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Original Research

A20 is overexpressed in glioma cells and may serve as a potential therapeutic target

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Pages 733-741 | Published online: 04 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Liping Li, Chao Qi, Yuanyuan Liu, Youliang Shen, Xia Zhao, Han Qin, Yi Zhang & Tengbo Yu. (2021) MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). Bioengineered 12:2, pages 9902-9913.
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Jin Ho Paik, Heounjeong Go, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim & Yoon Kyung Jeon. (2013) Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment. Leukemia & Lymphoma 54:9, pages 1934-1941.
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Zhenhua Li, Jang-Won Lee, Debraj Mukherjee, Jianfei Ji, Sunil P Jeswani, Keith L Black & John S Yu. (2012) Immunotherapy targeting glioma stem cells – insights and perspectives. Expert Opinion on Biological Therapy 12:2, pages 165-178.
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Articles from other publishers (24)

Yongyu Shi, Xinyu Wang, Jianing Wang, Xiaoyan Wang, Huaiyu Zhou & Lining Zhang. (2021) The dual roles of A20 in cancer. Cancer Letters 511, pages 26-35.
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Yagiz Alp Aksoy, Biyao Yang, Wenjie Chen, Tzongtyng Hung, Rhiannon P. Kuchel, Nathan W. Zammit, Shane T. Grey, Ewa M. Goldys & Wei Deng. (2020) Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System. ACS Applied Materials & Interfaces 12:47, pages 52433-52444.
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Jinyoung Park, Jinhong Cho & Eun Joo Song. (2020) Ubiquitin–proteasome system (UPS) as a target for anticancer treatment. Archives of Pharmacal Research 43:11, pages 1144-1161.
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Fernanda Wisnieski, Leonardo Caires Santos, Danielle Queiroz Calcagno, Jaqueline Cruz Geraldis, Carolina Oliveira Gigek, Ana Carolina Anauate, Elizabeth Suchi Chen, Lucas Trevizani Rasmussen, Spencer Luiz Marques Payão, Ricardo Artigiani, Samia Demachki, Paulo Pimentel Assumpção, Laercio Gomes Lourenço, Carlos Haruo Arasaki, Stephan Pabinger, Julie Krainer, Mariana Ferreira Leal, Rommel Rodriguez Burbano & Marilia Arruda Cardoso Smith. (2020) The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer. Journal of Molecular Medicine 98:5, pages 707-717.
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Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi & Diana Panayotova-Dimitrova. (2020) A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes. Cells 9:2, pages 351.
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Arne Martens & Geert van Loo. (2020) A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity. Cold Spring Harbor Perspectives in Biology 12:1, pages a036418.
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Peng Sheng Yi, Yan Shu, Wang Xiu Bi, Xiao Bo Zheng, Wan Jing Feng, Lin Ye He & Jian Shui Li. (2019) Emerging role of zinc finger protein A20 as a suppressor of hepatocellular carcinoma. Journal of Cellular Physiology 234:12, pages 21479-21484.
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Chang Ik Yoon, Sung Gwe Ahn, Soong June Bae, Yun Jin Shin, Chihwan Cha, So Eun Park, Ji-Hyung Lee, Akira Ooshima, Hye Sun Lee, Kyung-Min Yang, Seong-Jin Kim, Seok Hee Park & Joon Jeong. (2019) High A20 expression negatively impacts survival in patients with breast cancer. PLOS ONE 14:8, pages e0221721.
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Chuanzhen Yang, Weicheng Zang, Zefang Tang, Yapeng Ji, Ruidan Xu, Yongfeng Yang, Aiping Luo, Bin Hu, Zemin Zhang, Zhihua Liu & Xiaofeng Zheng. (2018) A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy. Cancer Research 78:4, pages 1069-1082.
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Ji-Hyung Lee, Su Myung Jung, Kyung-Min Yang, Eunjin Bae, Sung Gwe Ahn, Jin Seok Park, Dongyeob Seo, Minbeom Kim, Jihoon Ha, Jaewon Lee, Jun-Hyeong Kim, Jun Hwan Kim, Akira Ooshima, Jinah Park, Donghyuk Shin, Youn Sook Lee, Sangho Lee, Geert van Loo, Joon Jeong, Seong-Jin Kim & Seok Hee Park. (2017) A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1. Nature Cell Biology 19:10, pages 1260-1273.
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Wei-Lin Jin, Xiao-Yuan Mao & Guan-Zhong Qiu. (2017) Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges. Medicinal Research Reviews 37:3, pages 627-661.
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Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li & Hongyang Wang. (2015) A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression. Molecular Cancer 14:1.
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Yi Xu, Junyan Hu, Xu Wang, Li Xuan, Jing Lai, Ling Xu, Shaohua Chen, Lijian Yang, Gengxin Luo, Kanger Zhu, Xiuli Wu & Yangqiu Li. (2015) Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia. Cancer Cell International 15:1.
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Yimin Wang, Ming Wan, Qingxin Zhou, Hao Wang, Zhidong Wang, Xiangyu Zhong, Lei Zhang, Sheng Tai & Yunfu Cui. (2015) The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. PLOS ONE 10:10, pages e0141165.
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Shuying Chen, Haiyan Xing, Shouyun Li, Jing Yu, Huan Li, Shuang Liu, Zheng Tian, Kejing Tang, Qing Rao, Min Wang & Jianxiang Wang. (2015) Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells. Leukemia Research 39:9, pages 976-983.
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Asghar Abbasi, Kirsi Forsberg & Felix Bischof. (2015) The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes. Frontiers in Molecular Neuroscience 8.
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Nicolas Goffart, Matthias Dedobbeleer & Bernard Rogister. (2014) Glioblastoma stem cells: new insights in therapeutic strategies. Future Neurology 9:6, pages 639-653.
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Libing Song, Chuyong Lin, Hui Gong, Chanjuan Wang, Liping Liu, Jueheng Wu, Sha Tao, Bo Hu, Shi-Yuan Cheng, Mengfeng Li & Jun Li. (2012) miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops. Cell Research 23:2, pages 274-289.
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Qing Wang, Lijuan Yuan, Ziyu Liu, Jikai Yin, Xue Jiang & Jianguo Lu. (2012) Expression of A20 is reduced in pancreatic cancer tissues. Journal of Molecular Histology 43:3, pages 319-325.
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Edward W. Harhaj & Vishva M. Dixit. (2012) Regulation of NF-κB by deubiquitinases. Immunological Reviews 246:1, pages 107-124.
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Noula Shembade & Edward W Harhaj. (2012) Regulation of NF-κB signaling by the A20 deubiquitinase. Cellular & Molecular Immunology 9:2, pages 123-130.
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Bingfei Dong, Guoyue Lv, Quan Wang & Guangyi Wang. (2012) Targeting A20 enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications 418:2, pages 433-438.
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Philip Schmalz, Michael Shen & John Park. (2011) Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells. Cancers 3:1, pages 621-635.
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Anita B. Hjelmeland, Qiulian Wu, Sarah Wickman, Christine Eyler, John Heddleston, Qing Shi, Justin D. Lathia, Jennifer MacSwords, Jeongwu Lee, Roger E. McLendon & Jeremy N. Rich. (2010) Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. PLoS Biology 8:2, pages e1000319.
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