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Review

Osteopontin: an emerging therapeutic target for anticancer therapy

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Pages 81-90 | Published online: 07 Dec 2006

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Monalisa Bandopadhyay, Anuradha Bulbule, Ramesh Butti, Goutam Chakraborty, Priyanka Ghorpade, Pompom Ghosh, Mahadeo Gorain, Smita Kale, Dhiraj Kumar, Santosh Kumar, Kumar VS Totakura, Gaurab Roy, Priyanka Sharma, Dattatrya Shetti, Gowrishankar Soundararajan, Dhanashri Thorat, Deepti Tomar, Radha Nalukurthi, Remya Raja, Rosalin Mishra, Amit S Yadav & Gopal C Kundu. (2014) Osteopontin as a therapeutic target for cancer. Expert Opinion on Therapeutic Targets 18:8, pages 883-895.
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Mansoor Ahmed, Reeti Behera, Goutam Chakraborty, Shalini Jain, Vinit Kumar, Priyanka Sharma, Anuradha Bulbule, Smita Kale, Santosh Kumar, Rosalin Mishra, Remya Raja, Supriya Saraswati, Rajinder Kaur, Gowrishankar Soundararajan, Dhiraj Kumar, Dhanashri Thorat, Megha Sanyal, Anuja Ramdasi, Pompom Ghosh & Gopal C Kundu. (2011) Osteopontin: a potentially important therapeutic target in cancer. Expert Opinion on Therapeutic Targets 15:9, pages 1113-1126.
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Kumiko Sekiguchi, Akihisa Matsuda, Marina Yamada, Satoshi Matsumoto, Nobuyuki Sakurazawa, Youichi Kawano, Takeshi Yamada, Masao Miyashita & Hiroshi Yoshida. (2022) The utility of serum osteopontin levels for predicting postoperative complications after colorectal cancer surgery. International Journal of Clinical Oncology 27:11, pages 1706-1716.
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Eunji Im, Changhwan Yeo & Eun-Ok Lee. (2018) Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells. Life Sciences 209, pages 259-266.
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Xia Jin, Hua Xu & Michael S. McGrath. (2018) Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes. PLOS ONE 13:3, pages e0192680.
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Akash Sabarwal, Kunal Kumar, Ritis Shyanti & Rana P. Singh. 2018. Functional Food and Human Health. Functional Food and Human Health 329 374 .
Anna De Filippis, Elisabetta Buommino, Marina Di Domenico, Antonia Feola, Raffaella Brunetti-Pierri & Antonietta Rizzo. (2017) Chlamydia trachomatis induces an upregulation of molecular biomarkers podoplanin, Wilms’ tumour gene 1, osteopontin and inflammatory cytokines in human mesothelial cells. Microbiology 163:5, pages 654-663.
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Chi Gu Kang, Eunji Im, Hyo-Jeong Lee & Eun-Ok Lee. (2017) Plumbagin reduces osteopontin-induced invasion through inhibiting the Rho-associated kinase signaling pathway in A549 cells and suppresses osteopontin-induced lung metastasis in BalB/c mice. Bioorganic & Medicinal Chemistry Letters 27:9, pages 1914-1918.
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Chi Gu Kang, Hyo-Jeong Lee, Sung-Hoon Kim & Eun-Ok Lee. (2015) Zerumbone Suppresses Osteopontin-Induced Cell Invasion Through Inhibiting the FAK/AKT/ROCK Pathway in Human Non-Small Cell Lung Cancer A549 Cells. Journal of Natural Products 79:1, pages 156-160.
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Jules Lin, Amy L. Myers, Zhuwen Wang, Derek J. Nancarrow, Daysha Ferrer-Torres, Amy Handlogten, Kimmy Leverenz, Julia Bao, Dafydd G. Thomas, Thomas D. Wang, Mark B. Orringer, Rishindra M. Reddy, Andrew C. Chang, David G. Beer & Lin Lin. (2015) Osteopontin (OPN/ SPP1 ) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma . Oncotarget 6:26, pages 22239-22257.
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Courtney Schaal, Jaya Padmanabhan & Srikumar Chellappan. (2015) The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression. Cancers 7:3, pages 1447-1471.
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Chi Gu Kang, Hwa Jeong Han, Hyo-Jeong Lee, Sung-Hoon Kim & Eun-Ok Lee. (2015) Rho-associated kinase signaling is required for osteopontin-induced cell invasion through inactivating cofilin in human non-small cell lung cancer cell lines. Bioorganic & Medicinal Chemistry Letters 25:9, pages 1956-1960.
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I-Shan Hsieh, Rong-Sen Yang & Wen-Mei Fu. (2014) Osteopontin Upregulates the Expression of Glucose Transporters in Osteosarcoma Cells. PLoS ONE 9:10, pages e109550.
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J. N. Kornegay, C. F. Spurney, P. P. Nghiem, C. L. Brinkmeyer-Langford, E. P. Hoffman & K. Nagaraju. (2014) Pharmacologic Management of Duchenne Muscular Dystrophy: Target Identification and Preclinical Trials. ILAR Journal 55:1, pages 119-149.
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Samapika Routray, Supriya M. Kheur & Mohit Kheur. (2013) Osteopontin: a marker for invasive oral squamous cell carcinoma but not for potentially malignant epithelial dysplasias. Annals of Diagnostic Pathology 17:5, pages 421-424.
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Santosh Kumar, Priyanka Sharma, Dhiraj Kumar, Goutam Chakraborty, Mahadeo Gorain & Gopal C. Kundu. (2013) Functional Characterization of Stromal Osteopontin in Melanoma Progression and Metastasis. PLoS ONE 8:7, pages e69116.
