814
Views
66
CrossRef citations to date
0
Altmetric
Reviews

Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages

, &
Pages 505-518 | Published online: 01 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Pei Shang, Ying Zhang, Di Ma, Yulei Hao, Xinyu Wang, Meiying Xin, Yunhai Zhang, Mingqin Zhu & Jiachun Feng. (2019) Inflammation resolution and specialized pro-resolving lipid mediators in CNS diseases. Expert Opinion on Therapeutic Targets 23:11, pages 967-986.
Read now

Articles from other publishers (65)

Cheryl Yi‐Pin Lee, Wai Hon Chooi, Shi‐Yan Ng & Sing Yian Chew. (2022) Modulating neuroinflammation through molecular, cellular and biomaterial‐based approaches to treat spinal cord injury. Bioengineering & Translational Medicine 8:2.
Crossref
Jie Ren, Bin Zhu, Guangjin Gu, Wencan Zhang, Junjin Li, Hongda Wang, Min Wang, Xiaomeng Song, Zhijian Wei & Shiqing Feng. (2023) Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury. Cell Death & Disease 14:1.
Crossref
Cinzia Stigliano, Allison Frazier & Philip J Horner. (2022) Modulation of Neuroinflammation via Selective Nanoparticle‐Mediated Drug Delivery to Activated Microglia/Macrophages in Spinal Cord Injury. Advanced Therapeutics 5:11, pages 2200083.
Crossref
Valerie A. Dietz, Nolan Roberts, Katelyn Knox, Sherilynne Moore, Michael Pitonak, Chris Barr, Jesus Centeno, Scott Leininger, Kent C. New, Peter Nowell, Matthew Rodreick, Cedric G. Geoffroy, Argyrios Stampas & Jennifer N. Dulin. (2022) Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury. Frontiers in Cellular Neuroscience 16.
Crossref
Veronica EstradaEllen OldenburgOvidiu PopaHans Werner Müller. (2022) Mapping the Long Rocky Road to Effective Spinal Cord Injury Therapy: A Meta-Review of Pre-Clinical and Clinical Research. Journal of Neurotrauma 39:9-10, pages 591-612.
Crossref
Hui Chen, Zhou Feng, Lingxia Min, Weiwei Deng, Mingliang Tan, Jian Hong, Qiuwen Gong, Dongyun Zhang, Hongliang Liu & Jingming Hou. (2022) Vagus Nerve Stimulation Reduces Neuroinflammation Through Microglia Polarization Regulation to Improve Functional Recovery After Spinal Cord Injury. Frontiers in Neuroscience 16.
Crossref
Seyed Mohammad Piri, Zahra Ghodsi, Sina Shool, Ali Anjomshoa, Amir Azarhomayoun, Ehsan Jangholi, Hamid Reza Dehghan, Rasha Atlasi, Alexander R. Vaccaro & Vafa Rahimi-Movaghar. (2021) Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review. European Spine Journal 30:6, pages 1474-1494.
Crossref
Takumi KajitaniToshiki EndoNaoya IwabuchiTomoo InoueYoshiharu TakahashiTakatsugu AbeKuniyasu Niizuma & Teiji Tominaga. (2021) Association of intravenous administration of human Muse cells with deficit amelioration in a rat model of spinal cord injury. Journal of Neurosurgery: Spine 34:4, pages 648-655.
Crossref
Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Åsa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlén & Elisabet Åkesson. (2020) Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy. Stem Cell Research & Therapy 11:1.
Crossref
Zhongyuan Liu, Xinqiang Yao, Wangsheng Jiang, Wei Li, Siyuan Zhu, Congrui Liao, Lin Zou, Ruoting Ding & Jianting Chen. (2020) Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury. Journal of Neuroinflammation 17:1.
Crossref
Ingo Spitzbarth, Sarah A. Moore, Veronika M. Stein, Jonathan M. Levine, Bianca Kühl, Ingo Gerhauser & Wolfgang Baumgärtner. (2020) Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury. Frontiers in Veterinary Science 7.
Crossref
Moosa Javdani & Abolfazl Barzegar-Bafrouei. (2020) The Key Role of Macrophages and Monocytes in Spinal Cord Injury: Development of Novel Therapeutic Approaches. The Neuroscience Journal of Shefaye Khatam 8:4, pages 90-102.
