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Review

Targeting the bradykinin B1 receptor to reduce pain

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Pages 21-35 | Published online: 07 Dec 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Éva Bozó, János Éles & György M Keserű. (2012) Bradykinin B1 receptor antagonists: a patent update 2009 – 2012. Expert Opinion on Therapeutic Patents 22:12, pages 1443-1452.
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Christopher I Fincham, Alessandro Bressan, Marielle Paris, Cristina Rossi & Daniela Fattori. (2009) Bradykinin receptor antagonists – a review of the patent literature 2005 – 2008. Expert Opinion on Therapeutic Patents 19:7, pages 919-941.
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Mariia A. Slepukhina, Dmitriy V. Ivashchenko, Maria A. Sheina, Andranik Alexandrovich Muradian, Dmitriy Alexeevich Blagovestnov & Dmitriy A. Sychev. (2020) Pain pharmacogenetics. Drug Metabolism and Drug Interactions 35:3.
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Damien P. Kuffler. (2019) Mechanisms for Reducing Neuropathic Pain. Molecular Neurobiology 57:1, pages 67-87.
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Elena I. Fedoros, Alexey A. Orlov, Alexander Zherebker, Ekaterina A. Gubareva, Mikhail A. Maydin, Andrey I. Konstantinov, Konstantin A. Krasnov, Ruben N. Karapetian, Ekaterina I. Izotova, Sergey E. Pigarev, Andrey V. Panchenko, Margarita L. Tyndyk, Dmitry I. Osolodkin, Evgeny N. Nikolaev, Irina V. Perminova & Vladimir N. Anisimov. (2018) Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets in silico and in vitro . Oncotarget 9:26, pages 18578-18593.
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A. KÁDKOVÁ, V. SYNYTSYA, J. KRUSEK, L. ZÍMOVÁ & V. VLACHOVÁ. (2017) Molecular Basis of TRPA1 Regulation in Nociceptive Neurons. A Review. Physiological Research, pages 425-439.
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B. A. Duclos, C. A. Rugg, J. White, J. T. Ross, M. Darling, D. Huczek, J. Curry, S. Alexander-Bowman, A. Townley, D. Garcia-Tapia, C. Chio & S. Kamerling. (2017) Pharmacological evaluation of a selective bradykinin B 1 antagonist in a canine model of arthritis . Journal of Veterinary Pharmacology and Therapeutics 40:1, pages 70-76.
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Cecylia S. Lupala, Patricia Gomez-Gutierrez & Juan J. Perez. (2016) New insights into the stereochemical requirements of the bradykinin B1 receptor antagonists binding. Journal of Molecular Graphics and Modelling 68, pages 184-196.
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Noemí Vila, Pedro Besada, Tamara Costas, Mª Carmen Costas-Lago & Carmen Terán. (2015) Phthalazin-1(2H)-one as a remarkable scaffold in drug discovery. European Journal of Medicinal Chemistry 97, pages 462-482.
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Mathias Hallberg. (2015) Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors. Medicinal Research Reviews 35:3, pages 464-519.
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N. Schuelert, S. Just, L. Corradini, R. Kuelzer, C. Bernloehr & H. Doods. (2014) The bradykinin B 1 receptor antagonist BI 113823 reverses inflammatory hyperalgesia by desensitization of peripheral and spinal neurons . European Journal of Pain 19:1, pages 132-142.
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Lok-Hi Chow, Pao-Luh Tao, Jin-Chung Chen, Ruey-Ming Liao, En-Pei Chang & Eagle Yi-Kung Huang. (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides 39, pages 21-28.
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Wenyuan Qian, Jian Jeffrey Chen, Jason Human, Toshihiro Aya, Jiawang Zhu, Kaustav Biswas, Tanya Peterkin, Randall W. Hungate, Leyla Arik, Eileen Johnson, Gondi Kumar, Smriti Joseph, Janan Jona, Hong-Xun Guo & Zufan Wu. (2012) Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency. Bioorganic & Medicinal Chemistry Letters 22:2, pages 1061-1067.
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Marian C. Bryan, Kaustav Biswas, Tanya A.N. Peterkin, Robert M. Rzasa, Leyla Arik, Sonya G. Lehto, Hong Sun, Feng-Yin Hsieh, Cen Xu, Robert T. Fremeau & Jennifer R. Allen. (2012) Chromenones as potent bradykinin B1 antagonists. Bioorganic & Medicinal Chemistry Letters 22:1, pages 619-622.
