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Review

The yeast two-hybrid system and its role in drug discovery

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Pages 505-515 | Published online: 18 Mar 2008

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Jürgen J Heinisch. (2008) Baker's yeast as a tool for the development of antifungal drugs which target cell integrity – an update. Expert Opinion on Drug Discovery 3:8, pages 931-943.
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Sudip Dhakal & Ian Macreadie. (2022) The Use of Yeast in Biosensing. Microorganisms 10:9, pages 1772.
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Tiancong Sun, Yu Chen, Rongsheng Mi, Haiyan Gong, Shasha Zhou, Xiangan Han, Yan Huang & Zhaoguo Chen. (2022) Fibrillarin RNA methylase is an interacting protein of Cryptosporidium parvum calmodulin-like protein (CpCML). Microbial Pathogenesis 170, pages 105679.
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Ian Macreadie & Sudip Dhakal. (2022) ‘The awesome power of yeast’. Microbiology Australia 43:1, pages 19-21.
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Hiren Banerjee, Paul LaPointe, Gary Eitzen & Richard A. Rachubinski. (2021) A Small Molecule Inhibitor of Pex3–Pex19 Interaction Disrupts Glycosome Biogenesis and Causes Lethality in Trypanosoma brucei. Frontiers in Cell and Developmental Biology 9.
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Jingjing Li, Jin Gao, Lei Han, Yinjie Zhang, Wen Guan, Liang Zhou, Yan Yu & Wei Han. (2016) Development of a membrane-anchored ligand and receptor yeast two-hybrid system for ligand-receptor interaction identification. Scientific Reports 6:1.
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Z.-X. Zhu, Z.-M. Yu, J. L. Taylor, Y.-H. Wu & J. Ni. (2016) The application of yeast hybrid systems in protein interaction analysis. Molecular Biology 50:5, pages 663-670.
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Mingming Liu, Lijun Jia, Jixu Li, Shujiang Xue, Xu Gao, Longzheng Yu & Shoufa Zhang. (2014) Interactive host cells related to Mycoplasma suis α-enolase by yeast two-hybrid analysis. Research in Veterinary Science 97:2, pages 282-287.
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Er Meng, Tian-Fu Cai, Hui Zhang, Si Tang, Meng-Jie Li, Wen-Ying Li, Peng-Fei Huang, Kai Liu, Lei Wu, Ling-Yun Zhu, Long Liu, Kuan Peng, Xian-Dong Dai, Hui Jiang, Xiong-Zhi Zeng, Song-Ping Liang & Dong-Yi Zhang. (2014) Screening for Voltage-Gated Sodium Channel Interacting Peptides. Scientific Reports 4:1.
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Irene Stefanini, Carlotta De Filippo & Duccio Cavalieri. 2013. Diversity-Oriented Synthesis. Diversity-Oriented Synthesis 455 482 .
Raphaela RidJulia HerzogRichard H. MaierHarald HundsbergerAndreas EgerHelmut HintnerJohann W. BauerKamil Önder. (2013) Real-Time Monitoring of Relative Peptide–Protein Interaction Strengths in the Yeast Two-Hybrid System. ASSAY and Drug Development Technologies 11:4, pages 269-275.
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Allan R. Shepard, Raymond E. Conrow, Iok-Hou Pang, Nasreen Jacobson, Mandana Rezwan, Katrin Rutschmann, Daniel Auerbach, Rohitha SriRamaratnam & Virginia W. Cornish. (2013) Identification of PDE6D as a Molecular Target of Anecortave Acetate via a Methotrexate-Anchored Yeast Three-Hybrid Screen . ACS Chemical Biology 8:3, pages 549-558.
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Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi & Erica A. Golemis. 2013. Inhibitors of the Ras Superfamily G-proteins, Part A. Inhibitors of the Ras Superfamily G-proteins, Part A 213 248 .
Kai Kang, Kangkang Guo, Qinhai Tang, Yanming Zhang, Jiang Wu, Weiwei Li & Zhi Lin. (2012) Interactive cellular proteins related to classical swine fever virus non-structure protein 2 by yeast two-hybrid analysis. Molecular Biology Reports 39:12, pages 10515-10524.
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Isaac Vizcaino-Caston, Chris Wyre & Tim W. Overton. (2011) Fluorescent proteins in microbial biotechnology—new proteins and new applications. Biotechnology Letters 34:2, pages 175-186.
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Florian Nigsch. 2011. Computational Approaches in Cheminformatics and Bioinformatics. Computational Approaches in Cheminformatics and Bioinformatics 239 259 .
Julia Petschnigg, Orson W Moe & Igor Stagljar. (2011) Using yeast as a model to study membrane proteins. Current Opinion in Nephrology and Hypertension 20:4, pages 425-432.
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Julia Petschnigg, Jamie Snider & Igor Stagljar. (2011) Interactive proteomics research technologies: recent applications and advances. Current Opinion in Biotechnology 22:1, pages 50-58.
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James T. Heeres & Paul J. Hergenrother. (2011) High-throughput screening for modulators of protein–protein interactions: use of photonic crystal biosensors and complementary technologies. Chem. Soc. Rev. 40:8, pages 4398-4410.
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James J. La Clair. (2010) Natural product mode of action (MOA) studies: a link between natural and synthetic worlds. Natural Product Reports 27:7, pages 969.
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Nathan C. Tedford, Amy B. Hall, James R. Graham, Cheryl E. Murphy, Neal F. Gordon & Jeffrey A. Radding. (2009) Quantitative analysis of cell signaling and drug action via mass spectrometry-based systems level phosphoproteomics. PROTEOMICS 9:6, pages 1469-1487.
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Bernhard Suter, Saranya Kittanakom & Igor Stagljar. (2008) Two-hybrid technologies in proteomics research. Current Opinion in Biotechnology 19:4, pages 316-323.
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Tiancong Sun, Yu Chen, Rongsheng Mi, Haiyan Gong, Shasha Zhou, Xiangan Han, Yan Huang & Zhaoguo Chen. (2022) Fibrillarin Rna Methylase is an Interacting Protein of Cryptosporidium Parvum Calmodulin-Like Protein (Cpcml). SSRN Electronic Journal.
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