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Update on emerging drugs for cancer cachexia

, PhD & , PhD
Pages 619-632 | Published online: 27 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Xuqing Zhang & Zhihua Sui. (2013) Deciphering the selective androgen receptor modulators paradigm. Expert Opinion on Drug Discovery 8:2, pages 191-218.
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Tora S. Solheim, Kenneth C. H. Fearon, David Blum & Stein Kaasa. (2013) Non-steroidal anti-inflammatory treatment in cancer cachexia: A systematic literature review. Acta Oncologica 52:1, pages 6-17.
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Kate T Murphy & Gordon S Lynch. (2012) Editorial update on emerging drugs for cancer cachexia. Expert Opinion on Emerging Drugs 17:1, pages 5-9.
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Stefan M Gehrig & Gordon S Lynch. (2011) Emerging drugs for treating skeletal muscle injury and promoting muscle repair. Expert Opinion on Emerging Drugs 16:1, pages 163-182.
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Articles from other publishers (31)

Haruyo Matsuo & Kunihiro Sakuma. (2022) Pathophysiology of cachexia and characteristics of dysphagia in chronic diseases. Asia-Pacific Journal of Oncology Nursing 9:10, pages 100120.
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Ryo Ohno. (2021) Rehabilitation Medicine and Clinical Nutrition in Dysphagia of Cancer Patientsがんの嚥下障害におけるリハビリテーションと臨床栄養. The Japanese Journal of Rehabilitation Medicine 58:8, pages 896-904.
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Haruyo Matsuo & Kunihiro Sakuma. 2021. Sarcopenia. Sarcopenia 267 293 .
Takahiro ShibaYohei Sawaya, Tamaki HiroseMasahiro Ishizaka, Akira Kubo & Tomohiko Urano. (2020) Prevalence and risk factors of sarcopenia in commuting rehabilitation service users通所リハビリテーション利用者におけるサルコペニアの有病率と危険因子. Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 57:2, pages 149-154.
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Angela C. Greenman, Dawn M. Albrecht, Richard B. Halberg & Gary M. Diffee. (2020) Sex differences in skeletal muscle alterations in a model of colorectal cancer. Physiological Reports 8:5.
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Rodrigo R. Duarte, M. Cristina Gonzalez, Jacqueline F. Oliveira, Patrícia C. Oliveira & Iran Castro. (2019) Adductor pollicis muscle and nutritional status in heart failure patients: Is there an association?. Nutrition 67-68, pages 110536.
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Anush Barkhudaryan, Nadja Scherbakov, Jochen Springer & Wolfram Doehner. (2017) Cardiac muscle wasting in individuals with cancer cachexia. ESC Heart Failure 4:4, pages 458-467.
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Shinichiro Morishita, Atsuhiro Tsubaki & Jack B. Fu. 2017. Frailty and Sarcopenia - Onset, Development and Clinical Challenges. Frailty and Sarcopenia - Onset, Development and Clinical Challenges.
Yuko Iwata, Nobuyuki Suzuki, Hitomi Ohtake, Shinya Kamauchi, Naohiro Hashimoto, Tohru Kiyono & Shigeo Wakabayashi. (2016) Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2-independent mechanisms, unlike muscular dystrophy. Journal of Cachexia, Sarcopenia and Muscle 7:3, pages 366-376.
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Maurizio Bossola, Emanuele Marzetti, Fausto Rosa & Fabio Pacelli. (2016) Skeletal muscle regeneration in cancer cachexia. Clinical and Experimental Pharmacology and Physiology 43:5, pages 522-527.
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Claudia A Penafuerte, Bruno Gagnon, Jacinthe Sirois, Jessica Murphy, Neil MacDonald & Michel L Tremblay. (2016) Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia. British Journal of Cancer 114:6, pages 680-687.
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Amelia J. Johnston, Kate T. Murphy, Laura Jenkinson, David Laine, Kerstin Emmrich, Pierre Faou, Ross Weston, Krishnath M. Jayatilleke, Jessie Schloegel, Gert Talbo, Joanne L. Casey, Vita Levina, W. Wei-Lynn Wong, Helen Dillon, Tushar Sahay, Joan Hoogenraad, Holly Anderton, Cathrine Hall, Pascal Schneider, Maria Tanzer, Michael Foley, Andrew M. Scott, Paul Gregorevic, Spring Yingchun Liu, Linda C. Burkly, Gordon S. Lynch, John Silke & Nicholas J. Hoogenraad. (2015) Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival. Cell 162:6, pages 1365-1378.
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J Farup, L Madaro, P L Puri & U R Mikkelsen. (2015) Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease. Cell Death & Disease 6:7, pages e1830-e1830.
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Joanne Reid, David Scott, Olinda Santin, Chris R. Cardwell, Michael Donnelly, W. George Kernohan, Peter Dominic O'Halloran, Joan Regan & Sam Porter. (2014) Evaluation of a Psychoeducational intervention for patients with Advanced Cancer who have Cachexia and their lay Carers (EPACaCC): study protocol. Journal of Advanced Nursing 70:5, pages 1174-1183.
