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Emerging drugs for neuropathic pain

, MD MSc FRCPC & , PhD FmedSci

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Shaogen Wu, Jamie Bono & Yuan-Xiang Tao. (2019) Long noncoding RNA (lncRNA): a target in neuropathic pain. Expert Opinion on Therapeutic Targets 23:1, pages 15-20.
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Paula Morales, Laura Hernandez-Folgado, Pilar Goya & Nadine Jagerovic. (2016) Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update. Expert Opinion on Therapeutic Patents 26:7, pages 843-856.
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Xu Gao, Long-fei Gao, Xiang-qing Kong, Ya-nan Zhang, Shu Jia & Chun-yang Meng. (2023) Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy. International Immunopharmacology 115, pages 109695.
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Khemchand R. SuranaAbhijeet G. ParkheEknath D. AhireAnuprita R. PawarSurvarna KhairnarSunil K. MahajanDhananjay M. PatilDeepak D. SonawaneSanjay J. Kshirsagar. (2022) Current Therapeutic Targets for Neuropathic Pain. Asian Journal of Pharmaceutical Research, pages 96-104.
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Harsha Shanthanna. 2022. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics 121 130 .
Cheng Hu, Menglin He, Qian Xu & Weiqian Tian. (2021) Advances With Non-coding RNAs in Neuropathic Pain. Frontiers in Neuroscience 15.
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Margaret-Ann Tait, Daniel S J Costa, Rachel Campbell, Richard Norman, Stephan Schug & Claudia Rutherford. (2021) A Quality-of-Life Evaluation Study Assessing Health-Related Quality of Life in Patients Receiving Medicinal Cannabis (the QUEST Initiative): Protocol for a Longitudinal Observational Study. JMIR Research Protocols 10:11, pages e32327.
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Harvinder S. Virk, Michael S. Biddle, Dawn T. Smallwood, Cathryn A. Weston, Emily Castells, Viona W. Bowman, Jamie McCarthy, Yassine Amrani, S. Mark Duffy, Peter Bradding & Katy M. Roach. (2021) TGFβ1 induces resistance of human lung myofibroblasts to cell death via down‐regulation of TRPA1 channels. British Journal of Pharmacology 178:15, pages 2948-2962.
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Wenwen Zhang, Tingting Yu, Xiangyan Cui, Hong Yu & Xinbai Li. (2020) Analgesic effect of dexmedetomidine in rats after chronic constriction injury by mediating microRNA‐101 expression and the E2F2–TLR4–NF‐κB axis. Experimental Physiology 105:9, pages 1588-1597.
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Zdravko Lacković. (2020) New analgesic: Focus on botulinum toxin. Toxicon 179, pages 1-7.
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Anna Rapacz, Sabina Rybka, Jolanta Obniska, Aleksandra Jodłowska, Małgorzata Góra, Paulina Koczurkiewicz, Elżbieta Pękala, Agata Siwek & Barbara Filipek. (2020) Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain. European Journal of Pharmacology 869, pages 172890.
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Ian Gilron, Fiona Blyth & Blair H. Smith. (2020) Translating clinical trials into improved real-world management of pain: convergence of translational, population-based, and primary care research. Pain 161:1, pages 36-42.
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Monika Haack, Norah Simpson, Navil Sethna, Satvinder Kaur & Janet Mullington. (2019) Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology 45:1, pages 205-216.
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H. S. Virk, M. Z. Rekas, M. S. Biddle, A. K. A. Wright, J. Sousa, C. A. Weston, L. Chachi, K. M. Roach & P. Bradding. (2019) Validation of antibodies for the specific detection of human TRPA1. Scientific Reports 9:1.
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Morena Brazil Sant’Anna, Flavia Souza Ribeiro Lopes, Louise Faggionato Kimura, Aline Carolina Giardini, Osvaldo Augusto Sant’Anna & Gisele Picolo. (2019) Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice. Toxins 11:12, pages 679.
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A. Alcántara Montero, C.I. Sánchez Carnerero & C. Goicoechea García. (2019) Emerging therapies in clinical development and new contributions for neuropathic pain. Revista Española de Anestesiología y Reanimación (English Edition) 66:6, pages 324-334.
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A. Alcántara Montero, C.I. Sánchez Carnerero & C. Goicoechea García. (2019) Terapias emergentes en desarrollo clínico y nuevas aportaciones en dolor neuropático. Revista Española de Anestesiología y Reanimación 66:6, pages 324-334.
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Ian Gilron, Fiona M. Blyth, Louisa Degenhardt, Marta Di Forti, Christopher Eccleston, Simon Haroutounian, Andrew Moore, Andrew S.C. Rice & Mark Wallace. (2019) Risks of harm with cannabinoids, cannabis, and cannabis-based medicine for pain management relevant to patients receiving pain treatment: protocol for an overview of systematic reviews. PAIN Reports 4:3, pages e742.
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Rouvin Kurian, Kazim Raza & Harsha Shanthanna. (2019) A systematic review and meta‐analysis of memantine for the prevention or treatment of chronic pain. European Journal of Pain.
