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The future is today: emerging drugs for the treatment of erectile dysfunction

, MD, , MD, , MD & , MD
Pages 467-480 | Published online: 23 Apr 2010

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Zachary Melchiode, Tivoli Nguyen, Omar Dawood, Graham A. Bobo & Wayne J.G. Hellstrom. (2023) Phosphodiesterase 5 inhibitors: preclinical and early-phase breakthroughs for impotence treatments. Expert Opinion on Investigational Drugs 32:7, pages 635-642.
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U. Milenkovic, J. Campbell, E. Roussel & M. Albersen. (2018) An update on emerging drugs for the treatment of erectile dysfunction. Expert Opinion on Emerging Drugs 23:4, pages 319-330.
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Li Smith-Harrison, Nathan R. Starke, Ryan P. Smith & Jason R. Kovac. (2017) Drugs in preclinical to phase II clinical development for the treatment of erectile dysfunction. Expert Opinion on Investigational Drugs 26:6, pages 669-675.
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Olivier Defert & Sandro Boland. (2017) Rho kinase inhibitors: a patent review (2014 – 2016). Expert Opinion on Therapeutic Patents 27:4, pages 507-515.
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Igor Voznesensky, Kenneth J. DeLay & Wayne J. G. Hellstrom. (2016) Advances in pharmacotherapy for erectile dysfunction and associated cardiac impact. Expert Opinion on Pharmacotherapy 17:17, pages 2281-2289.
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Maarten Albersen, Ching-Shwun Lin & Tom Lue. (2013) Stem-cell therapy for erectile dysfunction. Arab Journal of Urology 11:3, pages 237-244.
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Michael J Curtis & Michael K Pugsley. (2012) Attrition in the drug discovery process: lessons to be learned from the safety pharmacology paradigm. Expert Review of Clinical Pharmacology 5:3, pages 237-240.
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Ashok Kumar, Netra Prasad Neupane, Habibullah Khalilullah, Vinesh Dahiya, SS Agrawal & Amita Verma. (2023) The Efficacy of Tribulus terrestris and Cumminum cyminium Against Sexual Dysfunction in Diabetic Male Rats. Current Traditional Medicine 9:1.
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Metin Kilic, Anil Erkan, Salim Zengin, Gokce Dundar & Caglar Boyaci. (2023) Inflammatory biomarkers may predict response to phosphodiesterase type 5 inhibitor treatment in patients with erectile dysfunction. Investigative and Clinical Urology 64:4, pages 404.
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Tajudeen O. Yahaya, Esther O. Oladele, Mutiu O. Sifau, Kasimu Shehu, A.A. Aliero & Tayo Bakare. (2022) Genes Predisposing to Erectile Dysfunction and Management: A Review. Serbian Journal of Experimental and Clinical Research 0:0.
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Lance J. Lyons, Kristi Y. Wu, Keith H. Baratz & Arthur J. Sit. (2022) Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature. Cornea 41:2, pages 243-248.
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Gur Serap. (2021) Potential therapeutic applications of mesenchymal stem cells for erectile dysfunction in diabetes mellitus: From preclinical/clinical perspectives. Studies on Stem Cells Research and Therapy, pages 001-011.
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Serap Gur & Wayne J.G. Hellstrom. (2020) Harnessing Stem Cell Potential for the Treatment of Erectile Function in Men with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering. Current Stem Cell Research & Therapy 15:4, pages 308-320.
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Hussein O. Ammar, Mina I. Tadros, Nahla M. Salama & Amira M. Ghoneim. (2020) Therapeutic Strategies for Erectile Dysfunction With Emphasis on Recent Approaches in Nanomedicine. IEEE Transactions on NanoBioscience 19:1, pages 11-24.
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Rana Assaly, François Giuliano, Pierre Clement, Miguel Laurin, Maryline Favier, Pearline Teo, Jacques Bernabe, Laurent Alexandre & Delphine Behr-Roussel. (2019) Extracorporeal Shock Waves Therapy Delivered by Aries Improves Erectile Dysfunction in Spontaneously Hypertensive Rats Through Penile Tissue Remodeling and Neovascularization. Sexual Medicine 7:4, pages 441-450.
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Kelsey M. Greathouse, Benjamin W. Henderson, Erik G. Gentry & Jeremy H. Herskowitz. (2019) Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. Behavioural Brain Research 373, pages 112083.
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Carolina Nunes da Silva, Kênia Pedrosa Nunes, Flávia De Marco Almeida, Fábio Lucas Silva Costa, Perla Villani Borges, Paulo Lacativa, Adriano Monteiro C. Pimenta & Maria Elena de Lima. (2019) PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration. The Journal of Sexual Medicine 16:3, pages 365-374.
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Manon Auffret, Sophie Drapier & Marc Vérin. (2019) New tricks for an old dog: A repurposing approach of apomorphine. European Journal of Pharmacology 843, pages 66-79.
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K‐E Andersson. (2018) PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery. British Journal of Pharmacology 175:13, pages 2554-2565.
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Lauro S. Gómez-Guerra, J. Iván Robles-Torres, Alejandra Garza-Bedolla & Consuelo Mancías-Guerra. (2018) Erectile dysfunction treated with intracavernous stem cells: A promising new therapy?. Revista Internacional de Andrología 16:3, pages 119-127.
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Maartje Dijkstra, Rik H.W. van Lunsen, Katherine W. Kooij, Udi Davidovich, Rosan A. van Zoest, Ferdinand W.M.N. Wit, Maria Prins, Peter Reiss & Maarten F. Schim van der Loeff. (2018) HIV-1 status is independently associated with decreased erectile function among middle-aged MSM in the era of combination antiretroviral therapy. AIDS 32:9, pages 1137-1146.
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Uroš Milenković & Maarten Albersen. 2018. Neuro-Urology. Neuro-Urology 313 333 .
Jeffrey Campbell & Arthur Burnett. (2017) Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury. International Journal of Molecular Sciences 18:8, pages 1794.
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Yehia F. El-Garem, Adel A. Emam & Kamal Z. Shaeer. (2014) Safety and efficacy of 20 mg pentadafil in Egyptian male patients with erectile dysfunction. Human Andrology 4:2, pages 38-43.
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