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Expert Opinion on Emerging Drugs Volume 18, 2013 - Issue 1
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Emerging VEGF-receptor inhibitors for colorectal cancer

Erika MartinelliOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
, MD PhD,
Teresa TroianiOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
, MD PhD,
Floriana MorgilloOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
, MD PhD,
Michele OrdituraOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
, MD PhD,
Fernando De VitaOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
, MD PhD,
Giulio BelliOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected];Chirurgia Generale Epato-bilio-pancreatica e D’Urgenza, P.O. S. Maria di Loreto Nuovo, Via A. Vespucci 26, 80142 Napoli, Italia
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Fortunato CiardielloOncologia Medica and Immunologia Clinica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale F. Magrassi e A. Lanzara, Seconda Università degli Studi di Napoli, Via S. Pansini 5, 80131 Napoli, Italia+39 081 5666745; +39 081 5666725; +39 0815666732; [email protected], [email protected]; [email protected]
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Pages 25-37 | Published online: 06 Dec 2012

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M. Tampellini, C. Sonetto & G. V. Scagliotti. (2016) Novel anti-angiogenic therapeutic strategies in colorectal cancer. Expert Opinion on Investigational Drugs 25:5, pages 507-520.
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Articles from other publishers (21)

Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An & Lunzhi Dai. (2023) Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications. MedComm 4:3.
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Yu-Chen S. H. Yang, Po-Jui Ko, Yi-Shin Pan, Hung-Yun Lin, Jacqueline Whang-Peng, Paul J. Davis & Kuan Wang. (2021) Role of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers. Journal of Biomedical Science 28:1.
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Li-Gang Yu, Su-Qin Chen & Guo-Liang Mao. (2020) Relationship between EZH2 and VEGF expression and prognosis in colorectal cancer. World Chinese Journal of Digestology 28:5, pages 155-166.
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Xiu-Ping Tong, Xin-Ming Lei & Liu He. (2020) Meta-analysis of safety and efficacy of antiangiogenic drug aflibercept for metastatic colorectal cancer. World Chinese Journal of Digestology 28:1, pages 18-25.
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Pietro Paolo Vitiello, Claudia Cardone, Giulia Martini, Davide Ciardiello, Valentina Belli, Nunzia Matrone, Giusi Barra, Stefania Napolitano, Carmina Della Corte, Mimmo Turano, Maria Furia, Teresa Troiani, Floriana Morgillo, Ferdinando De Vita, Fortunato Ciardiello & Erika Martinelli. (2019) Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines. Journal of Experimental & Clinical Cancer Research 38:1.
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Martini Giulia, Troiani Teresa, Cardone Claudia, Vitiello Pietro Paolo, Ciardiello Davide, Morgillo Floriana, Ciardiello Fortunato & Martinelli Erika. (2019) Anti-angiogenic Treatment in Metastatic Colorectal Cancer: Current Issues and Future Aims. Current Cancer Therapy Reviews 15:3, pages 184-191.
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Hikaru Nagano, Chisato Tomida, Naoko Yamagishi & Shigetada Teshima-Kondo. (2019) VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells. International Journal of Molecular Sciences 20:22, pages 5608.
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Giulia Martini, Claudia Cardone, Pietro Paolo Vitiello, Valentina Belli, Stefania Napolitano, Teresa Troiani, Davide Ciardiello, Carminia Maria Della Corte, Floriana Morgillo, Nunzia Matrone, Vincenzo Sforza, Gianpaolo Papaccio, Vincenzo Desiderio, Mariel C. Paul, Veronica Moreno-Viedma, Nicola Normanno, Anna Maria Rachiglio, Virginia Tirino, Evaristo Maiello, Tiziana Pia Latiano, Daniele Rizzi, Giuseppe Signoriello, Maria Sibilia, Fortunato Ciardiello & Erika Martinelli. (2019) EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer. Molecular Cancer Therapeutics 18:4, pages 845-855.
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Yun Dai, George Wilson & Liang Qiao. 2017. Encyclopedia of Cancer. Encyclopedia of Cancer 1128 1135 .
Guido Giordano, Antonio Febbraro, Eugenio Tomaselli, Maria Lucia Sarnicola, Pietro Parcesepe, Domenico Parente, Nicola Forte, Alessio Fabozzi, Andrea Remo, Andrea Bonetti, Erminia Manfrin, Somayehsadat Ghasemi, Michele Ceccarelli, Luigi Cerulo, Flavia Bazzoni & Massimo Pancione. (2015) Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer. Journal of Experimental & Clinical Cancer Research 34:1.
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Xuan Liu, Qing Ji, Zhongze Fan & Qi Li. (2015) Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents. Future Oncology 11:21, pages 2911-2922.
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Lei Wang, Shan Ji & Zeneng Cheng. (2015) Association between Polymorphisms in Vascular Endothelial Growth Factor Gene and Response to Chemotherapies in Colorectal Cancer: A Meta-Analysis. PLOS ONE 10:5, pages e0126619.
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Ni Liu, Jianyong Yang, Yonghui Huang, Bin Chen, Wei Chen & Jiaping Li. (2015) Vascular Endothelial Growth Factor Accelerates Establishment of a Model of Hepatic Metastasis in Walker-256 Tumor-Bearing Rats. The American Journal of the Medical Sciences 349:3, pages 234-239.
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Chisato Tomida, Kana Aibara, Naoko Yamagishi, Chiaki Yano, Hikaru Nagano, Tomoki Abe, Ayako Ohno, Katsuya Hirasaka, Takeshi Nikawa & Shigetada Teshima-Kondo. (2015) The malignant progression effects of regorafenib in human colon cancer cells. The Journal of Medical Investigation 62:3.4, pages 195-198.
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Jonas Kügler. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 1855 1870 .
Teresa Troiani, Stefania Napolitano, Donata Vitagliano, Floriana Morgillo, Anna Capasso, Vincenzo Sforza, Anna Nappi, Davide Ciardiello, Fortunato Ciardiello & Erika Martinelli. (2014) Primary and Acquired Resistance of Colorectal Cancer Cells to Anti-EGFR Antibodies Converge on MEK/ERK Pathway Activation and Can Be Overcome by Combined MEK/EGFR Inhibition. Clinical Cancer Research 20:14, pages 3775-3786.
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L. Fornaro, S. Lonardi, G. Masi, F. Loupakis, F. Bergamo, L. Salvatore, C. Cremolini, M. Schirripa, C. Vivaldi, G. Aprile, A. Zaniboni, S. Bracarda, G. Fontanini, E. Sensi, C. Lupi, M. Morvillo, V. Zagonel & A. Falcone. (2013) FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type (KRAS, NRAS, HRAS, BRAF) metastatic colorectal cancer patients: a phase II trial by the Gruppo Oncologico Nord Ovest (GONO). Annals of Oncology 24:8, pages 2062-2067.
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