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Expert Opinion on Therapeutic Targets Volume 14, 2010 - Issue 10
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Original Research

Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions

Md. Shenuarin Bhuiyan Tohoku University, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan +81 22 795 6837; +81 22 795 6835; [email protected]
,
Hideaki Tagashira Tohoku University, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan +81 22 795 6837; +81 22 795 6835; [email protected]
,
Norifumi Shioda Tohoku University, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan +81 22 795 6837; +81 22 795 6835; [email protected]
&
Kohji Fukunaga Tohoku University, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan +81 22 795 6837; +81 22 795 6835; [email protected]
Pages 1009-1022 | Published online: 19 Aug 2010

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Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang & Bo Yang. (2022) Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension. Bioengineered 13:4, pages 10843-10856.
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Colin G. Rousseaux & Stephanie F. Greene. (2016) Sigma receptors [σRs]: biology in normal and diseased states. Journal of Receptors and Signal Transduction 36:4, pages 327-388.
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Teruo Hayashi, Shang-Yi Tsai, Tomohisa Mori, Michiko Fujimoto & Tsung-Ping Su. (2011) Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders. Expert Opinion on Therapeutic Targets 15:5, pages 557-577.
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Md. Shenuarin Bhuiyan & Kohji Fukunaga. (2011) Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection. Expert Opinion on Therapeutic Targets 15:2, pages 145-155.
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Articles from other publishers (43)

Taylor S. Robinson & Mahasin A. Osman. (2023) An Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer. Cancers 15:13, pages 3464.
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Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Sadia S. Nitu, James Traylor, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, A. Wayne Orr & Md. Shenuarin Bhuiyan. (2023) Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels. Frontiers in Physiology 14.
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Francisco Javier Munguia-Galaviz, Alejandra Guillermina Miranda-Diaz, Miguel Alejandro Cardenas-Sosa & Raquel Echavarria. (2023) Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases. International Journal of Molecular Sciences 24:3, pages 1997.
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Jiahao Zhao, Junli Li, Guoyong Li & Mao Chen. (2022) The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases. Frontiers in Cardiovascular Medicine 9.
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Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li & Kai Yao. (2022) Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms. International Journal of Molecular Sciences 23:14, pages 7572.
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Yiran E. Li, James R. Sowers, Claudio Hetz & Jun Ren. (2022) Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases. Cell Death & Disease 13:5.
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Fiona Thoi, Daniel J. Scherer, David M. Kaye, Prashanthan Sanders & Michael B. Stokes. (2022) Methamphetamine-Associated Cardiomyopathy: Addressing the Clinical Challenges. Heart, Lung and Circulation 31:5, pages 616-622.
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Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Naznin Sultana Remex, Mahboob Morshed, Sadia Nitu, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, James Traylor, Christopher G. Kevil, A. Wayne Orr & Md. Shenuarin Bhuiyan. (2022) The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes. Mitochondrion 62, pages 159-175.
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Richa Aishwarya, Chowdhury S. Abdullah, Naznin S. Remex, Shafiul Alam, Mahboob Morshed, Sadia Nitu, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, A. Wayne Orr, Christopher G. Kevil & Md. Shenuarin Bhuiyan. (2022) Molecular Characterization of Skeletal Muscle Dysfunction in Sigma 1 Receptor (Sigmar1) Knockout Mice. The American Journal of Pathology 192:1, pages 160-177.
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Barinderjit KaurMuthuraman A.Surya P Gautam. (2021) Sigma Receptors Ligands: New insights into the Cardioprotective Potential. Research Journal of Pharmacy and Technology, pages 6753-6760.
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Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa & Seigo Kinuya. (2021) Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging. Circulation Journal 85:11, pages 2102-2108.
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Lixia Lou, Chunhong Li, Jie Wang, Aiming Wu, Ting Zhang, Zhe Ma, Limin Chai, Dongmei Zhang, Yizhou Zhao, Bo Nie, Qiushuo Jin, Huiyang Chen & Wei Liu. (2021) Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine 22:5.
