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Review

Targeting survivin in cancer therapy

, PhD, , PhD & , PhD
Pages 463-476 | Published online: 18 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Roberta Soares Faccion, Lidia Maria Magalhães Rezende, Sérgio de Oliveira Romano, Ricardo de Sá Bigni, Gelcio Luiz Quintella Mendes & Raquel Ciuvalschi Maia. (2012) Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins. Cancer Investigation 30:5, pages 404-414.
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Jagat R Kanwar, Sishir K Kamalapuram & Rupinder K Kanwar. (2010) Targeting survivin in cancer: patent review. Expert Opinion on Therapeutic Patents 20:12, pages 1723-1737.
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Julia V Kichina, Anna Goc, Belal Al-Husein, Payaningal R Somanath & Eugene S Kandel. (2010) PAK1 as a therapeutic target. Expert Opinion on Therapeutic Targets 14:7, pages 703-725.
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Puja Sapra, Maoliang Wang, Raj Bandaru, Hong Zhao, LeeM. Greenberger & IvanD. Horak. (2010) Down-Modulation of Survivin Expression and Inhibition of Tumor Growth In Vivo by EZN-3042, A Locked Nucleic Acid Antisense Oligonucleotide. Nucleosides, Nucleotides & Nucleic Acids 29:2, pages 97-112.
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Malte Buchholz & Thomas M Gress. (2009) Molecular changes in pancreatic cancer. Expert Review of Anticancer Therapy 9:10, pages 1487-1497.
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Articles from other publishers (124)

Jerry Xiao, Joseph R. McGill, Apsra Nasir, Alexander Lekan, Bailey Johnson, Devan J. Wilkins, Gray W. Pearson, Kandice Tanner, Hani Goodarzi, Eric Glasgow, Richard Schlegel & Seema Agarwal. (2022) Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231. Molecular Biomedicine 3:1.
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Noha Said Helal, Zeinab Omran & Mona Moussa. (2022) Assessment of survivin and p27 expression as potential prognostic markers in urothelial cell carcinoma of urinary bladder in Egyptian patients. African Journal of Urology 28:1.
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Mohammed A. S. Abourehab, Sheersha Pramanik, Mohamed A. Abdelgawad, Bassam M. Abualsoud, Ammar Kadi, Mohammad Javed Ansari & A. Deepak. (2022) Recent Advances of Chitosan Formulations in Biomedical Applications. International Journal of Molecular Sciences 23:18, pages 10975.
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Xun Weng, YangYang & Yujiao Cai. (2022) Clinical Significance of Circulating Tumor Cells (CTCs) and Survivin on Predicting Prognosis in Thyroid Cancer Patients. Disease Markers 2022, pages 1-8.
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Dariimaa Ganbat, Bat-Erdene Jugder, Lkhamaa Ganbat, Miki Tomoeda, Erdenetsogt Dungubat, Ambaga Miyegombo, Gantsetseg Garmaa, Yoshihisa Takahashi, Ryuji Fukuzawa, Ichiro Mori, Takayuki Shiomi, Akinori Nakata & Yasuhiko Tomita. (2022) Use of the Naphthoquinone YM155 (Sepantronium Bromide) in the Treatment of Cancer: A Systematic Review and Meta-Synthesis. Oncologie 24:2, pages 195-225.
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Parinaz Zivarpour, Jamal Hallajzadeh, Zatollah Asemi, Fatemeh Sadoughi & Mehran Sharifi. (2021) Chitosan as possible inhibitory agents and delivery systems in leukemia. Cancer Cell International 21:1.
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Mohamed E. Alkafafy, Samy M. Sayed, Ahmed M. El‐Shehawi, Samir El‐Shazly, Samy Farouk, Saqer S. Alotaibi, Doaa A. Madkour, Sahar H. Orabi, Hamed T. Elbaz & Mohamed M. Ahmed. (2021) Moringa oleifera ethanolic extract ameliorates the testicular dysfunction resulted from HFD‐induced obesity rat model . Andrologia 53:8.
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Hemavathy Subramaiam, Wan-Loy Chu, Ammu Kutty Radhakrishnan, Srikumar Chakravarthi, Kanga Rani Selvaduray & Yih-Yih Kok. (2021) Evaluating Anticancer and Immunomodulatory Effects of Spirulina (Arthrospira) platensis and Gamma-Tocotrienol Supplementation in a Syngeneic Mouse Model of Breast Cancer. Nutrients 13:7, pages 2320.
