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Dickkopf-1: a suitable target for the management of myeloma bone disease

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Pages 839-848 | Published online: 17 Jun 2009

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Martina Kleber, Ioannis Ntanasis-Stathopoulos, Meletios A. Dimopoulos & Evangelos Terpos. (2019) Monoclonal antibodies against RANKL and sclerostin for myeloma-related bone disease: can they change the standard of care?. Expert Review of Hematology 12:8, pages 651-663.
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Maria Gavriatopoulou, Meletios A. Dimopoulos, Efstathios Kastritis & Evangelos Terpos. (2017) Emerging treatment approaches for myeloma-related bone disease. Expert Review of Hematology 10:3, pages 217-228.
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Flaminia Coluzzi, Ilenia Mandatori & Consalvo Mattia. (2011) Emerging therapies in metastatic bone pain. Expert Opinion on Emerging Drugs 16:3, pages 441-458.
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Articles from other publishers (51)

Fang Qiu, Jie Huang, Xuekun Fu & Chao Liang. 2022. Handbook of Cancer and Immunology. Handbook of Cancer and Immunology 1 26 .
Hewen Jiang, Zongkang Zhang, Yuanyuan Yu, Hang Yin Chu, Sifan Yu, Shanshan Yao, Ge Zhang & Bao-Ting Zhang. (2022) Drug Discovery of DKK1 Inhibitors. Frontiers in Pharmacology 13.
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Tsuyoshi Suda, Taro Yamashita, Hajime Sunagozaka, Hikari Okada, Kouki Nio, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda & Shuichi Kaneko. (2022) Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma. International Journal of Molecular Sciences 23:5, pages 2801.
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Divaya Bhutani, Rajshekhar Chakraborty & Suzanne Lentzsch. 2022. Hypercalcemia. Hypercalcemia 157 169 .
Shiva Kumar Reddy Mukkamalla & Dhatri Malipeddi. (2021) Myeloma Bone Disease: A Comprehensive Review. International Journal of Molecular Sciences 22:12, pages 6208.
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Jeng-Shiun Du, Chia-Hung Yen, Chin-Mu Hsu & Hui-Hua Hsiao. (2021) Management of Myeloma Bone Lesions. International Journal of Molecular Sciences 22:7, pages 3389.
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Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Eirini Katodritou, Marie-Christine Kyrtsonis, Vassiliki Douka, Emmanouil Spanoudakis, Athanasios Papatheodorou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Maria Gavriatopoulou, Polyzois Makras, Efstathios Kastritis & Meletios A Dimopoulos. (2021) Carfilzomib Improves Bone Metabolism in Patients with Advanced Relapsed/Refractory Multiple Myeloma: Results of the CarMMa Study. Cancers 13:6, pages 1257.
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Aristea-Maria Papanota, Paraskevi Karousi, Christos K. Kontos, Ioannis Ntanasis-Stathopoulos, Andreas Scorilas & Evangelos Terpos. (2021) Multiple Myeloma Bone Disease: Implication of MicroRNAs in Its Molecular Background. International Journal of Molecular Sciences 22:5, pages 2375.
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Samuel S. McCachren, Kavita M. Dhodapkar & Madhav V. Dhodapkar. (2021) Co-evolution of Immune Response in Multiple Myeloma: Implications for Immune Prevention. Frontiers in Immunology 12.
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Ioannis Ntanasis-Stathopoulos & Evangelos Terpos. 2021. Management of Bone Disease and Kidney Failure in Multiple Myeloma. Management of Bone Disease and Kidney Failure in Multiple Myeloma 111 137 .
Rebecca E. Andrews, Andrew D. Chantry & A. John Ashcroft. 2021. Management of Bone Disease and Kidney Failure in Multiple Myeloma. Management of Bone Disease and Kidney Failure in Multiple Myeloma 7 36 .
Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Stefania Raimondo, Alessia Gallo, Elisa Taiana, Riccardo Alessandro, Marco Rossi, Antonino Neri, Giuseppe Viglietto & Nicola Amodio. (2020) Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology. Non-Coding RNA 6:3, pages 37.
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Bart O. Williams & Mark L. Johnson. 2020. Principles of Bone Biology. Principles of Bone Biology 177 204 .
Evangelos Terpos, Efstathios Kastritis, Ioannis Ntanasis‐Stathopoulos, Dimitrios Christoulas, Athanasios Papatheodorou, Evangelos Eleutherakis‐Papaiakovou, Nikolaos Kanellias, Despina Fotiou, Dimitrios C. Ziogas, Magdalini Migkou, Maria Roussou, Ioannis P. Trougakos, Maria Gavriatopoulou & Meletios A. Dimopoulos. (2019) Consolidation therapy with the combination of bortezomib and lenalidomide (VR) without dexamethasone in multiple myeloma patients after transplant: Effects on survival and bone outcomes in the absence of bisphosphonates. American Journal of Hematology 94:4, pages 400-407.
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Danielle Harmer, Carolyne Falank & Michaela R. Reagan. (2019) Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma. Frontiers in Endocrinology 9.
