Mature B-Cell Lymphoproliferative Disorders. American Journal of Clinical Pathology 148:1, pages 33-41.
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Yuliya Vladimirovna Mirolyubova, E.A. Stadnik, T.S. Nikulina, V.V. Strugov, T.O. Andreeva, Yu.V Virts, R.V. Grozov & A.Yu. Zaritskey. (2017) Role of Superficial CD200 Marker in Differential Diagnosis of Malignant B-Cell Lymphoproliferative Diseases. Clinical oncohematology 10:2, pages 169-175.
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Zhengming Xiong, Elisabet Ampudia-Mesias, Rob Shaver, Craig M Horbinski, Christopher L Moertel & Michael R Olin. (2016) Tumor-derived vaccines containing CD200 inhibit immune activation: implications for immunotherapy. Immunotherapy 8:9, pages 1059-1071.
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Preetesh Jain & Susan O'Brien. 2015. Targeted Therapy in Translational Cancer Research. Targeted Therapy in Translational Cancer Research 130 144 .
Xiaohong Zhang & Nadine S. Aguilera. 2015. Handbook of Practical Immunohistochemistry. Handbook of Practical Immunohistochemistry 591 628 .
Xiaohong (Mary) ZhangNadine Aguilera. (2014) New Immunohistochemistry for B-Cell Lymphoma and Hodgkin Lymphoma. Archives of Pathology & Laboratory Medicine 138:12, pages 1666-1672.
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Pramoda ChallagundlaL. Jeffrey MedeirosRashmi Kanagal-ShamannaRoberto N. MirandaJeffrey L. Jorgensen. (2014) Differential Expression of CD200 in B-Cell Neoplasms by Flow Cytometry Can Assist in Diagnosis, Subclassification, and Bone Marrow Staging. American Journal of Clinical Pathology 142:6, pages 837-844.
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Ying Xiao, Jonathan S. Williams & Isaac Brownell. (2014) Merkel cells and touch domes: more than mechanosensory functions?. Experimental Dermatology 23:10, pages 692-695.
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Vinodh Pillai, Olga Pozdnyakova, Karry Charest, Betty Li, Aliakbar Shahsafaei & David M. Dorfman. (2013) CD200 Flow Cytometric Assessment and Semiquantitative Immunohistochemical Staining Distinguishes Hairy Cell Leukemia From Hairy Cell Leukemia-Variant and Other B-Cell Lymphoproliferative Disorders. American Journal of Clinical Pathology 140:4, pages 536-543.
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Munir Akkaya, Marie-Laure Aknin, Billur Akkaya & A. Neil Barclay. (2013) Dissection of Agonistic and Blocking Effects of CD200 Receptor Antibodies. PLoS ONE 8:5, pages e63325.
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Douglas G WalkerLih-Fen Lue. (2013) Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?. Future Neurology 8:3, pages 321-332.
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Ali Memarian, Maryam Nourizadeh, Farimah Masoumi, Mina Tabrizi, Amir Hossein Emami, Kamran Alimoghaddam, Jamshid Hadjati, Mahroo Mirahmadian & Mahmood Jeddi-Tehrani. (2012) Upregulation of CD200 is associated with Foxp3+ regulatory T cell expansion and disease progression in acute myeloid leukemia. Tumor Biology 34:1, pages 531-542.
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David M Dorfman, Aliakbar Shahsafaei & Miguel A Alonso. (2012) Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers. Modern Pathology 25:12, pages 1637-1643.
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Tomasz P Rygiel & Linde Meyaard. (2012) CD200R signaling in tumor tolerance and inflammation: A tricky balance. Current Opinion in Immunology 24:2, pages 233-238.
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David M. Dorfman & Aliakbar Shahsafaei. (2011) CD200 (OX-2 Membrane Glycoprotein) is Expressed by Follicular T Helper Cells and in Angioimmunoblastic T-cell Lymphoma. The American Journal of Surgical Pathology 35:1, pages 76-83.
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David M. Dorfman & Aliakbar Shahsafaei. (2010) CD200 (OX-2 Membrane Glycoprotein) Expression in B Cell–Derived Neoplasms. American Journal of Clinical Pathology 134:5, pages 726-733.
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Zhiqi Chen, Xuezhong Ma, Jianhua Zhang, Jim Hu & Reginald M. Gorczynski. (2010) Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF. Nucleic Acids Research 38:19, pages 6684-6696.
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Giuseppe A. Palumbo, Nunziatina Parrinello, Giovannella Fargione, Katia Cardillo, Annalisa Chiarenza, Salvatore Berretta, Concetta Conticello, Loredana Villari & Francesco Di Raimondo. (2009) CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia. Leukemia Research 33:9, pages 1212-1216.
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E. Porpaczy, M. Bilban, G. Heinze, M. Gruber, K. Vanura, I. Schwarzinger, S. Stilgenbauer, B. Streubel, C. Fonatsch & U. Jaeger. (2009) Gene expression signature of chronic lymphocytic leukaemia with Trisomy 12. European Journal of Clinical Investigation 39:7, pages 568-575.
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Lisa Pleyer, Alexander Egle, Tanja Nicole Hartmann & Richard Greil. (2009) Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nature Reviews Clinical Oncology 6:7, pages 405-418.
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T. Aoki, Y. Matsumoto, K. Hirata, K. Ochiai, M. Okada, K. Ichikawa, M. Shibasaki, T. Arinami, R. Sumazaki & E. Noguchi. (2009) Expression profiling of genes related to asthma exacerbations. Clinical & Experimental Allergy 39:2, pages 213-221.
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