Crossref
Hadi Abou-El-Hassan, Shadi Bsat, Fares Sukhon, Edwyn Jeremy Assaf, Stefania Mondello, Firas Kobeissy, Kevin K. W. Wang, Howard L. Weiner & Ibrahim Omeis. (2020) Protein Degradome of Spinal Cord Injury: Biomarkers and Potential Therapeutic Targets. Molecular Neurobiology 57:6, pages 2702-2726.
Crossref
Eun-Ah Chang, Sung-Won Jin, Myung-Hyun Nam & Sang-Dae Kim. (2019) Human Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases. Journal of Korean Neurosurgical Society 62:5, pages 493-501.
Crossref
Soha J. ChhayaDaniel Quiros-MolinaAlessandra D. Tamashiro-OrregoJohn D. HouléMegan Ryan Detloff. (2019) Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury. Journal of Neurotrauma 36:6, pages 877-890.
Crossref
Dong Chen, Siyuan Hu, Jie Liu & Shaohua Li. (2019) E‑cadherin regulates biological behaviors of neural stem cells and promotes motor function recovery following spinal cord injury. Experimental and Therapeutic Medicine.
Crossref
Samantha L. Payne, Brian G. Ballios, M. Douglas Baumann, Michael J. Cooke & Molly S. Shoichet. 2019. Principles of Regenerative Medicine. Principles of Regenerative Medicine 1199 1221 .
Guodong Sun, Guangqiang Li, Dehai Li, Wanjun Huang, Renwen Zhang, Hua Zhang, Yuanyuan Duan & Baocheng Wang. (2018) hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation. Materials Science and Engineering: C 89, pages 194-204.
Crossref
Michael B. Orr & John C. Gensel. (2018) Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses. Neurotherapeutics 15:3, pages 541-553.
Crossref
Nicole Steffensen, Annika Lehmbecker, Ingo Gerhauser, Yimin Wang, Regina Carlson, Andrea Tipold, Wolfgang Baumgärtner & Veronika M. Stein. (2018) Generation and characterization of highly purified canine Schwann cells from spinal nerve dorsal roots as potential new candidates for transplantation strategies. Journal of Tissue Engineering and Regenerative Medicine 12:1, pages e422-e437.
Crossref
Michael B. OrrJennifer SimkinWilliam M. BaileyNeha S. KadambiAnna Leigh McVicarAmy K. VeldhorstJohn C. Gensel. (2017) Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury. Journal of Neurotrauma 34:15, pages 2342-2352.
Crossref
Sergey Kolesov, Andrey Panteleyev, Maxim Sazhnev & Arkadiy Kazmin. (2017) DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD. Coluna/Columna 16:2, pages 145-148.
Crossref
Woon Ryoung Kim, Minjin Kang, Heejoo Park, Hyun-Joo Ham, Hyunji Lee & Dongho Geum. (2017) Functional Test Scales for Evaluating Cell-Based Therapies in Animal Models of Spinal Cord Injury. Stem Cells International 2017, pages 1-12.
Crossref
S. V Kolesov, A. A Panteleev, M. L Sazhnev & A. I Kaz’min. (2016) Elaboration of New Treatment Methods for Spinal Cord Injuries Using Magnetic Nanoparticles in Combination with Electromagnetic Field (Experimental Study). N.N. Priorov Journal of Traumatology and Orthopedics 23:4, pages 55-60.
Crossref
Faith H. Brennan, Nyoman D. Kurniawan, Jana Vukovic, Perry F. Bartlett, Fabian Käsermann, Thiruma V. Arumugam, Milan Basta & Marc J. Ruitenberg. (2016) IVIg attenuates complement and improves spinal cord injury outcomes in mice. Annals of Clinical and Translational Neurology 3:7, pages 495-511.
Crossref
Shushi Kabu, Yue Gao, Brian K. Kwon & Vinod Labhasetwar. (2015) Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. Journal of Controlled Release 219, pages 141-154.
Crossref
Bei-Yu Chen, Min-Hua Zheng, Yan Chen, Yan-Ling Du, Xiao-Long Sun, Xing Zhang, Li Duan, Fang Gao, Liang Liang, Hong-Yan Qin, Zhuo-Jing Luo & Hua Han. (2014) Myeloid-Specific Blockade of Notch Signaling by RBP-J Knockout Attenuates Spinal Cord Injury Accompanied by Compromised Inflammation Response in Mice. Molecular Neurobiology 52:3, pages 1378-1390.
