Citations (144)
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Claudiu T. Supuran. (2022) Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2478-2488.
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Pulala Raghuveer Yadav, Syed Hussain Basha & Pavan Kumar Pindi. (2022) Role of Thr199 residue in human β-carbonic anhydrase-II pH-dependent activity elucidated by microsecond simulation analysis. Journal of Biomolecular Structure and Dynamics 40:11, pages 5016-5025.
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Alane Beatriz Vermelho, Giseli Capaci Rodrigues & Claudiu T. Supuran. (2020) Why hasn’t there been more progress in new Chagas disease drug discovery?. Expert Opinion on Drug Discovery 15:2, pages 145-158.
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Emma Langella, Vincenzo Alterio, Katia D’Ambrosio, Roberta Cadoni, Jean-Yves Winum, Claudiu T. Supuran, Simona Maria Monti, Giuseppina De Simone & Anna Di Fiore. (2019) Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1498-1505.
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Giuseppina De Simone, Anna Di Fiore, Emanuela Truppo, Emma Langella, Daniela Vullo, Claudiu T. Supuran & Simona Maria Monti. (2019) Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1506-1510.
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Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran & Giuseppina De Simone. (2018) Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 151-157.
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Shruti Gupta, Jennifer J. Gao, Michael Emmett & Andrew Z. Fenves. (2017) Topiramate and metabolic acidosis: an evolving story. Hospital Practice 45:5, pages 192-195.
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Arun John, Muthukumaran Sivashanmugam, Vetrivel Umashankar & Sulochana Konerirajapuram Natarajan. (2017) Virtual screening, molecular dynamics, and binding free energy calculations on human carbonic anhydrase IX catalytic domain for deciphering potential leads. Journal of Biomolecular Structure and Dynamics 35:10, pages 2155-2168.
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Simonetta Caira, Antonio Iannelli, Rosaria Sciarrillo, Gianluca Picariello, Giovanni Renzone, Andrea Scaloni & Pietro Addeo. (2017) Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 672-682.
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Ahmed M. Alafeefy, Hatem A. Abdel-Aziz, Daniela Vullo, Abdul-Malek S. Al-Tamimi, Amani S. Awaad, Menshawy A. Mohamed, Clemente Capasso & Claudiu T. Supuran. (2015) Inhibition of human carbonic anhydrase isozymes I, II, IX and XII with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 30:1, pages 52-56.
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Natalia Paola Catoira, Luciano Viale, Guillermo Di Girolamo & Claudio Gonzalez. (2014) New centrally acting agents for appetite control: from biological mechanisms to clinical efficacy. Current Medical Research and Opinion 30:6, pages 961-969.
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Andrea Scozzafava, Claudiu T Supuran & Fabrizio Carta. (2013)
Antiobesity carbonic anhydrase inhibitors: a literature and patent review
. Expert Opinion on Therapeutic Patents 23:6, pages 725-735.
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Mohammad-Ali Abtahi, Seyed-Hossein Abtahi, Farhad Fazel, Peyman Roomizadeh, Masoud Etemadifar, Keivan Jenab & Mojtaba Akbari. (2012) Topiramate and the vision: a systematic review. Clinical Ophthalmology 6, pages 117-131.
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Huseyin Sahin, Zehra Can, Oktay Yildiz, Sevgi Kolayli, Alessio Innocenti, Gabriele Scozzafava & Claudiu T. Supuran. (2012) Inhibition of carbonic anhydrase isozymes I and II with natural products extracted from plants, mushrooms and honey. Journal of Enzyme Inhibition and Medicinal Chemistry 27:3, pages 395-402.
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Claudiu T Supuran. (2012) Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. Expert Opinion on Emerging Drugs 17:1, pages 11-15.
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Ahmed Sadiq Sheikh, Reem Altaf, Humaira Nadeem, Muhammad Tariq Khan & Babar Murtaza. (2023) Formation of morpholine-acetamide derivatives as potent anti-tumor drug candidates: Pharmacological evaluation and molecular docking studies. Heliyon 9:11, pages e22183.
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Claudiu T. Supuran. (2023) A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation. Bioorganic & Medicinal Chemistry Letters 93, pages 129411.
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Yao Zheng, Cai Chen, Mengli Wang, Ali Shoaib Moawad, Xiaoyan Wang & Chengyi Song. (2023) SINE Insertion in the Pig Carbonic Anhydrase 5B (CA5B) Gene Is Associated with Changes in Gene Expression and Phenotypic Variation. Animals 13:12, pages 1942.
