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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 9
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Original Research

Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis

Patrícia RM Souza Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Carlos R Zárate-Bladés Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Juliana I Hori Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Simone G Ramos Departamento de Patologia, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Deison S Lima Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
,
Tatiana Schneider Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
,
Rogério S Rosada Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
,
Lucimara GL Torre Universidade de Campinas, Faculdade de Engenharia Química, UNICAMP, 13083-970/6066, SP, Brasil
,
Maria Helena A Santana Universidade de Campinas, Faculdade de Engenharia Química, UNICAMP, 13083-970/6066, SP, Brasil
,
Izaíra T Brandão Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Ana P Masson Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Arlete AM Coelho-Castelo Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Vânia L Bonato Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
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Fabio CS Galetti Farmacore Biotecnologia Ltda., Campus da USP-Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brasil +55 16 36023086; +55 16 36336840; [email protected]
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Eduardo D Gonçalves Farmacore Biotecnologia Ltda., Campus da USP-Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brasil +55 16 36023086; +55 16 36336840; [email protected]
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Domingos A Botte Farmacore Biotecnologia Ltda., Campus da USP-Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brasil +55 16 36023086; +55 16 36336840; [email protected]
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Jeanne BM Machado Farmacore Biotecnologia Ltda., Campus da USP-Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brasil +55 16 36023086; +55 16 36336840; [email protected]
&
Celio L Silva Universidade de São Paulo, Núcleo de Pesquisas em Tuberculose, Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, FMRP-USP, 14049-900 Ribeirão Preto, SP, Brasil
 show all
Pages 1255-1264 | Published online: 11 Aug 2008

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Pryscilla Fanini Wowk, Luís Henrique Franco, Denise Morais da Fonseca, Marina Oliveira Paula, Élcio dos Santos Oliveira Vianna, Ana Paula Wendling, Valéria Maria Augusto, Silvana Maria Elói-Santos, Andréa Teixeira-Carvalho, Flávia Dias Coelho Silva, Solange Alves Vinhas, Olindo Assis Martins-Filho, Moisés Palaci, Célio Lopes Silva & Vânia Luiza Deperon Bonato. (2017) Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients. Human Vaccines & Immunotherapeutics 13:5, pages 1040-1050.
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Nayara TS Doimo, Carlos R Zárate-Bladés, Rodrigo F Rodrigues, Cristiane Tefé-Silva, Marcele NS Trotte, Patrícia RM Souza, Luana S Soares, Wendy M Rios, Elaine M Floriano, Izaira T Brandão, Ana P Masson, Verônica Coelho, Simone G Ramos & Celio L Silva. (2014) Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity. Human Vaccines & Immunotherapeutics 10:5, pages 1238-1243.
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Carlos R. Zárate-Bladés, Rodrigo F. Rodrigues, Patricia R. M. Souza, Wendy M. Rios, Luana S. Soares, Rogério S. Rosada, Izaíra T. Brandão, Ana Paula Masson, Elaine M. Floriano, Simone G. Ramos & Celio L. Silva. (2013) Evaluation of the overall IFN-γ and IL-17 pro-inflammatory responses after DNA therapy of tuberculosis. Human Vaccines & Immunotherapeutics 9:5, pages 1093-1103.
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Articles from other publishers (15)

