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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 11
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Original Research

Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration

Pieranna Chiarella University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; CNR – Institute of Neurobiology and Molecular Medicine, Laboratory of Molecular Pathology and Experimental Oncology, Area Ricerca Tor Vergata, Via Fosso del Cavaliere 100, 00133 Rome, Italy +39 0649934232; +39 0649934257; [email protected]
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Emanuela Massi University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; CNR – Institute of Neurobiology and Molecular Medicine, Laboratory of Molecular Pathology and Experimental Oncology, Area Ricerca Tor Vergata, Via Fosso del Cavaliere 100, 00133 Rome, Italy +39 0649934232; +39 0649934257; [email protected]
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Mariangela De Robertis University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; CNR – Institute of Neurobiology and Molecular Medicine, Laboratory of Molecular Pathology and Experimental Oncology, Area Ricerca Tor Vergata, Via Fosso del Cavaliere 100, 00133 Rome, Italy +39 0649934232; +39 0649934257; [email protected]
,
Annarita Sibilio University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; Bio-Ker s.r.l., Pula (CA), Italy
,
Paola Parrella IRCCS H. ‘Casa Sollievo della Sofferenza’, Laboratory of Oncology, San Giovanni Rotondo (FG), Italy
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Vito Michele Fazio University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; IRCCS H. ‘Casa Sollievo della Sofferenza’, Laboratory of Oncology, San Giovanni Rotondo (FG), Italy
&
Emanuela Signori University ‘Campus Bio-Medico of Rome’, CIR, Laboratory of Molecular Medicine and Biotechnology, Rome, Italy; CNR – Institute of Neurobiology and Molecular Medicine, Laboratory of Molecular Pathology and Experimental Oncology, Area Ricerca Tor Vergata, Via Fosso del Cavaliere 100, 00133 Rome, Italy +39 0649934232; +39 0649934257; [email protected]
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Pages 1645-1657 | Published online: 10 Oct 2008

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Poulam M. Patel, Christian H. Ottensmeier, Clive Mulatero, Paul Lorigan, Ruth Plummer, Hardev Pandha, Somaia Elsheikh, Efthymios Hadjimichael, Naty Villasanti, Sally E. Adams, Michelle Cunnell, Rachael L. Metheringham, Victoria A. Brentville, Lee Machado, Ian Daniels, Mohamed Gijon, Drew Hannaman & Lindy G. Durrant. (2018) Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial. OncoImmunology 7:6.
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Wei Xue, Rachael L. Metheringham, Victoria A. Brentville, Barbara Gunn, Peter Symonds, Hideo Yagita, Judith M. Ramage & Lindy G. Durrant. (2016) SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade. OncoImmunology 5:6.
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Laure Lambricht, Alessandra Lopes, Spela Kos, Gregor Sersa, Véronique Préat & Gaëlle Vandermeulen. (2016) Clinical potential of electroporation for gene therapy and DNA vaccine delivery. Expert Opinion on Drug Delivery 13:2, pages 295-310.
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Christophe Y Calvet, Franck M André & Lluis M Mir. (2014) Dual therapeutic benefit of electroporation-mediated DNA vaccination in vivo. OncoImmunology 3:4.
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Christophe Y Calvet, Delphine Famin, Franck M André & Lluis M Mir. (2014) Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells. OncoImmunology 3:4.
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Gleb Kichaev, Janess M Mendoza, Dinah Amante, Trevor RF Smith, Jay R McCoy, Niranjan Y Sardesai & Kate E Broderick. (2013) Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses. Human Vaccines & Immunotherapeutics 9:10, pages 2041-2048.
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Fadi Saade & Nikolai Petrovsky. (2012) Technologies for enhanced efficacy of DNA vaccines. Expert Review of Vaccines 11:2, pages 189-209.
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Mariana Ingolotti, Omkar Kawalekar, Devon J Shedlock, Karuppiah Muthumani & David B Weiner. (2010) DNA vaccines for targeting bacterial infections. Expert Review of Vaccines 9:7, pages 747-763.
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Sylvia van Drunen Littel-van den Hurk & D Hannaman. (2010) Electroporation for DNA immunization: clinical application. Expert Review of Vaccines 9:5, pages 503-517.
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Xuan Gong, Zhou Chen, Jason J. Hu & Chao Liu. (2022) Advances of Electroporation-Related Therapies and the Synergy with Immunotherapy in Cancer Treatment. Vaccines 10:11, pages 1942.
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Tina Batista Napotnik, Tamara Polajžer & Damijan Miklavčič. (2021) Cell death due to electroporation – A review. Bioelectrochemistry 141, pages 107871.
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T. Komel, M. Bosnjak, S. Kranjc Brezar, M. De Robertis, M. Mastrodonato, G. Scillitani, G. Pesole, E. Signori, G. Sersa & M. Cemazar. (2021) Gene electrotransfer of IL-2 and IL-12 plasmids effectively eradicated murine B16.F10 melanoma. Bioelectrochemistry 141, pages 107843.
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Jean Carlos dos Santos da Luz, Fernanda Antunes, Maria Alejandra Clavijo-Salomon, Emanuela Signori, Nayara Gusmão Tessarollo & Bryan E. Strauss. (2021) Clinical Applications and Immunological Aspects of Electroporation-Based Therapies. Vaccines 9:7, pages 727.
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Emilia Sokołowska & Agnieszka Urszula Błachnio-Zabielska. (2019) A Critical Review of Electroporation as A Plasmid Delivery System in Mouse Skeletal Muscle. International Journal of Molecular Sciences 20:11, pages 2776.
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