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A. ARIA TZIKA, CIBELY CRISTINE FONTES-OLIVEIRA, ALEXANDER A. SHESTOV, CATERINA CONSTANTINOU, NIKOLAOS PSYCHOGIOS, VALERIA RIGHI, DIONYSSIOS MINTZOPOULOS, SILVIA BUSQUETS, FRANCISCO J. LOPEZ-SORIANO, SYLVAIN MILOT, FRANCOIS LEPINE, MICHAEL N. MINDRINOS, LAURENCE G. RAHME & JOSEP M. ARGILES. (2013) Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model. International Journal of Oncology 43:3, pages 886-894.
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Kate T. Murphy, Annabel Chee, Jennifer Trieu, Timur Naim & Gordon S. Lynch. (2013) Inhibition of the renin-angiotensin system improves physiological outcomes in mice with mild or severe cancer cachexia. International Journal of Cancer 133:5, pages 1234-1246.
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Yang Quanjun, Wan Lili, Zhou Zhiyong, Li Yan, Yu Qi, Liu Liya, Li bin & Guo Cheng. (2013) Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma. Phytomedicine 20:11, pages 992-998.
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Kate T. Murphy, Adam Struk, Cathy Malcontenti-Wilson, Christopher Christophi & Gordon S. Lynch. (2013) Physiological characterization of a mouse model of cachexia in colorectal liver metastases. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304:10, pages R854-R864.
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Kate T. MurphyAndrew M. Allen, Annabel CheeTimur NaimGordon S. Lynch. (2012) Disruption of muscle renin-angiotensin system in AT 1a −/− mice enhances muscle function despite reducing muscle mass but compromises repair after injury . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 303:3, pages R321-R331.
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C M M Prado, T Bekaii-Saab, L A Doyle, S Shrestha, S Ghosh, V E Baracos & M B Sawyer. (2012) Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma. British Journal of Cancer 106:10, pages 1583-1586.
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Joanne Reid, Moyra Mills, Marie M Cantwell, Chris R Cardwell, Liam J Murray & Michael Donnelly. (2012) Thalidomide for managing cancer cachexia. Cochrane Database of Systematic Reviews 2021:5.
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W. King Engel & Valerie Askanas. 2012. Muscle Aging, Inclusion‐Body Myositis and Myopathies. Muscle Aging, Inclusion‐Body Myositis and Myopathies 1 32 .
Kate T. Murphy, Annabel Chee, Jennifer Trieu, Timur Naim & Gordon S. Lynch. (2012) Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia. Disease Models & Mechanisms.
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Marc-André Caron, Steve J Charette, François Maltais & Richard Debigaré. (2011) Variability of protein level and phosphorylation status caused by biopsy protocol design in human skeletal muscle analyses. BMC Research Notes 4:1.
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Elaine S Rogers, Roderick D MacLeod, Joanna Stewart, Stephen P Bird & Justin WL Keogh. (2011) A randomised feasibility study of EPA and Cox-2 inhibitor (Celebrex) versus EPA, Cox-2 inhibitor (Celebrex), Resistance Training followed by ingestion of essential amino acids high in leucine in NSCLC cachectic patients - ACCeRT Study. BMC Cancer 11:1.
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Dongsheng Cai & Tiewen Liu. (2011) Hypothalamic inflammation: a double-edged sword to nutritional diseases. Annals of the New York Academy of Sciences 1243:1, pages E1-E39.
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Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. Lam, John C. Dolan, Jennifer L. Gibbs & Brian L. Schmidt. (2011) Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia. Molecular Cancer Therapeutics 10:9, pages 1667-1676.
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Kate T. Murphy, Annabel Chee, Ben G. Gleeson, Timur Naim, Kristy Swiderski, René Koopman & Gordon S. Lynch. (2011) Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301:3, pages R716-R726.
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Victoria C. Foletta, Lloyd J. White, Amy E. Larsen, Bertrand Léger & Aaron P. Russell. (2011) The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy. Pflügers Archiv - European Journal of Physiology 461:3, pages 325-335.
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Shontelle DodsonVickie E. BaracosAminah JatoiWilliam J. EvansDavid CellaJames T. DaltonMitchell S. Steiner. (2011) Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies. Annual Review of Medicine 62:1, pages 265-279.
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Joanne Reid, Michael Donnelly, Marie Cantwell, Chris R Cardwell, Moyra Mills & Liam J Murray. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.

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