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Yingchao Gong, Jun Lin, Zetao Ma, Mei Yu, Meihui Wang, Dongwu Lai & Guosheng Fu. (2021) Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure. Life Sciences 278, pages 119511.
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Richa Aishwarya, Chowdhury S. Abdullah, Mahboob Morshed, Naznin Sultana Remex & Md. Shenuarin Bhuiyan. (2021) Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology. Frontiers in Physiology 12.
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S. A. Kryzhanovskii, I. A. Miroshkina & E. O. Ionova. (2021) Role of Sigma-1 Receptors in the Regulation of Heart Function: II. Cardioprotective Role of Sigma-1 Receptors. Human Physiology 47:4, pages 478-487.
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Jing Qu, Miaoling Li, Dongxu Li, Yanguo Xin, Junli Li, Song Lei, Wenchao Wu & Xiaojing Liu. (2021) Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment. Oxidative Medicine and Cellular Longevity 2021, pages 1-25.
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Yuhong Fo, Cui Zhang, Xiuhuan Chen, Xin Liu, Tianxin Ye, Yan Guo, Chuan Qu, Shaobo Shi & Bo Yang. (2020) Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility to ventricular arrhythmias after myocardial infarction in rats. European Journal of Pharmacology 889, pages 173614.
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Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Mahboob Morshed, Naznin Sultana Remex, Sadia Nitu, Gopi K. Kolluru, James Traylor, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Sunitha Chandran, Matthew D. Woolard, Xiuping Yu, Nicholas E. Goeders, Paari Dominic, Connie L. Arnold, Karen Stokes, Christopher G. Kevil, A. Wayne Orr & Md. Shenuarin Bhuiyan. (2020) Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function. Communications Biology 3:1.
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Zeinab Y. Motawe, Salma S. Abdelmaboud, Javier Cuevas & Jerome W. Breslin. (2020) PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation. The International Journal of Biochemistry & Cell Biology 126, pages 105803.
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Alejandro Silva-Palacios, Cecilia Zazueta & José Pedraza-Chaverri. (2020) ER membranes associated with mitochondria: Possible therapeutic targets in heart-associated diseases. Pharmacological Research 156, pages 104758.
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Rebecca Lewis, Jiaqi Li, Peter J McCormick, Christopher L-H Huang & Kamalan Jeevaratnam. (2020) Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review. IJC Heart & Vasculature 26, pages 100449.
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Xin Liu, Chuan Qu, Shaobo Shi, Tianxin Ye, Linglin Wang, Steven Liu, Cui Zhang, Jinjun Liang, Dan Hu & Bo Yang. (2019) The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism. Frontiers in Physiology 10.
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I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, S. A. Kryzhanovskii & S. B. Seredenin. (2019) Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. Bulletin of Experimental Biology and Medicine 167:5, pages 634-636.
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Jacob Horsager, Tatyana D. Fedorova, Nathalie V.D. Berge, Mette W. Klinge, Karoline Knudsen, Allan K. Hansen, Aage K.O. Alstrup, Klaus Krogh, Lars Gormsen & Per Borghammer. (2019) Cardiac 11 C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation . Journal of Cardiovascular Pharmacology and Therapeutics 24:4, pages 365-370.
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Nancy Paniagua, Carlos Goicoechea, Raquel Abalo, Visitacion López‐Miranda, J. Miguel Vela, Manuel Merlos, María Isabel Martín Fontelles & Rocio Girón. (2018) May a sigma‐1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?. European Journal of Pain.
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Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Mohammad Alfrad Nobel Bhuiyan, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Hanna Osinska, Jeffrey Robbins, John N. Lorenz & Md. Shenuarin Bhuiyan. (2018) Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics. Journal of the American Heart Association 7:20.
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Shafiul AlamChowdhury S. AbdullahRicha AishwaryaA. Wayne OrrJames TraylorSumitra MiriyalaManikandan PanchatcharamChristopher B. PattilloMd. Shenuarin Bhuiyan. (2017) Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Bioscience Reports 37:4.
