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Review

Targeting Nur77 translocation

Pages 69-79 | Published online: 07 Dec 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Ju-Ha Kim, Hyemin Lee, Eun Ah Shin, Dong Hee Kim, Jhin Baek Choi & Sung-Hoon Kim. (2017) Implications of Bcl-2 and its interplay with other molecules and signaling pathways in prostate cancer progression. Expert Opinion on Therapeutic Targets 21:9, pages 911-920.
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Erik Hedrick, Syng-Ook Lee, Ravi Doddapaneni, Mandip Singh & Stephen Safe. (2016) NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Molecular and Cellular Biology 36:9, pages 1383-1394.
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Sally KY To, Jin-Zhang Zeng & Alice ST Wong. (2012) Nur77: a potential therapeutic target in cancer. Expert Opinion on Therapeutic Targets 16:6, pages 573-585.
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Syng-Ook Lee, Xi Li, Shaheen Khan & Stephen Safe. (2011) Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion on Therapeutic Targets 15:2, pages 195-206.
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Andrea Schweitzer, Shirley K Knauer & Roland H Stauber. (2008) Therapeutic potential of nuclear receptors. Expert Opinion on Therapeutic Patents 18:8, pages 861-888.
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Muding Li, Yingyun Hu, Hao Zhou & Yundai Chen. (2023) NR4A1 Aggravates Myocardial Ischaemia–Reperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion. Journal of Cardiovascular Translational Research 16:5, pages 1050-1063.
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Ting Niu, Zhiying Wei, Jiao Fu, Shu Chen, Ru Wang, Yuya Wang & Ruihe Zheng. (2023) Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway. Frontiers in Pharmacology 13.
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Hyo-Seon Lee, Stephen Safe & Syng-Ook Lee. (2017) Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicology and Applied Pharmacology 332, pages 32-39.
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Xiu-Ming Li, Tian-Yu Yang, Xiao-Shun He, Jing-Ru Wang, Wen-Juan Gan, Shen Zhang, Jian-Ming Li & Hua Wu. (2017) Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20. Oncotarget 8:37, pages 61025-61035.
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Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li & Hua Wu. (2016) Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice. Journal of Inflammation 13:1.
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Peng-Da Guo, Xing-Xing Lu, Wen-Juan Gan, Xiu-Ming Li, Xiao-Shun He, Shen Zhang, Qing-Hua Ji, Feng Zhou, Yue Cao, Jing-Ru Wang, Jian-Ming Li & Hua Wu. (2016) RARγ Downregulation Contributes to Colorectal Tumorigenesis and Metastasis by Derepressing the Hippo–Yap Pathway. Cancer Research 76:13, pages 3813-3825.
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Erik Hedrick, Syng-Ook Lee, Gyungeun Kim, Maen Abdelrahim, Un-Ho Jin, Stephen Safe & Ala Abudayyeh. (2015) Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLOS ONE 10:6, pages e0128308.
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Syng-Ook LeeXi Li, Erik HedrickUn-Ho JinRonald B. TjalkensDonald S. BackosLi Li, Yi Zhang, Qiao Wu & Stephen Safe. (2014) Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells. Molecular Endocrinology 28:10, pages 1729-1739.
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Syng-Ook Lee, Un-Ho Jin, Jeong Han Kang, Sang Bae Kim, Aaron S. Guthrie, Sandeep Sreevalsan, Ju-Seog Lee & Stephen Safe. (2014) The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells. Molecular Cancer Research 12:4, pages 527-538.
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