Advanced search
Publication Cover
Expert Opinion on Emerging Drugs Volume 20, 2015 - Issue 4
Submit an article Journal homepage
2,671
Views
53
CrossRef citations to date
0
Altmetric
Editorial

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

Michael ChoppHenry Ford Hospital, Henry Ford Health System, Neurology Research, Room E&R-3056, 2799 W. Grand Boulevard, Detroit, MI 48202, [email protected]
, PhD &
Zheng Gang ZhangHenry Ford Hospital, Neurology Research, E&R Bldg, Room 3049, 2799 W. Grand Boulevard, Detroit, MI 48202, USA
Pages 523-526 | Published online: 01 Jul 2015

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Julian P. Tuazon, Vanessa Castelli & Cesar V. Borlongan. (2019) Drug-like delivery methods of stem cells as biologics for stroke. Expert Opinion on Drug Delivery 16:8, pages 823-833.
Read now
Ron J. Leavitt, Charles L. Limoli & Janet E. Baulch. (2019) miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury. International Journal of Radiation Biology 95:4, pages 427-435.
Read now
Kimbra Kenney, Bao-Xi Qu, Chen Lai, Christina Devoto, Vida Motamedi, William C. Walker, Harvey S. Levin, Tracy Nolen, Elisabeth A. Wilde, Ramon Diaz-Arrastia & Jessica Gill. (2018) Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury. Brain Injury 32:10, pages 1276-1284.
Read now

Articles from other publishers (50)