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Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics
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Sudabeh Iraninasab, Sana Sharifian, Ahmad Homaei, Mozafar Bagherzadeh Homaee, Tanvi Sharma, Ashok Kumar Nadda, John F. Kennedy, Muhammad Bilal & Hafiz M. N. Iqbal. (2021) Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review. Bioprocess and Biosystems Engineering 45:3, pages 431-451.
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Rohit Pal, Bhupinder Kumar, Md. Jawaid Akhtar & Pooja A. Chawla. (2021) Voltage gated sodium channel inhibitors as anticonvulsant drugs: A systematic review on recent developments and structure activity relationship studies. Bioorganic Chemistry 115, pages 105230.
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Ayça AKTAŞ KARAÇELİK & Hüseyin ŞAHİN. (2021) Determination of Chemical Compositions, Antioxidant and Enzyme Inhibitory Activities of Naturally Growing Chenopodium album subsp. iranicum AellenDetermination of Chemical Compositions, Antioxidant and Enzyme Inhibitory Activities of Naturally Growing Chenopodium album subsp. iranicum Aellen. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 11:3, pages 2091-2101.
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Francesca Mancuso, Anna Di Fiore, Laura De Luca, Andrea Angeli, Giuseppina De Simone, Claudiu T. Supuran & Rosaria Gitto. (2021) Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorganic & Medicinal Chemistry 44, pages 116279.
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Katia D’Ambrosio, Anna Di Fiore, Martina Buonanno, Shikha Kumari, Manisha Tiwari, Claudiu T. Supuran, Chandra Bhushan Mishra, Simona Maria Monti & Giuseppina De Simone. (2021)
The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-
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. New Journal of Chemistry 45:1, pages 147-152.
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İlhami Gülçin, Boris Trofimov, Ruya Kaya, Parham Taslimi, Lyubov Sobenina, Elena Schmidt, Olga Petrova, Svetlana Malysheva, Nina Gusarova, Vagif Farzaliyev, Afsun Sujayev, Saleh Alwasel & Claudiu T. Supuran. (2020) Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds – Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibition properties. Bioorganic Chemistry 103, pages 104171.
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Zan Li, Li Jiang & Shinya Toyokuni. (2020) Role of carbonic anhydrases in ferroptosis-resistance. Archives of Biochemistry and Biophysics 689, pages 108440.
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Giulio Poli, Murat Bozdag, Emanuela Berrino, Andrea Angeli, Tiziano Tuccinardi, Fabrizio Carta & Claudiu T. Supuran. (2020) N-aryl-N′-ureido-O-sulfamates as potent and selective inhibitors of hCA VB over hCA VA: Deciphering the binding mode of new potential agents in mitochondrial dysfunctions. Bioorganic Chemistry 100, pages 103896.
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Francesca Mancuso, Anna Di Fiore, Laura De Luca, Andrea Angeli, Simona M. Monti, Giuseppina De Simone, Claudiu T. Supuran & Rosaria Gitto. (2020) Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms. ACS Medicinal Chemistry Letters 11:5, pages 1000-1005.
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Heba T. Abdel-Mohsen, Ahmed M. El Kerdawy, Mohamed A. Omar, Emanuela Berrino, Ahmed S. Abdelsamie, Hoda I. El Diwani & Claudiu T. Supuran. (2020) New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies. Bioorganic & Medicinal Chemistry 28:5, pages 115329.
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Begüm Nurpelin Sağlık, Ulviye Acar Çevik, Derya Osmaniye, Serkan Levent, Betul Kaya Çavuşoğlu, Yeliz Demir, Sinem Ilgın, Yusuf Özkay, Ali Savaş Koparal, Şükrü Beydemir & Zafer Asım Kaplancıklı. (2019) Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives. Bioorganic Chemistry 91, pages 103153.
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Mehtap Tugrak, Halise Inci Gul, Kenjiro Bandow, Hiroshi Sakagami, Ilhami Gulcin, Yusuf Ozkay & Claudiu T. Supuran. (2019) Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors. Bioorganic Chemistry 90, pages 103095.
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Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran & Fabrizio Carta. (2019) State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes. Current Medicinal Chemistry 26:15, pages 2558-2573.
