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Review

ABCA2 as a therapeutic target in cancer and nervous system disorders

, PhD, , MS & , PhD DSc
Pages 491-504 | Published online: 18 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Narges Aberuyi, Soheila Rahgozar, Zohreh Khosravi Dehaghi, Alireza Moafi, Andrea Masotti & Alessandro Paolini. (2017) The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia. OncoTargets and Therapy 10, pages 3373-3380.
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Soheila Rahgozar, Alireza Moafi, Marjan Abedi, Mansureh Entezar-e-ghaem, Jamal Moshtaghian, Kamran Ghaedi, Abolghasem Esmaeili & Fatemeh Montazeri. (2014) mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2. Cancer Biology & Therapy 15:1, pages 35-41.
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Articles from other publishers (23)

Areti-Maria Vasilogianni, Sarah Alrubia, Eman El-Khateeb, Zubida M. Al-Majdoub, Narciso Couto, Brahim Achour, Amin Rostami-Hodjegan & Jill Barber. (2024) Complementarity of two proteomic data analysis tools in the identification of drug-metabolising enzymes and transporters in human liver. Molecular Omics.
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Yanwen Hou, Wei Yan, Guangke Li & Nan Sang. (2023) Transcriptome sequencing analysis reveals a potential role of lncRNA NONMMUT058932.2 and NONMMUT029203.2 in abnormal myelin development of male offspring following prenatal PM2.5 exposure. Science of The Total Environment 895, pages 165004.
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Robert S. Molday, Fabian A. Garces, Jessica Fernandes Scortecci & Laurie L. Molday. (2022) Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration. Progress in Retinal and Eye Research 89, pages 101036.
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Veronica Ferrucci, Pasqualino de Antonellis, Francesco Paolo Pennino, Fatemeh Asadzadeh, Antonella Virgilio, Donatella Montanaro, Aldo Galeone, Iolanda Boffa, Ida Pisano, Iolanda Scognamiglio, Luigi Navas, Donatella Diana, Emilia Pedone, Sara Gargiulo, Matteo Gramanzini, Arturo Brunetti, Laura Danielson, Marianeve Carotenuto, Lucia Liguori, Antonio Verrico, Lucia Quaglietta, Maria Elena Errico, Valentina Del Monaco, Valeria D’Argenio, Felice Tirone, Angela Mastronuzzi, Vittoria Donofrio, Felice Giangaspero, Daniel Picard, Marc Remke, Livia Garzia, Craig Daniels, Olivier Delattre, Fredrik J Swartling, William A Weiss, Francesco Salvatore, Roberto Fattorusso, Louis Chesler, Michael D Taylor, Giuseppe Cinalli & Massimo Zollo. (2018) Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition. Brain 141:5, pages 1300-1319.
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Warren DavisJr.Jr. & Kenneth D. Tew. (2018) ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target. Biochemical Pharmacology 151, pages 188-200.
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Soheila Rahgozar, Narges Aberuyi & Hadi Moafi. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 477 482 .
Li-Min Mu, Rui-Jun Ju, Rui Liu, Ying-Zi Bu, Jing-Ying Zhang, Xue-Qi Li, Fan Zeng & Wan-Liang Lu. (2017) Dual-functional drug liposomes in treatment of resistant cancers. Advanced Drug Delivery Reviews 115, pages 46-56.
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Kinga Hadzsiev, Katalin Komlosi, Marta Czako, Balazs Duga, Renata Szalai, Andras Szabo, Etelka Postyeni, Titanilla Szabo, Gyorgy Kosztolanyi & Bela Melegh. (2016) Kleefstra syndrome in Hungarian patients: additional symptoms besides the classic phenotype. Molecular Cytogenetics 9:1.
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Georgia-Persephoni Voulgaridou, Magdalini Kiziridou, Theodora Mantso, Katerina Chlichlia, Alex Galanis, Michael I. Koukourakis, Rodrigo Franco, Mihalis I. Panayiotidis & Aglaia Pappa. (2016) Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells. The International Journal of Biochemistry & Cell Biology 77, pages 120-128.
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Saeed Kachalaki, Mina Ebrahimi, Leila Mohamed Khosroshahi, Sina Mohammadinejad & Behzad Baradaran. (2016) Cancer chemoresistance; biochemical and molecular aspects: a brief overview. European Journal of Pharmaceutical Sciences 89, pages 20-30.