Ye Xiong, Asim Mahmood & Michael Chopp. (2024) Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration. Neural Regeneration Research 19:1, pages 49-54.
Crossref
Inês Figueira, Paulo Bastos, Antonio González-Sarrías, Juan Carlos Espín, Bruno Costa-Silva & Cláudia Nunes dos Santos. (2023) Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?. Food & Function 14:1, pages 15-31.
Crossref
Caterina Allegretta, Emanuele D’Amico, Virginia Manuti, Carlo Avolio & Massimo Conese. (2022) Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Use in Central Nervous System Demyelinating Disorders. International Journal of Molecular Sciences 23:7, pages 3829.
Crossref
Lianxu Cui, Yasmeen Saeed, Haomin Li & Jingli Yang. (2022) Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies. Regenerative Medicine 17:1, pages 37-53.
Crossref
Jing Zhang, Benjamin A. Buller, Zheng Gang Zhang, Yi Zhang, Mei Lu, Douglas L. Rosene, Maria Medalla, Tara L. Moore & Michael Chopp. (2022) Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Experimental Neurology 347, pages 113895.
Crossref
Richard F. Keep, Jianming Xiang, Ningna Zhou & Anuska V. Andjelkovic. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain 699 722 .
Yan Huang, Midie Xu, Chuyu Jing, Xiaohua Wu, Xiaojun Chen & Wei Zhang. (2021) Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer. Discover Oncology 12:1.
Crossref
Dayu Pan, Weixiao Liu, Shibo Zhu, Baoyou Fan, Nanxi Yu, Guangzhi Ning & Shiqing Feng. (2021) Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury. Journal of Orthopaedic Translation 31, pages 33-40.
Crossref
Jessica Dörnen & Thomas Dittmar. (2021) The Role of MSCs and Cell Fusion in Tissue Regeneration. International Journal of Molecular Sciences 22:20, pages 10980.
Crossref
Samira Ahmadvand Koohsari, Abdorrahim Absalan & Davood Azadi. (2021) Human umbilical cord mesenchymal stem cell-derived extracellular vesicles attenuate experimental autoimmune encephalomyelitis via regulating pro and anti-inflammatory cytokines. Scientific Reports 11:1.
Crossref
Hongqi Xin, Zhongwu Liu, Benjamin Buller, Yanfeng Li, William Golembieski, Xinling Gan, Fengjie Wang, Mei Lu, Meser M Ali, Zheng G Zhang & Michael Chopp. (2020) MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke. Journal of Cerebral Blood Flow & Metabolism 41:5, pages 1131-1144.
Crossref
Junyi Ma, Xiang Cao, Fangyu Chen, Qing Ye, Ruomeng Qin, Yue Cheng, Xiaolei Zhu & Yun Xu. (2021) Exosomal MicroRNAs Contribute to Cognitive Impairment in Hypertensive Patients by Decreasing Frontal Cerebrovascular Reactivity. Frontiers in Neuroscience 15.
Crossref
Felipe Bustamante, Maxs Méndez-Ruette, Ursula Wyneken, Luis Federico Bátiz & Roberto Henzi. 2021. Stress: Genetics, Epigenetics and Genomics. Stress: Genetics, Epigenetics and Genomics 179 193 .
Morteza Jafarinia, Fereshteh Alsahebfosoul, Hossein Salehi, Nahid Eskandari, Maryam Azimzadeh, Merat Mahmoodi, Sedigheh Asgary & Mazdak Ganjalikhani Hakemi. (2020) Therapeutic effects of extracellular vesicles from human adipose‐derived mesenchymal stem cells on chronic experimental autoimmune encephalomyelitis. Journal of Cellular Physiology 235:11, pages 8779-8790.
Crossref
Kryshawna BeardDavid F. MeaneyDavid Issadore. (2020) Clinical Applications of Extracellular Vesicles in the Diagnosis and Treatment of Traumatic Brain Injury. Journal of Neurotrauma 37:19, pages 2045-2056.
Crossref
Naohiro Egawa, Hidefumi Suzuki, Ryosuke Takahashi, Kazuhide Hayakawa, Wenlu Li, Eng H Lo, Ken Arai & Haruhisa Inoue. (2020) From in vitro to in vivo reprogramming for neural transdifferentiation: An approach for CNS tissue remodeling using stem cell technology. Journal of Cerebral Blood Flow & Metabolism 40:9, pages 1739-1751.
Crossref
Man-Man Wang, Ya-Shuo Feng, Zi-Xuan Tan, Ying Xing, Fang Dong & Feng Zhang. (2020) The role of exosomes in stroke. Molecular Biology Reports 47:8, pages 6217-6228.
Crossref
Saihua Huang, Ping Xue, Xiao Han, Caiyan Zhang, Lan Yang, Lijuan Liu, Xiang Wang, Hao Li, Jinrong Fu & Yufeng Zhou. (2020) Exosomal miR-130b-3p targets SIK1 to inhibit medulloblastoma tumorigenesis. Cell Death & Disease 11:6.
Crossref
Aaron M. Williams, Umar F. Bhatti, Jordana F. Brown, Ben E. Biesterveld, Ranganath G. Kathawate, Nathan J. Graham, Kiril Chtraklin, Ali Z. Siddiqui, Simone E. Dekker, Anuska Andjelkovic, Gerald A. Higgins, Benjamin Buller & Hasan B. Alam. (2020) Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock. Journal of Trauma and Acute Care Surgery 88:2, pages 207-218.
Crossref
Veronica Go, Bethany G. E. Bowley, Monica A. Pessina, Zheng Gang Zhang, Michael Chopp, Seth P. Finklestein, Douglas L. Rosene, Maria Medalla, Benjamin Buller & Tara L. Moore. (2019) Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. GeroScience 42:1, pages 1-17.
Crossref
Gui-hong Zhang, Krishna Dilip Murthy, Rahmawati Binti Pare & Yi-hua Qian. (2020) Protective effect of Tβ4 on central nervous system tissues and its developmental prospects. European Journal of Inflammation 18, pages 205873922093455.
Crossref
Zhenyu Yin, Zhaoli Han, Tianpeng Hu, Shishuang Zhang, Xintong Ge, Shan Huang, Lu Wang, Jinwen Yu, Wenzhu Li, Yan Wang, Dai li, Jing Zhao, Yifeng Wang, Yan Zuo, Ying Li, Xiaodong Kong, Fanglian Chen & Ping Lei. (2020) Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture. Brain, Behavior, and Immunity 83, pages 270-282.
Crossref
Tamara Roitbak. (2019) MicroRNAs and Regeneration in Animal Models of CNS Disorders. Neurochemical Research 45:1, pages 188-203.
Crossref
Si Yun Ng & Alan Yiu Wah Lee. (2019) Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets. Frontiers in Cellular Neuroscience 13.
Crossref
Joanna Izabela Lachowicz, Mariusz Jaremko, Lukasz Jaremko, Giuseppina Pichiri, Pierpaolo Coni & Marco Piludu. (2019) Metal coordination of thymosin β4: Chemistry and possible implications. Coordination Chemistry Reviews 396, pages 117-123.