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Hassan H. Fakih, Adam Katolik, Elise Malek-Adamian, Johans J. Fakhoury, Sepideh Kaviani, Masad J. Damha & Hanadi F. Sleiman. (2021) Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs). Chemical Science 12:8, pages 2993-3003.
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Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan & Ying Sun. (2021) Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials 269, pages 120478.
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Atieh Rafatmanesh, Mohaddeseh Behjati, Narges Mobasseri, Mostafa Sarvizadeh, Tahereh Mazoochi & Mohammad Karimian. (2019) The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer. Journal of Cellular Physiology 235:2, pages 725-744.
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Zheng WanXiaohong ZhangYuyang LuoBin Zhao. (2019) Identification of Hepatocellular Carcinoma-Related Potential Genes and Pathways Through Bioinformatic-Based Analyses. Genetic Testing and Molecular Biomarkers 23:11, pages 766-777.
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Magdalena Stobiecka, Katarzyna Ratajczak & Slawomir Jakiela. (2019) Toward early cancer detection: Focus on biosensing systems and biosensors for an anti-apoptotic protein survivin and survivin mRNA. Biosensors and Bioelectronics 137, pages 58-71.
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Cenk Daglioglu & Fatma Necmiye Kaci. (2019) Cascade therapy with doxorubicin and survivin-targeted tailored nanoparticles: An effective alternative for sensitization of cancer cells to chemotherapy. International Journal of Pharmaceutics 561, pages 74-81.
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Ghazala Khan, Kim Orchard & Barbara-ann Guinn. (2019) Antigenic Targets for the Immunotherapy of Acute Myeloid Leukaemia. Journal of Clinical Medicine 8:2, pages 134.
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Rong Yan, Jie Chen, Jianhao Wang, Jiaming Rao, Xuancheng Du, Yongming Liu, Leshuai Zhang, Lin Qiu, Bo Liu, Yuan‐Di Zhao, Pengju Jiang, Chunying Chen & Yong‐Qiang Li. (2018) A NanoFlare‐Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy. Small 14:50, pages 1802745.
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Min‑Gu Lee, Kyu‑Shik Lee & Kyung‑Soo Nam. (2018) The association of changes in RAD51 and survivin expression levels with the proton beam sensitivity of Capan‑1 and Panc‑1 human pancreatic cancer cells. International Journal of Oncology.
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Junguo Ma & Xiaoyu Li. (2018) Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide. Environmental Pollution 242, pages 1337-1345.
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Marcin Wojnilowicz, Quinn A. Besford, Yun-Long Wu, Xian Jun Loh, Julia A. Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso & Francesca Cavalieri. (2018) Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids. Biomaterials 176, pages 34-49.
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Hui Lyu, Jingcao Huang, Zhimin He & Bolin Liu. (2018) Epigenetic mechanism of survivin dysregulation in human cancer. Science China Life Sciences 61:7, pages 808-814.
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Katarzyna Ratajczak, Bartlomiej E. Krazinski, Anna E. Kowalczyk, Beata Dworakowska, Slawomir Jakiela & Magdalena Stobiecka. (2018) Hairpin–Hairpin Molecular Beacon Interactions for Detection of Survivin mRNA in Malignant SW480 Cells. ACS Applied Materials & Interfaces 10:20, pages 17028-17039.
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Sanam Arami, Majid Mahdavi, Mohammad-Reza Rashidi, Reza Yekta, Mohammad Rahnamay, Leila Molavi, Mohammad-Saeid Hejazi & Nasser Samadi. (2017) Apoptosis induction activity and molecular docking studies of survivin siRNA carried by Fe3O4-PEG-LAC-chitosan-PEI nanoparticles in MCF-7 human breast cancer cells. Journal of Pharmaceutical and Biomedical Analysis 142, pages 145-154.
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Wei Huang, Liqing Chen, Lin Kang, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao & You Han Bae. (2017) Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews 115, pages 82-97.
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Zhichen Pu, Guang-Zhen Wu & QiFei Wang. (2017) Clinicalpathological and prognostic significance of survivin expression in renal cell carcinoma: a meta-analysis. Oncotarget 8:12, pages 19825-19833.
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S Arami, MR Rashidi, M Mahdavi, M Fathi & AA Entezami. (2016) Synthesis and characterization of Fe 3 O 4 -PEG-LAC-chitosan-PEI nanoparticle as a survivin siRNA delivery system . Human & Experimental Toxicology 36:3, pages 227-237.