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Soheila Rahgozar, Narges Aberuyi & Hadi Moafi. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 6 .
Wandong Zhang, Michelle Bamji-Mirza, Nina Chang, Arsalan Haqqani & Danica Stanimirovic. 2015. The Blood-Brain Barrier in Health and Disease, Volume One. The Blood-Brain Barrier in Health and Disease, Volume One 172 214 .
Ellen L. Hedditch, Bo Gao, Amanda J. Russell, Yi Lu, Catherine Emmanuel, Jonathan Beesley, Sharon E. Johnatty, Xiaoqing Chen, Paul Harnett, Joshy George, Rebekka T. Williams, Claudia Flemming, Diether Lambrechts, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Peter Fasching, Matthias W. Beckmann, Arif B. Ekici, Alexander Hein, Keitaro Matsuo, Satoyo Hosono, Toru Nakanishi, Yasushi Yatabe, Tanja Pejovic, Yukie Bean, Florian Heitz, Philipp Harter, Andreas du Bois, Ira Schwaab, Estrid Hogdall, Susan K. Kjaer, Allan Jensen, Claus Hogdall, Lene Lundvall, Svend Aage Engelholm, Bob Brown, James Flanagan, Michelle D Metcalf, Nadeem Siddiqui, Thomas Sellers, Brooke Fridley, Julie Cunningham, Joellen Schildkraut, Ed Iversen, Rachel P. Weber, Andrew Berchuck, Ellen Goode, David D. Bowtell, Georgia Chenevix-Trench, Anna deFazio, Murray D. Norris, Stuart MacGregor, Michelle Haber & Michelle J. Henderson. (2014) ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer. JNCI: Journal of the National Cancer Institute 106:7.
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Annabelle Trojan, Lina M. Jay, Heliodor Kasprzak, Donald D. Anthony & Jerzy Trojan. (2014) Immunotherapy of Malignant Tumors Using Antisense Anti-IGF-I Approach: Case of Glioblastoma. Journal of Cancer Therapy 05:07, pages 685-705.
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Jerzy Trojan, Yuexin X. Pan, Ming X. Wei, Adama Ly, Alexander Shevelev, Maciej Bierwagen, Marie-Yvonne Ardourel, Ladislas A. Trojan, Alvaro Alvarez, Christian Andres, Maria C. Noguera, Ignacio Briceno, Beatriz H. Aristizabal, Heliodor Kasprzak, Huynh T. Duc & Donald D. Anthony. (2012) Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours. Chemotherapy Research and Practice 2012, pages 1-12.
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Vasiliki Michaki, Francesc X. Guix, Krist'l Vennekens, Sebastian Munck, Colin Dingwall, John B. Davis, Danyelle M. Townsend, Kenneth D. Tew, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti & Tina Wahle. (2012) Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization. Journal of Biological Chemistry 287:2, pages 1100-1111.
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Iryna Voloshyna & Allison B. Reiss. (2011) The ABC transporters in lipid flux and atherosclerosis. Progress in Lipid Research 50:3, pages 213-224.
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Jody T. Mack, Kristi L. Helke, Gabrielle Normand, CoDanielle Green, Danyelle M. Townsend & Kenneth D. Tew. (2011) ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Letters 300:2, pages 154-161.
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Jamie I. Fletcher, Michelle Haber, Michelle J. Henderson & Murray D. Norris. (2010) ABC transporters in cancer: more than just drug efflux pumps. Nature Reviews Cancer 10:2, pages 147-156.
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Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang & Yong-Qing Yang. (2009) Use of serial analysis of gene expression to reveal the specific regulation of gene expression profile in asthmatic rats treated by acupuncture. Journal of Biomedical Science 16:1.
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Raymond J. Winquist, Diane M. Boucher, Mark Wood & Brinley F. Furey. (2009) Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine. Biochemical Pharmacology 78:4, pages 326-334.
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Fabien Gosselet, Pietra Candela, Emmanuel Sevin, Vincent Berezowski, Roméo Cecchelli & Laurence Fenart. (2009) Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model. Brain Research 1249, pages 34-42.
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Bi-Botti Celestin Youan. (2008) Impact of nanoscience and nanotechnology on controlled drug delivery. Nanomedicine 3:4, pages 401-406.
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