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Joydeb Chanda, Pulok K. Mukherjee, Rajarshi Biswas, Sayan Biswas, Amrendra Kumar Tiwari & Ashish Pargaonkar. (2019)
UPLC-QTOF-MS analysis of a carbonic anhydrase-inhibiting extract and fractions of
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Roger Alberto, Giuseppe Meola & Daniel Hernández Valdés. 2019. Advances in Bioorganometallic Chemistry. Advances in Bioorganometallic Chemistry
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Ian M. Thornell, Xiaopeng Li, Xiao Xiao Tang, Christian M. Brommel, Philip H. Karp, Michael J. Welsh & Joseph Zabner. (2018) Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing. Physiological Reports 6:2, pages e13569.
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Ylenia Cau, Daniela Vullo, Mattia Mori, Elena Dreassi, Claudiu Supuran & Maurizio Botta. (2017) Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII. Molecules 23:1, pages 17.
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Claudiu T. Supuran. (2017) Bortezomib inhibits mammalian carbonic anhydrases. Bioorganic & Medicinal Chemistry 25:19, pages 5064-5067.
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Petr Koutnik, Elena G. Shcherbakova, Samer Gozem, Mehmet G. Caglayan, Tsuyoshi Minami & Pavel AnzenbacherJr.Jr.. (2017) Fluorescence-Based Assay for Carbonic Anhydrase Inhibitors. Chem 2:2, pages 271-282.
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Giosuè Costa, Maria Concetta Gidaro, Daniela Vullo, Claudiu T. Supuran & Stefano Alcaro. (2016) Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques. Journal of Agricultural and Food Chemistry 64:26, pages 5295-5300.
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Mohamed Bejaoui, Eirini Pantazi, Viviana De Luca, Arnau Panisello, Emma Folch-Puy, Anna Serafin, Clemente Capasso, Supuran C. T.Joan Rosselló-Catafau. (2015) Acetazolamide Protects Steatotic Liver Grafts against Cold Ischemia Reperfusion Injury. Journal of Pharmacology and Experimental Therapeutics 355:2, pages 191-198.
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Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso. (2015) Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4970-4975.
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Alessio Nocentini, Fabrizio Carta, Mariangela Ceruso, Gianluca Bartolucci & Claudiu T. Supuran. (2015) Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 23:21, pages 6955-6966.
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İbrahim Esirden, Ramazan Ulus, Burak Aday, Muhammet Tanç, Claudiu T. Supuran & Muharrem Kaya. (2015) Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 23:20, pages 6573-6580.
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Lei Zhang, Xiao-Peng An, Xiao-Rui Liu, Ming-Zhe Fu, Peng Han, Jia-Yin Peng, Jing-Xing Hou, Zhan-Qin Zhou, Bin-Yun Cao & Yu-Xuan Song. (2015) Characterization of the Transcriptional Complexity of the Receptive and Pre-receptive Endometria of Dairy Goats. Scientific Reports 5:1.
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Utpal Raychaudhuri. (2015) Reduced Erythrocyte Carbonic Anhydrase Activity by Swietenia Macrophylla Seeds in Diabetic Rats. Journal of Diabetes, Metabolic Disorders & Control 2:2.
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Yin Shen Wee, Janis J. Weis, Lorise C. Gahring, Scott W. Rogers & John H. Weis. (2015) Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins. PLOS ONE 10:4, pages e0123218.
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Giuseppina De Simone, Anna Di Fiore, Clemente Capasso & Claudiu T. Supuran. (2015) The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families. Bioorganic & Medicinal Chemistry Letters 25:7, pages 1385-1389.
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Alberto Verrotti, Pasquale Parisi, Sergio Agostinelli, Giulia Loiacono, Francesca Marra, Giangennaro Coppola, Laura Rosa Pisani, Gaetano Gorgone, Pasquale Striano, Francesco Pisani & Vincenzo Belcastro. (2015) Weight Regain after Discontinuation of Topiramate Treatment in Patients with Migraine: a Prospective Observational Study. CNS Drugs 29:2, pages 163-169.
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Anna Di Fiore, Alessandro Vergara, Marco Caterino, Vincenzo Alterio, Simona M. Monti, Joanna Ombouma, Pascal Dumy, Daniela Vullo, Claudiu T. Supuran, Jean-Yves Winum & Giuseppina De Simone. (2015) Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors. Chemical Communications 51:57, pages 11519-11522.