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Liying Geng & Jing Wang. (2017) Molecular effectors of radiation resistance in colorectal cancer. Precision Radiation Oncology 1:1, pages 27-33.
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Xiang YanHan Su. (2017) YM155 Down-Regulates Survivin and Induces P53 Up-Regulated Modulator of Apoptosis (PUMA)-Dependent in Oral Squamous Cell Carcinoma Cells. Medical Science Monitor 23, pages 1963-1972.
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Cenk Daglioglu & Burcu Okutucu. (2016) Therapeutic Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in Sensitization and Elimination of Cancer Cells via Survivin Targeting. Pharmaceutical Research 34:1, pages 175-184.
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Changqing Su. (2016) Survivin in survival of hepatocellular carcinoma. Cancer Letters 379:2, pages 184-190.
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Junguo Ma, Yiyi Feng, Yang Liu & Xiaoyu Li. (2016) PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway. Chemosphere 157, pages 241-249.
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Rita Q. Cruz, Catarina M. Morais, Ana M. Cardoso, Sandra G. Silva, Maria L. Vale, Eduardo F. Marques, Maria C. Pedroso de Lima & Amália S. Jurado. (2016) Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes. European Journal of Pharmaceutics and Biopharmaceutics 104, pages 7-18.
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Adam Rhodes & Thomas Hillen. (2016) Mathematical Modeling of the Role of Survivin on Dedifferentiation and Radioresistance in Cancer. Bulletin of Mathematical Biology 78:6, pages 1162-1188.
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Meng-dong Liu, Shi-jiang Xiong, Fei Tan & Yi Liu. (2016) Physcion 8-O-β-glucopyranoside induces mitochondria-dependent apoptosis of human oral squamous cell carcinoma cells via suppressing survivin expression. Acta Pharmacologica Sinica 37:5, pages 687-697.
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Cenk Daglioglu & Burcu Okutucu. (2016) Synthesis and Characterization of AICAR and DOX Conjugated Multifunctional Nanoparticles as a Platform for Synergistic Inhibition of Cancer Cell Growth. Bioconjugate Chemistry 27:4, pages 1098-1111.
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Seyed H. Ghaffari, Meysam Yousefi, Majid Zaki Dizaji, Majid Momeny, Davood Bashash, Ali Zekri, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2016) Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-κB-Mediated Mechanism. Asian Pacific Journal of Cancer Prevention 17:3, pages 1553-1564.
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Xiao Jiao Cheng, Jia Cheng Lin, Yan Fei Ding, Liming Zhu, Jing Ye & Shui Ping Tu. (2016) Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues. Oncotarget 7:6, pages 7096-7109.
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Ryousei Sasaki, Shigeki Ito, Maki Asahi & Yoji Ishida. (2015) YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells. Leukemia Research 39:12, pages 1473-1479.
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SIDA QIN, CHONGWEN XU, SHUO LI, XIFANG WANG, XIN SUN, PEILI WANG, BOXIANG ZHANG & HONG REN. (2015) Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer. Oncology Reports 34:5, pages 2656-2664.
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Francesca Cavalieri, Giovanni L. Beretta, Jiwei Cui, Julia A. Braunger, Yan Yan, Joseph J. Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni & Frank Caruso. (2015) Redox-Sensitive PEG–Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells. Biomacromolecules 16:7, pages 2168-2178.
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YANSHENG GAO, LINGZHEN LI & LAIJUN SONG. (2015) Expression of p16 and Survivin in gliomas and their correlation with cell proliferation. Oncology Letters 10:1, pages 301-306.
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Ji-Ae Shin, Mi Heon Ryu, Ki-Han Kwon, BuYoung Choi & Sung-Dae Cho. (2015) Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines . Journal of Oral Pathology & Medicine 44:6, pages 420-428.
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Sang Yoon Jung, Chulwon Kim, Wan-Seok Kim, Seok-Geun Lee, Jun-Hee Lee, Bum Sang Shim, Sung-Hoon Kim, Kyoo Seok Ahn & Kwang Seok Ahn. (2015) Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells. Phytotherapy Research 29:7, pages 1062-1072.
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Yunhui Hu, Kun Xu & Ernesto Yagüe. (2015) miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast Cancer Research and Treatment 151:2, pages 269-280.
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Neha Singh, Subramanian Krishnakumar, Rupinder K. Kanwar, Chun Hei Antonio Cheung & Jagat R. Kanwar. (2015) Clinical aspects for survivin: a crucial molecule for targeting drug-resistant cancers. Drug Discovery Today 20:5, pages 578-587.
