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Thymus hormones as prospective anti-inflammatory agents

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Pages 775-786 | Published online: 10 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Sergey Lunin, Maxim Khrenov, Olga Glushkova, Svetlana Parfenyuk, Tatyana Novoselova & E Novoselova. (2020) Precursors of thymic peptides as stress sensors. Expert Opinion on Biological Therapy 20:12, pages 1461-1475.
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Maxim S. Kondratyev, Sergey M. Lunin, Artem V. Kabanov, Alexandr A. Samchenko, Vladislav M. Komarov, Evgeny E. Fesenko & Elena G. Novoselova. (2014) Structural and dynamic properties of thymopoietin mimetics. Journal of Biomolecular Structure and Dynamics 32:11, pages 1793-1801.
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Sergey M. Lunin, Olga V. Glushkova, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Evgeny E. Fesenko & Elena G. Novoselova. (2011) Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades. Expert Opinion on Therapeutic Targets 15:12, pages 1337-1346.
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Articles from other publishers (32)

E. G. Novoselova, O. V. Glushkova, M. O. Khrenov, S. M. Lunin, M. G. Sharapov, R. G. Goncharov, E. K. Mubarakshina, T. V. Novoselova & S. B. Parfenyuk. (2023) The Thymic Hormone Thymosin-1α Reduces the Pro-Inflammatory Response of Raw 264.7 Cells Induced by Endotoxin. Molecular Biology 57:6, pages 1004-1013.
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Jiali Yang, Juan Liu, Jiayu Liang, Fan Li, Wenwen Wang, Huan Chen & Xiang Xie. (2023) Epithelial-mesenchymal transition in age-associated thymic involution: Mechanisms and therapeutic implications. Ageing Research Reviews 92, pages 102115.
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S.M. Lunin, E.G. Novoselova, O.V. Glushkova, S.B. Parfenyuk, A.A. Kuzekova, T.V. Novoselova, M.G. Sharapov, E.K. Mubarakshina, R.G. Goncharov & M.O. Khrenov. (2023) Protective effect of exogenous peroxiredoxin 6 and thymic peptide thymulin on BBB conditions in an experimental model of multiple sclerosis. Archives of Biochemistry and Biophysics 746, pages 109729.
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Si-Jia Peng, Ya Feng, Xuan Li, Xi-Xi Wang, Yu Wang, Bu-Tian Zhou, Ye Liu, Te Liu & Yun-Cheng Wu. (2023) Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway. International Immunopharmacology 119, pages 110109.
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Elbouny HAMZA, Ouahzizi BRAHİM, Sellam KHALİD & Alem CHAKİB. (2023) In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extractsIn vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts. International Journal of Secondary Metabolite 10:1, pages 48-58.
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Sergey M. Lunin, Elena G. Novoselova, Olga V. Glushkova, Svetlana B. Parfenyuk, Tatyana V. Novoselova & Maxim O. Khrenov. (2022) Cell Senescence and Central Regulators of Immune Response. International Journal of Molecular Sciences 23:8, pages 4109.
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Ebtesam A. Al-Suhaimi, Meneerah A. Aljafary, Fadwa M. Alkhulaifi, Hanan A. Aldossary, Thamer Alshammari, Ayman AL-Qaaneh, Razan Aldahhan, Zahra Alkhalifah, Zagit Z. Gaymalov, Adeeb Shehzad & Abdelgadir M. Homeida. (2021) Thymus Gland: A Double Edge Sword for Coronaviruses. Vaccines 9:10, pages 1119.
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Annarita Del Gatto, Michele Saviano & Laura Zaccaro. (2021) An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis. Molecules 26:17, pages 5227.
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Fernando Zuniga-Navarrete, Sofia Guadalupe Zavala-Meneses, Vladimir Zelnik, Juraj Kopacek & Ludovit Skultety. (2021) Initial proteomic characterization of IMMODIN, commercially available dialysable leukocytes extract. Chemical Papers 75:5, pages 1959-1968.
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Jiaxing Tang, Yan Zou, Long Li, Fengping Lu, Hongtao Xu, Pengxuan Ren, Fang Bai, Gabriele Niedermann & Xuekai Zhu. (2021) BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor. Frontiers in Pharmacology 12.
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Rita Rezzani, Caterina Franco, Rüdiger Hardeland & Luigi Fabrizio Rodella. (2020) Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing. International Journal of Molecular Sciences 21:22, pages 8806.
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Quan-xing Shi, Bing Chen, Chuang Nie, Zhi-ping Zhao, Jun-hai Zhang, Shao-yan Si, Shao-jie Cui & Jian-wen Gu. (2020) Improvement in cognitive dysfunction following blast induced traumatic brain injury by thymosin α1 in rats: Involvement of inhibition of tau phosphorylation at the Thr205 epitope. Brain Research 1747, pages 147038.
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Amanda C. Palmer, Kerry J. Schulze, Subarna K. Khatry & Keith P. WestJr.Jr.. (2019) Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal. Journal of Developmental Origins of Health and Disease 11:2, pages 127-135.
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Sridhar Muthusami, Balasubramanian Vidya, Esaki M Shankar, Jamuna Vadivelu, Ilangovan Ramachandran, Jone A Stanley & Nagarajan Selvamurugan. (2020) The Functional Significance of Endocrine-immune Interactions in Health and Disease. Current Protein & Peptide Science 21:1, pages 52-65.
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Gui-hong Zhang, Krishna Dilip Murthy, Rahmawati Binti Pare & Yi-hua Qian. (2020) Protective effect of Tβ4 on central nervous system tissues and its developmental prospects. European Journal of Inflammation 18, pages 205873922093455.
