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Hitting a complex target: an update on interleukin-6 trans-signalling

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Pages 225-236 | Published online: 13 Feb 2012

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Michael Maes, George Anderson, Marta Kubera & Michael Berk. (2014) Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?. Expert Opinion on Therapeutic Targets 18:5, pages 495-512.
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Shili Xu & Nouri Neamati. (2013) gp130: a promising drug target for cancer therapy. Expert Opinion on Therapeutic Targets 17:11, pages 1303-1328.
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Jil-Madeline Homeier, Katrin Bundkirchen, Marcel Winkelmann, Tilman Graulich, Borna Relja, Claudia Neunaber & Christian Macke. (2021) Selective Inhibition of IL-6 Trans-Signaling Has No Beneficial Effect on the Posttraumatic Cytokine Release after Multiple Trauma in Mice. Life 11:11, pages 1252.
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Andrew N. Wilkinson, Karshing ChangRachel D. KunsAndrea S. Henden, Simone A. MinnieKathleen S. EnsbeyAndrew D. CloustonPing Zhang, Motoko KoyamaJuan Hidalgo, Stefan Rose-John, Antiopi Varelias, Slavica VuckovicKate H. Gartlan & Geoffrey R. Hill. (2019) IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling. Blood 134:23, pages 2092-2106.
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T. A. Lisitsyna, D. Yu. Veltishchev, A. M. Lila & E. L. Nasonov. (2019) Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders. Rheumatology Science and Practice 57:3, pages 318-327.
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K Aden, A Breuer, A Rehman, H Geese, F Tran, J Sommer, G H Waetzig, T M Reinheimer, S Schreiber, S Rose-John, J Scheller & P Rosenstiel. (2016) Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair. Oncogenesis 5:11, pages e270-e270.
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