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Katia D’Ambrosio, Giuseppina De Simone & Claudiu T. Supuran. 2015. Carbonic Anhydrases as Biocatalysts. Carbonic Anhydrases as Biocatalysts
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Mariangela Ceruso, Sabrina Antel, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2014) Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I–XIV. Bioorganic & Medicinal Chemistry 22:24, pages 6768-6775.
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João Marcus Oliveira Andrade, Fernanda de Oliveira Lemos, Simone da Fonseca Pires, Ruben Dario Sinisterra Millán, Frederico Barros de Sousa, André Luiz Sena Guimarães, Mahboob Qureshi, John David Feltenberger, Alfredo Maurício Batista de Paula, Jaime Tolentino Miranda Neto, Miriam Teresa Paz Lopes, Hélida Monteiro de Andrade, Robson Augusto Souza Santos & Sérgio Henrique Sousa Santos. (2014) Proteomic white adipose tissue analysis of obese mice fed with a high-fat diet and treated with oral angiotensin-(1–7). Peptides 60, pages 56-62.
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Jayashree Pichake, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2014) Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation of Novel Sulfonyl Semicarbazide Derivatives. ACS Medicinal Chemistry Letters 5:7, pages 793-796.
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Amrita K. Saluja, Meena Tiwari, Daniela Vullo & Claudiu T. Supuran. (2014) Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII. Bioorganic & Medicinal Chemistry Letters 24:5, pages 1310-1314.
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Melissa D’Ascenzio, Simone Carradori, Celeste De Monte, Daniela Secci, Mariangela Ceruso & Claudiu T. Supuran. (2014) Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII. Bioorganic & Medicinal Chemistry 22:6, pages 1821-1831.
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Aiga Grandane, Muhammet Tanc, Raivis Zalubovskis & Claudiu T. Supuran. (2014) Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII. Bioorganic & Medicinal Chemistry 22:5, pages 1522-1528.
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Mariya al-Rashida, Sajad Hussain, Mehwish Hamayoun, Aisha Altaf & Jamshed Iqbal. (2014) Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs. BioMed Research International 2014, pages 1-10.
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Laura De Luca, Stefania Ferro, Francesca M. Damiano, Claudiu T. Supuran, Daniela Vullo, Alba Chimirri & Rosaria Gitto. (2014) Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors. European Journal of Medicinal Chemistry 71, pages 105-111.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Viviana De Luca, Andrea Scozzafava, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2014) Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii. Bioorganic & Medicinal Chemistry Letters 24:1, pages 275-279.
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Ahmed M. Alafeefy, Hatem A. Abdel-Aziz, Daniela Vullo, Abdul-Malek S. Al-Tamimi, Nabila A. Al-Jaber, Clemente Capasso & Claudiu T. Supuran. (2014) Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties. Bioorganic & Medicinal Chemistry 22:1, pages 141-147.
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Murat Bozdag, Marta Ferraroni, Elisa Nuti, Daniela Vullo, Armando Rossello, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2014) Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry 22:1, pages 334-340.
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Mariangela Ceruso, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2013) Inhibition of human carbonic anhydrase isoforms I–XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties. Bioorganic & Medicinal Chemistry 21:22, pages 6929-6936.
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Shyamasri Biswas, Robert McKenna & Claudiu T. Supuran. (2013) Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters 23:20, pages 5646-5649.
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Takashi Ando, Nobuko Iizuka, Toshiyuki Sato, Masahide Chikada, Manae S. Kurokawa, Mitsumi Arito, Kazuki Okamoto, Naoya Suematsu, Haruo Makuuchi & Tomohiro Kato. (2013) Autoantigenicity of carbonic anhydrase 1 in patients with abdominal aortic aneurysm, revealed by proteomic surveillance. Human Immunology 74:7, pages 852-857.
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Hélène Carreyre, Jean-Marie Coustard, Grégoire Carré, Clarisse Vandebrouck, Jocelyn Bescond, Maurice Ouédraogo, Jérôme Marrot, Daniella Vullo, Claudiu T. Supuran & Sébastien Thibaudeau. (2013) Natural product hybrid and its superacid synthesized analogues: Dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV. Bioorganic & Medicinal Chemistry 21:13, pages 3790-3794.
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Rui Gao, Sha Liao, Chen Zhang, Weilong Zhu, Liyan Wang, Jin Huang, Zhenjiang Zhao, Honglin Li, Xuhong Qian & Yufang Xu. (2013) Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship. European Journal of Medicinal Chemistry 62, pages 597-604.