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Kristina Bojanić, Ines Bilić Ćurčić, Lucija Kuna, Tomislav Kizivat, Robert Smolic, Nikola Raguž Lučić, Kristina Kralik, Vatroslav Šerić, Gordana Ivanac, Sandra Tucak-Zorić, Aleksandar Včev & Martina Smolić. (2018) Association of Wnt Inhibitors, Bone Mineral Density and Lifestyle Parameters in Women with Breast Cancer Treated with Anastrozole Therapy. Journal of Clinical Medicine 7:9, pages 287.
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Evangelos Terpos, Dimitrios Christoulas & Maria Gavriatopoulou. (2018) Biology and treatment of myeloma related bone disease. Metabolism 80, pages 80-90.
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Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou & Meletios A. Dimopoulos. (2018) Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Blood Cancer Journal 8:1.
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E. Terpos, D. Christoulas, M. Gavriatopoulou & M.A. Dimopoulos. (2017) Mechanisms of bone destruction in multiple myeloma. European Journal of Cancer Care 26:6, pages e12761.
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Jianqi Liu, Xiaobin Ren, Mingzhu Zhang, Yayan Lei, Yuhua Chen & Hongbing He. (2017) Roles of Wnt3a and Dkk1 in experimental periodontitis. Journal of Dental Sciences 12:3, pages 220-225.
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Hao Xi, Ran An, Lu Li, Gang Wang, Yi Tao & Lu Gao. (2016) Myeloma bone disease: Progress in pathogenesis. Progress in Biophysics and Molecular Biology 122:2, pages 149-155.
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Li Zhang, Hui Ouyang, Zhen Xie, Zhi-Hui Liang & Xiong-Wen Wu. (2016) Serum DKK-1 level in the development of ankylosing spondylitis and rheumatic arthritis: a meta-analysis. Experimental & Molecular Medicine 48:4, pages e228-e228.
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Stijn Van Hees, Peter Michielsen & Thomas Vanwolleghem. (2016) Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma. World Journal of Gastroenterology 22:37, pages 8271.
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F. Richard Bringhurst, Marie B. Demay & Henry M. Kronenberg. 2016. Williams Textbook of Endocrinology. Williams Textbook of Endocrinology 1253 1322 .
Sha He, Yi Lu, Xia Liu, Xin Huang, Evan T. Keller, Chao-Nan Qian & Jian Zhang. (2015) Wnt3a: functions and implications in cancer. Chinese Journal of Cancer 34:3.
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XIAO JUN XIANG, YA WEN LIU, DIAN DIAN CHEN & SHUANG YU. (2015) Differential expression of Dickkopf-1 among non-small cell lung cancer cells. Molecular Medicine Reports 12:2, pages 1935-1940.
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Young Bok Ko, Boh-Ram Kim, Kyungsil Yoon, Eun Kyung Choi, Seung Hee Seo, Yeonah Lee, Min A. Lee, Jung Bo Yang, Mi Sun Park & Seung Bae Rho. (2014) WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1. Cellular Signalling 26:11, pages 2562-2572.
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Ioannis Kyvernitakis, Tilman D. Rachner, Anja Urbschat, Olaf Hars, Lorenz C. Hofbauer & Peyman Hadji. (2014) Effect of aromatase inhibition on serum levels of sclerostin and dickkopf-1, bone turnover markers and bone mineral density in women with breast cancer. Journal of Cancer Research and Clinical Oncology 140:10, pages 1671-1680.
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Lorenz C Hofbauer, Tilman D Rachner, Robert E Coleman & Franz Jakob. (2014) Endocrine aspects of bone metastases. The Lancet Diabetes & Endocrinology 2:6, pages 500-512.
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E Terpos, D Christoulas, E Kastritis, M Roussou, M Migkou, E Eleutherakis-Papaiakovou, M Gavriatopoulou, M Gkotzamanidou, N Kanellias, E Manios, C Papadimitriou & M A Dimopoulos. (2013) VTD consolidation, without bisphosphonates, reduces bone resorption and is associated with a very low incidence of skeletal-related events in myeloma patients post ASCT. Leukemia 28:4, pages 928-934.
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Sakshi Sikka, Muthu K. Shanmugam, Radhamani Kannaiyan, Rohit Surana, Eun Myoung Shin, Alan Prem Kumar, Gautam Sethi & Kwang Seok Ahn. (2013) Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma. Phytochemistry Reviews 13:1, pages 79-106.
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Tilman D Rachner, Andy Göbel, Stefanie Thiele, Martina Rauner, Peggy Benad-Mehner, Peyman Hadji, Thomas Bauer, Michael H Muders, Gustavo B Baretton, Franz Jakob, Regina Ebert, Martin Bornhäuser, Christian Schem & Lorenz C Hofbauer. (2014) Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. Breast Cancer Research 16:1.
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Abdul HameedJennifer J. BradyPaul DowlingMartin ClynesPeter O'Gorman. (2014) Bone Disease in Multiple Myeloma: Pathophysiology and Management. Cancer Growth and Metastasis 7, pages CGM.S16817.
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Fuling Zhou, Shan Meng, Huanjin Song & François X. Claret. (2013) Dickkopf-1 is a key regulator of myeloma bone disease: Opportunities and challenges for therapeutic intervention. Blood Reviews 27:6, pages 261-267.