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Masaaki Niino & Seiji Kikuchi. (2011) Osteopontin and multiple sclerosis: An update. Clinical and Experimental Neuroimmunology 2:2, pages 33-40.
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Rong-Xin Chen, Yun-Hong Xia, Tong-Chun Xue & Sheng-Long Ye. (2010) Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression. Journal of Experimental & Clinical Cancer Research 29:1.
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Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter W?rl, Helge Taubert & Dirk Vordermark. (2010) Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients. BMC Cancer 10:1.
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Sander R. Piersma, Ulrike Fiedler, Simone Span, Andreas Lingnau, Thang V. Pham, Steffen Hoffmann, Michael H. G. Kubbutat & Connie R. Jiménez. (2010) Workflow Comparison for Label-Free, Quantitative Secretome Proteomics for Cancer Biomarker Discovery: Method Evaluation, Differential Analysis, and Verification in Serum. Journal of Proteome Research 9:4, pages 1913-1922.
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Xu Tao, Chen Juxiang, Lu Yicheng, Zhou Jinxu, Yan Yong, Hu Guohan, Luo Chun & Huang Yan. (2010) Lentiviral-mediated siRNA against osteopotin in U251 glioma cell line. Journal of Medical Colleges of PLA 25:1, pages 1-10.
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Hafiz Ahmed, Francesco Cappello, Vito Rodolico & Gerardo R. Vasta. (2009) Evidence of Heavy Methylation in the Galectin 3 Promoter in Early Stages of Prostate Adenocarcinoma: Development and Validation of a Methylated Marker for Early Diagnosis of Prostate Cancer. Translational Oncology 2:3, pages 146-156.
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Galina Chipitsyna, Qiaoke Gong, Rathai Anandanadesan, Amer Alnajar, Surinder K. Batra, Uwe A. Wittel, Diane M. Cullen, Mohammed P. Akhter, David T. Denhardt, Charles J. Yeo & Hwyda A. Arafat. (2009) Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. International Journal of Cancer 125:2, pages 276-285.
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Laura Paleari, Nicola Rotolo, Andrea Imperatori, Roberto Puzone, Fausto Sessa, Francesca Franzi, Elisa Meacci, Pierpaolo Camplese, Alfredo Cesario & Michela Paganuzzi. (2018) Osteopontin is not a Specific Marker in Malignant Pleural Mesothelioma. The International Journal of Biological Markers 24:2, pages 112-117.
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Charlotte Anderberg, Hong Li, Linda Fredriksson, Johanna Andrae, Christer Betsholtz, Xuri Li, Ulf Eriksson & Kristian Pietras. (2009) Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts. Cancer Research 69:1, pages 369-378.
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Alicia Plumer, Hongyi Duan, Sripriya Subramaniam, F Lee Lucas, Susan Miesfeldt, Ah-Kau Ng & Lucy Liaw. (2008) Development of fragment-specific osteopontin antibodies and ELISA for quantification in human metastatic breast cancer. BMC Cancer 8:1.
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Misa Imai, Miho Muraki, Kiyoshi Takamatsu, Hidekazu Saito, Motoharu Seiki & Yuji Takahashi. (2008) Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line. BMC Cancer 8:1.
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Goutam Chakraborty, Shalini Jain, Tushar V. Patil & Gopal C. Kundu. (2008) Down-regulation of osteopontin attenuates breast tumour progression in vivo . Journal of Cellular and Molecular Medicine 12:6a, pages 2305-2318.
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Erika B. Schulze, Benjamin D. Hedley, David Goodale, Carl O. Postenka, Waleed Al-Katib, Alan B. Tuck, Ann F. Chambers & Alison L. Allan. (2007) The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. Breast Cancer Research and Treatment 112:2, pages 243-254.
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Guo-Hua Fong. (2008) Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis 11:2, pages 121-140.
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Goutam Chakraborty, Shalini Jain & Gopal C. Kundu. (2008) Osteopontin Promotes Vascular Endothelial Growth Factor–Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms. Cancer Research 68:1, pages 152-161.
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Alan B. Tuck, Ann F. Chambers & Alison L. Allan. (2007) Osteopontin overexpression in breast cancer: Knowledge gained and possible implications for clinical management. Journal of Cellular Biochemistry 102:4, pages 859-868.
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Ni Dai, Quan Bao, Aiping Lu & Jiyou Li. (2007) Protein Expression of Osteopontin in Tumor Tissues Is an Independent Prognostic Indicator in Gastric Cancer. Oncology 72:1-2, pages 89-96.
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Vipin Kumar & Namakkal G. Ramesh. (2007) A versatile strategy for the synthesis of N-linked glycoamino acids from glycals. Organic & Biomolecular Chemistry 5:23, pages 3847.
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