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Sergey M. Lunin, Maxim O. Khrenov, Olga V. Glushkova, Svetlana B. Parfenyuk, Tatyana V. Novoselova & Elena G. Novoselova. (2019) Protective Effect of PBCA Nanoparticles Loaded with Thymulin Against the Relapsing-Remitting Form of Experimental Autoimmune Encephalomyelitis in Mice. International Journal of Molecular Sciences 20:21, pages 5374.
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Behzad Nasseri, Jalal Zaringhalam, Samira Daniali, Homa Manaheji, Zahra Abbasnejad & Vida Nazemian. (2019) Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways. International Immunopharmacology 70, pages 225-234.
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T. M. Sokolova, V. V. Poloskov, A. N. Shuvalov, O. S. Burova & Z. A. Sokolova. (2019) Signaling TLR/RLR-mechanisms of immunomodulating action of ingavirin and thymogen preparations. Russian Journal of Biotherapy 18:1, pages 60-66.
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Martina Severa, Jing Zhang, Elena Giacomini, Fabiana Rizzo, Marilena Paola Etna, Melania Cruciani, Enrico Garaci, Michael Chopp & Eliana Marina Coccia. (2019) Thymosins in multiple sclerosis and its experimental models: moving from basic to clinical application. Multiple Sclerosis and Related Disorders 27, pages 52-60.
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Kyung Sook Cho, Dong-Jin Kim, Bomee Shim, Jung Yeon Kim, Jun Mo Kang, Seon Hwa Park, Sang-Ho Lee, Hyung-In Yang & Kyoung Soo Kim. (2018) An Investigation on the Therapeutic Effect of Thymosin 4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice . BioMed Research International 2018, pages 1-8.
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Elena G. Novoselova, Sergey M. Lunin, Olga V. Glushkova, Maxim O. Khrenov, Svetlana B. Parfenyuk, Nadezhda M. Zakharova & Evgeny E. Fesenko. (2018) Thymulin, free or bound to PBCA nanoparticles, protects mice against chronic septic inflammation. PLOS ONE 13:5, pages e0197601.
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Erhui Jin, Man Ren, Wenwen Liu, Shuang Liang, Qianqian Hu, Youfang Gu & Shenghe Li. (2017) Effect of Boron on Thymic Cytokine Expression, Hormone Secretion, Antioxidant Functions, Cell Proliferation, and Apoptosis Potential via the Extracellular Signal-Regulated Kinases 1 and 2 Signaling Pathway. Journal of Agricultural and Food Chemistry 65:51, pages 11280-11291.
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Sergey M Lunin, Maxim O Khrenov, Olga V Glushkova, Elena V Vinogradova, Valery A Yashin, Evgeny E Fesenko & Elena G Novoselova. (2017) Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosis. International Journal of Immunopathology and Pharmacology 30:1, pages 58-69.
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Fang Liu, Hong-Mei Wang, Tiansheng Wang, Ya-Mei Zhang & Xi Zhu. (2016) The efficacy of thymosin α1 as immunomodulatory treatment for sepsis: a systematic review of randomized controlled trials. BMC Infectious Diseases 16:1.
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Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Tatyana V. Novoselova, Svetlana B. Parfenyuk & Evgeny E. Fesenko. (2016) Signaling, stress response and apoptosis in pre-diabetes and diabetes: restoring immune balance in mice with alloxan-induced type 1 diabetes mellitus. International Immunopharmacology 31, pages 24-31.
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I.F. Labunets, S.A. Talanov, R.G. Vasilyev, A.E. Rodnichenko, N.A. Utko, I.A. Kyzminova, B.S. Kopjak, E.V. Podjachenko, V.F. Sagach & G.M. Butenko. (2015) THYMIC HORMONES, ANTIOXIDANT ENZYMES AND NEUROGENESIS OF BULBUS OLFACTORIUS IN RATS WITH PARKINSONISM: THE EFFECT OF MELATONIN. Fiziolohichnyĭ zhurnal 61:5, pages 35-45.
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S.M. Lunin, M.O. Khrenov, T.V. Novoselova, S.B. Parfenyuk, O.V. Glushkova, E.E. Fesenko & E.G. Novoselova. (2015) Modulation of inflammatory response in mice with severe autoimmune disease by thymic peptide thymulin and an inhibitor of NF-kappaB signalling. International Immunopharmacology 25:2, pages 260-266.
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Fabiana Rodrigues de Santana, Cidéli de Paula Coelho, Thayná Neves Cardoso, Márcia Dalastra Laurenti, Elizabeth Cristina Perez Hurtado & Leoni Villano Bonamin. (2014) Modulation of inflammation response to murine cutaneous Leishmaniosis by homeopathic medicines: Thymulin 5cH. Homeopathy 103:4, pages 275-284.
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FIORENZO MIGNINI, MAURIZIO SABBATINI, LAURA MATTIOLI, MONICA COSENZA, MARCO ARTICO & CARLO CAVALLOTTI. (2014) Neuro-immune modulation of the thymus microenvironment (Review). International Journal of Molecular Medicine 33:6, pages 1392-1400.
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I. F. Labunets. (2014) The peculiarities of age-related changes in the cellular composition of bone marrow, pineal melatonin-forming function, and thymus endocrine function in mice of different strains. Advances in Gerontology 4:2, pages 134-139.
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E. G. Novoselova, M. O. Khrenov, O. V. Glushkova, S. M. Lunin, S. B. Parfenyuk, T. V. Novoselova & E. E. Fesenko. (2014) Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice. Mediators of Inflammation 2014, pages 1-10.
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S.M. Lunin, O.V. Glushkova, M.O. Khrenov, T.V. Novoselova, S.B. Parfenyuk, E.E. Fesenko & E.G. Novoselova. (2013) Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis. Immunobiology 218:3, pages 402-407.
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