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Expert Opinion on Emerging Drugs Volume 14, 2009 - Issue 4
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Reviews

Emerging Raf inhibitors

James A McCubrey Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, 600 Moye Boulevard, Greenville, NC 27858, USA +1 252 744 2704; +1 252 744 3104; [email protected]
,
Linda S Steelman Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, 600 Moye Boulevard, Greenville, NC 27858, USA +1 252 744 2704; +1 252 744 3104; [email protected]
,
Steven L Abrams Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, 600 Moye Boulevard, Greenville, NC 27858, USA +1 252 744 2704; +1 252 744 3104; [email protected]
,
William H Chappell Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, 600 Moye Boulevard, Greenville, NC 27858, USA +1 252 744 2704; +1 252 744 3104; [email protected]
,
Suzanne Russo Brody School of Medicine at East Carolina University, Leo Jenkins Cancer Center, Department of Radiation Oncology, 600 Moye Blvd, Greenville 27834, USA
,
Roger Ove Brody School of Medicine at East Carolina University, Leo Jenkins Cancer Center, Department of Radiation Oncology, 600 Moye Blvd, Greenville 27834, USA
,
Michele Milella Regina Elena Cancer Center, Via Elio Chianesi n.53, Rome 00144, Italy
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Agostino Tafuri University of Rome, Department of Hematology-Oncology, La Sapienza, Via Benevento 6, Rome 99161, Italy
,
Paolo Lunghi University of Parma, Department of Clinical Sciences, Via Gramsci n.14, Parma 43100, Italy
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Antonio Bonati University of Parma, Department of Clinical Sciences, Via Gramsci n.14, Parma 43100, Italy; University Hospital of Parma, Unit of Hematology and Bone-Marrow Transplantation, Via Gramsi n.14, Parma 43100, Italy
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Franca Stivala University of Catania, Department of Biological Sciences, Via Androne 83, Catania 95124, Italy
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Ferdinando Nicoletti University of Catania, Department of Biological Sciences, Via Androne 83, Catania 95124, Italy
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Massimo Libra University of Catania, Department of Biological Sciences, Via Androne 83, Catania 95124, Italy
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Alberto M Martelli University of Bologna, Department of Human Anatomical Sciences, Via Imerio 48, Bologna, Italy
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Giuseppe Montalto University of Palermo, Department of Clinical Medicine and Emerging Pathologies, 141 Via del Vespro, Palermo 90127, Italy
&
Melchiorre Cervello Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare “Alberto Monroy”, Via Ugo La Malfa 153, Palermo 90146, Italy
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Pages 633-648 | Published online: 28 Aug 2009

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Mohamed Moussaoui, Mouna Baassi, Soukayna Baammi, Hatim Soufi, Mohammed Salah, Rachid Daoud, Achraf EL Allali, M.E. Belghiti & Said Belaaouad. (2023) In silico design of novel CDK2 inhibitors through QSAR, ADMET, molecular docking and molecular dynamics simulation studies. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
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Melissa M. McKay, Alyson K. Freeman & Deborah K. Morrison. (2011) Complexity in KSR function revealed by Raf inhibitor and KSR structure studies. Small GTPases 2:5, pages 276-281.
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James A McCubrey, Linda S Steelman, Steven L Abrams, William H Chappell, Suzanne Russo, Roger Ove, Michele Milella, Agostino Tafuri, Paolo Lunghi, Antonio Bonati, Franca Stivala, Ferdinando Nicoletti, Massimo Libra, Alberto M Martelli, Giuseppe Montalto & Melchiorre Cervello. (2010) Emerging MEK inhibitors. Expert Opinion on Emerging Drugs 15:2, pages 203-223.
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Yanyang Li, Xiangfei Shi, Ning Xie, Yanjin Zhao & Shuxin Li. (2013) 3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors. Med. Chem. Commun. 4:2, pages 367-370.
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Joyce James, Bruce Ruggeri, Robert C. Armstrong, Martin W. Rowbottom, Susan Jones-Bolin, Ruwanthi N. Gunawardane, Pawel Dobrzanski, Michael F. Gardner, Hugh Zhao, Merryl D. Cramer, Kathryn Hunter, Ronald R. Nepomuceno, Mangeng Cheng, Dana Gitnick, Mehran Yazdanian, Darren E. Insko, Mark A. Ator, Julius L. Apuy, Raffaella Faraoni, Bruce D. Dorsey, Michael Williams, Shripad S. Bhagwat & Mark W. Holladay. (2012) CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity . Molecular Cancer Therapeutics 11:4, pages 930-941.
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L S Steelman, R A Franklin, S L Abrams, W Chappell, C R Kempf, J Bäsecke, F Stivala, M Donia, P Fagone, F Nicoletti, M Libra, P Ruvolo, V Ruvolo, C Evangelisti, A M Martelli & J A McCubrey. (2011) Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. Leukemia 25:7, pages 1080-1094.
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Jasbir Singh, Harmeet Kaur, Aditi Kaushik & Sapna Peer. (2011) A Review of Antisense Therapeutic Interventions for Molecular Biological Targets in Various Diseases. International Journal of Pharmacology 7:3, pages 294-315.
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Zhi Sheng, Sara K. Evans & Michael R. Green. (2010) An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy. Oncotarget 1:6, pages 457-460.
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Gajanan S. Inamdar, SubbaRao V. Madhunapantula & Gavin P. Robertson. (2010) Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail. Biochemical Pharmacology 80:5, pages 624-637.
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Rong Huang, Isabel Martinez-Ferrando & Philip A Cole. (2010) Enhanced interrogation: emerging strategies for cell signaling inhibition. Nature Structural & Molecular Biology 17:6, pages 646-649.
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Zhi Sheng, Li Li, Lihua J Zhu, Thomas W Smith, Andrea Demers, Alonzo H Ross, Richard P Moser & Michael R Green. (2010) A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nature Medicine 16:6, pages 671-677.
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