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Expert Opinion on Therapeutic Targets Volume 13, 2009 - Issue 12
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In vitro and in vivo biological activity of PEDF against a range of tumors

Matthew L Broadhead University of Melbourne, St. Vincent's Hospital, Department of Orthopaedics and Surgery, L3, Daly Wing, 35 Victoria Pde., Fitzroy 3065, VIC, Australia +61 3 9288 3990; +61 3 9416 3610; [email protected]
, Bsc (Med) MBBS,
Crispin R Dass University of Melbourne, St. Vincent's Hospital, Department of Orthopaedics and Surgery, L3, Daly Wing, 35 Victoria Pde., Fitzroy 3065, VIC, Australia +61 3 9288 3990; +61 3 9416 3610; [email protected]
, PhD &
Peter FM Choong University of Melbourne, St. Vincent's Hospital, Department of Orthopaedics and Surgery, L3, Daly Wing, 35 Victoria Pde., Fitzroy 3065, VIC, Australia +61 3 9288 3990; +61 3 9416 3610; [email protected]; Peter MacCallum Cancer Institute, Sarcoma Service, East Melbourne VIC, Australia
, MBBS MD FRACS FAOrthA
Pages 1429-1438 | Published online: 04 Oct 2009

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Behzad Shahbazi, Seyed Shahriar Arab, Ladan Mafakher, Kayhan Azadmansh & Ladan Teimoori-Toolabi. (2023) Computational assessment of pigment epithelium-derived factor as an anti-cancer protein during its interaction with the receptors. Journal of Biomolecular Structure and Dynamics 41:10, pages 4575-4591.
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Katrina B Manalo, Peter FM Choong, S Patricia Becerra & Crispin R Dass. (2011) Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective. Expert Opinion on Therapeutic Patents 21:2, pages 121-130.
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Articles from other publishers (28)