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Shyamasri Biswas, Fabrizio Carta, Andrea Scozzafava, Robert McKenna & Claudiu T. Supuran. (2013) Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry 21:8, pages 2314-2318.
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Guillaume Bernadat, Claudiu T. Supuran & Bogdan I. Iorga. (2013) Carbonic anhydrase binding site parameterization in OPLS-AA force field. Bioorganic & Medicinal Chemistry 21:6, pages 1427-1430.
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Frank Döring, Kai Lüersen, Constance Schmelzer, Steffen Hennig, Iris S. Lang, Solvig Görs, Charlotte Rehfeldt, Winfried Otten & Cornelia C. Metges. (2012) Influence of maternal low protein diet during pregnancy on hepatic gene expression signature in juvenile female porcine offspring. Molecular Nutrition & Food Research 57:2, pages 277-290.
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Benoît Métayer, Agnès Mingot, Daniella Vullo, Claudiu. T. Supuran & Sébastien Thibaudeau. (2013) New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides. Chemical Communications 49:54, pages 6015.
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Vincenzo Alterio, Anna Di Fiore, Katia D’Ambrosio, Claudiu T. Supuran & Giuseppina De Simone. (2012) Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?. Chemical Reviews 112:8, pages 4421-4468.
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Jayanthi Maniam & Margaret J. Morris. (2012) The link between stress and feeding behaviour. Neuropharmacology 63:1, pages 97-110.
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Giuseppina De Simone & Claudiu T. Supuran. (2012) (In)organic anions as carbonic anhydrase inhibitors. Journal of Inorganic Biochemistry 111, pages 117-129.
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Rosaria Gitto, Francesca M. Damiano, Pavel Mader, Laura De Luca, Stefania Ferro, Claudiu T. Supuran, Daniela Vullo, Jiří Brynda, Pavlína Řezáčová & Alba Chimirri. (2012) Synthesis, Structure–Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. Journal of Medicinal Chemistry 55:8, pages 3891-3899.
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Susan L. McElroy, Erin Winstanley, Nicole Mori, Brian Martens, Jessica McCoy, Dianna Moeller, Anna I. Guerdjikova & Paul E. Keck. (2012) A Randomized, Placebo-Controlled Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain. Journal of Clinical Psychopharmacology 32:2, pages 165-172.
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Sumeyye Turkoglu, Alfonso Maresca, Meltem Alper, Feray Kockar, Semra Işık, Selma Sinan, Ozen Ozensoy, Oktay Arslan & Claudiu T. Supuran. (2012) Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: Influences on the catalytic activity and affinity for inhibitors. Bioorganic & Medicinal Chemistry 20:7, pages 2208-2213.
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Anna Di Fiore, Alfonso Maresca, Claudiu T. Supuran & Giuseppina De Simone. (2012) Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors. Chemical Communications 48:70, pages 8838.
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Jean-Yves Winum, Alfonso Maresca, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2012) Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases. Chemical Communications 48:66, pages 8177.
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Seppo Parkkila, Daniela Vullo, Alfonso Maresca, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2012) Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases. Chemical Communications 48:29, pages 3551.
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Alberto Verrotti, Alessandra Scaparrotta, Sergio Agostinelli, Sabrina Di Pillo, Francesco Chiarelli & Salvatore Grosso. (2011) Topiramate-induced weight loss: A review. Epilepsy Research 95:3, pages 189-199.
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Isao Nishimori, Tomoko Minakuchi, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2011) Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates. Bioorganic & Medicinal Chemistry 19:16, pages 5023-5030.
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Daniela Vullo, Isao Nishimori, Tomoko Minakuchi, Andrea Scozzafava & Claudiu T. Supuran. (2011) Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3591-3595.
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Marouan Rami, Alfonso Maresca, Fatma-Zhora Smaine, Jean-Louis Montero, Andrea Scozzafava, Jean-Yves Winum & Claudiu T. Supuran. (2011) Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII. Bioorganic & Medicinal Chemistry Letters 21:10, pages 2975-2979.
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Alfonso Maresca & Claudiu T. Supuran. (2011) (R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases. Bioorganic & Medicinal Chemistry Letters 21:5, pages 1334-1337.
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Daniel M. Kaplon, Kristina L. Penniston & Stephen Y. Nakada. (2011) Patients With and Without Prior Urolithiasis Have Hypocitraturia and Incident Kidney Stones While on Topiramate. Urology 77:2, pages 295-298.
