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Review

Emerging lipid-lowering drugs: squalene synthase inhibitors

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Pages 309-322 | Published online: 08 Jun 2008

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Simon Horvat, Jim Mcwhir & Damjana Rozman. (2011) Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments. Drug Metabolism Reviews 43:1, pages 69-90.
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Irina A Pikuleva. (2008) Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering. Expert Opinion on Drug Metabolism & Toxicology 4:11, pages 1403-1414.
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Articles from other publishers (14)

Suling Sun, Wei Wang, Nan Wang, Yu Zhang, Zuoyi Zhu, Xue Li, Junhong Wang, Qihe Chen, Faizan Ahmed Sadiq, Hua Yang, Qianhui Qi & Guohua Zhang. (2021) HPP and SGQR peptides from silkworm pupae protein hydrolysates regulated biosynthesis of cholesterol in HepG2 cell line. Journal of Functional Foods 77, pages 104328.
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Farid Khallouki, Mohamed Eddouks, Akdad Mourad, Andrea Breuer & Robert Owen. (2017) Ethnobotanic, Ethnopharmacologic Aspects and New Phytochemical Insights into Moroccan Argan Fruits. International Journal of Molecular Sciences 18:11, pages 2277.
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Alastair G. Kerr, Lawrence C. S. Tam, Ashley B. Hale, Milena Cioroch, Gillian Douglas, Sarina Agkatsev, Olivia Hibbitt, Joseph Mason, James Holt-Martyn, Carole J. R. Bataille, Graham M. Wynne, Keith M. Channon, Angela J. Russell & Richard Wade-Martins. (2017) A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor. Journal of Pharmacology and Experimental Therapeutics 361:3, pages 417-428.
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Vicent Ribas, Carmen García‐Ruiz & José C. Fernández‐Checa. (2016) Mitochondria, cholesterol and cancer cell metabolism. Clinical and Translational Medicine 5:1.
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Mirjana Skočibušić, Renata Odžak, Zoran Štefanić, Ivana Križić, Lucija Krišto, Ozren Jović, Tomica Hrenar, Ines Primožič & Darija Jurašin. (2016) Structure–property relationship of quinuclidinium surfactants—Towards multifunctional biologically active molecules. Colloids and Surfaces B: Biointerfaces 140, pages 548-559.
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Annalisa Marcuzzi, Elisa Piscianz, Claudia Loganes, Liza Vecchi Brumatti, Alessandra Knowles, Sabrine Bilel, Alberto Tommasini, Roberta Bortul & Marina Zweyer. (2015) Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway. International Journal of Molecular Sciences 17:1, pages 47.
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Yogita Bansal & Om Silakari. (2014) Multifunctional compounds: Smart molecules for multifactorial diseases. European Journal of Medicinal Chemistry 76, pages 31-42.
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Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer & Raymond J. Hohl. (2011) A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. Journal of Lipid Research 52:11, pages 1957-1964.
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Laura Trapani, Marco Segatto, Paolo Ascenzi & Valentina Pallottini. (2011) Potential role of nonstatin cholesterol lowering agents. IUBMB Life 63:11, pages 964-971.
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Nils Griebenow, Anja Buchmueller, Peter Kolkhof, Jens Schamberger & Hilmar Bischoff. (2011) Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3648-3653.
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Angeliki P. Kourounakis, Alexios N. Matralis & Anastasios Nikitakis. (2010) Design of more potent squalene synthase inhibitors with multiple activities. Bioorganic & Medicinal Chemistry 18:21, pages 7402-7412.
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Bernd Schäfer. (2010) Statine. Cholesterolsenker. Chemie in unserer Zeit 44:5, pages 344-364.
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Ali Koohang, Jessica L. Bailey, Robert M. Coates, Hans K. Erickson, David Owen & C. Dale Poulter. (2010) Enantioselective Inhibition of Squalene Synthase by Aziridine Analogues of Presqualene Diphosphate. The Journal of Organic Chemistry 75:14, pages 4769-4777.
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Maria Lúcia Bonfleur, Emerielle Cristine Vanzela, Rosane Aparecida Ribeiro, Gabriel de Gabriel Dorighello, Carolina Prado de França Carvalho, Carla Beatriz Collares-Buzato, Everardo Magalhães Carneiro, Antonio Carlos Boschero & Helena Coutinho Franco de Oliveira. (2010) Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801:2, pages 183-190.
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