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Qiuli He, Tingting Wang, Huadong Ni, Qianying Liu, Kang An, Jiachun Tao, Yajing Chen, Longsheng Xu, Chunyan Zhu & Ming Yao. (2019) Endoplasmic reticulum stress promoting caspase signaling pathway-dependent apoptosis contributes to bone cancer pain in the spinal dorsal horn. Molecular Pain 15, pages 174480691987615.
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Debnath Bhuniya, Rajendra K. Kharul, Atul Hajare, Nadim Shaikh, Sandeep Bhosale, Sandip Balwe, Fouzia Begum, Siddhartha De, Sonalee Athavankar, Dhananjay Joshi, Vamsi Madgula, Kaushal Joshi, Amol A. Raje, Ashwinkumar V. Meru, Amol Magdum, Kasim A. Mookhtiar & Rashmi Barbhaiya. (2019) Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model. Bioorganic & Medicinal Chemistry Letters 29:2, pages 238-243.
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Longhe Xu, Yaobo Liu, Yuhui Sun, Hao Li, Weidong Mi & Yuge Jiang. (2018) Analgesic effects of TLR4/NF-κB signaling pathway inhibition on chronic neuropathic pain in rats following chronic constriction injury of the sciatic nerve. Biomedicine & Pharmacotherapy 107, pages 526-533.
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Kim Lawson. (2018) Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis. World Journal of Pharmacology 7:1, pages 1-9.
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Nayereh Ghoreishi-Haack, Jessica M. Priebe, Jacqueline D. Aguado, Elizabeth M. Colechio, Jeffrey S. Burgdorf, M. Scott Bowers, Cassia N. Cearley, M. Amin Khan & Joseph R. Moskal. (2018) NYX-2925 Is a Novel N -Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain . Journal of Pharmacology and Experimental Therapeutics 366:3, pages 485-497.
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Didier Bouhassira & Nadine Attal. (2017) Emerging therapies for neuropathic pain: new molecules or new indications for old treatments?. Pain 159:3, pages 576-582.
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Xiaonan Liang, Gang Yu & Ruibin Su. (2018) Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. European Journal of Pharmacology 823, pages 27-34.
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Gisèle Pickering & Véronique Morel. (2018) Memantine for the treatment of general neuropathic pain: a narrative review. Fundamental & Clinical Pharmacology 32:1, pages 4-13.
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Anna Rapacz, Jolanta Obniska, Paulina Koczurkiewicz, Katarzyna Wójcik-Pszczoła, Agata Siwek, Anna Gryboś, Sabina Rybka, Aleksandra Karcz, Elżbieta Pękala & Barbara Filipek. (2018) Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice. European Journal of Pharmacology 821, pages 39-48.
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Sangdon Han, Lars Thoresen, Jae-Kyu Jung, Xiuwen Zhu, Jayant Thatte, Michelle Solomon, Ibragim Gaidarov, David J. Unett, Woo Hyun Yoon, Jeremy Barden, Abu Sadeque, Amin Usmani, Chuan Chen, Graeme Semple, Andrew J. Grottick, Hussein Al-Shamma, Ronald Christopher & Robert M. Jones. (2017) Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain . ACS Medicinal Chemistry Letters 8:12, pages 1309-1313.
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Cristina D. Peterson, Kelley F. KittoEyup Akgün, Mary M. Lunzer, Maureen S. RiedlLucy VulchanovaGeorge L. Wilcox, Philip S. Portoghese & Carolyn A. Fairbanks. (2017) Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice. Pain 158:12, pages 2431-2441.
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Vanessa D. G. Silva, Angélica S. Reis, Mikaela P. Pinz, Caren A. R. da Fonseca, Luis Fernando B. Duarte, Juliano A. Roehrs, Diego Alves, Cristiane Luchese & Ethel A. Wilhelm. (2017) Further analysis of acute antinociceptive and anti-inflammatory actions of 4-phenylselenyl-7-chloroquinoline in mice. Fundamental & Clinical Pharmacology 31:5, pages 513-525.
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Janna Warendorf, Alexander FJE Vrancken, Ivo N van Schaik, Richard AC Hughes & Nicolette C Notermans. (2017) Drug therapy for chronic idiopathic axonal polyneuropathy. Cochrane Database of Systematic Reviews 2017:6.
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Bin Huang, Fengying Zhang, Gang Yu, Yan Song, Xintong Wang, Meiliang Wang, Zehui Gong, Ruibin Su & Yanxing Jia. (2016) Gram Scale Syntheses of (−)-Incarvillateine and Its Analogs. Discovery of Potent Analgesics for Neuropathic Pain. Journal of Medicinal Chemistry 59:8, pages 3953-3963.
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Xudong Cao, Yin Chen, Yifang Zhang, Yu Lan, Juecheng Zhang, Xiangqing Xu, Yinli Qiu, Song Zhao, Xin Liu, Bi-Feng Liu & Guisen Zhang. (2016) Synthesis and Biological Evaluation of Novel σ 1 Receptor Ligands for Treating Neuropathic Pain: 6-Hydroxypyridazinones . Journal of Medicinal Chemistry 59:7, pages 2942-2961.
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