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Anna Di Fiore, Alfonso Maresca, Vincenzo Alterio, Claudiu T. Supuran & Giuseppina De Simone. (2011) Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II. Chemical Communications 47:42, pages 11636.
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Peter Burghout, Daniela Vullo, Andrea Scozzafava, Peter W.M. Hermans & Claudiu T. Supuran. (2011) Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?. Bioorganic & Medicinal Chemistry 19:1, pages 243-248.
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Alfonso Maresca, Andrea Scozzafava & Claudiu T. Supuran. (2010) 7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorganic & Medicinal Chemistry Letters 20:24, pages 7255-7258.
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Alessio Innocenti & Claudiu T. Supuran. (2010) Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of α- but not of β-, γ- and ζ-carbonic anhydrases. Bioorganic & Medicinal Chemistry Letters 20:21, pages 6208-6212.
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Beate Beer, Kathrin Libiseller, Herbert Oberacher & Marion Pavlic. (2010) A fatal intoxication case involving topiramate. Forensic Science International 202:1-3, pages e9-e11.
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Anna Di Fiore, Emanuela Truppo, Claudiu T. Supuran, Vincenzo Alterio, Nina Dathan, Fatemeh Bootorabi, Seppo Parkkila, Simona Maria Monti & Giuseppina De Simone. (2010) Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5023-5026.
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Alessio Innocenti, Ilhami Gülçin, Andrea Scozzafava & Claudiu T. Supuran. (2010) Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I–XV. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5050-5053.
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Francesca Viparelli, Simona Maria Monti, Giuseppina De Simone, Alessio Innocenti, Andrea Scozzafava, Yan Xu, François M.M. Morel & Claudiu T. Supuran. (2010) Inhibition of the R1 fragment of the cadmium-containing ζ-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions. Bioorganic & Medicinal Chemistry Letters 20:16, pages 4745-4748.
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Balendu Sankara Avvaru, Jason M. Wagner, Alfonso Maresca, Andrea Scozzafava, Arthur H. Robbins, Claudiu T. Supuran & Robert McKenna. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4376-4381.
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Alfonso Maresca & Claudiu T. Supuran. (2010) Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4511-4514.
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Jonathan C. Pfeifer, Robert A. Kowatch & Melissa P. DelBello. (2010) Pharmacotherapy of Bipolar Disorder in Children and Adolescents. CNS Drugs 24:7, pages 575-593.
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Jason Wagner, Balendu Sankara Avvaru, Arthur H. Robbins, Andrea Scozzafava, Claudiu T. Supuran & Robert McKenna. (2010) Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. Bioorganic & Medicinal Chemistry 18:14, pages 4873-4878.
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Rosaria Gitto, Stefano Agnello, Stefania Ferro, Daniela Vullo, Claudiu T. Supuran & Alba Chimirri. (2010) Identification of Potent and Selective Human Carbonic Anhydrase VII (hCA VII) Inhibitors. ChemMedChem 5:6, pages 823-826.
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Claudiu T. Supuran. (2010) Carbonic anhydrase inhibitors. Bioorganic & Medicinal Chemistry Letters 20:12, pages 3467-3474.
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Anna Di Fiore, Simona Maria Monti, Alessio Innocenti, Jean-Yves Winum, Giuseppina De Simone & Claudiu T. Supuran. (2010) Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I–XV. Bioorganic & Medicinal Chemistry Letters 20:12, pages 3601-3605.
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Preeta Kaur Narula, H.S. Rehan, K.E.S. Unni & Neeraj Gupta. (2010) Topiramate for prevention of olanzapine associated weight gain and metabolic dysfunction in schizophrenia: A double-blind, placebo-controlled trial. Schizophrenia Research 118:1-3, pages 218-223.
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Daniela Vullo, Isao Nishimori, Andrea Scozzafava, Stephan Köhler, Jean-Yves Winum & Claudiu T. Supuran. (2010) Inhibition studies of a β-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides. Bioorganic & Medicinal Chemistry Letters 20:7, pages 2178-2182.
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Alessio Innocenti, Serdar Durdagi, Nadjmeh Doostdar, T. Amanda Strom, Andrew R. Barron & Claudiu T. Supuran. (2010) Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance. Bioorganic & Medicinal Chemistry 18:8, pages 2822-2828.