Yanze Li, Kai Xu, Ye Zhang, Hu Mao, Qiangmin Qiu, Zhiwei Yan, Xiuheng Liu, Yang Du & Zhiyuan Chen. (2023) Identification of a basement membrane-related genes signature with immune correlation in bladder urothelial carcinoma and verification in vitro. BMC Cancer 23:1.
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Xing-hui Li, Yan-di Wu, Tong-sheng Huang, Teng Wu, Xin-lu Fu, Jiang Qian, Yan Zou, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Hui-ting Zheng, Yuan-jun Ji & Wei-bin Cai. (2023) Expression Patterns and Functions of Cardiac Pigment Epithelium-Derived Factor During Cardiac Development. Cardiovascular Innovations and Applications 8:1.
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Yanjie Li, Hui Gao, Hongyan Dong, Weiwei Wang, Zhengqing Xu, Guozhang Wang, Yahui Liu, Haiyang Wang, Wen Ju, Jianlin Qiao, Kailin Xu, Chunling Fu & Lingyu Zeng. (2022) PEDF reduces malignant cells proliferation and inhibits the progression of myelofibrosis in myeloproliferative neoplasms. Biochemical Pharmacology 199, pages 115013.
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Yolanda Diego‐Otero, Rosa María Giráldez‐Pérez, Elena Lima‐Cabello, Raúl Heredia‐Farfan, Rocío Calvo Medina, Lourdes Sanchez‐Salido & Lucía Pérez Costillas. (2020) Pigment epithelium‐derived factor ( PEDF ) and PEDF‐receptor in the adult mouse brain: Differential spatial/temporal localization pattern . Journal of Comparative Neurology 529:1, pages 141-158.
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Da Ma, Lin Chen, Junhe Shi, Yan Zhao, Shruti Vasani, Kevin Chen, Bruna Romana‐Souza, Jack Henkin & Luisa A. DiPietro. (2020) Pigment epithelium‐derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars. Wound Repair and Regeneration 28:5, pages 684-695.
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Mia Baxter-Holland & Crispin R Dass. (2018) Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy. Journal of Pharmacy and Pharmacology 70:9, pages 1127-1138.
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Philip Newsholme, Kevin N. Keane, Mina Elahy & Vinicius Fernandes Cruzat. 2017. L-Arginine in Clinical Nutrition. L-Arginine in Clinical Nutrition 85 94 .
Alexander Emmert, Angelika Oellerich, Laszlo Füzesi, Regina Waldmann-Beushausen, Friedrich A. Schöndube, Hanibal Bohnenberger & Bernhard C. Danner. (2016) Prognostic Significance of Pigment Epithelium-Derived Factor Expression in Patients with Non-Small-Cell-Lung Cancer. Advances in Lung Cancer 05:03, pages 30-38.
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Mateusz S. Wietecha, Mateusz J. Król, Elizabeth R. Michalczyk, Lin Chen, Peter G. Gettins & Luisa A. DiPietro. (2015) Pigment epithelium-derived factor as a multifunctional regulator of wound healing. American Journal of Physiology-Heart and Circulatory Physiology 309:5, pages H812-H826.
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Guo Cheng, Ming Zhong, Riki Kawaguchi, Miki Kassai, Muayyad Al-Ubaidi, Jun Deng, Mariam Ter-Stepanian & Hui Sun. (2014) Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. eLife 3.
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Honghai Hong, Ti Zhou, Shuhuan Fang, Minghan Jia, Zumin Xu, Zhiyu Dai, Cen Li, Shuai Li, Lei Li, Ting Zhang, Weiwei Qi, Adham Sameer A. Bardeesi, Zhonghan Yang, Weibin Cai, Xia Yang & Guoquan Gao. (2014) Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Research and Treatment 148:1, pages 61-72.
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Lei Li, Ya-Chao Yao, Shu-Huan Fang, Cai-Qi Ma, Yi Cen, Zu-Min Xu, Zhi-Yu Dai, Cen Li, Shuai Li, Ting Zhang, Hong-Hai Hong, Wei-Wei Qi, Ti Zhou, Chao-Yang Li, Xia Yang & Guo-Quan Gao. (2014) Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation. Journal of Biological Chemistry 289:44, pages 30785-30799.
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Jin-Peng He, Yun Hao, Xiao-Lin Wang, Xiao-Jin Yang, Jing-Fan Shao, Feng-Jin Guo & Jie-Xiong Feng. (2014) Review of the Molecular Pathogenesis of Osteosarcoma. Asian Pacific Journal of Cancer Prevention 15:15, pages 5967-5976.
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SHA-SHA HE, QIN-JIE WU, CHANG YANG GONG, SHUN-TAO LUO, SHUANG ZHANG, MENG LI, LIAN LU, YU-QUAN WEI & LI YANG. (2014) Enhanced efficacy of combination therapy with adeno-associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. Molecular Medicine Reports 9:6, pages 2069-2076.
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Maria Demestre, Menderes Yusuf Terzi, Victor Mautner, Peter Vajkoczy, Andreas Kurtz & Ana Luisa Piña. (2013) Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs). Journal of Neuro-Oncology 115:3, pages 391-399.
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Hee-Young Yang, Joseph Kwon, Min-Suk Kook, Seong Soo Kang, Se Eun Kim, Sungoh Sohn, Seunggon Jung, Sang-Oh Kwon, Hyung-Seok Kim, Jae Hyuk Lee & Tae-Hoon Lee. (2013) Proteomic Analysis of Gingival Tissue and Alveolar Bone during Alveolar Bone Healing. Molecular & Cellular Proteomics 12:10, pages 2674-2688.
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Guofang Fu, Xuan Che, Yanmei Sun, Xiufeng Huang, Hong Xu, Caiyun Zhou & Xinmei Zhang. (2013) Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis. Acta Histochemica 115:4, pages 301-307.
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Jacob E. Koskimaki, Elena V. Rosca, Corban G. Rivera, Esak Lee, William Chen, Niranjan B. Pandey & Aleksander S. Popel. (2012) Serpin-Derived Peptides Are Antiangiogenic and Suppress Breast Tumor Xenograft Growth. Translational Oncology 5:2, pages 92-97.
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Asunción Fernández-Barral, José Luis Orgaz, Valentí Gomez, Luis del Peso, María José Calzada & Benilde Jiménez. (2012) Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism. PLoS ONE 7:3, pages e32989.
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Liqing Chen, Ruijia Fan, Xiufeng Huang, Hong Xu & Xinmei Zhang. (2012) Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis. Reproductive Sciences 19:1, pages 64-69.
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Vijay Chandolu & Crispin R. Dass. (2012) Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular. Journal of Biomedicine and Biotechnology 2012, pages 1-9.
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P. Subramanian, M. Deshpande, S. Locatelli-Hoops, S. Moghaddam-Taaheri, D. Gutierrez, D. P. Fitzgerald, S. Guerrier, M. Rapp, V. Notario & S. P. Becerra. (2012) Identification of Pigment Epithelium-Derived Factor Protein Forms with Distinct Activities on Tumor Cell Lines. Journal of Biomedicine and Biotechnology 2012, pages 1-12.
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Mina Elahy, Swati Baindur-Hudson & Crispin R. Dass. (2012) The Emerging Role of PEDF in Stem Cell Biology. Journal of Biomedicine and Biotechnology 2012, pages 1-6.
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Matthew L. Broadhead, Peter F. M. Choong & Crispin R. Dass. (2012) Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and Metastasis. Journal of Biomedicine and Biotechnology 2012, pages 1-10.
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M L Broadhead, C R Dass & P F M Choong. (2011) Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model. British Journal of Cancer 105:10, pages 1503-1511.
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Liqing Chen, Ruijia Fan, Xiufeng Huang, Hong Xu & Xinmei Zhang. (2011) Decreased concentrations of pigment epithelium–derived factor in peritoneal fluid of patients with endometriosis. Fertility and Sterility 95:5, pages 1798-1800.
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Katrina B. Manalo, Peter F.M. Choong & Crispin R. Dass. (2011) Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis. Molecular Carcinogenesis 50:2, pages 67-72.
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Preeti Subramanian, Susan E. Crawford & S. Patricia Becerra. 2011. Biology of Serpins. Biology of Serpins 183 204 .

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