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Qinxue Bao, Mingyue Zhao, Li Chen, Yu Wang, Siyuan Wu, Wenchao Wu & Xiaojing Liu. (2017) MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor. Life Sciences 175, pages 1-10.
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Kohji Fukunaga & Shigeki Moriguchi. 2017. Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Sigma Receptors: Their Role in Disease and as Therapeutic Targets 201 211 .
N. Paniagua, R. Girón, C. Goicoechea, V. López-Miranda, J.M. Vela, M. Merlos & M.I. Martín Fontelles. (2017) Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats. European Journal of Pain 21:1, pages 61-72.
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Yasuharu Shinoda, Hideaki Tagashira, Md. Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Chen Zhang, Feng Han & Kohji Fukunaga. (2016) Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression. PLOS ONE 11:10, pages e0163992.
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Yasuharu Shinoda, Hideaki Tagashira, Md. Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai & Kohji Fukunaga. (2016) Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction. Journal of Pharmacological Sciences 131:3, pages 172-183.
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Tibor Stracina, Iva Slaninova, Hana Polanska, Martina Axmanova, Veronika Olejnickova, Petr Konecny, Michal Masarik, Olga Krizanova & Marie Novakova. (2015) Long-Term Haloperidol Treatment Prolongs QT Interval and Increases Expression of Sigma 1 and IP<sub>3</sub> Receptors in Guinea Pig Hearts. The Tohoku Journal of Experimental Medicine 236:3, pages 199-207.
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Kohga Hirano, Hideaki Tagashira & Kohji Fukunaga. (2014) Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503選択的Sigma-1受容体アゴニストSA4503の心筋保護作用. YAKUGAKU ZASSHI 134:6, pages 707-713.
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Hideaki Tagashira, Md. Shenuarin Bhuiyan, Norifumi Shioda & Kohji Fukunaga. (2014) Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through σ1-receptor in hypertrophic cardiomyocytes. Life Sciences 95:2, pages 89-100.
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Hideaki TagashiraMd. Shenuarin Bhuiyan & Kohji Fukunaga. (2013) Diverse regulation of IP 3 and ryanodine receptors by pentazocine through σ 1 -receptor in cardiomyocytes . American Journal of Physiology-Heart and Circulatory Physiology 305:8, pages H1201-H1212.
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Hideaki Tagashira, Chen Zhang, Ying-mei Lu, Hideyuki Hasegawa, Hiroshi Kanai, Feng Han & Kohji Fukunaga. (2013) Stimulation of σ1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:4, pages 3082-3094.
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Md. Shenuarin Bhuiyan, Hideaki Tagashira & Kohji Fukunaga. (2013) Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure. Journal of Pharmacological Sciences, pages 177-184.
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Hideaki Tagashira, Takayuki Matsumoto, Kumiko Taguchi, Chen Zhang, Feng Han, Keiko Ishida, Shingo Nemoto, Tsuneo Kobayashi & Kohji Fukunaga. (2013) Vascular Endothelial σ<sub>1</sub>-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding. Circulation Journal 77:11, pages 2831-2840.
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Kenji Hashimoto. (2013) Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression. Progress in Neurobiology 100, pages 15-29.
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Hideaki Tagashira & Kohji Fukunaga. (2012) Cardioprotective Effect of Fluvoxamine, Sigma-1 Receptor High Affinity AgonistSigma-1受容体アゴニストであるfluvoxamineの心筋保護作用. YAKUGAKU ZASSHI 132:2, pages 167-172.
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Hideaki Tagashira, Shenuarin Bhuiyan, Norifumi Shioda & Kohji Fukunaga. (2011) Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload–induced hypertrophy in ovariectomized female rats. Menopause 18:12, pages 1317-1326.
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Wei Wang, Jinquan Cui, Xiaoxia Lu, Prashanth K. Padakanti, Jinbin Xu, Stanley M. Parsons, Robert R. Luedtke, Nigam P. Rath & Zhude Tu. (2011) Synthesis and in Vitro Biological Evaluation of Carbonyl Group-Containing Analogues for σ 1 Receptors . Journal of Medicinal Chemistry 54:15, pages 5362-5372.
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