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Expert Opinion on Emerging Drugs Volume 16, 2011 - Issue 1
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Emerging drugs for ocular hypertension

Anne J Lee Eye Associates, Floor 4, 187 Macquarie Street, Sydney, NSW 2000, Australia [email protected]; Sydney Eye Hospital, Glaucoma Unit, Sydney, Australia; University of Sydney, Discipline of Ophthalmology, Sydney, Australia
, MBBS PhD FRANZCO &
Ivan Goldberg Eye Associates, Floor 4, 187 Macquarie Street, Sydney, NSW 2000, Australia [email protected]; Sydney Eye Hospital, Glaucoma Unit, Sydney, Australia; University of Sydney, Discipline of Ophthalmology, Sydney, Australia
, MBBS FRANZCO FRACS
Pages 137-161 | Published online: 25 Feb 2011

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Irene Giorgi & Paola Nieri. (2013) Adenosine A1 modulators: a patent update (2008 to present). Expert Opinion on Therapeutic Patents 23:9, pages 1109-1121.
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Almudena Crooke, Fernando Huete-Toral, Alejandro Martínez-Águila, Basilio Colligris & Jesus Pintor. (2012) Ocular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential. Expert Opinion on Drug Discovery 7:10, pages 989-1001.
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Kenneth J Mandell, Matthew R Kudelka & Barbara Wirostko. (2011) Rho kinase inhibitors for treatment of glaucoma. Expert Review of Ophthalmology 6:6, pages 611-622.
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Ting Wang, Avinash Soundararajan, Jeffrey Rabinowitz, Anant Jaiswal, Timothy Osborne & Padmanabhan Paranji Pattabiraman. (2023) Identification of the novel role of sterol regulatory element binding proteins ( SREBPs ) in mechanotransduction and intraocular pressure regulation . The FASEB Journal 37:11.
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Jo-Hsuan Wu, Sheng-Nan Chang, Takashi Nishida, Bo-I Kuo & Jou-Wei Lin. (2021) Intraocular pressure-lowering efficacy and ocular safety of Rho-kinase inhibitor in glaucoma: a meta-analysis and systematic review of prospective randomized trials. Graefe's Archive for Clinical and Experimental Ophthalmology 260:3, pages 937-948.
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Tatsuo ItakuraAndrew WebsterShravan K. ChintalaYuchen WangJose M. GonzalezJr.Jr., J.C. TanJanice A. VrankaTed AcottCheryl Mae CraftMaria E. Sibug SaberShinwu JeongW. Daniel StamerKirill A. MartemyanovM. Elizabeth Fini. (2019) GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. Journal of Ocular Pharmacology and Therapeutics 35:4, pages 203-215.
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Elizabeth A. CairnsAnna-Maria SzczesniakAlex J. StraikerPushkar M. KulkarniRoger G. PertweeGanesh A. ThakurWilliam H. BaldridgeMelanie E.M. Kelly. (2017) The In Vivo Effects of the CB 1 -Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice . Journal of Ocular Pharmacology and Therapeutics 33:8, pages 582-590.
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Raffaele Nuzzi & Federico Tridico. (2017) Glaucoma: Biological Trabecular and Neuroretinal Pathology with Perspectives of Therapy Innovation and Preventive Diagnosis. Frontiers in Neuroscience 11.
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Upendra A. Argikar, Jennifer L. Dumouchel, Valerie M. Kramlinger, Amanda L. Cirello, Mithat Gunduz, Christine E. Dunne & Bindi Sohal. (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?. Journal of Pharmaceutical Sciences 106:9, pages 2276-2281.
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Ponugoti Vasantha Rao, Padmanabhan P. Pattabiraman & Casey Kopczynski. (2017) Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. Experimental Eye Research 158, pages 23-32.
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Elizabeth A. Cairns, William H. Baldridge & Melanie E. M. Kelly. (2016) The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plasticity 2016, pages 1-10.
