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Targeting YAP and Hippo signaling pathway in liver cancer

, MA, , MD PhD, , MD PhD, , MD PhD FACS & , DMedSc
Pages 855-868 | Published online: 14 Jun 2010

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Jianlin Wang, Haimin Li, Congcong Xia, Xisheng Yang, Bin Dai, Kaishan Tao & Kefeng Dou. (2019) Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1. OncoTargets and Therapy 12, pages 869-882.
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Xiaofei Xu, Yan Chen, Xi Wang & Xingguo Mu. (2019) Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis. Cancer Management and Research 11, pages 7577-7585.
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Jia Zhao, Xiangnan Li, Yang Yang, Dengyan Zhu, Chunyang Zhang, Donglei Liu, Kai Wu & Song Zhao. (2016) Effect of YAP1 silencing on esophageal cancer. OncoTargets and Therapy 9, pages 3137-3146.
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Angela M Liu, Zhi Xu & John M Luk. (2012) An update on targeting Hippo-YAP signaling in liver cancer. Expert Opinion on Therapeutic Targets 16:3, pages 243-247.
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Articles from other publishers (72)

Xiaomin Li, Qing Liu, Songyu Xie, Xiaoping Wu & Junsheng Fu. (2023) Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway. Food Science and Human Wellness, pages 1-21.
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Jiayao Feng, Shuting Qiu, Shipeng Zhou, Yue Tan, Yan Bai, Hua Cao, Jiao Guo & Zhengquan Su. (2022) mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences 23:16, pages 9196.
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Aijia Zhang, Weilong Wang, Zhijun Chen, Dan Pang, Xiaofeng Zhou, Kui Lu, Jinghan Hou, Sujie Wang, Can Gao, Benjie Lv, Ziyi Yan, Zhen Chen, Jian Zhu, Lidong Wang, Ting Zhuang & Xiumin Li. (2020) SHARPIN Inhibits Esophageal Squamous Cell Carcinoma Progression by Modulating Hippo Signaling. Neoplasia 22:2, pages 76-85.
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Jing Wang, Tiefang Song, Suiyang Zhou & Xianchao Kong. (2019) YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11. Molecular Medicine 25:1.
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Chun Chen, Zhe Yang & Zan-Song Huang. (2019) Progress in research on association between cell signal transduction pathways and hepatocellular carcinoma. World Chinese Journal of Digestology 27:21, pages 1330-1338.
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Eman AE. Badr, Ibrahim El Tantawy El Sayed, Mohamed FA. Assar, Sahar AM. Ali & Nehal S. Ibrahim. (2019) A pilot study of Livin gene and Yes-associated protein 1 expression in hepatocellular carcinoma patients. Heliyon 5:11, pages e02798.
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Cong Ye, Yubo Hu, Junrong Wang, Dahai Liu & Jianshi Du. (2019) Mono (2-ethylhexyl) phthalate (MEHP) triggers the proliferation of hemangioma-derived endothelial cells via YAP signals. Chemico-Biological Interactions 311, pages 108773.
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Panpan An, Jiexin Li, Linlin Lu, Yingmin Wu, Yuyi Ling, Jun Du, Zhuojia Chen & Hongsheng Wang. (2019) Histone deacetylase 8 triggers the migration of triple negative breast cancer cells via regulation of YAP signals. European Journal of Pharmacology 845, pages 16-23.
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Chun Feng, Yuxiao Li, Yan Lin, Xianbao Cao, Dongdong Li, Honglei Zhang & Xiaoguang He. (2018) CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer. International Journal of Molecular Medicine.
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Hang-Lung Chang, Hsin-An Chen, Oluwaseun Adebayo Bamodu, Kwai-Fong Lee, Yew-Min Tzeng, Wei-Hwa Lee & Jo-Ting Tsai. (2018) Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. Toxicology in Vitro 51, pages 74-82.
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Yu Fang, Chun Liu, Bo Shu, Mimi Zhai, Chaolin Deng, Chao He, Ming Luo, Tong Han, Wei Zheng, Jingyao Zhang & Sushun Liu. (2018) Axis of serotonin -pERK-YAP in liver regeneration. Life Sciences 209, pages 490-497.
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Zhize Chen, Jingjing Xu, Yang Wu, Shaoqing Lei, Huimin Liu, Qingtao Meng & Zhongyuan Xia. (2018) Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma. Biochemical and Biophysical Research Communications 503:3, pages 1181-1185.
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Zhenhai Fan, Hongwei Xia, Huanji Xu, Ji Ma, Sheng Zhou, Wanting Hou, Qiulin Tang, Qiyong Gong, Yongzhan Nie & Feng Bi. (2018) Standard CD44 modulates YAP1 through a positive feedback loop in hepatocellular carcinoma. Biomedicine & Pharmacotherapy 103, pages 147-156.
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Han-Byul Kim & Seung-Jae Myung. (2018) Clinical implications of the Hippo-YAP pathway in multiple cancer contexts. BMB Reports 51:3, pages 119-125.
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Chunlin Ou, Zhenqiang Sun, Shen Li, Guiyuan Li, Xiayu Li & Jian Ma. (2017) Dual roles of yes-associated protein (YAP) in colorectal cancer. Oncotarget 8:43, pages 75727-75741.
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Liang Shan, Hongyuan Jiang, Lifang Ma & Yongchun Yu. (2017) Yes-associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma. Oncology Letters 14:3, pages 3291-3296.
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Lijuan Song, Hongbo Tang, Wenjing Liao, Xinggu Luo, Yanmei Li, Tao Chen & Xiaowen Zhang. (2017) FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma. Experimental Cell Research 357:1, pages 17-24.
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Ting‐Huan Chen, Chen‐Yu Chen, Hui‐Chin Wen, Chia‐Chu Chang, Horng‐Dar Wang, Chih‐Pin Chuu & Chung‐Ho Chang. (2017) YAP promotes myogenic differentiation via the MEK5‐ERK5 pathway. The FASEB Journal 31:7, pages 2963-2972.
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Xiao-Yang Dai, Lin-Han Zhuang, Dan-Dan Wang, Tian-Yi Zhou, Lin-Lin Chang, Ren-Hua Gai, Di-Feng Zhu, Bo Yang, Hong Zhu & Qiao-Jun He. (2016) Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget 7:6, pages 6933-6947.
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Cameron L. Noland, Sarah Gierke, Paul D. Schnier, Jeremy Murray, Wendy N. Sandoval, Meredith Sagolla, Anwesha Dey, Rami N. Hannoush, Wayne J. Fairbrother & Christian N. Cunningham. (2016) Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling. Structure 24:1, pages 179-186.
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Chang-Jiang Lei, Lei Li, Xia Gao, Jun Zhang, Qing-Yun Pan, Hao-Cheng Long, Chun-Zhou Chen, De-Fa Ren & Gang Zheng. (2015) Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP. Cell Biochemistry and Function 33:5, pages 326-333.
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