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Giuseppina Salzano, Gemma Navarro, Malav S. Trivedi, Giuseppe De Rosa & Vladimir P. Torchilin. (2015) Multifunctional Polymeric Micelles Co-loaded with Anti–Survivin siRNA and Paclitaxel Overcome Drug Resistance in an Animal Model of Ovarian Cancer. Molecular Cancer Therapeutics 14:4, pages 1075-1084.
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Amanda M. Smith, Erica B. Little, Andjelija Zivanovic, Priscilla Hong, Alfred K.S. Liu, Rachel Burow, Caedyn Stinson, Andrew R. Hallahan & Andrew S. Moore. (2015) Targeting Survivin with YM155 (Sepantronium Bromide): A novel therapeutic strategy for paediatric acute myeloid leukaemia. Leukemia Research 39:4, pages 435-444.
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Gang Chen, Di Liu, Chunbai He, Theodore R. Gannett, Wenbin Lin & Yossi Weizmann. (2015) Enzymatic Synthesis of Periodic DNA Nanoribbons for Intracellular pH Sensing and Gene Silencing. Journal of the American Chemical Society 137:11, pages 3844-3851.
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Hua Guo, Yuexun Wang, Tao Song, Tao Xin, Zhiming Zheng, Peng Zhong & Xiaoli Zhang. (2014) Silencing of Survivin Using YM155 Inhibits Invasion and Suppresses Proliferation in Glioma Cells. Cell Biochemistry and Biophysics 71:2, pages 587-593.
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Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim & Kwang Seok Ahn. (2015) The Hydrolysed Products of Iridoid Glycosides Can Enhance Imatinib Mesylate-Induced Apoptosis in Human Myeloid Leukaemia Cells. Phytotherapy Research 29:3, pages 434-443.
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Shang Xie, Hui Xu, Xiaofeng Shan, Baozhong Liu, Kan Wang & Zhigang Cai. (2015) Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis. PLOS ONE 10:2, pages e0116517.
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Letteria Minutoli, Salvatore Arena, Pietro Antonuccio, Carmelo Romeo, Alessandra Bitto, Carlo Magno, Mariagrazia Rinaldi, Antonio Micali, Natasha Irrera, Gabriele Pizzino, Federica Galfo, Francesco Squadrito, Domenica Altavilla & Herbert Marini. (2015) Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele. BioMed Research International 2015, pages 1-9.
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Viviana A. Rivarola & Ingrid Sol Cogno. 2015. Resistance to Photodynamic Therapy in Cancer. Resistance to Photodynamic Therapy in Cancer 163 182 .
Qin Qin, Hongyan Cheng, Jing Lu, Liangliang Zhan, Jianchao Zheng, Jing Cai, Xi Yang, Liping Xu, Hongcheng Zhu, Chi Zhang, Jia Liu, Jianxin Ma, Xizhi Zhang, Shengbin Dai & Xinchen Sun. (2014) Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair. Journal of Hematology & Oncology 7:1.
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Salma Khan, Heather Ferguson Bennit, David Turay, Mia Perez, Saied Mirshahidi, Yuan Yuan & Nathan R Wall. (2014) Early diagnostic value of survivin and its alternative splice variants in breast cancer. BMC Cancer 14:1.
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Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo & Giuseppe Morgia. (2014) Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene. Journal of Biomedical Science 21:1.
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Christiana M. Neophytou, Constantina Constantinou, Panagiotis Papageorgis & Andreas I. Constantinou. (2014) d-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells. Biochemical Pharmacology 89:1, pages 31-42.
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Anastasia Pavlidou, Christos Kroupis, Nikolaos Goutas, Maria Dalamaga & Kleanthi Dimas. (2014) Validation of a Real-Time Quantitative Polymerase Chain Reaction Method for the Quantification of 3 Survivin Transcripts and Evaluation in Breast Cancer Tissues. Clinical Breast Cancer 14:2, pages 122-131.
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JUNYAN ZHANG, ZHI ZHU, ZHE SUN, XUREN SUN, ZHENNING WANG & HUIMIAN XU. (2014) Survivin gene expression increases gastric cancer cell lymphatic metastasis by upregulating vascular endothelial growth factor-C expression levels. Molecular Medicine Reports 9:2, pages 600-606.
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Shunzeng Lv, Ekaterina Turlova, Shigang Zhao, Huihui Kang, Mingzhi Han & Hong-Shuo Sun. (2013) Prognostic and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis. Tumor Biology 35:2, pages 1565-1574.