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Anthony F. Alario, Travis D. Strong & Stefano Pizzirani. (2015) Medical Treatment of Primary Canine Glaucoma. Veterinary Clinics of North America: Small Animal Practice 45:6, pages 1235-1259.
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Padmanabhan P. Pattabiraman, Toshihiro Inoue & P. Vasantha Rao. (2015) Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork. Experimental Eye Research 136, pages 29-33.
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Kolko M. (2015) Present and New Treatment Strategies in the Management of Glaucoma. The Open Ophthalmology Journal 9:1, pages 89-100.
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Padmanabhan P. Pattabiraman, Tommy Rinkoski, Eric Poeschla, Alan Proia, Pratap Challa & Ponugoti V. Rao. (2015) RhoA GTPase-Induced Ocular Hypertension in a Rodent Model Is Associated with Increased Fibrogenic Activity in the Trabecular Meshwork. The American Journal of Pathology 185:2, pages 496-512.
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Fernando Huete-Toral, Almudena Crooke, Alejandro Martínez-Águila & Jesús Pintor. (2015) Melatonin Receptors Trigger cAMP Production and Inhibit Chloride Movements in Nonpigmented Ciliary Epithelial Cells. Journal of Pharmacology and Experimental Therapeutics 352:1, pages 119-128.
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Hanan Alkozi & Jesús Pintor. 2014. Melatonin. Melatonin 269 288 .
Ponugoti Vasantha Rao. (2014) Bioactive Lysophospholipids: Role in Regulation of Aqueous Humor Outflow and Intraocular Pressure in the Context of Pathobiology and Therapy of Glaucoma. Journal of Ocular Pharmacology and Therapeutics 30:2-3, pages 181-190.
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A. Rocha-Sousa, J. Rodrigues-Araújo, Petra Gouveia, João Barbosa-Breda, S. Azevedo-Pinto, P. Pereira-Silva & A. Leite-Moreira. (2013) New Therapeutic Targets for Intraocular Pressure Lowering. ISRN Ophthalmology 2013, pages 1-14.
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Yisheng Zhong, Zijian Yang, Wei-Chieh Huang & Xunda Luo. (2013) Adenosine, adenosine receptors and glaucoma: An updated overview. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:4, pages 2882-2890.
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Daniel D. Long, Bryan Frieman, Sharath S. Hegde, Craig M. Hill, Lan Jiang, Samuel Kintz, Daniel G. Marquess, Hans Purkey, Jeng-Pyng Shaw, Tod Steinfeld, Michael S. Wilson & Kevin Wrench. (2013) A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma. Bioorganic & Medicinal Chemistry Letters 23:4, pages 939-943.
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Simon E. Skalicky & Ivan Goldberg. (2013) Adherence and Persistence. Asia-Pacific Journal of Ophthalmology 2:6, pages 356-361.
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Sara McNally & Colm J. O’Brien. (2013) Drug discovery in glaucoma and the role of animal models. Drug Discovery Today: Disease Models 10:4, pages e207-e214.
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Padmanabhan P. PattabiramanFred B. Lih, Kenneth B. Tomer & Ponugoti Vasantha Rao. (2012) The role of calcium-independent phospholipase A 2 γ in modulation of aqueous humor drainage and Ca 2+ sensitization of trabecular meshwork contraction . American Journal of Physiology-Cell Physiology 302:7, pages C979-C991.
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W. Daniel Stamer & Ted S. Acott. (2012) Current understanding of conventional outflow dysfunction in glaucoma. Current Opinion in Ophthalmology 23:2, pages 135-143.
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Hae-Young Lopilly Park, Jie Hyun Kim, Kyung Min Lee & Chan Kee Park. (2012) Effect of prostaglandin analogues on tear proteomics and expression of cytokines and matrix metalloproteinases in the conjunctiva and cornea. Experimental Eye Research 94:1, pages 13-21.
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