Crossref
John C. Gensel & Bei Zhang. (2015) Macrophage activation and its role in repair and pathology after spinal cord injury. Brain Research 1619, pages 1-11.
Crossref
Florentia Papastefanaki & Rebecca Matsas. (2015) From demyelination to remyelination : The road toward therapies for spinal cord injury . Glia 63:7, pages 1101-1125.
Crossref
. Experimental and Clinical Transplantation 13:3.
Crossref
Li-Xin Zhang, Yan-Mei Yin, Zhi-Qiang Zhang & Ling-Xiao Deng. (2014) Grafted Bone Marrow Stromal Cells. The Neuroscientist 21:3, pages 277-289.
Crossref
Tarun Saxena, Kristin H. Loomis, S. Balakrishna Pai, Lohitash Karumbaiah, Eric Gaupp, Ketki Patil, Radhika Patkar & Ravi V. Bellamkonda. (2015) Nanocarrier-Mediated Inhibition of Macrophage Migration Inhibitory Factor Attenuates Secondary Injury after Spinal Cord Injury. ACS Nano 9:2, pages 1492-1505.
Crossref
Barbara G. McMahill, Dori L. Borjesson, Maya Sieber-Blum, Jan A. Nolta & Beverly K. Sturges. (2014) Stem Cells in Canine Spinal Cord Injury – Promise for Regenerative Therapy in a Large Animal Model of Human Disease. Stem Cell Reviews and Reports 11:1, pages 180-193.
Crossref
Paul Z. Elias & Myron Spector. (2015) Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor. Journal of Tissue Engineering and Regenerative Medicine 9:2, pages 137-150.
Crossref
Jocie F. Cherry, Neal K. Bennett, Melitta Schachner & Prabhas V. Moghe. (2014) Engineered N-cadherin and L1 biomimetic substrates concertedly promote neuronal differentiation, neurite extension and neuroprotection of human neural stem cells. Acta Biomaterialia 10:10, pages 4113-4126.
Crossref
Ona Bloom. (2014) Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury. Experimental Neurology 258, pages 130-140.
Crossref
John C. Gensel. 2014. Neuroinflammation and CNS Disorders. Neuroinflammation and CNS Disorders 339 361 .
Barbara Gericota, Joseph S. Anderson, Gaela Mitchell, Dori L. Borjesson, Beverly K. Sturges, Jan A. Nolta & Maya Sieber-Blum. (2014) Canine Epidermal Neural Crest Stem Cells: Characterization and Potential as Therapy Candidate for a Large Animal Model of Spinal Cord Injury. Stem Cells Translational Medicine 3:3, pages 334-345.
Crossref
R. Vawda, M. Soubeyrand, J.A. Zuccato & M.G. Fehlings. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease 593 638 .
Billy Y.B. Lau, Stephanie M. Fogerson, Rylie B. Walsh & Jennifer R. Morgan. (2013) Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury. Experimental Neurology 250, pages 31-42.
Crossref
Faith H. Brennan, Gary J. Cowin, Nyoman D. Kurniawan & Marc J. Ruitenberg. (2013) Longitudinal assessment of white matter pathology in the injured mouse spinal cord through ultra-high field (16.4T) in vivo diffusion tensor imaging. NeuroImage 82, pages 574-585.
Crossref
Lars Olson. (2013) Combinatory treatments needed for spinal cord injury. Experimental Neurology 248, pages 309-315.
Crossref
Stuart I. Hodgetts, Paul J. Simmons & Giles W. Plant. (2013) A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin. Experimental Neurology 248, pages 343-359.
Crossref
Sarah A. Woller & Michelle A. Hook. (2013) Opioid administration following spinal cord injury: Implications for pain and locomotor recovery. Experimental Neurology 247, pages 328-341.
Crossref
Adam Stein, Arti Panjwani, Cristina Sison, Lisa Rosen, Radhika Chugh, Christine Metz, Matthew Bank & Ona Bloom. (2013) Pilot Study: Elevated Circulating Levels of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor in Patients With Chronic Spinal Cord Injury. Archives of Physical Medicine and Rehabilitation 94:8, pages 1498-1507.
Crossref
Chloe N. Vaughn, Julia L. Iafrate, Jessica B. Henley, Edward K. Stevenson, Igor G. Shlifer & T. Bucky Jones. (2013) Cellular Neuroinflammation in a Lateral Forceps Compression Model of Spinal Cord Injury. The Anatomical Record 296:8, pages 1229-1246.
