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Expert Opinion on Therapeutic Targets Volume 13, 2009 - Issue 7
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Reviews

Potential therapeutic targets in obstructive sleep apnoea

Julian P Saboisky Brigham and Women's Hospital, Harvard Medical School, Division of Sleep Medicine, 221 Longwood Avenue, Boston, Massachusetts, 02115, USA +1 617 732 6541; +1 617 732 7337; [email protected]
,
Nancy L Chamberlin Harvard Medical School, Beth Israel Deaconess Medical Center, Department of Neurology, Boston, Massachusetts, USA
&
Atul Malhotra Brigham and Women's Hospital, Harvard Medical School, Division of Sleep Medicine, 221 Longwood Avenue, Boston, Massachusetts, 02115, USA +1 617 732 6541; +1 617 732 7337; [email protected]
Pages 795-809 | Published online: 17 Jun 2009

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Richard L. Horner. (2023) Targets for obstructive sleep apnea pharmacotherapy: principles, approaches, and emerging strategies. Expert Opinion on Therapeutic Targets 27:7, pages 609-626.
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Qiaojun Wang, Yezhou Li, Jie Li, Jing Wang, Jiucheng Shen, Huaman Wu, Kaida Guo & Rui Chen. (2021) Low Arousal Threshold: A Potential Bridge Between OSA and Periodic Limb Movements of Sleep. Nature and Science of Sleep 13, pages 229-238.
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Articles from other publishers (17)

Vrushabh G Gomase, Prasad Deshmukh & Vedant Y Lekurwale. (2023) Obstructive Sleep Apnea and Its Management: A Narrative Review. Cureus.
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Brandon Nokes, Christopher N. Schmickl, Rebbecca Brena, Nana Naa‐Oye Bosompra, Dillon Gilbertson, Scott A. Sands, Rakesh Bhattacharjee, Dwayne L. Mann, Robert L. Owens, Atul Malhotra & Jeremy E. Orr. (2022) The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation. Physiological Reports 10:12.
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Jing Kang & Ming-Xian Li. (2018) Effects of Habenular Stimulation Frequencies on Obstructive Sleep Apnea Induced by Stimulation of Insular Cortex. Canadian Respiratory Journal 2018, pages 1-5.
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Sandeep S. Dhaliwal, Seyyed M. Hesabgar, Seyyed M. H. Haddad, Hanif Ladak, Abbas Samani & Brian W. Rotenberg. (2018) Constructing a patient-specific computer model of the upper airway in sleep apnea patients. The Laryngoscope 128:1, pages 277-282.
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Icilio Cavero & Henry Holzgrefe. (2015) 14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations. Journal of Pharmacological and Toxicological Methods 75, pages 143-157.
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Julian P. Saboisky, Jane E. Butler, Billy L. Luu & Simon C. Gandevia. (2015) Neurogenic Changes in the Upper Airway of Obstructive Sleep Apnoea. Current Neurology and Neuroscience Reports 15:4.
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Chantal DarquenneCharles B. Hicks & Atul Malhotra. (2015) The ongoing need for good physiological investigation: obstructive sleep apnea in HIV patients as a paradigm. Journal of Applied Physiology 118:2, pages 244-246.
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Jinghua Wang, Min Wang, Zhifeng Wei, Mingxian Li, Min Huang & Shao Wang. (2013) The lateral habenular nucleus mediates signal transduction from the insular cortex in OSA rats. Sleep and Breathing 18:3, pages 491-497.
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Richard L. HornerStuart W. HughesAtul Malhotra. (2014) State-dependent and reflex drives to the upper airway: basic physiology with clinical implications. Journal of Applied Physiology 116:3, pages 325-336.
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Amy S Jordan, David G McSharry & Atul Malhotra. (2014) Adult obstructive sleep apnoea. The Lancet 383:9918, pages 736-747.
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David G. McSharry, Julian P. Saboisky, Pam DeYoung, Paul Matteis, Amy S. Jordan, John Trinder, Erik Smales, Lauren Hess, Mengshuang Guo & Atul Malhotra. (2013) A Mechanism for Upper Airway Stability during Slow Wave Sleep. Sleep 36:4, pages 555-563.
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Marie‐Noëlle Fiamma, Edward T. O’Connor, Arijit Roy, Ines Zuna & Richard J. A. Wilson. (2013) The essential role of peripheral respiratory chemoreceptor inputs in maintaining breathing revealed when CO 2 stimulation of central chemoreceptors is diminished . The Journal of Physiology 591:6, pages 1507-1521.
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Kingman P. Strohl, James P. Butler & Atul Malhotra. 2011. Comprehensive Physiology. Comprehensive Physiology 1853 1872 .
Jeffrey M. Ellenbogen & Edward F. Pace-Schott. (2011) Drug-induced sleep: theoretical and practical considerations. Pflügers Archiv - European Journal of Physiology 463:1, pages 177-186.
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E. Fiona Bailey. (2011) Activities of human genioglossus motor units. Respiratory Physiology & Neurobiology 179:1, pages 14-22.
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Danny J. EckertRobert L. OwensGeoffrey B. KehlmannAndrew WellmanShilpa RahangdaleSusie Yim-YehDavid P. WhiteAtul Malhotra. (2011) Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold. Clinical Science 120:12, pages 505-514.
Crossref
Julian P. Saboisky, Amy S. Jordan, Danny J. Eckert, David P. White, John A. Trinder, Christian L. Nicholas, Shiva Gautam & Atul Malhotra. (2010) Recruitment and rate-coding strategies of the human genioglossus muscle. Journal of Applied Physiology 109:6, pages 1939-1949.
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