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Expert Opinion on Emerging Drugs Volume 14, 2009 - Issue 3
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Emerging drugs for the treatment of ulcerative colitis

Luca Pastorelli Research Associate, Case Western Reserve University School of Medicine, Department of Pathology, 2103 Cornell Road, Room 5501, Cleveland, OH, 44106, USA; University of Milan, School of Medicine, Department of Medical Sciences, Milan, Italy
, MD,
Theresa T Pizarro Associate Professor, Case Western Reserve University School of Medicine, Department of Pathology, 2103 Cornell Road, Room 5501, Cleveland, OH, 44106, USA
, PhD,
Fabio Cominelli Professor of Medicine, Case Western Reserve University, University Hospital Case Medical Center, Digestive Health Center, Division of Gastroenterology and Liver Disease, 11100 Euclid Avenue, Cleveland, OH, 44106, USA
, MD PhD &
Maurizio Vecchi University of Milan, School of Medicine, Department of Medical Sciences, Milan, Italy; Associate Professor, University of Milan, Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, MI, 20097, Italy +39 025 277 4652; +39 025 277 4655; [email protected]
, MD
Pages 505-521 | Published online: 05 Aug 2009

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Carolina L. Bellera, Mauricio E. Di Ianni & Alan Talevi. (2018) The application of molecular topology for ulcerative colitis drug discovery. Expert Opinion on Drug Discovery 13:1, pages 89-101.
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Shaherin Basith, Balachandran Manavalan, Gwang Lee, Sang Geon Kim & Sangdun Choi. (2011) Toll-like receptor modulators: a patent review (2006 – 2010). Expert Opinion on Therapeutic Patents 21:6, pages 927-944.
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Articles from other publishers (20)

Xiaochun Yang, Deyong Zeng, Chongyang Li, Wenchen Yu, Guilin Xie, Yingchun Zhang & Weihong Lu. (2023) Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review. Food Science and Human Wellness 12:6, pages 2135-2150.
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T. Louwies & B. Greenwood-Van Meerveld. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 132 163 .
M. M. Pathan & A. D. Kshirsagar. (2021) Estimation of Mesalamine in Human Plasma Using Rapid and Sensitive LC-ESI-MS/MS Method. Pharmaceutical Chemistry Journal 55:8, pages 835-844.
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Liu Zeng Chen, Xing Xing Zhang, Ming Ming Liu, Jing Wu, Duo Ma, Liang Zhuo Diao, Qingshan Li, Yan Shuang Huang, Rui Zhang, Ban Feng Ruan & Xin Hua Liu. (2021) Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis. Journal of Medicinal Chemistry 64:18, pages 13633-13657.
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El Bethel Lalthavel Hmar, Sujata Paul, Nayanmoni Boruah, Priyanka Sarkar, Sudarshana Borah & Hemanta Kumar Sharma. (2021) Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?. Current Pathobiology Reports 9:1, pages 9-32.
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Guang Li, Bowen Zhang, Jianyu Hao, Xiaojing Chu, Miriam Wiestler, Markus Cornberg, Cheng-Jian Xu, Xinjuan Liu & Yang Li. (2021) Identification of Novel Population-Specific Cell Subsets in Chinese Ulcerative Colitis Patients Using Single-Cell RNA Sequencing. Cellular and Molecular Gastroenterology and Hepatology 12:1, pages 99-117.
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Lijun Zheng, Meihua Luo, Gaobo Kuang, Yangyang Liu, Debao Liang, Haiqing Huang, Xiaomin Yi, Congfeng Wang, Ye Wang, Qiuling Xie & Fachao Zhi. (2020) Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form. Frontiers in Pharmacology 11.
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Renren Bai, Xiaokang Jie, Chuansheng Yao & Yuanyuan Xie. (2020) Discovery of small-molecule candidates against inflammatory bowel disease. European Journal of Medicinal Chemistry 185, pages 111805.
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Si-Yu CAO, Sheng-Jie YE, Wei-Wei WANG, Bing WANG, Tong ZHANG & Yi-Qiong PU. (2019) Progress in active compounds effective on ulcerative colitis from Chinese medicines. Chinese Journal of Natural Medicines 17:2, pages 81-102.
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Mahesh Kandula, KB Sunil Kumar, Sivanesan Palanichamy & Ashok Rampal. (2016) Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. International Immunopharmacology 40, pages 443-451.
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Iris Dotan, Etgar Levy-Nissenbaum, Yehuda Chowers, Alexander Fich, Eran Israeli, Tomer Adar, Shimon Shteingart, Hermona Soreq & Eran Goldin. (2016) Ameliorating Active Ulcerative Colitis via an Orally Available Toll-Like Receptor-9 Modifier: A Prospective Open-Label, Multicenter Phase II Trial. Digestive Diseases and Sciences 61:11, pages 3246-3254.
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Rachel Archer, Paul Tappenden, Shijie Ren, Marrissa Martyn-St James, Rebecca Harvey, Hasan Basarir, John Stevens, Christopher Carroll, Anna Cantrell, Alan Lobo & Sami Hoque. (2016) Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262): clinical effectiveness systematic review and economic model. Health Technology Assessment 20:39, pages 1-326.
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Cleopatra Kozlowski, Surinder Jeet, Joseph Beyer, Steve Guerrero, Justin Lesch, Xiaoting Wang, Jason DeVoss & Lauri Diehl. (2013) An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides. Disease Models & Mechanisms 6:3, pages 855-865.
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Vijayakumar Gosu, Shaherin Basith, O-Pil Kwon & Sangdun Choi. (2012) Therapeutic Applications of Nucleic Acids and Their Analogues in Toll-like Receptor Signaling. Molecules 17:11, pages 13503-13529.
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Robert E. W. Hancock, Anastasia Nijnik & Dana J. Philpott. (2012) Modulating immunity as a therapy for bacterial infections. Nature Reviews Microbiology 10:4, pages 243-254.
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Jida ChoiSuyoung BaeJaewoo HongSoyoon RyooHyunjhung JhunKwangwon HongDoyoung YoonSiyoung Lee, Erk Her, Wonhyuk Choi, Jeonghwan Kim, Tania Azam, Charles A. Dinarello & Soohyun Kim. (2010) Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis. Proceedings of the National Academy of Sciences 107:49, pages 21082-21086.
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Moon-Moo Kim & Se-Kwon Kim. (2010) Effect of phloroglucinol on oxidative stress and inflammation. Food and Chemical Toxicology 48:10, pages 2925-2933.
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Elizabeth J. Hennessy, Andrew E. Parker & Luke A. J. O'Neill. (2010) Targeting Toll-like receptors: emerging therapeutics?. Nature Reviews Drug Discovery 9:4, pages 293-307.
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Daan Crommelin, Pieter Stolk, Luc Besançon, Vinod Shah, Kamal Midha & Hubert Leufkens. (2010) Pharmaceutical sciences in 2020. Nature Reviews Drug Discovery 9:2, pages 99-100.
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Stefano Guandalini. 2011. Diarrhea. Diarrhea 459 474 .

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