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Kaustav Biswas, Tanya A. N. Peterkin, Marian C. Bryan, Leyla Arik, Sonya G. Lehto, Hong Sun, Feng-Yin Hsieh, Cen Xu, Robert T. Fremeau & Jennifer R. Allen. (2011) Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists. Journal of Medicinal Chemistry 54:20, pages 7232-7246.
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Jian Jeffrey Chen, Thomas Nguyen, Derin C. D’Amico, Wenyuan Qian, Jason Human, Toshihiro Aya, Kaustav Biswas, Christopher Fotsch, Nianhe Han, Qingyian Liu, Nobuko Nishimura, Tanya A.N. Peterkin, Kevin Yang, Jiawang Zhu, Babak Bobby Riahi, Randall W. Hungate, Neil G. Andersen, John T. Colyer, Margaret M. Faul, Augustus Kamassah, Judy Wang, Janan Jona, Gondi Kumar, Eileen Johnson & Benny C. Askew. (2011) 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. Bioorganic & Medicinal Chemistry Letters 21:11, pages 3384-3389.
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Steven C. Leiser, John Dunlop, Mark R. Bowlby & David M. Devilbiss. (2011) Aligning strategies for using EEG as a surrogate biomarker: A review of preclinical and clinical research. Biochemical Pharmacology 81:12, pages 1408-1421.
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Ernest M. Hoffman & Kenneth E. Miller. (2010) Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat. Neuroscience Letters 472:3, pages 157-160.
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Irina Vetter & Richard J. Lewis. (2010) Characterization of endogenous calcium responses in neuronal cell lines. Biochemical Pharmacology 79:6, pages 908-920.
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Wei-Hung Yang, Jung-Tzu Chang, Sheng-Feng Hsu, Te-Mao Li, Der-Yang Cho, Chun-Yin Huang, Yi-Chin Fong & Chih-Hsin Tang. (2009) Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathways. Journal of Cellular Biochemistry, pages n/a-n/a.
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Artur Gieldon, Jakob J. Lopez, Clemens Glaubitz & Harald Schwalbe. (2008) Theoretical Study of the Human Bradykinin-Bradykinin B2 Receptor Complex. ChemBioChem 9:15, pages 2487-2497.
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Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Vellarkad N. Viswanadhan, Benny C. Askew, Stephen Hitchcock, Randall W. Hungate, Leyla Arik & Eileen Johnson. (2008) Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4477-4481.
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Emad E. Ayesh, Troels S. Jensen & Peter Svensson. (2008) Effects of intra-articular ketamine on pain and somatosensory function in temporomandibular joint arthralgia patients. Pain 137:2, pages 286-294.
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Jakob J. Lopez, Arun K. Shukla, Christoph Reinhart, Harald Schwalbe, Hartmut Michel & Clemens Glaubitz. (2008) The Structure of the Neuropeptide Bradykinin Bound to the Human G‐Protein Coupled Receptor Bradykinin B2 as Determined by Solid‐State NMR Spectroscopy. Angewandte Chemie International Edition 47:9, pages 1668-1671.
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Jakob J. Lopez, Arun K. Shukla, Christoph Reinhart, Harald Schwalbe, Hartmut Michel & Clemens Glaubitz. (2008) The Structure of the Neuropeptide Bradykinin Bound to the Human G‐Protein Coupled Receptor Bradykinin B2 as Determined by Solid‐State NMR Spectroscopy. Angewandte Chemie 120:9, pages 1692-1695.
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Shi-Jie Yang, Makoto Katori & Masataka Majima. (2008) A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats. Journal of Pharmacological Sciences 106:2, pages 249-256.
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Michael R. Wood, Kathy M. Schirripa, June J. Kim, Scott D. Kuduk, Ronald K. Chang, Christina N. Di Marco, Robert M. DiPardo, Bang-Lin Wan, Kathy L. Murphy, Richard W. Ransom, Raymond S.L. Chang, Marie A. Holahan, Jacquelynn J. Cook, Wei Lemaire, Scott D. Mosser, Rodney A. Bednar, Cuyue Tang, Thomayant Prueksaritanont, Audrey A. Wallace, Qin Mei, Jian Yu, Dennis L. Bohn, Frank C. Clayton, Emily D. Adarayn, Gary R. Sitko, Yvonne M. Leonard, Roger M. Freidinger, Douglas J. Pettibone & Mark G. Bock. (2008) ?-Hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorganic & Medicinal Chemistry Letters 18:2, pages 716-720.
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Jian Jeffrey Chen & Kaustav Biswas. 2008. Progress in Medicinal Chemistry Volume 46. Progress in Medicinal Chemistry Volume 46 173 204 .

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