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Yi-Ming Tao, Zhen Liu & He-Li Liu. (2013) Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma. Digestive and Liver Disease 45:3, pages 251-257.
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Francesco Piazza, Sabrina Manni & Gianpietro Semenzato. (2013) Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3. Leukemia Research 37:2, pages 221-227.
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Saeid Abroun, Najmaldin Saki, Rahim Fakher & Farahnaz Asghari. (2012) Biology and Bioinformatics of Myeloma Cell. Laboratory Hematology 18:4, pages 30-41.
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Evangelos Terpos, Efstathios Kastritis & Meletios A. Dimopoulos. (2012) Prevention and Treatment of Myeloma Bone Disease. Current Hematologic Malignancy Reports 7:4, pages 249-257.
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Julie C. Baker-LePain & Nancy E. Lane. (2012) Role of bone architecture and anatomy in osteoarthritis. Bone 51:2, pages 197-203.
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Alfiya Akhmetshina, Katrin Palumbo, Clara Dees, Christina Bergmann, Paulius Venalis, Pawel Zerr, Angelika Horn, Trayana Kireva, Christian Beyer, Jochen Zwerina, Holm Schneider, Anika Sadowski, Marc-Oliver Riener, Ormond A. MacDougald, Oliver Distler, Georg Schett & Jörg H.W. Distler. (2012) Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nature Communications 3:1.
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Helmut Glantschnig, Kevin Scott, Richard Hampton, Nan Wei, Paul McCracken, Pascale Nantermet, Jing Z. Zhao, Salvatore Vitelli, Lingyi Huang, Peter Haytko, Ping Lu, John E. Fisher, Punam Sandhu, Jacquelynn Cook, Donald Williams, William Strohl, Osvaldo Flores, Donald Kimmel, Fubao Wang & Zhiqiang An. (2011) A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody. Journal of Pharmacology and Experimental Therapeutics 338:2, pages 568-578.
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Alexandra Filipovich, Iris Gehrke, Simon J. Poll-Wolbeck & Karl-Anton Kreuzer. (2011) Physiological inhibitors of Wnt signaling. European Journal of Haematology 86:6, pages 453-465.
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Evangelos TerposLia A. MoulopoulosMeletios A. Dimopoulos. (2011) Advances in Imaging and the Management of Myeloma Bone Disease. Journal of Clinical Oncology 29:14, pages 1907-1915.
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Michel Delforge, Evangelos Terpos, Paul G. Richardson, Ofer Shpilberg, Nuriet K. Khuageva, Rudolf Schlag, Meletios A. Dimopoulos, Martin Kropff, Ivan Spicka, Maria T. Petrucci, Olga S. Samoilova, Maria-Victoria Mateos, Hila Magen-Nativ, Hartmut Goldschmidt, Dixie-Lee Esseltine, Deborah S. Ricci, Kevin Liu, William Deraedt, Andrew Cakana, Helgi van de Velde & Jesús F. San Miguel. (2011) Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma. European Journal of Haematology 86:5, pages 372-384.
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F. Richard Bringhurst, Marie B. Demay & Henry M. Kronenberg. 2011. Williams Textbook of Endocrinology. Williams Textbook of Endocrinology 1237 1304 .
Xiaoyi Dun, Hua Jiang, Jianfeng Zou, Jun Shi, Lili Zhou, Rong Zhu & Jian Hou. (2010) Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma. Molecular Cancer 9:1.
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Sittisak Honsawek, Aree Tanavalee, Pongsak Yuktanandana, Srihatach Ngarmukos, Natthaphon Saetan & Saran Tantavisut. (2010) Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients. BMC Musculoskeletal Disorders 11:1.
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Helmut Glantschnig, Richard A. Hampton, Ping Lu, Jing Z. Zhao, Salvatore Vitelli, Lingyi Huang, Peter Haytko, Tara Cusick, Cheryl Ireland, Stephen W. Jarantow, Robin Ernst, Nan Wei, Pascale Nantermet, Kevin R. Scott, John E. Fisher, Fabio Talamo, Laura Orsatti, Alfred A. Reszka, Punam Sandhu, Donald Kimmel, Osvaldo Flores, William Strohl, Zhiqiang An & Fubao Wang. (2010) Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo. Journal of Biological Chemistry 285:51, pages 40135-40147.
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Julie C Baker-LePain & Nancy E Lane. (2010) Relationship between joint shape and the development of osteoarthritis. Current Opinion in Rheumatology 22:5, pages 538-543.
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Fu-ling Zhou, Shan Meng, Wang-gang Zhang, Yong-chang Wei, Xing-mei Cao, Gai-gai Bai & Bai-yan Wang. (2010) Peptide-based immunotherapy for multiple myeloma: Current approaches. Vaccine 28:37, pages 5939-5946.
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Stergios A. Polyzos, Athanasios D. Anastasilakis & Evangelos Terpos. (2009) Transient secondary hyperparathyroidism following intravenous infusion of zoledronic acid. Supportive Care in Cancer 17:10, pages 1329-1330.
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