Crossref
Changheon Kim & Kangwon Lee. (2019) Polydiacetylene (PDA) Liposome-Based Immunosensor for the Detection of Exosomes. Biomacromolecules 20:9, pages 3392-3398.
Crossref
Paola Riva, Cristina Battaglia & Marco Venturin. (2019) Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases. International Journal of Molecular Sciences 20:17, pages 4113.
Crossref
Kelly Cristine Santos Roballo, Juliano Coelho da Silveira, Fabiana Fernandes Bressan, Aline Fernanda de Souza, Vitoria Mattos Pereira, Jorge Eliecer Pinzon Porras, Felipe Augusto Rós, Lidia Hildebrand Pulz, Ricardo de Francisco Strefezzi, Daniele dos Santos Martins, Flavio Vieira Meirelles & Carlos Eduardo Ambrósio. (2019) Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration. Scientific Reports 9:1.
Crossref
T.L. Moore, B.G.E. Bowley, M.A. Pessina, S.M. Calderazzo, M. Medalla, V. Go, Z.G. Zhang, M. Chopp, S. Finklestein, A.G. Harbaugh, D.L. Rosene & B. Buller. (2019) Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury. Restorative Neurology and Neuroscience 37:4, pages 347-362.
Crossref
Yuxia HanDon Seyfried, Yuling MengDongmei YangLonni Schultz, Michael Chopp & Donald Seyfried. (2019) Multipotent mesenchymal stromal cell–derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat. Journal of Neurosurgery 131:1, pages 290-300.
Crossref
Xizhi Wang, Benson O. A. Botchway, Yong Zhang, Jiaying Yuan & Xuehong Liu. (2019) Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury. Frontiers in Molecular Neuroscience 12.
Crossref
Zheng Gang Zhang, Benjamin Buller & Michael Chopp. (2019) Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury. Nature Reviews Neurology 15:4, pages 193-203.
Crossref
Xiaodan Bai, Shengyu Hua, Junping Zhang & Shixin Xu. (2019) The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster. BioMed Research International 2019, pages 1-11.
Crossref
Poornima Venkat, Jieli Chen & Michael Chopp. (2018) Exosome-mediated amplification of endogenous brain repair mechanisms and brain and systemic organ interaction in modulating neurological outcome after stroke. Journal of Cerebral Blood Flow & Metabolism 38:12, pages 2165-2178.
Crossref
Nicole Osier, Vida Motamedi, Katie Edwards, Ava Puccio, Ramon Diaz-Arrastia, Kimbra Kenney & Jessica Gill. (2018) Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. Molecular Neurobiology 55:12, pages 9280-9293.
Crossref
Robin L. Webb, Erin E. Kaiser, Shelley L. Scoville, Tyler A. Thompson, Sumbul Fatima, Chirayukumar Pandya, Karishma Sriram, Raymond L. Swetenburg, Kumar Vaibhav, Ali S. Arbab, Babak Baban, Krishnan M. Dhandapani, David C. Hess, M. N. Hoda & Steven L. Stice. (2017) Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model. Translational Stroke Research 9:5, pages 530-539.
Crossref
J. David Spence. (2018) Big Surprise: The Brain Can Recover Many Years After a Stroke. Frontiers for Young Minds 6.
Crossref
Dema NajemKerry RennieMaria Ribecco-LutkiewiczDao LyJulie HaukenfrersQing LiuMunyao NzauDouglas D. FraserMahmud Bani-Yaghoub. (2018) Traumatic brain injury: classification, models, and markers. Biochemistry and Cell Biology 96:4, pages 391-406.
Crossref
Ye Xiong, Asim Mahmood & Michael Chopp. (2018) Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities. Chinese Journal of Traumatology 21:3, pages 137-151.
Crossref
Jieli ChenMichael Chopp. (2018) Exosome Therapy for Stroke. Stroke 49:5, pages 1083-1090.
Crossref
Guangwen Li, Kahlilia C. Morris-Blanco, Mary S. Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti & Yumin Luo. (2018) Impact of microRNAs on ischemic stroke: From pre- to post-disease. Progress in Neurobiology 163-164, pages 59-78.
Crossref
Katherine A. Ruppert, Tin T. Nguyen, Karthik S. Prabhakara, Naama E. Toledano Furman, Amit K. Srivastava, Matthew T. Harting, Charles S. CoxJr.Jr. & Scott D. Olson. (2018) Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modify Microglial Response and Improve Clinical Outcomes in Experimental Spinal Cord Injury. Scientific Reports 8:1.
Crossref
Shan Huang, Xintong Ge, Jinwen Yu, Zhaoli Han, Zhenyu Yin, Ying Li, Fanglian Chen, Haichen Wang, Jianning Zhang & Ping Lei. (2017) Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons . The FASEB Journal 32:1, pages 512-528.
Crossref
Yi Shen, Poornima Venkat, Michael Chopp & Jieli Chen. 2018. Cellular and Molecular Approaches to Regeneration and Repair. Cellular and Molecular Approaches to Regeneration and Repair 217 237 .
Zhanfeng Liang, Yang Zhao, Linhui Ruan, Linnan Zhu, Kunlin Jin, Qichuan Zhuge, Dong-Ming Su & Yong Zhao. (2017) Impact of aging immune system on neurodegeneration and potential immunotherapies. Progress in Neurobiology 157, pages 2-28.
Crossref
Peter Sörös, Robert Teasell, Daniel F. Hanley & J. David Spence. (2017) Motor recovery beginning 23 years after ischemic stroke. Journal of Neurophysiology 118:2, pages 778-781.
Crossref
Ye Xiong, Asim Mahmood & Michael Chopp. (2017) Emerging potential of exosomes for treatment of traumatic brain injury. Neural Regeneration Research 12:1, pages 19.
Crossref
Yanhong Zhang & Honghong Yao. (2017) Potential Therapeutic Mechanisms and Tracking of Transplanted Stem Cells: Implications for Stroke Treatment. Stem Cells International 2017, pages 1-11.
Crossref
Marci G. Crowley, M. Grant Liska & Cesar V. Borlongan. 2017. Cell Therapy. Cell Therapy 53 72 .
Anuradha Kalani, Pankaj Chaturvedi, Pradip K. Kamat, Claudio Maldonado, Philip Bauer, Irving G. Joshua, Suresh C. Tyagi & Neetu Tyagi. (2016) Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury. The International Journal of Biochemistry & Cell Biology 79, pages 360-369.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.