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Metalloproteases as potential therapeutic targets in arthritis treatment

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Pages 1-18 | Published online: 13 Dec 2007

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Mohammad Amjad Hossain, Aravinthan Adithan, Md Jahangir Alam, Spandana Rajendra Kopalli, Bumseok Kim, Chang-Won Kang, Ki-Chul Hwang & Jong-Hoon Kim. (2021) IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis. Journal of Inflammation Research 14, pages 3555-3568.
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Edward A Lin & Chuan-ju Liu. (2009) The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases. Open Access Rheumatology: Research and Reviews 1, pages 121-131.
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Qi Jiang & Shufang Zhang. (2023) Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy. Small 19:23.
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Dan Liu, Xingxing Li, Lin Zhang, Bin Hu, Sang Hu, Xiao Zhang & Jing Hu. (2023) Small molecule inhibitors of osteoarthritis: Current development and future perspective. Frontiers in Physiology 14.
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Zhanghao Gu, Jiayi Wang, Yu Fu, Hao Pan, Hongyan He, Qi Gan & Changsheng Liu. (2023) Smart Biomaterials for Articular Cartilage Repair and Regeneration. Advanced Functional Materials 33:10.
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Azza M. Elamir, Amr Zahra, Soha H. Senara, Eman M. Ezzat & Hassan S. El Sayed. (2023) Diagnostic value of matrix metalloproteinases-1, −3 and −13 in patients with primary knee osteoarthritis: Relation to radiological severity. The Egyptian Rheumatologist 45:1, pages 17-20.
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Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang & Zongsheng Yin. (2022) 3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy. Frontiers in Pharmacology 13.
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A. I. Matyushkin, E. A. Ivanova & T. A. Voronina. (2022) New Directions in the Development of Pharmacotherapy for Osteoarthrosis Based on Modern Concepts of the Disease Pathogenesis (A Review). Pharmaceutical Chemistry Journal 55:12, pages 1282-1287.
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Qichan Hu & Melanie Ecker. (2021) Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. International Journal of Molecular Sciences 22:4, pages 1742.
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Xiaohan Zhang, Jun Yao, Zhengyuan Wu, Kai Zou, Zhenyi Yang, Xing Huang, Zhiwei Luan, Jia Li & Qingjun Wei. (2020) Chondroprotective and antiarthritic effects of Daphnetin used in vitro and in vivo osteoarthritis models. Life Sciences 240, pages 116857.
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David A. Young, Matt J. Barter & David J. Wilkinson. (2019) Recent advances in understanding the regulation of metalloproteinases. F1000Research 8, pages 195.
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David J Wilkinson, Maria del Carmen Arques, Carmen Huesa & Andrew D Rowan. (2018) Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics. British Journal of Pharmacology 176:1, pages 38-51.
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Thomas Fischer & Rainer Riedl. (2017) Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor. Molecules 22:9, pages 1548.
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Chun Ming Chan, Christopher D. Macdonald, Gary J. Litherland, David J. Wilkinson, Andrew Skelton, G. Nicholas Europe-Finner & Andrew D. Rowan. (2017) Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation. Journal of Biological Chemistry 292:5, pages 1625-1636.
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Zhenhui Lu, Huayu Wu, Xiao Lin, Buming Liu, Cuiwu Lin, Li Zheng & Jinmin Zhao. (2016) Chondro-Protective and Antiarthritic Effects of Sulfonamido-Based Gallate–ZXHA-TC in Vitro and in Vivo . ACS Chemical Biology 11:6, pages 1613-1623.
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Thomas Fischer & Rainer Riedl. (2016) Molecular Recognition of the Catalytic Zinc(II) Ion in MMP-13: Structure-Based Evolution of an Allosteric Inhibitor to Dual Binding Mode Inhibitors with Improved Lipophilic Ligand Efficiencies. International Journal of Molecular Sciences 17:3, pages 314.
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Jianlu Wei, Brendon Richbourgh, Tanghong Jia & Chuanju Liu. (2014) ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation. Mediators of Inflammation 2014, pages 1-12.
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