Crossref
U Singh, Gita Handa & K B Sumalatha. (2013) Rehabilitation Medicine Implications of Stem Cell Therapy in Spinal Cord Injury–A Review. Indian Journal of Physical Medicine and Rehabilitation 24:1, pages 9-15.
Crossref
Linda V. Blomster, Gary J. Cowin, Nyoman D. Kurniawan & Marc J. Ruitenberg. (2013) Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI . NMR in Biomedicine 26:2, pages 141-150.
Crossref
Yi Ren & Wise Young. (2013) Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function. Neural Plasticity 2013, pages 1-9.
Crossref
Patricia Bock, Ingo Spitzbarth, Verena Haist, Veronika M. Stein, Andrea Tipold, Christina Puff, Andreas Beineke & Wolfgang Baumgärtner. (2012) Spatio‐Temporal Development of Axonopathy in Canine Intervertebral Disc Disease as a Translational Large Animal Model for Nonexperimental Spinal Cord Injury. Brain Pathology 23:1, pages 82-99.
Crossref
Matthew Light, Kenneth H Minor, Peter DeWitt, Kyle H Jasper & Stephen JA Davies. (2012) Multiplex array proteomics detects increased MMP-8 in CSF after spinal cord injury. Journal of Neuroinflammation 9:1.
Crossref
M.D. Schiller & R.J. Mobbs. (2012) The historical evolution of the management of spinal cord injury. Journal of Clinical Neuroscience 19:10, pages 1348-1353.
Crossref
Xuemei Jin, Hiroshi Ishii, Zhongbin Bai, Takahide Itokazu & Toshihide Yamashita. (2012) Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice. PLoS ONE 7:7, pages e41892.
Crossref
John C. Gensel & Phillip G. Popovich. 2012. Traumatic Brain and Spinal Cord Injury. Traumatic Brain and Spinal Cord Injury 272 279 .
. 2012. Traumatic Brain and Spinal Cord Injury. Traumatic Brain and Spinal Cord Injury 216 333 .
John C. Gensel, Kristina A. Kigerl, Shweta S. Mandrekar-Colucci, Andrew D. Gaudet & Phillip G. Popovich. (2012) Achieving CNS axon regeneration by manipulating convergent neuro-immune signaling. Cell and Tissue Research 349:1, pages 201-213.
Crossref
I. Spitzbarth, W. Baumgärtner & A. Beineke. (2012) The role of pro- and anti-inflammatory cytokines in the pathogenesis of spontaneous canine CNS diseases. Veterinary Immunology and Immunopathology 147:1-2, pages 6-24.
Crossref
Jared T. Wilcox, David Cadotte & Michael G. Fehlings. (2012) Spinal cord clinical trials and the role for bioengineering. Neuroscience Letters 519:2, pages 93-102.
Crossref
Kkot Nim Kang, Da Yeon Kim, So Mi Yoon, Ju Young Lee, Bit Na Lee, Jin Seon Kwon, Hyo Won Seo, Il Woo Lee, Ha Cheol Shin, Young Man Kim, Hyun Soo Kim, Jae Ho Kim, Byoung Hyun Min, Hai Bang Lee & Moon Suk Kim. (2012) Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells. Biomaterials 33:19, pages 4828-4835.
Crossref
Sarah A. WollerGeorgina L. MorenoNigel HartPaul J. WellmanJames W. GrauMichelle A. Hook. (2012) Analgesia or Addiction?: Implications for Morphine Use after Spinal Cord Injury. Journal of Neurotrauma 29:8, pages 1650-1662.
Crossref
R. Vawda, J. Wilcox & Michael G. Fehlings. (2012) Current stem cell treatments for spinal cord injury. Indian Journal of Orthopaedics 46:1, pages 10-18.
Crossref
F. Scholtes, G. Brook & D. Martin. 2012. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery 29 56 .
Larry I. Benowitz & Phillip G. Popovich. (2011) Inflammation and axon regeneration. Current Opinion in Neurology 24:6, pages 577-583.
Crossref
Michael G. Fehlings & Reaz Vawda. (2011) Cellular Treatments for Spinal Cord Injury: The Time is Right for Clinical Trials. Neurotherapeutics 8:4, pages 704-720.
Crossref
Frédéric Bretzner, Frédéric Gilbert, Françoise Baylis & Robert M. Brownstone. (2011) Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury. Cell Stem Cell 8:5, pages 468-475.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.