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Expert Opinion on Therapeutic Targets Volume 12, 2008 - Issue 11
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Toll-like receptor modulation: A novel therapeutic strategy in cardiovascular disease?

Athanasios Katsargyris National and Kapodistrian University of Athens, School of Medicine, ‘LAIKON’ Hospital, Vascular Division, 1st Department of Surgery, 75, Mikras Asias street, Goudi, 11527 Athens, Greece; National and Kapodistrian University of Athens, School of Medicine, Department of Forensic Medicine and Toxicology, Athens, Greece +30 210 7462413; +30 210 7716098; [email protected]
,
Chris Klonaris National and Kapodistrian University of Athens, School of Medicine, ‘LAIKON’ Hospital, Vascular Division, 1st Department of Surgery, 75, Mikras Asias street, Goudi, 11527 Athens, Greece
,
Elias Bastounis National and Kapodistrian University of Athens, School of Medicine, ‘LAIKON’ Hospital, Vascular Division, 1st Department of Surgery, 75, Mikras Asias street, Goudi, 11527 Athens, Greece
&
Stamatios Theocharis National and Kapodistrian University of Athens, School of Medicine, Department of Forensic Medicine and Toxicology, Athens, Greece +30 210 7462413; +30 210 7716098; [email protected]
Pages 1329-1346 | Published online: 14 Oct 2008

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Ioanna Vasileiou, Georgia Kostopanagiotou, Athanasios Katsargyris, Chris Klonaris, Despina Perrea & Stamatios Theocharis. (2010) Toll-like receptors: a novel target for therapeutic intervention in intestinal and hepatic ischemia–reperfusion injury?. Expert Opinion on Therapeutic Targets 14:8, pages 839-853.
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Athanasios Katsargyris, Stamatios E Theocharis, Sotirios Tsiodras, Konstantinos Giaginis, Elias Bastounis & Chris Klonaris. (2010) Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques. Expert Opinion on Therapeutic Targets 14:1, pages 1-10.
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Articles from other publishers (18)

Di-Di Tao, Ya Li, Xiao-Jiao Tian, Xing-Juan Liao, Zhong-Qin Yu & Zhao-Yan Xiang. (2023) Effect of FoxO1 on Cardiomyocyte Apoptosis and Inflammation in Viral Myocarditis <i>via</i> Modultion of the TLR4/NF-κB Signaling Pathway. International Heart Journal 64:4, pages 732-740.
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Melika Shafeghat, Sina Kazemian, Arya Aminorroaya, Zahra Aryan & Nima Rezaei. (2022) Toll-like receptor 7 regulates cardiovascular diseases. International Immunopharmacology 113, pages 109390.
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Iván Parra-Izquierdo, Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Jiaqing Pang, Tony J. Zheng, Kelley R. Jordan, Stéphanie E. Reitsma, Owen J. T. McCarty & Joseph E. Aslan. (2021) The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Frontiers in Immunology 12.
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Fatemeh Khoshkhouy, Alieh Farshbaf, Maryam Mahmoudabady & Zahra Gholamnezhad. (2021) Effects of moderate exercise on lipopolysaccharide-induced inflammatory responses in rat's cardiac tissue. Cytokine 138, pages 155409.
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Baiyang Sun, Yanfeng Shi, Xiaozhe Yang, Tong Zhao, Junchao Duan & Zhiwei Sun. (2018) DNA methylation: A critical epigenetic mechanism underlying the detrimental effects of airborne particulate matter. Ecotoxicology and Environmental Safety 161, pages 173-183.
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Marieke Rienks, Anna Papageorgiou, Kristiaan Wouters, Wouter Verhesen, Rick van Leeuwen, Paolo Carai, Georg Summer, Dirk Westermann & Stephane Heymans. (2016) A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis. Cellular and Molecular Life Sciences 74:8, pages 1511-1525.
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Haleh Vaez, Maryam Rameshrad, Moslem Najafi, Jaleh Barar, Abolfazl Barzegari & Alireza Garjani. (2016) Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart. European Journal of Pharmacology 772, pages 115-123.
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Emina Vorkapic, Anna M. Lundberg, Mikko I. M?yr?np??Per Eriksson & Dick W?gs?ter. (2015) TRIF adaptor signaling is important in abdominal aortic aneurysm formation. Atherosclerosis 241:2, pages 561-568.
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Shengbo Pan, Lang Lei, Shuai Chen, Houxuan Li & Fuhua Yan. (2014) Rosiglitazone impedes Porphyromonas gingivalis-accelerated atherosclerosis by downregulating the TLR/NF-?B signaling pathway in atherosclerotic mice. International Immunopharmacology 23:2, pages 701-708.
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Dehua Jiang, Dongye Li, Lijuan Cao, Lele Wang, Shasha Zhu, Tongda Xu, Cheng Wang & Defeng Pan. (2014) Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway. PLoS ONE 9:3, pages e92398.
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Yu. V. Bobryshev, V. P. Karagodin & A. N. Orekhov. (2013) Dendritic cells and their role in immune reactions of atherosclerosis. Cell and Tissue Biology 7:2, pages 113-125.
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Mona Hedayat, Kiyoshi Takeda & Nima Rezaei. (2010) Prophylactic and therapeutic implications of toll‐like receptor ligands. Medicinal Research Reviews 32:2, pages 294-325.
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Athanasios Katsargyris, Chris Klonaris, Sotirios Tsiodras, Elias Bastounis, Athanasios Giannopoulos & Stamatios Theocharis. (2011) Statin treatment is associated with reduced toll-like receptor 4 immunohistochemical expression on carotid atherosclerotic plaques: a novel effect of statins. Vascular 19:6, pages 320-326.
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Tuanzhu HaLi LiuJim KelleyRace KaoDavid WilliamsChuanfu Li. (2011) Toll-Like Receptors: New Players in Myocardial Ischemia/Reperfusion Injury. Antioxidants & Redox Signaling 15:7, pages 1875-1893.
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Louise E. Full & Claudia Monaco. (2011) Targeting Inflammation as a Therapeutic Strategy in Accelerated Atherosclerosis in Rheumatoid Arthritis. Cardiovascular Therapeutics 29:4, pages 231-242.
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M. L. Sales, R. Schreiber, M. C. S. Ferreira-Sae, M. N. Fernandes, C. S. C. Piveta, J. A. A. Cipolli, C. C. Cardoso, J. R. Matos-Souza, B. Geloneze, K. G. Franchini & W. Nadruz. (2010) Toll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women. American Journal of Hypertension 23:6, pages 649-654.
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Michael J. Haas & Arshag D. Mooradian. (2010) Therapeutic Interventions to Enhance Apolipoprotein A-I-Mediated Cardioprotection. Drugs 70:7, pages 805-821.
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Maria L. Sales, Roberto Schreiber, Maria C.S. Ferreira-Sae, Maruska N. Fernandes, Cristiane Piveta, José A.A. Cipolli, Antônio Calixto, José R. Matos-Souza, Bruno Geloneze, Kleber G. Franchini & Wilson NadruzJr.Jr.. (2010) The functional Toll-like receptor 4 Asp299Gly polymorphism is associated with lower left ventricular mass in hypertensive women. Clinica Chimica Acta 411:9-10, pages 744-748.
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