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Petr Krůpa, Svatopluk Řehák, Daniel Diaz-Garcia & Stanislav Filip. (2014) NANOTECHNOLOGY – NEW TRENDS IN THE TREATMENT OF BRAIN TUMOURS. Acta Medica (Hradec Kralove, Czech Republic) 57:4, pages 142-150.
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Yudan Chi, Xiang Wang, Yong Yang, Chao Zhang, Hildegund C J Ertl & Dongming Zhou. (2014) Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Molecular Therapy - Nucleic Acids 3, pages e208.
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Chanhoo Jeon, Myong Kim, Cheol Kwak, Hyeon Hoe Kim & Ja Hyeon Ku. (2013) Prognostic Role of Survivin in Bladder Cancer: A Systematic Review and Meta-Analysis. PLoS ONE 8:10, pages e76719.
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Anna Carbone, Marzia Pennati, Barbara Parrino, Alessia Lopergolo, Paola Barraja, Alessandra Montalbano, Virginia Spanò, Stefania Sbarra, Valentina Doldi, Michelandrea De Cesare, Girolamo Cirrincione, Patrizia Diana & Nadia Zaffaroni. (2013) Novel 1 H -Pyrrolo[2,3- b ]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models . Journal of Medicinal Chemistry 56:17, pages 7060-7072.
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DONG XU, QINGGUANG WANG, YONG AN & LIJIAN XU. (2013) miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin. Molecular Medicine Reports 8:2, pages 379-384.
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Fan Li, Xuedong Yin, Xinrong Luo, Hong-Yuan Li, Xinliang Su, Xiao-Yi Wang, Li Chen, Ke Zheng & Guo-Sheng Ren. (2013) Livin promotes progression of breast cancer through induction of epithelial–mesenchymal transition and activation of AKT signaling. Cellular Signalling 25:6, pages 1413-1422.
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Xia-Bin LiShi-Ning LiZhi-Hui YangLing CaoFang-Lei DuanXing-Wang Sun. (2013) Polymorphisms of Survivin and Its Protein Expression Are Associated with Colorectal Cancer Susceptibility in Chinese Population . DNA and Cell Biology 32:5, pages 236-242.
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Kothandharaman Subramaniam, Jayshree L. Hirpara, Lisa Tucker-Kellogg, Greg Tucker-Kellogg & Shazib Pervaiz. (2013) FLIP: A flop for execution signals. Cancer Letters 332:2, pages 151-155.
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Dario C. Altieri. (2013) Targeting survivin in cancer. Cancer Letters 332:2, pages 225-228.
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Roser Mir, Avelina Tortosa, Fina Martinez‐Soler, August Vidal, Enric Condom, Alba Pérez‐Perarnau, Tatiana Ruiz‐Larroya, Joan Gil & Pepita Giménez‐Bonafé. (2012) Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild‐type ovarian cancer cells . International Journal of Cancer 132:7, pages 1525-1536.
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Jing ChenCynthia A. Pise-Masison, Joanna H. Shih, John C. MorrisJohn E. JanikKevin C. ConlonAnne Keating & Thomas A. Waldmann. (2013) Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. Blood 121:11, pages 2029-2037.
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Xiaopeng Cai, Shuai Ma, Ming Gu, Cong Zu, Wenzhi Qu & Xinyu Zheng. (2012) Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer. Diagnostic Pathology 7:1.
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B. Greve, F. Sheikh-Mounessi, B. Kemper, I. Ernst, M. Götte & H.T. Eich. (2012) Survivin, a target to modulate the radiosensitivity of Ewing’s sarcomaSurvivin, ein Zielmolekül zur Modulation der Strahlenempfindlichkeit von Ewing-Sarkomen. Strahlentherapie und Onkologie 188:11, pages 1038-1047.
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Qinglian Hu, Wen Li, Xiurong Hu, Qida Hu, Jie Shen, Xue Jin, Jun Zhou, Guping Tang & Paul K. Chu. (2012) Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly. Biomaterials 33:27, pages 6580-6591.
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Md. Motarab Hossain, Naren L. Banik & Swapan K. Ray. (2012) Survivin knockdown increased anti-cancer effects of (−)-epigallocatechin-3-gallate in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Experimental Cell Research 318:13, pages 1597-1610.
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Hamdy A.A. Aly. (2012) Cancer therapy and vaccination. Journal of Immunological Methods 382:1-2, pages 1-23.