Celio Lopes Silva, Thiago Malardo & Aline Seiko Carvalho Tahyra. (2020) Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65). Frontiers in Medical Technology 2.
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Dennis J. Montoya, Priscila Andrade, Bruno J.A. Silva, Rosane M.B. Teles, Feiyang Ma, Bryan Bryson, Saheli Sadanand, Teia Noel, Jing Lu, Euzenir Sarno, Kristine B. Arnvig, Douglas Young, Ramanuj Lahiri, Diana L. Williams, Sarah Fortune, Barry R. Bloom, Matteo Pellegrini & Robert L. Modlin. (2019) Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response. Cell Reports 26:13, pages 3574-3585.e3.
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Paula Aline Zanetti Campanerut-Sá, Luciana Dias Ghiraldi-Lopes, Jean Eduardo Meneguello, Jorge Juarez Vieira Teixeira, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Terezinha Inez Estivalet Svidzinski, Fernando Rogério Pavan & Rosilene Fressatti Cardoso. (2017) Systematic review on the proteomic profile of Mycobacterium tuberculosis exposed to drugs . PROTEOMICS - Clinical Applications 11:11-12, pages 1600077.
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Peter Michael Moyle. (2017) Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines. Biotechnology Advances 35:3, pages 375-389.
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R. Q. Prado, T. B. Bertolini, A. R. Piñeros, A. F. Gembre, S. G. Ramos, C. L. Silva, M. C. Borges & V. L. D. Bonato. (2015) Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-γ-CCR2 signalling circuit. Clinical & Experimental Allergy 45:9, pages 1459-1471.
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Rodrigo F. Rodrigues, Carlos R. Zárate-Bladés, Wendy M. Rios, Luana S. Soares, Patricia R. M. Souza, Izaíra T. Brandão, Ana P. Masson, Frederico G. C. Arnoldi, Simone G. Ramos, Franck Letourneur, Sébastien Jacques, Nicolas Cagnard, Gilles Chiocchia & Celio L. Silva. (2015) Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis of murine tuberculosis. Journal of Antimicrobial Chemotherapy 70:6, pages 1774-1783.
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C.D. Rocha, A.P.F. Trombone, J.C.C. Lorenzi, L.P. Almeida, A.F. Gembre, E. Padilha, S.G. Ramos, C.L. Silva & A.A.M. Coelho-Castelo. (2012) Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis. Brazilian Journal of Medical and Biological Research 45:12, pages 1183-1194.
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D. M. Fonseca, P. F. Wowk, M. O. Paula, L. W. Campos, A. F. Gembre, W. M. Turato, S. G. Ramos, M. Dias-Baruffi, R. Barboza, E. Gomes, C. L. Silva, M. Russo & V. L. D. Bonato. (2012) Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway. Clinical & Experimental Allergy 42:1, pages 131-143.
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Marcia Berrêdo-Pinho, Dario E Kalume, Paloma R Correa, Leonardo HF Gomes, Melissa P Pereira, Renata F da Silva, Luiz RR Castello-Branco, Wim M Degrave & Leila Mendonça-Lima. (2011) Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur. BMC Microbiology 11:1.
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Thais de Paula Rigoletto, Maria Elisabete Darbello Zaniquelli, Maria Helena Andrade Santana & Lucimara Gaziola de la Torre. (2011) Surface miscibility of EPC/DOTAP/DOPE in binary and ternary mixed monolayers. Colloids and Surfaces B: Biointerfaces 83:2, pages 260-269.
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César Rodríguez-Narciso, Mayra Pérez-Tapia, Rosa María Rangel-Cano, Celio L. Silva, Mariana Meckes-Fisher, Rafael Salgado-Garciglia, Sergio Estrada-Parra, Rodolfo López-Gómez & Iris Estrada-García. (2010) Expression of Mycobacterium leprae HSP65 in tobacco and its effectiveness as an oral treatment in adjuvant-induced arthritis. Transgenic Research 20:2, pages 221-229.
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Carlos Rodrigo Zárate-Bladés, Celio Lopes Silva & Geraldo A. Passos. (2011) The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy. Clinical and Developmental Immunology 2011, pages 1-6.
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Julio CC Lorenzi, Ana PF Trombone, Carolina D Rocha, Luciana P Almeida, Ricardo L Lousada, Thiago Malardo, Isabela C Fontoura, Renata AM Rossetti, Ana F Gembre, Aristóbolo M Silva, Celio L Silva & Arlete AM Coelho-Castelo. (2010) Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis. BMC Biotechnology 10:1.
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Alice M. Ribeiro, Anamelia L. Bocca, André C. Amaral, Ana Camila C.O. Souza, Lúcia H. Faccioli, Arlete A.M. Coelho-Castelo, Florêncio Figueiredo, Célio L. Silva & Maria Sueli S. Felipe. (2010) HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis. Vaccine 28:6, pages 1528-1534.
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Fayaz-Ahmad Mir, Stefan H. E. Kaufmann & Ali Nasser Eddine. (2009) A Multicistronic DNA Vaccine Induces Significant Protection against Tuberculosis in Mice and Offers Flexibility in the Expressed Antigen Repertoire. Clinical and Vaccine Immunology 16:10, pages 1467-1475.
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