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Rosaria Gitto, Stefano Agnello, Stefania Ferro, Laura De Luca, Daniela Vullo, Jiri Brynda, Pavel Mader, Claudiu T. Supuran & Alba Chimirri. (2010)
Identification of 3,4-Dihydroisoquinoline-2(1
H
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. Journal of Medicinal Chemistry 53:6, pages 2401-2408.
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Pascale Joseph, François Turtaut, Safia Ouahrani-Bettache, Jean-Louis Montero, Isao Nishimori, Tomoko Minakuchi, Daniela Vullo, Andrea Scozzafava, Stephan Köhler, Jean-Yves Winum & Claudiu T. Supuran. (2010)
Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from
Brucella suis
. Journal of Medicinal Chemistry 53:5, pages 2277-2285.
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Alfonso Maresca, Claudia Temperini, Lionel Pochet, Bernard Masereel, Andrea Scozzafava & Claudiu T. Supuran. (2009) Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins. Journal of Medicinal Chemistry 53:1, pages 335-344.
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Danièle Bentué-Ferrer, Olivier Tribut & Marie-Clémence Verdier. (2010) Suivi thérapeutique pharmacologique du topiramate. Therapies 65:1, pages 17-22.
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Vincenzo Alterio, Simona Maria Monti, Emanuela Truppo, Carlo Pedone, Claudiu T. Supuran & Giuseppina De Simone. (2010) The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I–topiramate complex. Organic & Biomolecular Chemistry 8:15, pages 3528.
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Nasir Mirza, Anthony G. Marson & Munir Pirmohamed. (2009) Effect of topiramate on acid-base balance: extent, mechanism and effects. British Journal of Clinical Pharmacology 68:5, pages 655-661.
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Rosa Maria Vitale, Vincenzo Alterio, Alessio Innocenti, Jean-Yves Winum, Simona Maria Monti, Giuseppina De Simone & Claudiu T. Supuran. (2009) Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors. Journal of Medicinal Chemistry 52:19, pages 5990-5998.
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Jamie R. Robinson & Kevin D. Niswender. (2009) What are the risks and the benefits of current and emerging weight-loss medications?. Current Diabetes Reports 9:5, pages 368-375.
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Jean-Yves Winum, Alessio Innocenti, Daniela Vullo, Jean-Louis Montero & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors; Fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II. Bioorganic & Medicinal Chemistry Letters 19:17, pages 5082-5085.
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Özlen Güzel, Alessio Innocenti, Andrea Scozzafava, Aydın Salman & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB. Bioorganic & Medicinal Chemistry 17:14, pages 4894-4899.
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Alessio Innocenti, Rebecca A. Hall, Christine Schlicker, Andrea Scozzafava, Clemens Steegborn, Fritz A. Mühlschlegel & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal β-carbonic anhydrase from Candida albicans with sulfonamides. Bioorganic & Medicinal Chemistry 17:13, pages 4503-4509.
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Jean-Yves Winum, Alessio Innocenti, Andrea Scozzafava, Jean-Louis Montero & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids. Bioorganic & Medicinal Chemistry 17:10, pages 3649-3652.
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Alfonso Maresca, Claudia Temperini, Hoan Vu, Ngoc B. Pham, Sally-Ann Poulsen, Andrea Scozzafava, Ronald J. Quinn & Claudiu T. Supuran. (2009) Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors. Journal of the American Chemical Society 131:8, pages 3057-3062.
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Claudia Temperini, Alessandro Cecchi, Andrea Scozzafava & Claudiu T. Supuran. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorganic & Medicinal Chemistry 17:3, pages 1214-1221.
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Claudia Temperini, Alessandro Cecchi, Andrea Scozzafava & Claudiu T. Supuran. (2008) Carbonic Anhydrase Inhibitors. Comparison of Chlorthalidone and Indapamide X-ray Crystal Structures in Adducts with Isozyme II: When Three Water Molecules and the Keto−Enol Tautomerism Make the Difference. Journal of Medicinal Chemistry 52:2, pages 322-328.
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Fatma-Zohra Smaine, Fabio Pacchiano, Marouan Rami, Véronique Barragan-Montero, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum & Claudiu T. Supuran. (2008) Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. Bioorganic & Medicinal Chemistry Letters 18:24, pages 6332-6335.
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Daniela Vullo, Isao Nishimori, Andrea Scozzafava & Claudiu T. Supuran. (2008) Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines. Bioorganic & Medicinal Chemistry Letters 18:15, pages 4303-4307.
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