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Sara Ekeblad, Margareta Halin Lejonklou, Peter Stålberg & Britt Skogseid. (2011) Prognostic Relevance of Survivin in Pancreatic Endocrine Tumors. World Journal of Surgery 36:6, pages 1411-1418.
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Xiao‐Yuan Chu, Long‐Bang Chen, Jing‐Hua Wang, Quan‐Sheng Su, Ji‐Rong Yang, Yong Lin, Li‐Jun Xue, Xiao‐Bei Liu & Xiao‐Bei Mo. (2011) Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer. Journal of Surgical Oncology 105:6, pages 520-528.
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Kshitij Srivastava, Anvesha Srivastava & Balraj Mittal. (2011) Survivin promoter −31G/C (rs9904341) polymorphism and cancer susceptibility: a meta-analysis. Molecular Biology Reports 39:2, pages 1509-1516.
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HAO DENG, HONGYAN ZHEN, ZHENGQI FU, XUAN HUANG, HONGYAN ZHOU & LIJIANG LIU. (2012) The antagonistic effect between STAT1 and Survivin and its clinical significance in gastric cancer. Oncology Letters 3:1, pages 193-199.
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Jiamu Du, Alexander E. Kelly, Hironori Funabiki & Dinshaw J. Patel. (2012) Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure 20:1, pages 185-195.
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Yaghub Pazhang, Shahin Ahmadian, Massoud Mahmoudian & Mahshid Shafiezadeh. (2010) Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line. Medical Oncology 28:4, pages 1577-1583.
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S. Hendruschk, R. Wiedemuth, A. Aigner, K. Topfer, M. Cartellieri, D. Martin, M. Kirsch, C. Ikonomidou, G. Schackert & A. Temme. (2011) RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo. Neuro-Oncology 13:10, pages 1074-1089.
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Gou Young Kim, Sung-Jig Lim & Youn Wha Kim. (2011) Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Modern Pathology 24:10, pages 1336-1347.
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Sebastian Reichert, Claus Rödel, Johanna Mirsch, Patrick N. Harter, Maja T. Tomicic, Michel Mittelbronn, Bernd Kaina & Franz Rödel. (2011) Survivin inhibition and DNA double-strand break repair: A molecular mechanism to overcome radioresistance in glioblastoma. Radiotherapy and Oncology 101:1, pages 51-58.
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Jonathan M. Hernandez, Jeffrey M. Farma, Domenico Coppola, Ardeshir Hakam, William J. Fulp, Dung-Tsa Chen, Erin M. Siegel, Timothy J. Yeatman & David Shibata. (2011) Expression of the Antiapoptotic Protein Survivin in Colon Cancer. Clinical Colorectal Cancer 10:3, pages 188-193.
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Ji Young Heo, Hyun Jung Kim, Sung-Moo Kim, Kyung-Ran Park, Sang-Yoon Park, Seong Won Kim, Dongwoo Nam, Hyeung-Jin Jang, Seok-Geun Lee, Kyoo Seok Ahn, Sung-Hoon Kim, Bum Sang Shim, Seung-Hoon Choi & Kwang Seok Ahn. (2011) Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN. Cancer Letters 308:1, pages 71-80.
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S. Trabulo, A. M. Cardoso, T. Santos-Ferreira, A. L. Cardoso, S. Simões & M. C. Pedroso de Lima. (2011) Survivin Silencing as a Promising Strategy To Enhance the Sensitivity of Cancer Cells to Chemotherapeutic Agents. Molecular Pharmaceutics 8:4, pages 1120-1131.
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Aamir Ahmad, Wael A. Sakr & KM Wahidur Rahman. (2011) Mechanisms and Therapeutic Implications of Cell Death Induction by Indole Compounds. Cancers 3:3, pages 2955-2974.
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Yang Gao, Min Zhang, Huafei Zhang, Xianghui Yu, Wei Kong, Xiao Zha & Yuqing Wu. (2011) Thermal Stability and Structural Variations of Survivin and Its Deletants in Aqueous Solution as Revealed by Spectroscopy. The Journal of Physical Chemistry B 115:21, pages 7038-7044.
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Pablo E. Vivas-Mejia, Cristian Rodriguez-Aguayo, Hee-Dong Han, Mian M.K. Shahzad, Fatma Valiyeva, Mineko Shibayama, Arturo Chavez-Reyes, Anil K. Sood & Gabriel Lopez-Berestein. (2011) Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer. Clinical Cancer Research 17:11, pages 3716-3726.
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