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Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery

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Pages 753-765 | Published online: 17 Jun 2009

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Priyanca Ahlawat, Kanika Phutela, Amanjit Bal, Navneet Singh & Sadhna Sharma. (2022) Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma. Drug Delivery 29:1, pages 2403-2413.
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Herbert A Kirst. (2012) Recent derivatives from smaller classes of fermentation-derived antibacterials. Expert Opinion on Therapeutic Patents 22:1, pages 15-35.
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Hendrik Kirschner, Milena John, Tianyi Zhou, Nathalie Bachmann, André Schultz, Eckhard Hofmann, Julia Elisabeth Bandow, Jürgen Scherkenbeck, Nils Metzler‐Nolte & Raphael Stoll. (2023) Structural Insights into Antibacterial Payload Release from Gold Nanoparticles Bound to E. coli Peptide Deformylase . ChemMedChem.
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Vasiliki Mavrikaki, Alexandros Pagonis, Isabelle Poncin, Ivy Mallick, Stéphane Canaan, Victoria Magrioti & Jean-François Cavalier. (2022) Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. Bioorganic & Medicinal Chemistry Letters 64, pages 128692.
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Pravej Alam & Thamer H. Al balawi. (2022) Molecular Interaction Study to Explore the Nigella sativa Bioactive Components as an Inhibitor of Peptide Deformylase to Inhibit the Xanthomonas oryzae pv. oryzae via Applying Computational Approach. Phyton 91:9, pages 1923-1931.
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Basem Battah, Giulia Chemi, Stefania Butini, Giuseppe Campiani, Simone Brogi, Giovanni Delogu & Sandra Gemma. (2019) A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles. Molecules 24:23, pages 4373.
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Raivis Žalubovskis & Jean-Yves Winum. (2019) Inhibitors of Selected Bacterial Metalloenzymes. Current Medicinal Chemistry 26:15, pages 2690-2714.
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Anju Choorakottayil Pushkaran, Raja Biswas & C. Gopi Mohan. 2019. Structural Bioinformatics: Applications in Preclinical Drug Discovery Process. Structural Bioinformatics: Applications in Preclinical Drug Discovery Process 307 346 .
Yanfei Cai, Pete Chandrangsu, Ahmed Gaballa & John D Helmann. (2017) Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis. Microbiology 163:2, pages 185-196.
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Anas Allam, Laure Maigre, Mickael Alimi, Rodolphe Alves de Sousa, Assia Hessani, Erwan Galardon, Jean-Marie Pagès & Isabelle Artaud. (2014) New Peptides with Metal Binding Abilities and Their Use as Drug Carriers. Bioconjugate Chemistry 25:10, pages 1811-1819.
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Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao, Fengping Lv, Liping Yang, Yushe Yang & Wenhao Hu. (2014) Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. European Journal of Medicinal Chemistry 86, pages 133-152.
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A Sheth, S Escobar-Alvarez, J Gardner, L Ran, M L Heaney & D A Scheinberg. (2014) Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death & Disease 5:3, pages e1152-e1152.
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Herbert A. Kirst. 2014. Antimicrobials. Antimicrobials 267 286 .
Mark S Butler, Mark A Blaskovich & Matthew A Cooper. (2013) Antibiotics in the clinical pipeline in 2013. The Journal of Antibiotics 66:10, pages 571-591.
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Kar Kheng Yeoh, Mun Chiang Chan, Armin Thalhammer, Marina Demetriades, Rasheduzzaman Chowdhury, Ya-Min Tian, Ineke Stolze, Luke A. McNeill, Myung Kyu Lee, Esther C. Y. Woon, Mukram M. Mackeen, Akane Kawamura, Peter J. Ratcliffe, Jasmin Mecinović & Christopher J. Schofield. (2013) Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Org. Biomol. Chem. 11:5, pages 732-745.
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Reem Smoum, Abraham Rubinstein, Valery M. Dembitsky & Morris Srebnik. (2012) Boron Containing Compounds as Protease Inhibitors. Chemical Reviews 112:7, pages 4156-4220.
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Emilie Goemaere, Armelle Melet, Valéry Larue, Aurélie Lieutaud, Rodolphe Alves de Sousa, Jacqueline Chevalier, Liselotte Yimga-Djapa, Carmela Giglione, Florian Huguet, Mickael Alimi, Thierry Meinnel, Frédéric Dardel, Isabelle Artaud & Jean-Marie Pagès. (2012) New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity. Journal of Antimicrobial Chemotherapy 67:6, pages 1392-1400.
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Florian Huguet, Armelle Melet, Rodolphe Alves de Sousa, Aurélie Lieutaud, Jacqueline Chevalier, Laure Maigre, Patrick Deschamps, Alain Tomas, Nicolas Leulliot, Jean-Marie Pages & Isabelle Artaud. (2012) Hydroxamic Acids as Potent Inhibitors of Fe II and Mn II E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate- Ec MetAP-Mn Complexes . ChemMedChem 7:6, pages 1020-1030.
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Rachel Totoritis, Chaya Duraiswami, Amy N. Taylor, John J. Kerrigan, Nino Campobasso, Katherine J. Smith, Paris Ward, Bryan W. King, Monique Murrayz-Thompson, Amber D. Jones, Glenn S. Van Aller, Kelly M. Aubart, Magdalena Zalacain, Sara H. Thrall, Thomas D. Meek & Benjamin Schwartz. (2011) Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors. Biochemistry 50:31, pages 6642-6654.
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Stephen P. East, Andrew Ayscough, Ian Toogood-Johnson, Steven Taylor & Wayne Thomas. (2011) Peptidomimetic inhibitors of bacterial peptide deformylase. Bioorganic & Medicinal Chemistry Letters 21:13, pages 4032-4035.
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Mark S Butler & Matthew A Cooper. (2011) Antibiotics in the clinical pipeline in 2011. The Journal of Antibiotics 64:6, pages 413-425.
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Linliang Yu, Weicheng Zhou & Zhenyu Wang. (2011) Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors. Bioorganic & Medicinal Chemistry Letters 21:5, pages 1541-1544.
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Christopher B Oey. (2011) High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop. World Journal of Biological Chemistry 2:5, pages 90.
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Lynn L. Silver. (2011) Challenges of Antibacterial Discovery. Clinical Microbiology Reviews 24:1, pages 71-109.
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Zvi RappoportAntonello Mai. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Penghui Lin, Tiancen Hu, Jian Hu, Wenqi Yu, Cong Han, Jian Zhang, Guangrong Qin, Kunqian Yu, Friedrich Götz, Xu Shen, Hualiang Jiang & Di Qu. (2010) Characterization of peptide deformylase homologues from Staphylococcus epidermidis. Microbiology 156:10, pages 3194-3202.
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